HealthyNCT07029165
Kidney Blood Flow During Exercise in Older African American Adults
A study testing Acute exercise, Cold pressor test and Mental stress test in people with Healthy, run by University of Massachusetts, Boston at 1 site in United States.
Trial summary
The goal of this preliminary study is to learn if healthy older African American (AA) adults have a larger change in their kidney blood flow during exercise compared to White (W) adults. Read more about this study
- Who is it for?
- Ages 55 to 79 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Acute exercise, Cold pressor test and Mental stress test
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 12 participants
- Where
- 1 siteUnited States
- Study dates
- 4 Dec 2024to Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 55 to 79 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Self-report as either African American or White racial identity
- Born in United States
- Both biological parents identify as same racial identity as participant
- Recreationally active (participating in physical activity for at least 20 minutes per day, at least three times per week, but not training for competitive events)
- Fluent in English
Who cannot join
- Hispanic or Latino
- Females who are pregnant or lactating
- Cardiovascular or renal disease
- Hypertension (blood pressure of more than or equal to 130/80 mmHg)
- Diabetes
- Obesity (body mass index of more than or equal to 30 kg/m2)
Show all 9Show fewer
- Smoker/Tobacco user
- Acute medical conditions
- Taking prescribed cardiovascular, antihypertensive, or renal medications
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Massachusetts Boston
Boston, Massachusetts, 02125
About this study
Official title: Neurovascular Control of Renal Blood Flow During Exercise in Older African American Adults
The goal of this preliminary study is to learn if healthy older African American (AA) adults have a larger change in their kidney blood flow during exercise compared to White (W) adults. The main questions that this study aims to answer are:
- Do healthy older AA adults have a larger decrease in kidney blood flow during exercise compared to W adults?
- Do healthy older AA adults have a larger decrease in kidney blood flow during other types of stress compared to W adults?
Read more
During one visit in the research lab, participants will:
- Perform cycling exercise while lying down
- Undergo a cold hand test
- Perform a mental math test
Completing this preliminary study will help researchers to understand more about why many AA adults have heart and kidney problems, so future research can study ways to reduce the number of AA adults who have these health issues.
Read the detailed description
Racial disparities exist in the development of high blood pressure and heart and kidney disease. Over the last 25 years, African American (AA) adults have had the greatest prevalence of high blood pressure compared to any other racial identity group in the United States. In 2015, ~100,000 AA adults died from heart disease, accounting for one-third of all deaths in this population. AA adults also have a 2-3-times higher lifetime risk for developing end-stage kidney disease compared to White (W) adults. Further, advanced age is one of the most significant risk factors for developing high blood pressure, heart disease, and kidney disease. In 2013-2014, ~29% of deaths of adults aged 65 years or older were caused by heart disease, the leading cause of death in this population.
Elevated sympathetic nervous system activity is associated with increased incidence of heart and kidney disease. Physical activity, such as exercise, acutely increases sympathetic nervous system activity, notably directed towards the kidneys, resulting in reflex narrowing of small blood vessels inside the kidneys. This response reduces blood flow to the kidneys to deliver greater blood flow to the active skeletal muscles. Most of the research studies in this area have involved participant groups who were wholly or predominantly of W racial identity, with smaller proportions of individuals of other racial identities. This underrepresentation of non-W participants, including AA adults, has occurred despite the known health disparities such as the greater incidence of high blood pressure and heart disease and kidney disease experienced by these populations.
A larger decrease in kidney blood flow during exercise has been observed in patients with heart failure and peripheral arterial disease compared to healthy adults. However, it is not known whether the decrease in kidney blood flow during exercise is larger in healthy older AA adults compared to other racial identity groups. Given the greater level of chronic psychological stress often experienced by AA adults due to systemic racism and social and environmental factors, the associated cumulative negative impact on cardiovascular health could underlie a physiological difference observed between AA and W adults. Therefore, it is hypothesized that healthy older AA adults will exhibit a larger decrease in kidney blood flow during exercise compared to W adults. This greater response in older AA adults could be a significant factor contributing to the higher rates of heart and kidney disease in this population given the negative effect that this larger response could have over time, highlighting the clinical significance of this area.
The goal of this project is to collect preliminary data regarding the kidney blood flow response to exercise in healthy older AA compared to W adults. This will be achieved through the innovative use of Doppler ultrasound to noninvasively measure kidney blood flow in real time during cycling exercise in 6 healthy older AA adults and 6 healthy older W adults. The preliminary data collected in this project will be used to strengthen future proposals to secure external funding to complete this project on a larger scale. Findings from a larger-scale project will have important implications for developing preventative strategies to reduce the elevated risk of developing heart and kidney disease in the AA population.
- Conditions
- Healthy
- Being tested
- Acute exercise, Cold pressor test, Mental stress test
- Keywords
- Exercise, Cold stress, Mental stress
- Medical subject headings
- Motor Activity, Stress, Psychological
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Acute exerciseOther
Participants will lie in a semi-supine position with their feet attached to the pedals of a custom-arranged cycle ergometer. Participants' 40% heart rate reserve will be calculated, giving the target value to achieve during exercise based on appropriate resistance applied on the cycle ergometer, corresponding to a moderate exercise intensity. After a 5-minute resting baseline, participants will perform dynamic cycling exercise at steady state for up to 20 minutes. They will then stop exercising, and there will be a 5-minute recovery period. Beat-to-beat renal blood flow velocity (Doppler ultrasound), mean arterial blood pressure (finger photoplethysmographic cuff), and heart rate (electrocardiogram) will be recorded throughout. A rating of perceived exertion will be taken from participants during the last 30 seconds of steady-state cycling exercise.
Cold pressor testOther
Participants will lie in a semi-supine position, and after a 3-minute resting baseline, participants will have their hand immersed in ice water for 2 minutes. This cold pressor test represents the non-exercise, physical sympathetic stressor. Participants' hand will then be removed from the ice water, followed by a 3-minute recovery period. Beat-to-beat renal blood flow velocity (Doppler ultrasound), mean arterial blood pressure (finger photoplethysmographic cuff), and heart rate (electrocardiogram) will be recorded throughout. Ratings of hand pain and cold perception will be taken from participants during the last 30 seconds of the cold pressor test.
Mental stress testOther
Participants will lie in a semi-supine position, and after a 3-minute resting baseline, participants will perform a mental arithmetic task for 5 minutes. This mental stress test represents the non-exercise, psychological sympathetic stressor. Participants will be instructed to subtract a given number from a randomly selected three-digit number and verbally state their answer and continue to do so for the duration of the test. Participants will be instructed to state their answers as quickly and accurately as possible. Participants will then stop the arithmetic task, and a 3-minute recovery period will follow. Beat-to-beat renal blood flow velocity (Doppler ultrasound), mean arterial blood pressure (finger photoplethysmographic cuff), and heart rate (electrocardiogram) will be recorded throughout. A rating of perceived stress will be taken from participants during the last 30 seconds of the mental stress test.
| Study group | Role | What they receive |
|---|---|---|
| African American Adults | Experimental | African American adults will undergo the interventions of acute exercise, a cold pressor test, and a mental stress test while beat-to-beat renal blood flow velocity, mean arterial blood pressure, and heart rate are recorded. Receives: Other: Acute exercise; Other: Cold pressor test; Other: Mental stress test |
| White Adults | Experimental | White adults will undergo the interventions of acute exercise, a cold pressor test, and a mental stress test while beat-to-beat renal blood flow velocity, mean arterial blood pressure, and heart rate are recorded. Receives: Other: Acute exercise; Other: Cold pressor test; Other: Mental stress test |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in renal vascular resistance during acute exercise
For the acute exercise intervention, the percent change from pre-acute exercise to during steady-state exercise will be assessed.
Measured: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in renal vascular resistance during cold pressor test
For the cold pressor test intervention, the percent change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Measured: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in renal vascular resistance during mental stress test
For the mental stress test intervention, the percent change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Measured: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Secondary outcomes (24)
Change in renal blood flow velocity during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Measured: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in mean arterial blood pressure during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Measured: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in systolic blood pressure during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Measured: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in diastolic blood pressure during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Measured: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in heart rate during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Measured: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in cardiac output during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Measured: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in stroke volume during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Measured: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in total peripheral resistance during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Measured: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in renal blood flow velocity during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Measured: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in mean arterial blood pressure during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Measured: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in systolic blood pressure during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Measured: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in diastolic blood pressure during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Measured: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in heart rate during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Measured: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in cardiac output during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Measured: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in stroke volume during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Measured: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in total peripheral resistance during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Measured: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in renal blood flow velocity during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Measured: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in mean arterial blood pressure during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Measured: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in systolic blood pressure during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Measured: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in diastolic blood pressure during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Measured: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in heart rate during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Measured: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in cardiac output during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Measured: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in stroke volume during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Measured: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in total peripheral resistance during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Measured: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Jun 2025
- Study start4 Dec 2024
- Primary completionDec 2026 (estimated)
- Study completionDec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 12 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Massachusetts, Boston
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Rachel Drew, University of Massachusetts, Boston
- Investigators
- Rachel C Drew, PhD, Principal investigator, University of Massachusetts, Boston
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07029165
- Sponsor's protocol ID
- 3298
- Other IDs
- P20240000057554
- Status last verified
- Jul 2026
- First submitted
- 4 Jun 2025
- Last updated
- 15 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neurovascular Control of Renal Blood Flow During Exercise in Older African American Adults
- ClinicalTrials.gov ID
- NCT07029165
- Acronym / sponsor ID
- 3298
- Conditions
- Healthy
- Keywords
- Exercise, Cold stress, Mental stress
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 12 participants (estimated)
- Lead sponsor
- University of Massachusetts, BostonUniversity, hospital or other
- Study start
- 4 Dec 2024 (actual)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 19 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this preliminary study is to learn if healthy older African American (AA) adults have a larger change in their kidney blood flow during exercise compared to White (W) adults. The main questions that this study aims to answer are:
- Do healthy older AA adults have a larger decrease in kidney blood flow during exercise compared to W adults?
- Do healthy older AA adults have a larger decrease in kidney blood flow during other types of stress compared to W adults?
During one visit in the research lab, participants will:
- Perform cycling exercise while lying down
- Undergo a cold hand test
- Perform a mental math test
Completing this preliminary study will help researchers to understand more about why many AA adults have heart and kidney problems, so future research can study ways to reduce the number of AA adults who have these health issues.
Detailed description
Racial disparities exist in the development of high blood pressure and heart and kidney disease. Over the last 25 years, African American (AA) adults have had the greatest prevalence of high blood pressure compared to any other racial identity group in the United States. In 2015, ~100,000 AA adults died from heart disease, accounting for one-third of all deaths in this population. AA adults also have a 2-3-times higher lifetime risk for developing end-stage kidney disease compared to White (W) adults. Further, advanced age is one of the most significant risk factors for developing high blood pressure, heart disease, and kidney disease. In 2013-2014, ~29% of deaths of adults aged 65 years or older were caused by heart disease, the leading cause of death in this population.
Elevated sympathetic nervous system activity is associated with increased incidence of heart and kidney disease. Physical activity, such as exercise, acutely increases sympathetic nervous system activity, notably directed towards the kidneys, resulting in reflex narrowing of small blood vessels inside the kidneys. This response reduces blood flow to the kidneys to deliver greater blood flow to the active skeletal muscles. Most of the research studies in this area have involved participant groups who were wholly or predominantly of W racial identity, with smaller proportions of individuals of other racial identities. This underrepresentation of non-W participants, including AA adults, has occurred despite the known health disparities such as the greater incidence of high blood pressure and heart disease and kidney disease experienced by these populations.
A larger decrease in kidney blood flow during exercise has been observed in patients with heart failure and peripheral arterial disease compared to healthy adults. However, it is not known whether the decrease in kidney blood flow during exercise is larger in healthy older AA adults compared to other racial identity groups. Given the greater level of chronic psychological stress often experienced by AA adults due to systemic racism and social and environmental factors, the associated cumulative negative impact on cardiovascular health could underlie a physiological difference observed between AA and W adults. Therefore, it is hypothesized that healthy older AA adults will exhibit a larger decrease in kidney blood flow during exercise compared to W adults. This greater response in older AA adults could be a significant factor contributing to the higher rates of heart and kidney disease in this population given the negative effect that this larger response could have over time, highlighting the clinical significance of this area.
The goal of this project is to collect preliminary data regarding the kidney blood flow response to exercise in healthy older AA compared to W adults. This will be achieved through the innovative use of Doppler ultrasound to noninvasively measure kidney blood flow in real time during cycling exercise in 6 healthy older AA adults and 6 healthy older W adults. The preliminary data collected in this project will be used to strengthen future proposals to secure external funding to complete this project on a larger scale. Findings from a larger-scale project will have important implications for developing preventative strategies to reduce the elevated risk of developing heart and kidney disease in the AA population.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| African American Adults | Experimental | Other: Acute exercise, Other: Cold pressor test, Other: Mental stress testAfrican American adults will undergo the interventions of acute exercise, a cold pressor test, and a mental stress test while beat-to-beat renal blood flow velocity, mean arterial blood pressure, and heart rate are recorded. |
| White Adults | Experimental | Other: Acute exercise, Other: Cold pressor test, Other: Mental stress testWhite adults will undergo the interventions of acute exercise, a cold pressor test, and a mental stress test while beat-to-beat renal blood flow velocity, mean arterial blood pressure, and heart rate are recorded. |
Who may qualify
- Ages
- 55 to 79 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Self-report as either African American or White racial identity
- Born in United States
- Both biological parents identify as same racial identity as participant
- Recreationally active (participating in physical activity for at least 20 minutes per day, at least three times per week, but not training for competitive events)
- Fluent in English
Key exclusion criteria (9 listed)
- Hispanic or Latino
- Females who are pregnant or lactating
- Cardiovascular or renal disease
- Hypertension (blood pressure of more than or equal to 130/80 mmHg)
- Diabetes
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Acute exerciseParticipants will lie in a semi-supine position with their feet attached to the pedals of a custom-arranged cycle ergometer. Participants' 40% heart rate reserve will be calculated, giving the target value to achieve during exercise based on appropriate resistance applied on the cycle ergometer, corresponding to a moderate exercise intensity. After a 5-minute resting baseline, participants will perform dynamic cycling exercise at steady state for up to 20 minutes. They will then stop exercising, and there will be a 5-minute recovery period. Beat-to-beat renal blood flow velocity (Doppler ultrasound), mean arterial blood pressure (finger photoplethysmographic cuff), and heart rate (electrocardiogram) will be recorded throughout. A rating of perceived exertion will be taken from participants during the last 30 seconds of steady-state cycling exercise. | Other | African American Adults, White Adults |
| Cold pressor testParticipants will lie in a semi-supine position, and after a 3-minute resting baseline, participants will have their hand immersed in ice water for 2 minutes. This cold pressor test represents the non-exercise, physical sympathetic stressor. Participants' hand will then be removed from the ice water, followed by a 3-minute recovery period. Beat-to-beat renal blood flow velocity (Doppler ultrasound), mean arterial blood pressure (finger photoplethysmographic cuff), and heart rate (electrocardiogram) will be recorded throughout. Ratings of hand pain and cold perception will be taken from participants during the last 30 seconds of the cold pressor test. | Other | African American Adults, White Adults |
| Mental stress testParticipants will lie in a semi-supine position, and after a 3-minute resting baseline, participants will perform a mental arithmetic task for 5 minutes. This mental stress test represents the non-exercise, psychological sympathetic stressor. Participants will be instructed to subtract a given number from a randomly selected three-digit number and verbally state their answer and continue to do so for the duration of the test. Participants will be instructed to state their answers as quickly and accurately as possible. Participants will then stop the arithmetic task, and a 3-minute recovery period will follow. Beat-to-beat renal blood flow velocity (Doppler ultrasound), mean arterial blood pressure (finger photoplethysmographic cuff), and heart rate (electrocardiogram) will be recorded throughout. A rating of perceived stress will be taken from participants during the last 30 seconds of the mental stress test. | Other | African American Adults, White Adults |
Primary outcome
Change in renal vascular resistance during acute exercise
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
For the acute exercise intervention, the percent change from pre-acute exercise to during steady-state exercise will be assessed.
Change in renal vascular resistance during cold pressor test
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
For the cold pressor test intervention, the percent change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Change in renal vascular resistance during mental stress test
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
For the mental stress test intervention, the percent change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
24 secondary outcomes
Change in renal blood flow velocity during acute exercise
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in mean arterial blood pressure during acute exercise
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in systolic blood pressure during acute exercise
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in diastolic blood pressure during acute exercise
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in heart rate during acute exercise
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in cardiac output during acute exercise
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in stroke volume during acute exercise
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in total peripheral resistance during acute exercise
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in renal blood flow velocity during cold pressor test
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in mean arterial blood pressure during cold pressor test
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in systolic blood pressure during cold pressor test
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in diastolic blood pressure during cold pressor test
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in heart rate during cold pressor test
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in cardiac output during cold pressor test
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in stroke volume during cold pressor test
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in total peripheral resistance during cold pressor test
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in renal blood flow velocity during mental stress test
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in mean arterial blood pressure during mental stress test
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in systolic blood pressure during mental stress test
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in diastolic blood pressure during mental stress test
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in heart rate during mental stress test
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in cardiac output during mental stress test
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in stroke volume during mental stress test
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in total peripheral resistance during mental stress test
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Rachel C Drew, PhD principal investigator
University of Massachusetts, Boston
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Acute exercise, Cold pressor test and Mental stress test in people with Healthy, run by University of Massachusetts, Boston at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 15 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in renal vascular resistance during acute exercise (time frame: Pre-acute exercise and during 5 minutes of steady-state exercise). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Jul 2026.