Upper Extremity ProblemNCT07026084
Effects of Biofeedback-Guided Training on Muscle Strength and Postural Alignment in Upper Cross Syndrome.
A study testing Bio feedback training and conventional exercise program in people with Upper Extremity Problem and Muscle Weakness, run by Riphah International University at 1 site in Pakistan.
Trial summary
This randomized controlled trial investigates the effects of biofeedback-guided training versus conventional therapy on muscle strength and postural alignment in patients with Upper Cross Syndrome. Read more about this study
- Who is it for?
- Ages 25 to 45 years
- Conditions the study is for
- Upper Extremity Problem, Muscle Weakness, Postural Kyphosis
- What is being tested?
- Bio feedback training and conventional exercise program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 56 participants
- Where
- 1 sitePakistan
- Study dates
- 11 Aug 2025to 1 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 25 to 45 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- • Adults aged 25-45 years with both genders.
- Individuals meeting the following diagnostic criteria for upper cross syndrome will be included:
- Reduced strength of deep cervical flexors = unable to maintain pressure beyond 22-24 mm Hg (assessed via cranio-cervical flexion test).
- Limited cervical range of motion (Flexion: < 80 degrees, Extension: < 70 degrees, Rotation: < 90 degrees on both sides, Lateral Flexion: < 20 degrees)
- Postural deviations: forward head posture (CVA <50 degrees), increased thoracic kyphosis (via flexi curve >45 degrees).
- Neck pain with a duration of over 3 months
Who cannot join
- • History of recent neck surgery or injury.
- Patients with neurological disorders affecting muscle tone.
- Involvement in other physical therapy programs focused on UCS.
- Diagnosed musculoskeletal condition that could impact muscle performance.
Trial locations and contacts
1 site in 1 country.
About this study
This randomized controlled trial investigates the effects of biofeedback-guided training versus conventional therapy on muscle strength and postural alignment in patients with Upper Cross Syndrome. The study includes adults aged 25-45 years meeting diagnostic criteria for UCS, such as weak deep cervical flexors, restricted cervical ROM, forward head posture, increased thoracic kyphosis, and chronic neck pain >3 months. Participants are divided into two groups: Group A biofeedback training and Group B conventional therapy, receiving 12 sessions over 4 weeks ,3sessions/week. Assessments are conducted at baseline, post-1st session, and weekly intervals using standardized measures.The study aims to compare the efficacy of biofeedback-guided training in improving strength and posture in UCS patients.
Read the detailed description
Prolonged sitting and repetitive movements, common in desk jobs, poor ergonomics, and sedentary lifestyles, can lead to poor posture, discomfort, pain, and muscle or joint disability. A frequent result of poor posture is Upper Cross Syndrome, characterized by imbalances between upper body muscle groups. In Upper Cross Syndrome, overactive muscles like the pectoralis major, upper trapezius, and levator scapulae become tight, while the deep neck flexors, middle and lower trapezius, serratus anterior, and rhomboids weaken, disrupting movement patterns and increasing injury risk. Dr. Janda's 1988 model categorized muscles into postural (tonic) muscles, prone to tightness, and phasic muscles, prone to weakness. Upper cross Syndrome commonly causes neck, shoulder, and upper back pain, along with discomfort in the shoulder blades and neck stiffness.
Upper Cross Syndrome symptoms include neck, shoulder, and upper back pain, and can lead to forward head posture , increased thoracic kyphosis, and loss of cervical lordosis. Forward head posture, seen in 60% of individuals aged 20 to 50, causes neck strain, reduced mobility, and pain. With the rise of technology use, Upper cross syndrome has become more prevalent. Individuals often lean forward to view screens, exacerbating posture-related issues. Studies show Upper cross syndrome prevalence in IT professionals (67%), students (37.1%) and laundry workers (28%). Prevalence across different groups ranges from 11% to 60%. This condition leads to pain, discomfort, and reduced quality of life, prompting the need for effective treatment.
Effective manual therapy techniques for treating Upper Cross Syndrome aim to alleviate muscle tension, improve mobility, and correct postural imbalances. These include joint mobilization and manipulation, which restore normal motion and reduce pain, and soft tissue mobilization techniques like myofascial release and trigger point therapy that target tight muscles to enhance blood flow and reduce tension. Active Release Techniques identify and release muscle adhesions through specific movements and therapist-applied pressure, while transverse massage uses friction across muscle fibers to break down adhesions and promote healing. Post-Isometric Relaxation helps enhance flexibility and reduce tightness by contracting and stretching muscles, and neuro-mobilization addresses nerve entrapments commonly associated with Upper cross syndrome to alleviate pain.
A growing body of research has explored the effectiveness of various interventions for managing Upper cross syndrome, including manual therapy, and biofeedback-guided strength training. Karthi et al. found that motor control training of deep neck flexors using pressure biofeedback significantly reduced pain and disability, highlighting the efficacy of biofeedback in improving muscle activation and posture. Similarly, Ashfaq et al. demonstrated that cranio-cervical flexion training with biofeedback enhanced muscular endurance and reduced neck pain more effectively than conventional methods. These findings align with the clinical utility of biofeedback in correcting postural imbalances, a key feature of UCS. In addition, ART, which targets muscle adhesions and soft tissue dysfunction, has shown promise in improving range of motion and alleviating pain in UCS patients (Kang et al., 2016).Manual therapy techniques like joint mobilization and soft tissue manipulation are also effective in restoring normal movement patterns and reducing discomfort. Gumuscu et al. further supported these findings by showing that combining conventional program i.e. stabilization exercises with stretching and strengthening improved posture and respiratory function in office workers with forward head posture, suggesting that integrated approaches could enhance outcomes in Upper cross syndrome management.
Strength training has been widely used to correct Upper cross syndrome by targeting weak muscle groups, particularly DCFs. Studies have shown that resistance exercises can significantly improve posture and reduce associated pain by enhancing muscle endurance and correcting imbalances. However, conventional strength training lacks real-time feedback mechanisms, not providing neuromuscular control, potentially leading to compensatory movements and suboptimal outcomes.
- Conditions
- Upper Extremity Problem, Muscle Weakness, Postural Kyphosis
- Being tested
- Bio feedback training, conventional exercise program
- Keywords
- upper cross syndrome, forward head posture, young adults, bio feedback guided training, postural alignment
- Medical subject headings
- Muscle Weakness, Oculocerebral hypopigmentation syndrome type Preus
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Bio feedback trainingOther
Hot Pack: Applied for 10 minutes, mild warmth sensation to relax muscles and prepare for exercise.
- BPU (Biofeedback Pressure Unit): performed at 5 pressure levels (22, 24, 26, 28, 30 mmHg).
Each level involves a 10-second hold, with 30 seconds rest between levels.
Targeted muscles:
- Deep Cervical Flexors (Capitus Longus, Capitus Colli).
- Rhomboids
- Trapezius Total duration (BPU): 20 minutes/session, performed 3 times/week.
conventional exercise programOther
Hot Pack: Applied for 10 minutes, mild warmth sensation to relax muscles and prepare for exercise.
EXERCISE PROGRAM:
- 1. Supine: Neck curl with Chin Tucks (Deep Cervical Flexors Capitus Longus, Capitus Colli): 10 reps/session, holding each for 5 seconds.
- 2. Sitting: Chin tuck with Head pushing against palm.
- 3. Chin Up (Middle and Lower Trapezius): 10 reps/session, holding each for 5 seconds.
- 4. Scapular Squeezes (Rhomboids): 2-3 sets of 10 reps/session, holding each for 5 seconds• 5. Doorway Pectoral Stretch (pect major) 2-3 reps, 30 sec hold (36)Total duration: 20 minutes/session, performed 3 times/week.
| Study group | Role | What they receive |
|---|---|---|
| Experimental Group | Experimental | Biofeedback-Guided Strength Training:
Hot Pack: Applied for 10 minutes, mild warmth sensation to relax muscles and prepare for exercise.
1. BPU (Biofeedback Pressure Unit): performed at 5 pressure levels (22, 24, 26, 28, 30 mmHg).
Each level involves a 10-second hold, with 30 seconds rest between levels.
Targeted muscles:
* Deep Cervical Flexors (Capitus Longus, Capitus Colli).
* Rhomboids
* Trapezius Total duration (BPU): 20 minutes/session, performed 3 times/week. Receives: Other: Bio feedback training |
| Control Group | Active comparator | Conventional Therapy:
Hot Pack: Applied for 10 minutes, mild warmth sensation to relax muscles and prepare for exercise.
EXERCISE PROGRAM:
* 1. Supine: Neck curl with Chin Tucks (Deep Cervical Flexors Capitus Longus, Capitus Colli): 10 reps/session, holding each for 5 seconds.
* 2. Sitting: Chin tuck with Head pushing against palm.
* 3. Chin Up (Middle and Lower Trapezius): 10 reps/session, holding each for 5 seconds.
* 4. Scapular Squeezes (Rhomboids): 2-3 sets of 10 reps/session, holding each for 5 seconds
* 5. Doorway Pectoral Stretch (pect major) 2-3 reps, 30 sec hold (36) Total duration: 20 minutes/session, performed 3 times/week. Receives: Other: conventional exercise program |
What is being measured
The primary outcome is the main question the study is designed to answer.
cranio-cervical flexion test
craniocervical flexion test to measure strength and endurance of Deep cervical flexors. it ranges from 20 mm of hg to 30 mm of Hg based on increased strength
Measured: baseline to 4th week
Secondary outcomes (8)
NPRS
Pain is measured through NPRS scale. it has 11 level points from 0-10. where 0 indicate no pain and 10 indicate un-bearable pain
Measured: total of 5 measurements taken at baseline, at the end of 1st, 2nd , 3rd and 4th week
NECK DISABILITY INDEX
neck disability is measured through NDI. it has score from 0-50. where 0 indicate low disability and 50 indicate total disability
Measured: total of 5 measurements taken at baseline, at the end of 1st, 2nd , 3rd and 4th week
cervical Flexion
A goniometer is a reliable and valid tool for assessing joint angles. cervical flexion is mesaured when the chin tries to touch the chest. it ranges from o-40 degrees.
Measured: baseline to 4th week
cervical Extension
A goniometer is a reliable and valid tool for assessing joint angles. cervical extension is mesaured when the person tries to look up to the roof as max as he/she can go. it ranges from 0-70 degrees.
Measured: baseline to 4th week
cervical Rt rotation
A goniometer is a reliable and valid tool for assessing joint angles. cervical Rt rotation is measured when the person face tries to look to the right
Measured: baseline to 4th week
cervical Lt rotation
A goniometer is a reliable and valid tool for assessing joint angles. cervical Lt rotation is measured when the person face tries to look to the left. it ranges from 0-45 degrees
Measured: baseline to 4th week
cervical Lt flexion
A goniometer is a reliable and valid tool for assessing joint angles. cervical Lt flexion is measured when the lt ear tries to touch to the shoulder
Measured: baseline to 4th week
cervical Rt flexion
A goniometer is a reliable and valid tool for assessing joint angles. cervical Rt flexion is measured when the Rt ear tries to touch to the shoulder.
Measured: baseline to 4th week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Jun 2025
- Study start11 Aug 2025
- Primary completion1 Jan 2026
- Study completion1 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Upper Extremity ProblemStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- comparison based study on effects of bio feedback guided training and conventional exercise prorocol on muscle strength and postural training in upper cross syndrome
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 56 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Aisha Razzaq, PHD*, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07026084
- Sponsor's protocol ID
- Riphah IU Shizra Tayyab
- Status last verified
- Sep 2026
- First submitted
- 11 Jun 2025
- Last updated
- 10 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Biofeedback-Guided Training on Muscle Strength and Postural Alignment in Upper Cross Syndrome.
- ClinicalTrials.gov ID
- NCT07026084
- Acronym / sponsor ID
- Riphah IU Shizra Tayyab
- Conditions
- Upper Extremity Problem, Muscle Weakness, Postural Kyphosis
- Keywords
- upper cross syndrome, forward head posture, young adults, bio feedback guided training, postural alignment
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 56 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 11 Aug 2025 (actual)
- Primary completion
- 1 Jan 2026 (actual)
- Study completion
- 1 Jan 2026 (actual)
- First posted
- 18 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial investigates the effects of biofeedback-guided training versus conventional therapy on muscle strength and postural alignment in patients with Upper Cross Syndrome. The study includes adults aged 25-45 years meeting diagnostic criteria for UCS, such as weak deep cervical flexors, restricted cervical ROM, forward head posture, increased thoracic kyphosis, and chronic neck pain >3 months. Participants are divided into two groups: Group A biofeedback training and Group B conventional therapy, receiving 12 sessions over 4 weeks ,3sessions/week. Assessments are conducted at baseline, post-1st session, and weekly intervals using standardized measures.The study aims to compare the efficacy of biofeedback-guided training in improving strength and posture in UCS patients.
Detailed description
Prolonged sitting and repetitive movements, common in desk jobs, poor ergonomics, and sedentary lifestyles, can lead to poor posture, discomfort, pain, and muscle or joint disability. A frequent result of poor posture is Upper Cross Syndrome, characterized by imbalances between upper body muscle groups. In Upper Cross Syndrome, overactive muscles like the pectoralis major, upper trapezius, and levator scapulae become tight, while the deep neck flexors, middle and lower trapezius, serratus anterior, and rhomboids weaken, disrupting movement patterns and increasing injury risk. Dr. Janda's 1988 model categorized muscles into postural (tonic) muscles, prone to tightness, and phasic muscles, prone to weakness. Upper cross Syndrome commonly causes neck, shoulder, and upper back pain, along with discomfort in the shoulder blades and neck stiffness.
Upper Cross Syndrome symptoms include neck, shoulder, and upper back pain, and can lead to forward head posture , increased thoracic kyphosis, and loss of cervical lordosis. Forward head posture, seen in 60% of individuals aged 20 to 50, causes neck strain, reduced mobility, and pain. With the rise of technology use, Upper cross syndrome has become more prevalent. Individuals often lean forward to view screens, exacerbating posture-related issues. Studies show Upper cross syndrome prevalence in IT professionals (67%), students (37.1%) and laundry workers (28%). Prevalence across different groups ranges from 11% to 60%. This condition leads to pain, discomfort, and reduced quality of life, prompting the need for effective treatment.
Effective manual therapy techniques for treating Upper Cross Syndrome aim to alleviate muscle tension, improve mobility, and correct postural imbalances. These include joint mobilization and manipulation, which restore normal motion and reduce pain, and soft tissue mobilization techniques like myofascial release and trigger point therapy that target tight muscles to enhance blood flow and reduce tension. Active Release Techniques identify and release muscle adhesions through specific movements and therapist-applied pressure, while transverse massage uses friction across muscle fibers to break down adhesions and promote healing. Post-Isometric Relaxation helps enhance flexibility and reduce tightness by contracting and stretching muscles, and neuro-mobilization addresses nerve entrapments commonly associated with Upper cross syndrome to alleviate pain.
A growing body of research has explored the effectiveness of various interventions for managing Upper cross syndrome, including manual therapy, and biofeedback-guided strength training. Karthi et al. found that motor control training of deep neck flexors using pressure biofeedback significantly reduced pain and disability, highlighting the efficacy of biofeedback in improving muscle activation and posture. Similarly, Ashfaq et al. demonstrated that cranio-cervical flexion training with biofeedback enhanced muscular endurance and reduced neck pain more effectively than conventional methods. These findings align with the clinical utility of biofeedback in correcting postural imbalances, a key feature of UCS. In addition, ART, which targets muscle adhesions and soft tissue dysfunction, has shown promise in improving range of motion and alleviating pain in UCS patients (Kang et al., 2016).Manual therapy techniques like joint mobilization and soft tissue manipulation are also effective in restoring normal movement patterns and reducing discomfort. Gumuscu et al. further supported these findings by showing that combining conventional program i.e. stabilization exercises with stretching and strengthening improved posture and respiratory function in office workers with forward head posture, suggesting that integrated approaches could enhance outcomes in Upper cross syndrome management.
Strength training has been widely used to correct Upper cross syndrome by targeting weak muscle groups, particularly DCFs. Studies have shown that resistance exercises can significantly improve posture and reduce associated pain by enhancing muscle endurance and correcting imbalances. However, conventional strength training lacks real-time feedback mechanisms, not providing neuromuscular control, potentially leading to compensatory movements and suboptimal outcomes.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
- Model description
- comparison based study on effects of bio feedback guided training and conventional exercise prorocol on muscle strength and postural training in upper cross syndrome
| Arm | Type | Receives |
|---|---|---|
| Experimental Group | Experimental | Other: Bio feedback trainingBiofeedback-Guided Strength Training: Hot Pack: Applied for 10 minutes, mild warmth sensation to relax muscles and prepare for exercise. 1. BPU (Biofeedback Pressure Unit): performed at 5 pressure levels (22, 24, 26, 28, 30 mmHg). Each level involves a 10-second hold, with 30 seconds rest between levels. Targeted muscles: * Deep Cervical Flexors (Capitus Longus, Capitus Colli). * Rhomboids * Trapezius Total duration (BPU): 20 minutes/session, performed 3 times/week. |
| Control Group | Active comparator | Other: conventional exercise programConventional Therapy: Hot Pack: Applied for 10 minutes, mild warmth sensation to relax muscles and prepare for exercise. EXERCISE PROGRAM: * 1. Supine: Neck curl with Chin Tucks (Deep Cervical Flexors Capitus Longus, Capitus Colli): 10 reps/session, holding each for 5 seconds. * 2. Sitting: Chin tuck with Head pushing against palm. * 3. Chin Up (Middle and Lower Trapezius): 10 reps/session, holding each for 5 seconds. * 4. Scapular Squeezes (Rhomboids): 2-3 sets of 10 reps/session, holding each for 5 seconds * 5. Doorway Pectoral Stretch (pect major) 2-3 reps, 30 sec hold (36) Total duration: 20 minutes/session, performed 3 times/week. |
Who may qualify
- Ages
- 25 to 45 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- • Adults aged 25-45 years with both genders.
Key exclusion criteria (4 listed)
- • History of recent neck surgery or injury.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Bio feedback trainingHot Pack: Applied for 10 minutes, mild warmth sensation to relax muscles and prepare for exercise. 1. BPU (Biofeedback Pressure Unit): performed at 5 pressure levels (22, 24, 26, 28, 30 mmHg). Each level involves a 10-second hold, with 30 seconds rest between levels. Targeted muscles: * Deep Cervical Flexors (Capitus Longus, Capitus Colli). * Rhomboids * Trapezius Total duration (BPU): 20 minutes/session, performed 3 times/week. | Other | Experimental Group |
| conventional exercise programHot Pack: Applied for 10 minutes, mild warmth sensation to relax muscles and prepare for exercise. EXERCISE PROGRAM: * 1. Supine: Neck curl with Chin Tucks (Deep Cervical Flexors Capitus Longus, Capitus Colli): 10 reps/session, holding each for 5 seconds. * 2. Sitting: Chin tuck with Head pushing against palm. * 3. Chin Up (Middle and Lower Trapezius): 10 reps/session, holding each for 5 seconds. * 4. Scapular Squeezes (Rhomboids): 2-3 sets of 10 reps/session, holding each for 5 seconds• 5. Doorway Pectoral Stretch (pect major) 2-3 reps, 30 sec hold (36)Total duration: 20 minutes/session, performed 3 times/week. | Other | Control Group |
Primary outcome
cranio-cervical flexion test
Time frame: baseline to 4th week
craniocervical flexion test to measure strength and endurance of Deep cervical flexors. it ranges from 20 mm of hg to 30 mm of Hg based on increased strength
8 secondary outcomes
NPRS
Time frame: total of 5 measurements taken at baseline, at the end of 1st, 2nd , 3rd and 4th week
NECK DISABILITY INDEX
Time frame: total of 5 measurements taken at baseline, at the end of 1st, 2nd , 3rd and 4th week
cervical Flexion
Time frame: baseline to 4th week
cervical Extension
Time frame: baseline to 4th week
cervical Rt rotation
Time frame: baseline to 4th week
cervical Lt rotation
Time frame: baseline to 4th week
cervical Lt flexion
Time frame: baseline to 4th week
cervical Rt flexion
Time frame: baseline to 4th week
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Aisha Razzaq, PHD* principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Bio feedback training and conventional exercise program in people with Upper Extremity Problem and Muscle Weakness, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
cranio-cervical flexion test (time frame: baseline to 4th week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Sep 2026.