AgingNCT07027397
One Year of Velocity-based Resistance Training in Older People Living in Nursing Homes
A study testing Exercise in people with Aging and Muscle Mass and Strength, run by University of Castilla-La Mancha at 1 site in Spain.
Trial summary
This study is an exercise intervention assessing the efficacy of a velocity-based resistance training (VBRT) in institutionalized older adults. The aim of this study is to assess the effects of one year of velocity-based resistance training on skeletal muscle mass, muscle function, and physical and cognitive function… Read more about this study
- Who is it for?
- Ages 65 years and olderHealthy volunteers can take part
- Conditions the study is for
- Aging, Muscle Mass and Strength, Muscle Power
- What is being tested?
- Exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 27 participants
- Where
- 1 siteSpain
- Study dates
- 30 Sep 2024to 30 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- Healthy volunteers accepted
- Older adult
Who may be able to join
- Older people living permanently in nursing home.
- Age ≥ 65 years old.
- Are able to walk with/without assistance.
- Have ability to communicate with the research team.
Who cannot join
- Terminal illness.
- Any illness not controled (cardiac, pulmonary, etc).
- If there is a risk of bone fracture according to medical staff.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: One Year of Velocity-based Resistance Training in Older People Living in Nursing Homes: Effects on Skeletal Muscle Mass, Muscle Function, and Physical and Cognitive Function
This study is an exercise intervention assessing the efficacy of a velocity-based resistance training (VBRT) in institutionalized older adults.
The aim of this study is to assess the effects of one year of velocity-based resistance training on skeletal muscle mass, muscle function, and physical and cognitive function in older adults living in nursing homes.
Read the detailed description
Evidence supports the fact that resistance exercise training is effective in improving old adult's health and palliate age-related disorders. New approaches in resistance training are emerging to maximize monitoring control, providing more tailored and potentially more effective exercise interventions. Among them, the velocity-based resistance training (VBRT) is being established in healthy populations or populations with pathologies. However, the effects of long-term VBRT in institutionalized older adults are still unknown.
Thus, the aim of this study is to assess the effects of one year of velocity-based resistance training on skeletal muscle mass, muscle function, and physical and cognitive function in older adults living in nursing homes.
- Being tested
- Exercise
- Medical subject headings
- Frailty
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ExerciseOther
All participants will conduct a 2-day-a-week resistance training (RT) routine using the velocity-based method in the leg press exercise for one year. A tailored and constant intensity will be performed at 60% of the theoretical maximal isometric strength (F0) during the training intervention. Participants will conduct 3-4 sets, individualizing the repetitions numbers until they reach a velocity loss of 10-20%. A rest of 2 minutes was imposed between sets. A standardized warm-up will preced all RT session as follows: 4 minutes walking at usual gait speed and 6 minutes performing dynamic balance exercises.
| Study group | Role | What they receive |
|---|---|---|
| Exercise Group | Experimental | a 2-day-a-week resistance training (RT) routine using the velocity-based method in the leg press exercise at 60% of the theoretical maximal isometric strength Receives: Other: Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in muscle power
Muscle power assessed in leg press machine and sit to stand test.
Measured: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Changes in neuromuscular performance of lower-body
Change in the force-velocity relationship in leg press exercise.
Measured: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Secondary outcomes (6)
Change in physical function based on the Short Physical Performance Battery score
The Short Physical Performance Battery score ranges from 0 to 12 points. Higher scores indicate better physical function, while lower scores reflect poorer physical function.
Measured: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Change in frailty (score) using Fried's Frailty Criteria and Frailty Trait Scale - Short Form
Fried's frailty phenotype based on five criteria (habitual gait speed, handgrip strength , involuntary weight loss, exhaustion and low physical activity). The score ranges from 0 to 5, where each criterion met counts as one point. A score of 0 indicates best status, while a score of 5 indicates worst status.
Frailty Trait Scale - Short Form evaluates 5 domains, including body mass index, physical activity, static balance, habitual gait speed and handgrip strength. The score ranges from 0 to 50, where each criterion met counts as one point. A score of 0 indicates best status, while a score of 50 indicates worst status.
Measured: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Change in muscle mass using ultrasonography.
Muscle Cross-sectional area quadriceps femoris were assessed using ultrasonography.
Measured: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Change in disability using Barthel and Lawton scales
The Lawton scale assesses the ability to use the telephone, shopping, cooking, household duties, laundry, use of transportation, responsibility for their medication and handling of economic matters. Each item is assigned a numerical value (1 = independent, 0 = dependent), therefore, the maximum dependence would be marked by obtaining 0 points (worst) and total independence by obtaining 8 points (best).
The Barthel index is a 10-item questionnaire that provides information about the autonomy to cook food, wash, dress, groom, perform bowel movements and urination, go to the toilet, move from the bed to the chair, walk and climb stair.The total score ranges from 0 to 100, with higher scores indicating greater independence (best), and lower scores indicating higher levels of dependence in basic daily activities (worst).
Measured: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Change in cognitive function using Mini-Mental State Examination
Mini-Mental State Examination score ranges from 0 to 30 points. A higher score indicates better cognitive function, while a lower score reflects greater cognitive impairment.
Measured: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Change in handgrip strength
Change in maximum voluntary isometric handgrip strength, measured using a digital dynamometer.
Measured: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Jun 2025
- Study start30 Sep 2024
- Primary completion30 Jan 2026
- Study completion30 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for AgingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 27 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Castilla-La Mancha
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Julián Alcázar Caminero, University of Castilla-La Mancha
- Investigators
- Julian Alcazar, PhD, Principal investigator, University of Castilla-La Mancha
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07027397
- Sponsor's protocol ID
- 710P
- Status last verified
- Apr 2026
- First submitted
- 27 May 2025
- Last updated
- 30 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Buendia-Romero A, Gutierrez-Reguero H, Romero-Valia L, Higueras-Liebana E, Garcia-Aguirre M, Garcia-Albin D, Rosado Artalejo A, Torres Bertos A, Garcia-Garcia FJ, Alegre LM, Ara I, Alcazar J. Velocity-based resistance training in institutionalized older adults: protocol for an experimental study with follow-up. Front Aging. 2026 May 18;7:1827269. doi: 10.3389/fragi.2026.1827269. eCollection 2026.
PubMed 42232718
Study at a glance
From the registry record, last updated by the sponsor on 30 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- One Year of Velocity-based Resistance Training in Older People Living in Nursing Homes: Effects on Skeletal Muscle Mass, Muscle Function, and Physical and Cognitive Function
- ClinicalTrials.gov ID
- NCT07027397
- Acronym / sponsor ID
- 710P
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 27 participants (actual)
- Lead sponsor
- University of Castilla-La ManchaUniversity, hospital or other
- Study start
- 30 Sep 2024 (actual)
- Primary completion
- 30 Jan 2026 (actual)
- Study completion
- 30 Jan 2026 (actual)
- First posted
- 18 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is an exercise intervention assessing the efficacy of a velocity-based resistance training (VBRT) in institutionalized older adults.
The aim of this study is to assess the effects of one year of velocity-based resistance training on skeletal muscle mass, muscle function, and physical and cognitive function in older adults living in nursing homes.
Detailed description
Evidence supports the fact that resistance exercise training is effective in improving old adult's health and palliate age-related disorders. New approaches in resistance training are emerging to maximize monitoring control, providing more tailored and potentially more effective exercise interventions. Among them, the velocity-based resistance training (VBRT) is being established in healthy populations or populations with pathologies. However, the effects of long-term VBRT in institutionalized older adults are still unknown.
Thus, the aim of this study is to assess the effects of one year of velocity-based resistance training on skeletal muscle mass, muscle function, and physical and cognitive function in older adults living in nursing homes.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Exercise Group | Experimental | Other: Exercisea 2-day-a-week resistance training (RT) routine using the velocity-based method in the leg press exercise at 60% of the theoretical maximal isometric strength |
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Older adult
Key inclusion criteria (4 listed)
- Older people living permanently in nursing home.
- Age ≥ 65 years old.
- Are able to walk with/without assistance.
- Have ability to communicate with the research team.
Key exclusion criteria (3 listed)
- Terminal illness.
- Any illness not controled (cardiac, pulmonary, etc).
- If there is a risk of bone fracture according to medical staff.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ExerciseAll participants will conduct a 2-day-a-week resistance training (RT) routine using the velocity-based method in the leg press exercise for one year. A tailored and constant intensity will be performed at 60% of the theoretical maximal isometric strength (F0) during the training intervention. Participants will conduct 3-4 sets, individualizing the repetitions numbers until they reach a velocity loss of 10-20%. A rest of 2 minutes was imposed between sets. A standardized warm-up will preced all RT session as follows: 4 minutes walking at usual gait speed and 6 minutes performing dynamic balance exercises. | Other | Exercise Group |
Primary outcome
Change in muscle power
Time frame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Muscle power assessed in leg press machine and sit to stand test.
Changes in neuromuscular performance of lower-body
Time frame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Change in the force-velocity relationship in leg press exercise.
6 secondary outcomes
Change in physical function based on the Short Physical Performance Battery score
Time frame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Change in frailty (score) using Fried's Frailty Criteria and Frailty Trait Scale - Short Form
Time frame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Change in muscle mass using ultrasonography.
Time frame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Change in disability using Barthel and Lawton scales
Time frame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Change in cognitive function using Mini-Mental State Examination
Time frame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Change in handgrip strength
Time frame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Apr 2026.
- Derived from this study: PubMed 42232718Buendia-Romero A, Gutierrez-Reguero H, Romero-Valia L, Higueras-Liebana E, Garcia-Aguirre M, Garcia-Albin D, Rosado Artalejo A, Torres Bertos A, Garcia-Garcia FJ, Alegre LM, Ara I, Alcazar J. Velocity-based resistance training in institutionalized older adults: protocol for an experimental study with follow-up. Front Aging. 2026 May 18;7:1827269. doi: 10.3389/fragi.2026.1827269. eCollection 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Julian Alcazar, PhD principal investigator
University of Castilla-La Mancha
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exercise in people with Aging and Muscle Mass and Strength, run by University of Castilla-La Mancha at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in muscle power (time frame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07027397, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Apr 2026.