AzTrials
AzTrials

Atherosclerotic Cardiovascular DiseasePhase 3MARITIME-CVNCT07037433

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

A Phase 3 study testing Maridebart Cafraglutide in people with Atherosclerotic Cardiovascular Disease and Overweight, run by Amgen at 783 sites in 36 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
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Trial summary

The primary objective of this trial is to demonstrate that maridebart cafraglutide is superior to placebo when given as an adjunct to standard of care with respect to reducing cardiovascular (CV) morbidity and mortality. Read more about this study

Who is it for?
Ages 45 to 99 years
What is being tested?
Maridebart Cafraglutide
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
12,800 participants
Where
783 sitesin 36 countries
Study dates
25 Jul 2025to 29 Sep 2030
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 45 to 99 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Age ≥ 45 years at screening.
  • BMI of ≥ 27.0 kg/m^2 at screening.
  • History of Atherosclerotic Cardiovascular Disease (ASCVD) with a documented history of at least one of the following:
  • Prior MI (presumed atherothrombotic event due to plaque rupture/erosion).
  • Prior ischemic stroke (presumed due to atherosclerosis; may include ischemic stroke with hemorrhagic transformation).
  • Symptomatic peripheral arterial disease (PAD), as evidenced by intermittent claudication with ankle-brachial index (ABI) < 0.9 (at rest), or peripheral arterial revascularization procedure, or amputation due to atherosclerotic disease.

Who cannot join

  • History of any of the following within 60 days before screening or between screening and randomization: MI, hospitalization for unstable angina, arterial revascularization (eg, coronary, cerebrovascular or peripheral) major cardiovascular surgery, stroke, or transient ischemic attack (TIA).
  • New York Heart Association (NYHA) class IV HF during screening or hospitalization for HF within 60 days before screening or between screening and randomization.
  • Type 1 DM, or any other type of diabetes with the exception of T2DM or prior gestational diabetes. Participants with a history of gestational diabetes should be stratified according to their current diabetes classification.
  • For participants with T2DM (including those without a prior history of T2DM but with a HbA1c ≥ 6.5% during screening):
  • HbA1c > 10.0% (86 mmol/mol) at screening.
  • History of diabetic ketoacidosis or hyperosmolar state/coma within 12 months before randomization.
Show all 15Show fewer
  • One or more episodes of severe hypoglycemia within 6 months before randomization and/or history of hypoglycemia unawareness.
  • History of proliferative diabetic retinopathy, diabetic maculopathy, severe non-proliferative diabetic retinopathy, or currently receiving or planning to receive treatment for diabetic retinopathy and/or diabetic macular edema.
  • Use of any glucagon-like peptide-1 receptor agonist (GLP-1 RA), glucose-dependent insulinotropic polypeptide (GIP) agonists or antagonists, or amylin analogs within 90 days before randomization or planned use during the conduct of the trial.
  • History of chronic pancreatitis or history of acute pancreatitis in the 180 days before screening or between screening and randomization.
  • Family (first-degree relative[s]), or personal history of medullary thyroid carcinoma (MTC), or multiple endocrine neoplasia syndrome type 2 (MEN-2).
  • Calcitonin ≥ 50 ng/L (pg/mL) at screening.
  • Acute or chronic hepatitis; signs and symptoms of any liver disease other than metabolic dysfunction-associated steatotic liver disease, or alanine aminotransferase (ALT) > 3.0 x the upper limit of normal (ULN) during screening, or total bilirubin (TBL) > 1.8 x ULN during screening (for participants with a known diagnosis of Gilbert syndrome, direct bilirubin should be used instead of TBL).
  • History of malignancy within the last 5 years before screening or between screening and randomization (except for the following treated with curative intent: non-melanoma skin cancer, breast ductal carcinoma in situ, cervical carcinoma in situ, or prostate cancer in situ).
  • Participants of childbearing potential planning to become pregnant while on study or unwilling to use protocol-specified methods of contraception during treatment.

Trial locations and contacts

783 sites in 36 countries.

783 sites in 36 countries

United States140 sites

  • PharmaTex Research, LLC

    Amarillo, Texas, 79106

  • McFarland Clinic PC

    Ames, Iowa, 50010

  • Endeavor Health-Northwest Community Healthcare

    Arlington Heights, Illinois, 60005

  • Austin Heart

    Austin, Texas, 78705

  • Velocity Clinical Research - Austin

    Austin, Texas, 78759

  • Ascension Saint Agnes Heart Care

    Baltimore, Maryland, 21229

  • Velocity Clinical Research - Cleveland

    Beachwood, Ohio, 44122

  • Heritage Valley Multispecialty Group Inc

    Beaver, Pennsylvania, 15009

  • Velocity Clinical Research - Binghamton

    Binghamton, New York, 13905

  • Excel Medical Clinical Trials

    Boca Raton, Florida, 33434

  • Brigham and Womens Hospital

    Boston, Massachusetts, 02115

  • Capital Area Research LLC

    Camp Hill, Pennsylvania, 17011

  • East Coast Institute for Research LLC at Canton Georgia

    Canton, Georgia, 30114

  • Aultman Hospital, Cardiovascular Consultants, Inc

    Canton, Ohio, 44710

  • Novant Health Heart and Vascular Institute

    Charlotte, North Carolina, 28204

  • Eagle Clinical Research

    Chicago, Illinois, 60621

  • University of Chicago

    Chicago, Illinois, 60637

  • Velocity Clinical Research - Auburn

    Cincinnati, Ohio, 45219

  • StudyMetrix Research

    City of Saint Peters, Missouri, 63303

  • Endocrinology Associates Inc

    Columbus, Ohio, 43201

  • Valley Clinical Trials, LLC dba Flourish Research

    Covina, California, 91723

  • Cardiovascular Associates Research, LLC

    Covington, Louisiana, 70433

  • Vaught Neurological Services

    Crab Orchard, West Virginia, 25827

  • Thyroid Endocrinology and Diabetes

    Dallas, Texas, 75208

  • Soltero Cardiovascular Research Center

    Dallas, Texas, 75226

  • Zenos Clinical Research

    Dallas, Texas, 75230

  • Cedar Health Research, LLC

    Dallas, Texas, 75251

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390

  • Alliance For Multispecialty Research - Daphne

    Daphne, Alabama, 36526

  • Midwest Cardiovascular Research Foundation

    Davenport, Iowa, 52801

  • Velocity Clinical Research - Durham

    Durham, North Carolina, 27701

  • Velocity Clinical Research - Providence

    East Greenwich, Rhode Island, 02818

  • Velocity Clinical Research - New Smyrna Beach

    Edgewater, Florida, 32132

  • David Turbay, MD

    El Paso, Texas, 79905

  • Academy of Diabetes Thyroid and Endocrine

    El Paso, Texas, 79935

  • Inova Cardiology - Fairfax

    Fairfax, Virginia, 22031

  • Eastern Shore Research Institute

    Fairhope, Alabama, 36532

  • Virginia Heart

    Falls Church, Virginia, 22042

  • Alliance for Multispecialty Research - Fort Myers

    Fort Myers, Florida, 33912

  • Stern Cardiovascular Foundation Inc

    Germantown, Tennessee, 38138

  • Moses H Cone Memorial Hospital

    Greensboro, North Carolina, 27401

  • Elite Cardiac Research Center LLC

    Hialeah, Florida, 33013

  • Elite Clinical Research

    Hialeah, Florida, 33018

  • Zenith Clinical Research

    Hollywood, Florida, 33021

  • Encore Medical Research LLC

    Hollywood, Florida, 33024

  • Abington Medical Specialists

    Horsham, Pennsylvania, 19044

  • Biopharma Informatic, LLC

    Houston, Texas, 77043

  • Cardiovascular Specialists of Willowbrook

    Houston, Texas, 77070

  • PlanIt Research, PLLC

    Houston, Texas, 77079

  • Research Physicians Network, LLC

    Houston, Texas, 77089

  • Vital Heart and Vein

    Humble, Texas, 77338

  • Velocity Clinical Research- Huntington Park

    Huntington Park, California, 90255

  • Huntsville Clinical Research, LLC

    Huntsville, Alabama, 35801

  • Jackson Heart Clinic

    Jackson, Mississippi, 39216

  • East Coast Institute for Research, LLC

    Jacksonville, Florida, 32216

  • Alliance for Multispecialty Research - Kansas City

    Kansas City, Missouri, 64114

  • Kansas City Veterans Affairs Medical Center

    Kansas City, Missouri, 64128

  • Tcr Institute Llc

    Kingwood, Texas, 77339

  • Accellacare of Knoxville

    Knoxville, Tennessee, 37912

  • Velocity Clinical Research- Los Angeles

    La Mesa, California, 91942

  • Orange County Research Center

    Lake Forest, California, 92630

  • Helium Research Group

    Lake Jackson, Texas, 77566

  • Clinical Research of Central Florida

    Lakeland, Florida, 33805

  • Excel Clinical Research

    Las Vegas, Nevada, 89109

  • Vector Clinical Trials

    Las Vegas, Nevada, 89128

  • Epic Clinical Research

    Lewisville, Texas, 75057

  • Nexgen Research

    Lima, Ohio, 45801

  • Bryan Heart

    Lincoln, Nebraska, 68506

  • Monroe Biomedical Research

    Louisville, Kentucky, 40213

  • The Jones Center Clinical Research

    Macon, Georgia, 31210

  • Fairview Health Services M Health Fairview St Johns Hospital

    Maplewood, Minnesota, 55109

  • South Florida Clinical Research

    Margate, Florida, 33063

  • Tandem Clinical Research - Marrero

    Marrero, Louisiana, 70072

  • Biopharma Informatic-McAllen

    McAllen, Texas, 78503

  • Velocity Clinical Research - Boise

    Meridian, Idaho, 83642

  • Southern Endocrinology Associates PA

    Mesquite, Texas, 75149

  • Finlay Medical Research

    Miami, Florida, 33126

  • Suncoast Research Group LLC

    Miami, Florida, 33135

  • New Horizon Research Center

    Miami, Florida, 33165

  • Panax Clinical Research

    Miami Lakes, Florida, 33014

  • San Marcus Research Clinic Inc

    Miami Lakes, Florida, 33014

  • Indago Research and Health Center

    Miami Lakes, Florida, 33016

  • Minneapolis Heart Institute Foundation

    Minneapolis, Minnesota, 55407

  • Mobile Heart Specialists PC

    Mobile, Alabama, 36608

  • Monroe Biomedical Research

    Monroe, North Carolina, 28112

  • West Clinical Research

    Morehead City, North Carolina, 28557

  • Burke Primary Care Family Practice

    Morganton, North Carolina, 28655

  • Accellacare Charleston

    Mt. Pleasant, South Carolina, 29464

  • Cardiovascular Research of Northwest Indiana LLC

    Munster, Indiana, 46321

  • Btc of New Bedford

    New Bedford, Massachusetts, 02740

  • Alliance for Multispecialty Research - Norman

    Norman, Oklahoma, 73069

  • North Hills Medical Research

    North Richland Hills, Texas, 76180

  • Alliance For Multispecialty Research - Oak Brook

    Oak Brook, Illinois, 60523

  • West Orange Endocrinology

    Ocoee, Florida, 34761

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198

  • MD Medical Research

    Oxon Hill, Maryland, 20745

  • Cardiology Partners Clinical Research Institute

    Palm Beach Gardens, Florida, 33410

  • Primary Clinical Research

    Papillion, Nebraska, 68046

  • Synexus Clinical Research US, Inc.

    Phoenix, Arizona, 85020

  • Medical Advancement Centers of Arizona

    Phoenix, Arizona, 85044

  • Peace River Cardiovascular Center

    Port Charlotte, Florida, 33952

  • Progressive Medical Research

    Port Orange, Florida, 32127

  • Hudson Valley Cardiovascular Practice PC

    Poughkeepsie, New York, 12601

  • Cardiovascular Research of Knoxville North Knoxville Medical Center

    Powell, Tennessee, 37849

  • Boeson Research

    Provo, Utah, 84604

  • Accellacare of Raleigh

    Raleigh, North Carolina, 27609

  • Monument Health Clinical Research

    Rapid City, South Dakota, 57701

  • Biopharma Informatic - The Cardiovascular Center

    Redding, California, 96001

  • Rochester Clinical Research

    Rochester, New York, 14609

  • Velocity Clinical Research - Rockville

    Rockville, Maryland, 20854

  • Saint Johns Center for Clinical Research

    Saint Augustine, Florida, 32086

  • Bandera Family Health Care

    San Antonio, Texas, 78249

  • Acclaim Clinical Research

    San Diego, California, 92120

  • Intercoastal Medical Group

    Sarasota, Florida, 34239

  • Saratoga Clinical Research, LLC

    Saratoga Springs, New York, 12866

  • Velocity Clinical Research - Savannah

    Savannah, Georgia, 31419

  • VA Puget Sound Healthcare System

    Seattle, Washington, 98108

  • Consano Clinical Research - Shavano Park

    Shavano Park, Texas, 78231

  • Syed Research Consultants LLC

    Sheffield, Alabama, 35660

  • CardioMetabolic Collaborative Clinic

    Somerset, New Jersey, 08873

  • Velocity Clinical Research - Spokane

    Spokane, Washington, 99218

  • Encompass Clinical Research

    Spring Valley, California, 91978

  • Prarie Education and Research

    Springfield, Illinois, 62701

  • Saint Louis Heart and Vascular PC

    St Louis, Missouri, 63136

  • Accellacare of Piedmont Healthcare

    Statesville, North Carolina, 28625

  • Sugar Lakes Family Practice

    Sugar Land, Texas, 77479

  • Cotton-ONeil Diabetes and Endocrinology Center

    Topeka, Kansas, 66606

  • Tennessee Center for Clinical Trials

    Tullahoma, Tennessee, 37388

  • Cardiology Associates of North Mississippi

    Tupelo, Mississippi, 38801

  • Velocity Clinical Research - Valparaiso

    Valparaiso, Indiana, 46383

  • Diablo Clinical Research

    Walnut Creek, California, 94598

  • Aspirus Cardiovascular Associates

    Wausau, Wisconsin, 54401

  • Focus Clinical Research

    West Hills, California, 91307

  • Velocity Clinical Research - Salt Lake City

    West Jordan, Utah, 84088

  • Southgate Medical Group

    West Seneca, New York, 14224

  • Wichita Falls Heart Clinic

    Wichita Falls, Texas, 76301

  • Family Practice Associates

    Wilmington, Delaware, 19805

  • Brookview Hills Research Associates Llc

    Winston-Salem, North Carolina, 27103

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157

  • Winter Haven Hospital

    Winter Haven, Florida, 33881

Other trials in United States

Czechia41 sites

  • Innera sro

    Benešov, 256 01

  • Medicentrum Beroun as

    Beroun, 266 01

  • MUDr Libor Nechvatal sro

    Brno, 602 00

  • Centrum pro zdravi sro

    Brno, 603 00

  • MUDr Karel Kamenik sro

    Brno, 603 00

  • Kardiologicka ambulance Brno sro

    Brno, 612 00

  • Fakultni nemocnice Brno

    Brno, 625 00

  • Vojenska nemocnice Brno

    Brno, 636 00

  • Amkardia sro

    Brno, 639 00

  • CorMedico sro

    Bruntál, 792 01

  • Kardio Chlumec sro

    Chlumec nad Cidlinou, 503 51

  • Ordinace pro choroby srdce sro

    Chomutov, 430 02

  • Dika centrum sro

    Havirov - Mesto, 736 01

  • Edumed sro

    Hradec Králové, 500 02

  • Nemocnice Jihlava po

    Jihlava, 586 33

  • Interna a diabetologie MUDr Vodickova sro

    Liberec, 460 01

  • Kardiologie - Liberec sro

    Liberec, 460 01

  • Edumed sro

    Náchod, 547 01

  • Interni a diabetologicka ordinace sro

    Náchod, 547 01

  • PreventaMed sro

    Olomouc, 779 00

  • Ostin sro

    Ostrava, 700 30

  • CCR Ostrava sro

    Ostrava, 702 00

  • MUDr Miroslav Koliba sro

    Ostrava, 702 00

  • Diahelp sro

    Pardubice, 530 02

  • Pratia Czech sro

    Pardubice, 530 02

  • Kardiologie a Angiologie Praha sro - Komplexni Centrum Vyzkumu, Prevence a Lecby Kardiov Nemoci

    Prague, 101 00

  • Kardiologie a angiologie sro

    Prague, 101 00

  • Avicena - kardiologie, interna sro

    Prague, 110 00

  • Kardiologie Vinohrady sro

    Prague, 110 00

  • Kardiologie Vinohrady sro

    Prague, 120 00

  • Institut klinicke a experimentalni mediciny

    Prague, 140 21

  • Milan Kvapil sro

    Prague, 149 00

  • Restrial sro

    Prague, 181 00

  • Endokrinologie Cerny Most sro

    Prague, 198 00

  • Kardiologie Cor sro

    Praha 10 - Zabehlice, 106 00

  • Kardio Vaclavik sro

    Přerov, 750 02

  • MUDr Jarmila Otrubova

    Prostějov, 796 01

  • Nemocnice Slany

    Slaný, 274 01

  • MUDrych sro

    Svitavy, 568 02

  • Clinical Trials Service sro

    Uherské Hradiště, 686 01

  • Kardiologie - Usti nad Labem sro

    Ústí nad Labem, 400 01

Other trials in Czechia

China40 sites

  • Beijing Hospital

    Beijing, Beijing Municipality, 100020

  • Beijing Friendship Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100050

  • Peking University Third Hospital

    Beijing, Beijing Municipality, 100191

  • Beijing Tsinghua Changgung Hospital

    Beijing, Beijing Municipality, 102218

  • The First Affiliated Hospital of Bengbu Medical University

    Bengbu, Anhui, 233300

  • The First Bethune Hospital of Jilin University

    Changchun, Jilin, 130021

  • China Japan Union Hospital of Jilin University

    Changchun, Jilin, 130033

  • The Second Xiangya Hospital of Central South University

    Changsha, Hunan, 410011

  • West China Hospital Sichuan University

    Chengdu, Sichuan, 610041

  • Chengdu Fifth Peoples Hospital

    Chengdu, Sichuan, 611130

  • The Second Affiliated Hospital of Chongqing Medical University

    Chongqing, Sichuan, 400010

  • Guangdong Provincial Peoples Hospital

    Guangzhou, Guangdong, 510080

  • Sun Yat-sen Memorial Hospital Sun Yat-sen University

    Guangzhou, Guangdong, 510120

  • The Fourth Hospital of Harbin Medical University

    Harbin, Heilongjiang, 150001

  • Huizhou Central Peoples Hospital

    Huizhou, Guangdong, 516001

  • Jinan Central Hospital

    Jinan, Shandong, 250013

  • The First Affiliated Hospital of Henan University of Science And Technology

    Luoyang, Henan, 471000

  • The First Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330006

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, Jiangsu, 210011

  • Nanjing First Hospital

    Nanjing, Jiangsu, 210012

  • Zhongda Hospital Southeast University

    Nanjing, Jiangsu, 211000

  • The First Affiliated Hospital of Ningbo University

    Ningbo, Zhejiang, 315010

  • First Hospital of Qinhuangdao

    Qinhuangdao, Hebei, 066099

  • Shanghai Ninth Peoples Hospital Affiliated Shanghai JiaoTong University School of Medicine

    Shanghai, Shanghai Municipality, 200011

  • Zhongshan Hospital Fudan University

    Shanghai, Shanghai Municipality, 200032

  • Shanghai Tenth Peoples Hospital

    Shanghai, Shanghai Municipality, 200072

  • The Fifth Peoples Hospital of Shanghai, Fudan University

    Shanghai, Shanghai Municipality, 200240

  • The Peoples Hospital of Liaoning Province

    Shenyang, Liaoning, 110016

  • The Second Hospital of Hebei Medical University

    Shijiazhuang, Hebei, 050000

  • Tianjin Peoples Hospital

    Tianjin, Tianjin Municipality, 300121

  • Teda International Cardiovascular Hospital

    Tianjin, Tianjin Municipality, 300457

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, Hubei, 430022

  • Wuxi Peoples Hospital

    Wuxi, Jiangsu, 214023

  • Shaanxi Provincial Peoples Hospital

    Xi'an, Shaanxi, 710068

  • Xi'an Daxing Hospital

    Xi'an, Shaanxi, 710082

  • The First Affiliated Hospital of Xi An Jiao Tong University

    Xi’an, Shanxi, 710061

  • The Affiliated Hospital of Xuzhou Medical University

    Xuzhou, Jiangsu, 221006

  • The First Peoples Hospital of Yulin

    Yulin, Guangxi, 537006

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, 450052

  • Affiliated Hospital of Jiangsu University

    Zhenjiang, Jiangsu, 212001

Other trials in China

Germany39 sites

  • Zentrum fuer klinische Studien Bad Homburg

    Bad Homburg, 61348

  • Universitaets-Herzzentrum Freiburg - Bad Krozingen

    Bad Krozingen, 79189

  • Universitaetsklinikum der Ruhr-Universitaet Bochum

    Bad Oeynhausen, 32545

  • Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin

    Berlin, 12203

  • Studienzentrum Dr. Braun GmbH

    Berlin, 13187

  • Charite - Universitaetsmedizin Berlin, Campus Virchow

    Berlin, 13353

  • Berufsgenossenschaftliches Universitaetsklinikum Bergmannsheil gGmbH

    Bochum, 44789

  • Universitaetsklinikum Bonn

    Bonn, 53127

  • Klinikum Lippe

    Detmold, 32756

  • Diabeteszentrum Dortmund

    Dortmund, 44137

  • Sankt-Johannes-Hospital

    Dortmund, 44137

  • Cardiologicum Dresden und Pirna Facharztpraxis für Kardiologie und Angiologie

    Dresden, 01277

  • Universitaetsklinikum Dresden

    Dresden, 01307

  • Zentrum fuer Klinische Studien Suedbrandenburg GmbH

    Elsterwerda, 04910

  • Praxis am Markt Dr. Bernd Becker

    Essen, 45355

  • Unterfrintroper Hausarztzentrum

    Essen, 45359

  • Universitaetsklinikum Frankfurt

    Frankfurt am Main, 60590

  • ClinPhenomics CVC GmbH

    Frankfurt am Main, 60596

  • Universitaetsklinikum Hamburg-Eppendorf

    Hamburg, 20251

  • Cardiologicum Hamburg GbR

    Hamburg, 22041

  • Diabeteszentrum Hamburg West

    Hamburg, 22607

  • Diabetologische Schwerpunktpraxis Hohenmoelsen

    Hohenmölsen, 06679

  • Kardiopraxis Schirmer

    Kaiserslautern, 67655

  • Braun Ambulantes Herzzentrum Kassel

    Kassel, 34121

  • Universitaetsklinikum Leipzig

    Leipzig, 04103

  • AmBeNet GmbH

    Leipzig, 04107

  • Universitaetsklinikum Schleswig-Holstein - Luebeck

    Lübeck, 23538

  • Otto von Guericke Universitaet Magdeburg

    Magdeburg, 39120

  • Kardiologische Praxis Doktor Jens Taggeselle

    Markkleeberg, 04416

  • Klinikum rechts der Isar der TUM

    München, 80636

  • Centrum für Diagnostik und Gesundheit

    München, 80809

  • Institut für Diabetesforschung Münster GmbH

    Münster, 48145

  • Universitaetsklinikum Muenster

    Münster, 48149

  • Praxis Segner - Dr. Braun - Kirsch

    Oberwürzbach, 66386

  • Red-Institut GmbH

    Oldenburg, 23758

  • Kardiologische Gemeinschaftspraxis Papenburg

    Papenburg, 26871

  • Praxis Reinfeld Mitte Dr Joachim Weimer und Dr Katharina Pfeiffer

    Reinfeld (Holstein), 23858

  • Zentrum fuer klinische Forschung Allgaeu Oberschwaben

    Wangen, 88239

  • Praxis Dr med Ayham Al-Zoebi Facharzt fuer Innere Medizin und Kardiologie

    Wermsdorf, 04779

Other trials in Germany

Poland39 sites

  • Niepubliczny Zaklad Opieki Zdrowotnej Vita Diabetica Malgorzata Buraczyk

    Bialystok, 15-879

  • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca

    Bielsko-Biala, 43-316

  • Centrum Medyczne Kermed - Renata Bijata-Bronisz i Ewa Kowalinska Spolka Jawna

    Bydgoszcz, 85-231

  • Centrum Medyczne Lukamed Spzoo

    Chojnice, 89-600

  • American Heart of Poland Spolka Akcyjna

    Chrzanów, 32-500

  • Etg Lublin Spzoo

    Dębica, 39-200

  • Futuremeds Spolka z ograniczona odpowiedzialnoscia

    Gdynia, 81-384

  • Emc Silesia Spolka z ograniczona odpowiedzialnoscia

    Katowice, 40-353

  • Salvia-Lekston i Madej Spolka Jawna

    Katowice, 40-772

  • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca

    Kędzierzyn-Koźle, 47-200

  • Medyczne Centrum Diabetologiczno-Endokrynologiczno-Metaboliczne Diab-Endo-Met Sp zoo

    Krakow, 31-261

  • Unicardia And Unimedica And Uniestetica

    Krakow, 31-271

  • Futuremeds spolka z ograniczona odpowiedzialnoscia

    Krakow, 31-501

  • Beata Miklaszewicz i Dariusz Dabrowski Cardiamed Spolka Jawna

    Legnica, 59-220

  • Futuremeds spolka z ograniczona odpowiedzialnoscia

    Lodz, 91-363

  • Clinical Best Solutions Sp zoo Spolka Komandytowa Gabinet Lekarski

    Lublin, 20-011

  • Ekamed Spolka z Ograniczona Odpowiedzialnoscia

    Lublin, 20-718

  • Futuremeds spolka z ograniczona odpowiedzialnoscia

    Olsztyn, 10-165

  • Uniwersytecki Szpital Kliniczny w Opolu

    Opole, 45-401

  • G and G Medvision Spolka z ograniczona odpowiedzialnoscia

    Oświęcim, 32-600

  • Centrum Zdrowia Metabolicznego Pawel Bogdanski

    Poznan, 60-589

  • Praktyka Lekarska Ewa Krzyzagorska

    Poznan, 61-655

  • Centrum Medyczne Medyk Spolka z Ograniczona Odpowiedzialnoscia Spolka Komandytowa

    Rzeszów, 35-055

  • Nowe Zdrowie-Ck Kieltucki i Wspolnicy Spolka Jawna

    Staszów, 28-200

  • Osrodek Badan Klinicznych Labmed Sp zoo

    Szczecin, 71-526

  • Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M Zabowka E Zabowka Spolka cywilna

    Tarnów, 33-100

  • Metabolica Spolka z Ograniczona Odpowiedzialnoscia

    Tarnów, 33-100

  • Praktyka Lekarska Lidia Pawlowicz

    Torun, 87-100

  • Wojewodzki Szpital Zespolony im L Rydygiera w Toruniu

    Torun, 87-100

  • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca

    Tychy, 43-100

  • Futuremeds Spolka z ograniczona odpowiedzialnoscia

    Warsaw, 00-215

  • Clinical Best Solutions Sp zoo Spolka komandytowa

    Warsaw, 00-710

  • Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji

    Warsaw, 02-507

  • Szpital Grochowski imienia Doktora medycyny Rafala Masztaka Spzoo

    Warsaw, 04-073

  • Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy

    Warsaw, 04-635

  • 4 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ we Wroclawiu

    Wroclaw, 50-981

  • Futuremeds spolka z ograniczona odpowiedzialnoscia

    Wroclaw, 53-673

  • Velocity Nova Sp zoo Velocity Zamosc

    Zamość, 22-400

  • Halina Serafin NZOZ Centrum Medyczne "Serafin-Med"

    Żarów, 58-130

Other trials in Poland

Brazil37 sites

  • jmf Clinica do Coracao ltda

    Aracaju, Sergipe, 49055-530

  • Hospital Universitário João de Barros Barreto

    Belém, Pará, 66073-005

  • Santa Casa de Misericordia de Belo Horizonte

    Belo Horizonte, Minas Gerais, 30150-221

  • Ccih - Consultoria em Controle de Infecção Hospitalar

    Belo Horizonte, Minas Gerais, 30150-320

  • Cardresearch Cardiologia Assistencial de Pesquisa

    Belo Horizonte, Minas Gerais, 31110-580

  • Instituto de Ensino e Pesquisa do Hospital do Coracao do Brasil

    Brasília, Federal District, 70390-700

  • Assoc Amparo Saude Ensin e Pesquisa

    Brasília, Federal District, 71625-175

  • Loema Instituto de Pesquisa Clinica e Consultores Ltda - Clinica Loema

    Campinas, São Paulo, 13010-001

  • Instituto de Pesquisa Clinica de Campinas - Ipecc

    Campinas, São Paulo, 13060-080

  • Hospital Universitario Maria Aparecida Pedrossian

    Campo Grande, Mato Grosso do Sul, 79080-190

  • Quanta Diagnostico por Imagem

    Curitiba, Paraná, 80045-170

  • Centro de Pesquisas em Diabetes e Doencas Endocrino Metabolicas

    Fortaleza, Ceará, 60430-350

  • NS Clinica De Endocrinologia E Diabetes - Cendi

    Goiânia, Goiás, 74230-035

  • Hospital das Clinicas da Universidade Federal de Goias

    Goiânia, Goiás, 74605-020

  • Instituto do Coracao de Marilia

    Marília, São Paulo, 17515-000

  • Instituto Atena de Pesquisa Clínica

    Natal, Rio Grande do Norte, 59020-500

  • Hospital de Clinicas de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90410-000

  • Nucleo de Pesquisa do Rio Grande do Sul

    Porto Alegre, Rio Grande do Sul, 90430-001

  • Hospital Agamenon Magalhaes

    Recife, Pernambuco, 52051-380

  • IBPClin Instituto Brasil de Pesquisa Clinica

    Rio de Janeiro, 20241-180

  • Ruschel Medicina e Pesquisa Clinica

    Rio de Janeiro, 22270-060

  • Hospital Ana Nery

    Salvador, Estado de Bahia, 40301-155

  • Inovace Pesquisa Clinica

    Salvador, Estado de Bahia, 40301-155

  • Praxis Pesquisa Medica

    Santo André, São Paulo, 09090-790

  • Cemec Centro Multidisciplinar Estudos Clinicos

    São Bernardo do Campo, São Paulo, 09715-090

  • Hospital de Base de Sao Jose do Rio Preto

    São José do Rio Preto, São Paulo, 15090-000

  • Ispem - Instituto Sao Jose dos Campos em Pesquisas Medicas

    São José dos Campos, São Paulo, 12243-280

  • Centro de Pesquisas Clinicas Cpclin

    São Paulo, São Paulo, 01228-200

  • Instituto Dante Pazzanese de Cardiologia

    São Paulo, São Paulo, 04012-909

  • Br Trials - Ensaios Clínicos e Consultoria

    São Paulo, 01236-030

  • CPQuali Pesquisa Clinica Ltda

    São Paulo, 01240-020

  • Centro Paulista de Investigacao Clinica Cepic

    São Paulo, 04266-010

  • Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo

    São Paulo, 05403-000

  • Instituto de Molestias Cardiovasculares de Tatui

    Tatuí, São Paulo, 18270-170

  • Eurolatino Pesquisas Medicas

    Uberlândia, Minas Gerais, 38400-500

  • Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo

    Vitória, Espírito Santo, 29055-450

  • Integral Pesquisa e Ensino

    Votuporanga, São Paulo, 15501-405

Other trials in Brazil

Spain33 sites

  • Complexo Hospitalario Universitario A Coruña

    A Coruña, Galicia, 15006

  • Hospital Universitario de La Ribera

    Alzira, Valencia, 46600

  • Hospital Universitario de Badajoz

    Badajoz, Extremadura, 06080

  • Hospital Universitari Germans Trias i Pujol

    Badalona, Catalonia, 08916

  • Hospital Universitari Vall d Hebron

    Barcelona, Catalonia, 08035

  • Hospital Clinic i Provincial de Barcelona

    Barcelona, Catalonia, 08036

  • Hospital Vithas Sevilla

    Castilleja de la Cuesta, Andalusia, 41950

  • Hospital Universitario Reina Sofia

    Córdoba, Andalusia, 14004

  • Hospital Universitario Virgen de la Arrixaca

    El Palmar, Murcia, 30120

  • Complexo Hospitalario Universitario de Ferrol Hospital Universitario Arquitecto Marcide

    Ferrol, Galicia, 15405

  • Complejo Hospitalario de Jaen

    Jaén, Andalusia, 23007

  • Hospital Universitario de Leon

    León, 24008

  • FutureMeds Madrid

    Madrid, 28003

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28007

  • Hospital Universitario Sanitas la Zarzuela

    Madrid, 28023

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034

  • Hospital Clinico San Carlos

    Madrid, 28040

  • Hospital QuironSalud Malaga

    Málaga, Andalusia, 29004

  • Hospital Clinico Universitario Virgen de la Victoria

    Málaga, Andalusia, 29010

  • Hospital Regional Universitario de Malaga

    Málaga, Andalusia, 29011

  • Hospital Universitario Central de Asturias

    Oviedo, Principality of Asturias, 33011

  • Hospital de Navarra

    Pamplona, Navarre, 31008

  • Hospital Quiron Madrid

    Pozuelo de Alarcón, Madrid, 28223

  • Hospital Universitari Sant Joan de Reus

    Reus, Catalonia, 43204

  • Hospital Universitario de Canarias

    San Cristóbal de La Laguna, Canary Islands, 38320

  • Hospital Universitario Marques de Valdecilla

    Santander, Cantabria, 39008

  • Hospital Clinico Universitario de Santiago

    Santiago de Compostela, Galicia, 15706

  • Nuevas Tecnologias en Diabetes y Endocrinologia

    Seville, Andalusia, 41003

  • Hospital Universitario Virgen del Rocio

    Seville, Andalusia, 41013

  • Hospital Quironsalud Infanta Luisa

    Seville, 41010

  • Hospital Clinico Universitario de Valencia

    Valencia, Valencia, 46010

  • Hospital Universitario Doctor Peset

    Valencia, 46017

  • Hospital Alvaro Cunqueiro

    Vigo, Galicia, 36312

Other trials in Spain

Hungary32 sites

  • Lausmed Kft

    Baja, 6500

  • DRC Gyogyszervizsgalo Kozpont Kft

    Balatonfüred, 8230

  • Tagore Medical Center

    Balatonfüred, 8230

  • Dr Lakatos Ferenc Private Cardiology Practice

    Békéscsaba, 5600

  • Trial Pharma Kft

    Budapest, 1023

  • Clinexpert Kft

    Budapest, 1033

  • Obudai Egeszsegugyi Centrum Kft

    Budapest, 1036

  • PVN Kutato Kft

    Budapest, 1102

  • Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika

    Budapest, 1122

  • Eszak-Pesti Centrum Korhaz - Honvedkorhaz

    Budapest, 1134

  • MedKontroll Egeszsegkozpont

    Budapest, 1134

  • Budapesti Uzsoki Utcai Korhaz

    Budapest, 1145

  • Strazsahegy Medicina Bt

    Budapest, 1171

  • Borvo Clinic Kft

    Debrecen, 4025

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032

  • Obudai Egeszsegugyi Centrum Kft

    Dunaújváros, 2400

  • CRU Hungary Kft

    Encs, 3860

  • Gyongyosi Bugat Pal Korhaz

    Gyöngyös, 3200

  • BKS Research Kft

    Hatvan, 3000

  • Obudai Egeszsegugyi Centrum Kft

    Kaposvár, 7400

  • Trial Pharma Kft

    Kecskemét, 6000

  • Komaromi Selye Janos Korhaz

    Komárom, 2921

  • Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatokorhaz

    Miskolc, 3526

  • IPR Hungary Kft

    Miskolc, 3530

  • Borbanya Praxis Egeszsegugyi Kft

    Nyíregyháza, 4405

  • Dr Nagy Laszlo Kardiologiai maganrendeles es SMO

    Orosháza, 5900

  • COROMED-SMO Kft

    Pécs, 7623

  • DaVinci Maganklinika

    Pécs, 7635

  • KomplexLabor Diagnosztika Kft

    Szeged, 6724

  • Complex Rendelo Med Zrt

    Székesfehérvár, 8000

  • Vas-Oxy Kft

    Szombathely, 9700

  • Obudai Egeszsegugyi Centrum Kft

    Zalaegerszeg, 8900

Other trials in Hungary

Japan32 sites

  • Chiba University Hospital

    Chiba, Chiba, 260-8677

  • Medical Corporation Kenshinkai Minamino Cardiovascular Hospital

    Hachioji-shi, Tokyo, 192-0918

  • Japanese Red Cross Hamamatsu Hospital

    Hamamatsu, Shizuoka, 434-8533

  • Affiliated Central Clinic of Higashiyamato Hospital

    Higashiyamato-shi, Tokyo, 207-0014

  • Teikyo University Hospital

    Itabashi-ku, Tokyo, 173-8606

  • Tenyoukai Central Clinic

    Kagoshima, Kagoshima-ken, 892-0822

  • Ishikawa Prefectural Central Hospital

    Kanazawa, Ishikawa-ken, 920-8530

  • National Hospital Organization Kanazawa Medical Center

    Kanazawa, Ishikawa-ken, 920-8650

  • Kumamoto University Hospital

    Kumamoto, Kumamoto, 860-8556

  • Rakuwakai Otowa Hospital

    Kyoto, Kyoto, 607-8062

  • Tokyo Saiseikai Central Hospital

    Minato-ku, Tokyo, 108-0073

  • Miyazaki Medical Association Hospital

    Miyazaki, Miyazaki, 880-2102

  • Chubu Rosai Hospital

    Nagoya, Aichi-ken, 455-8530

  • Nakakinen Clinic

    Naka, Ibaraki, 311-0113

  • Oita Red Cross Hospital

    Ōita, Oita Prefecture, 870-0033

  • Okayama Rosai Hospital

    Okayama, Okayama-ken, 702-8055

  • Miyanosawa Clinic of Internal Medicine and Cardiology

    Sapporo, Hokkaido, 063-0826

  • Medical corporation Sekishin-kai Saitama Sekishinkai Hospital

    Sayama-shi, Saitama, 350-1305

  • Sayama Renal Clinic

    Sayama-shi, Saitama, 350-1305

  • KKR Tohoku Kosai Hospital

    Sendai, Miyagi, 980-0803

  • Tokuyama Central Hospital

    Shunan-shi, Yamaguchi, 745-8522

  • NewHeart Watanabe Institute

    Suginami-ku, Tokyo, 168-0065

  • Saiseikai Senri Hospital

    Suita-shi, Osaka, 565-0862

  • Takamatsu Red Cross Hospital

    Takamatsu, Kagawa-ken, 760-0017

  • Kagawa Prefectural Central Hospital

    Takamatsu, Kagawa-ken, 760-8557

  • JA Toride Medical Center

    Toride-shi, Ibaraki, 302-0022

  • Fujita Health University Hospital

    Toyoake-shi, Aichi-ken, 470-1192

  • Tsuchiura Kyodo General Hospital

    Tsuchiura-shi, Ibaraki, 300-0028

  • Urasoe General Hospital

    Urasoe-shi, Okinawa, 901-2102

  • Saiseikai Yokohamashi Tobu Hospital

    Yokohama, Kanagawa, 230-8765

  • Yokohama Minami Kyousai Hospital

    Yokohama, Kanagawa, 236-0037

  • Sanin Rosai Hospital

    Yonago-shi, Tottori, 683-8605

Other trials in Japan

Netherlands31 sites

  • Noordwest Ziekenhuisgroep

    Alkmaar, 1815 JD

  • Ziekenhuisgroep Twente

    Almelo, 7609 PP

  • EB Medical Research

    Almere Stad, 1311 RL

  • Meander Medisch Centrum

    Amersfoort, 3813 TZ

  • Ziekenhuis Amstelland

    Amstelveen, 1186 AM

  • Onze Lieve Vrouwe Gasthuis

    Amsterdam, 1091 AC

  • Amsterdam Universitair Medisch Centrum

    Amsterdam, 1105 AZ

  • Gelre Ziekenhuizen

    Apeldoorn, 7334 DZ

  • Rijnstate Ziekenhuis

    Arnhem, 6815 AD

  • Amphia ziekenhuis

    Breda, 4818 CK

  • Reinier de Graaf Gasthuis

    Delft, 2625 AD

  • Deventer Ziekenhuis

    Deventer, 7416 SE

  • Slingeland Ziekenhuis

    Doetinchem, 7009 BL

  • Albert Schweitzer Ziekenhuis location Dordwijk

    Dordrecht, 3318 AT

  • Albert Schweitzer Ziekenhuis, Locatie Dordwijk

    Dordrecht, 3318 AT

  • Catharina Ziekenhuis

    Eindhoven, 5623 EJ

  • Spaarne Gasthuis, locatie Haarlem Zuid

    Haarlem, 2035 RC

  • Sint Jansdal Ziekenhuis

    Harderwijk, 3844 DG

  • Elkerliek Ziekenhuis

    Helmond, 5707 HA

  • Tergooiziekenhuizen, locatie Hilversum

    Hilversum, 1213 XZ

  • Bethesda Diabetes Research Center

    Hoogeveen, 7909 AA

  • Frisius Medisch Centrum, locatie Leeuwarden

    Leeuwarden, 8934 AD

  • Leids Universitair Medisch Centrum

    Leiden, 2333 ZA

  • Radboud Universitair Medisch Centrum

    Nijmegen, 6525 GA

  • Erasmus Medisch Centrum

    Rotterdam, 3015 GD

  • Ikazia Ziekenhuis

    Rotterdam, 3083 AN

  • D and A Research and Genetics

    Sneek, 8601 ZR

  • Haga Ziekenhuis

    The Hague, 2545 AA

  • Ziekenhuis Rivierenland

    Tiel, 4002 WP

  • Universitair Medisch Centrum Utrecht

    Utrecht, 3584 CX

  • VieCuri Medisch Centrum

    Venlo, 5912 BL

Other trials in Netherlands

Argentina30 sites

  • Centro Medico Viamonte

    CABA, Buenos Aires, 1120

  • Imoba Investigaciones medicas

    CABA, Buenos Aires, 1178

  • Conexa Investigacion Clinica SA

    CABA, Buenos Aires, C1012AAY

  • Stat Research

    CABA, Buenos Aires, C1023AAB

  • Cedic - Centro de Investigacion Clinica

    CABA, Buenos Aires, C1060ABN

  • Cemedic Centro de Especialidades Medicas

    CABA, Buenos Aires, C1407GTN

  • Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada

    CABA, Buenos Aires, C1425AGC

  • Consultorios Medicos Dr Besada

    CABA, Buenos Aires, C1426ABP

  • Fundacion Respirar - Consultorios Medicos Dr Doreski

    CABA, Buenos Aires, C1426ABP

  • Glenny Corp SA

    CABA, Buenos Aires, C1430CKE

  • Centro Medico de Nutricion y Diabetes

    CABA, C1440AAD

  • Cinme - Centro de Investigaciones Metabolicas

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1056ABI

  • Ciprec - Centro de Investigacion y Prevencion Cardiovascular

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1061AAT

  • Centro Diabetologico Dr Waitman

    Córdoba, Córdoba Province, 5000

  • Clinica Privada del Prado

    Córdoba, Córdoba Province, 5000

  • Instituto Medico Damic

    Córdoba, X5003DCE

  • CIPADi

    Godoy Cruz, Mendoza Province, M5501ARP

  • Hospital Italiano de La Plata

    La Plata, Buenos Aires, B1900AUR

  • Centro de Investigaciones Medicas Mar del Plata

    Mar del Plata, Buenos Aires, B7600DHK

  • Instituto de Investigaciones clinicas de Mar del Plata

    Mar del Plata, Buenos Aires, B7600FZN

  • Dim Clinica Privada

    Ramos Meija, Buenos Aires, B1704ETD

  • Instituto Medico Rio Cuarto SA

    Río Cuarto, Córdoba Province, X5800AEV

  • Instituto Medico Catamarca Imec

    Rosario, Santa Fe Province, S2000AJU

  • INECO Neurociencias Oronio

    Rosario, S2000DSR

  • Instituto de Investigaciones Clinicas de San Nicolas

    San Nicolás de los Arroyos, Buenos Aires, 2900

  • Centro de Investigaciones Clinicas del Litoral

    Santa Fe, S3000FWO

  • mit - Medicina Investigacion y Tratamiento

    Santa Rosa, La Pampa Province, L6304BWE

  • Clinica Fusavim Privada SRL

    Villa María, Córdoba Province, 5900

  • Go Centro Medico San Nicolas

    Zárate, Buenos Aires, B2800DGH

  • Instituto de Investigaciones Clinicas Zarate

    Zárate, Buenos Aires, B2800DGH

Other trials in Argentina

United Kingdom28 sites

  • Heartlands Hospital

    Birmingham, B9 5SS

  • Waterloo Medical Centre

    Blackpool, FY4 3AD

  • Southmead Hospital

    Bristol, BS10 5NB

  • West Walk Surgery

    Bristol, BS37 4AX

  • Addenbrookes Hospital

    Cambridge, CB2 0QQ

  • Countess of Chester Hospital

    Chester, CH2 1UL

  • University Hospital Coventry

    Coventry, CV2 2DX

  • Russell Hall Hospital

    Dudley, DY1 2HQ

  • Ninewells Hospital and Medical School

    Dundee, DD1 9SY

  • Staploe Medical Centre

    Ely, CB7 5JD

  • Royal Devon and Exeter Hospital

    Exeter, EX2 5DW

  • Glasgow Royal Infirmary

    Glasgow, G31 2ER

  • Wycombe Hospital

    High Wycombe, HP11 2TT

  • Hull Royal Infirmary

    Hull, HU3 2JZ

  • Glenfield Hospital

    Leicester, LE3 9QP

  • Queen Mary University of London

    London, EC1M 6BQ

  • Chelsea and Westminster Hospital

    London, SW10 9NH

  • St Georges Hospital

    London, SW17 0QT

  • Northenden Group Practice

    Manchester, M22 4DH

  • Newcastle NIHR Commercial Research Delivery Centre

    Newcastle upon Tyne, NE1 4LP

  • University Hospital Llandough

    Penarth, CF64 2XX

  • Salford Royal Hospital

    Salford, M5 5AP

  • Lister Hospital

    Stevenage, SG1 4AB

  • Morriston Hospital

    Swansea, SA2 8PP

  • Musgrove Park Hospital

    Taunton, TA1 5DA

  • Torbay Hospital

    Torquay, TQ2 7AA

  • Bradford on Avon and Melksham Health Partnership

    Wiltshire, BA15 1DQ

  • Worcestershire Royal Hospital

    Worcester, WR5 1DD

Other trials in United Kingdom

Slovakia20 sites

  • Alian, sro

    Bardejov, 085 01

  • Dia-Clarus, sro

    Bojnice, 972 01

  • MediTask, sro

    Bratislava, 831 03

  • Novate sro

    Bratislava, 841 04

  • Medispektrum sro

    Bratislava, 851 01

  • Medical group Kosice sro

    Košice, 040 01

  • Cardio D and R, sro Kosice

    Košice, 040 22

  • Kardio 1 sro

    Lučenec, 984 01

  • MediVet, sro

    Malacky, 901 01

  • Poliklinika Nemocnicna as

    Malacky, 901 22

  • Nemocnica s poliklinikou Stefana Kukuru Michalovce, as

    Michalovce, 071 01

  • Oralek, sro

    Námestovo, 029 01

  • InterStom, sro

    Nitra, 949 11

  • Funkystuff sro

    Nové Zámky, 940 02

  • Intermedis sro

    Prešov, 080 01

  • Medispol, sro

    Prešov, 080 01

  • Tatratrial sro

    Rožňava, 048 01

  • Medi-Dia sro

    Sabinov, 083 01

  • Interna SK, sro

    Svidník, 089 01

  • Pentes, sro

    Žilina, 010 01

Other trials in Slovakia

Turkey (Türkiye)20 sites

  • Yuregir Baskent Hastanesi

    Adana, 01250

  • Adana Sehir Egitim ve Arastirma Hastanesi

    Adana, 01370

  • Afyonkarahisar Saglik Bilimleri Universitesi Hastanesi

    Afyonkarahisar, 03218

  • Ankara Bilkent Sehir Hastanesi

    Ankara, 06800

  • Akdeniz Universitesi Tip Fakultesi

    Antalya, 07058

  • Bursa Yuksek Ihtisas Egitim ve Arastirma Hastanesi

    Bursa, 16310

  • Pamukkale Universitesi Tip Fakultesi Hastanesi

    Denizli, 20160

  • Koc Universitesi Hastanesi

    Istanbul, 34010

  • Istanbul Universitesi Cerrahpasa Tip Fakultesi

    Istanbul, 34096

  • Bagcilar Medipol Mega Universite Hastanesi

    Istanbul, 34214

  • Sultangazi Haseki Egitim ve Arastirma Hastanesi

    Istanbul, 34265

  • Kanuni Sultan Suleyman Egitim ve Arastirma Hastanesi

    Istanbul, 34303

  • Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi

    Istanbul, 34722

  • Marmara Universitesi Tip Fakultesi Pendik Egitim ve Arastirma Hastanesi

    Istanbul, 34854

  • Ege Universitesi Tip Fakultesi Hastanesi

    Izmir, 35100

  • Izmir Sehir Hastanesi

    Izmir, 35540

  • Erciyes Universitesi Tip Fakultesi Hastanesi

    Kayseri, 38039

  • Kocaeli Universitesi Tip Fakultesi Hastanesi

    Kocaeli, 41380

  • Inonu Universitesi Turgut Ozal Tip Merkezi

    Malatya, 44280

  • Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi

    Samsun, 55320

Other trials in Turkey (Türkiye)

Australia18 sites

  • Advara HeartCare Wesley

    Auchenflower, Queensland, 4066

  • Flinders Medical Centre

    Bedford Park, South Australia, 5042

  • Novatrials

    Charlestown, New South Wales, 2290

  • Victorian Heart Hospital

    Clayton, Victoria, 3168

  • Momentum Clinical Research - Darlinghurst

    Darlinghurst, New South Wales, 2010

  • Barwon Health Geelong Hospital

    Geelong, Victoria, 3220

  • Austin Health, Heidelberg Repatriation Hospital

    Heidelberg West, Victoria, 3081

  • Royal Brisbane and Womens Hospital

    Herston, Queensland, 4029

  • Advara HeartCare Joondalup

    Joondalup, Western Australia, 6027

  • Advara HeartCare Leabrook

    Leabrook, South Australia, 5068

  • The Alfred Hospital

    Melbourne, Victoria, 3004

  • Core Research Group Pty Ltd

    Milton, Queensland, 4064

  • Advara HeartCare Mulgrave

    Mulgrave, Victoria, 3170

  • Fiona Stanley Hospital

    Murdoch, Western Australia, 6150

  • Linear Clinical Research Limited

    Nedlands, Western Australia, 6009

  • Royal North Shore Hospital

    St Leonards, New South Wales, 2065

  • The Queen Elizabeth Hospital

    Woodville South, South Australia, 5011

  • Dr Heart Pty Ltd

    Woolloongabba, Queensland, 4102

Other trials in Australia

Canada17 sites

  • Centricity Research Brampton

    Brampton, Ontario, L6S 0C6

  • Aggarwal and Associates Ltd

    Brampton, Ontario, L6T 0G1

  • Cambridge Cardiac Care Centre

    Cambridge, Ontario, N1R 6V6

  • Ecogene-21

    Chicoutimi, Quebec, G7H 7K9

  • Janek Senaratne Professional Medical Corporation

    Edmonton, Alberta, T6K 4C1

  • G A Research Associates Limited

    Moncton, New Brunswick, E1G 1A7

  • Montreal Heart Institute

    Montreal, Quebec, H1T 1C8

  • Centre de Recherche du Centre Hospitalier de l Universite de Montreal

    Montreal, Quebec, H2X 0C1

  • Research Institute of McGill University Health Center - Glen Site

    Montreal, Quebec, H4A 3J1

  • North York Diagnostic and Cardiac Centre

    North York, Ontario, M6B 3H7

  • Institut Universitaire de cardiologie et de pneumologie de Quebec

    Québec, Quebec, G1V 4G5

  • Centre intégré de santé et service sociaux de Lanaudière

    Saint-Charles-Borromée, Quebec, J6E 6J2

  • Heart Health Institute Research Incorporated

    Scarborough Village, Ontario, M1B 4Z8

  • KMH Cardiology Centres Incorporated Hamilton

    Stoney Creek, Ontario, L8J 3W2

  • Diabetes Heart Research Centre

    Toronto, Ontario, M6G 1M2

  • Vancouver General Hospital, Gordon and Leslie Diamond Health Care Centre

    Vancouver, British Columbia, V5Z 1M9

  • Discovery Clinical Services Ltd

    Victoria, British Columbia, V8T 5G4

Other trials in Canada

France16 sites

  • Centre Hospitalier Regional Universitaire de Besancon - Hopital Jean Minjoz

    Besançon, 25030

  • Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand

    Dijon, 21079

  • Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon

    Grenoble, 38700

  • Centre Hospitalier Louis Pasteur

    Le Coudray, 28630

  • Hopital le Creusot

    Le Creusot, 71200

  • Centre Hospitalier Saint Joseph Saint Luc

    Lyon, 69007

  • Hopital de la Conception

    Marseille, 13005

  • Centre Hospitalier Universitaire de Nice - Hopital Pasteur

    Nice, 06000

  • Hopital Europeen Georges Pompidou

    Paris, 75015

  • Hopital Bichat Claude Bernard

    Paris, 75018

  • Centre Hospitalier Universitaire de Bordeaux - Hopital Haut Leveque

    Pessac, 33604

  • Hospices Civils de Lyon - Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69495

  • Centre Hospitalier Regional Universitaire de Strasbourg - Hopital de Hautepierre

    Strasbourg, 67000

  • Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil

    Toulouse, 31059

  • Polyclinique Vauban

    Valenciennes, 59300

  • Centre Hospitalier Universitaire de Nancy - Hopital de Brabois

    Vandœuvre-lès-Nancy, 54511

Other trials in France

Romania15 sites

  • Cardioplus Center SRL

    Baia Mare, 430124

  • cmi Pop Lavinia

    Baia Mare, 430222

  • Mariodiab Clinic SRL

    Brasov, 500101

  • Thera Card SRL

    Brasov, 500102

  • Centrul Medical de Diagnostic si Tratament Ambulator Neomed

    Brasov, 500283

  • Geea Medical Easy Diet

    Bucharest, 010627

  • Centrul pentru Studiul Metabolismului - Hightech Medical Services SRL

    Bucharest, 011053

  • Institutul National de Diabet si Nutritie si Boli Metabolice N C Paulescu

    Bucharest, 030167

  • Spitalul Universitar de Urgenta Bucuresti

    Bucharest, 050098

  • Milena Sante

    Galati, 800001

  • Consultmed SRL

    Iași, 700544

  • Diabdana SRL

    Oradea, 410147

  • Clinica Korall

    Satu Mare, 440055

  • Mediab SRL

    Târgu Mureş, 540142

  • Cabinet Medical Individual Dr Podoleanu Cristian

    Târgu Mureş, 540143

Other trials in Romania

Greece14 sites

  • University Hospital of Alexandroupolis

    Alexandroupoli, 68100

  • Athens Naval Hospital

    Athens, 11521

  • General Hospital for Thoracic Diseases of Athens "Sotiria"

    Athens, 11527

  • General Hospital for Thoracic Diseases of Athens "Sotiria

    Athens, 11527

  • General Hospital of Athens Ippokrateio

    Athens, 11527

  • General Hospital of Athens Laiko

    Athens, 11527

  • Alexandra Hospital

    Athens, 11528

  • University General Hospital Attikon General Hospital Of West Attica H Agia Varvara

    Athens, 12462

  • Hygeia Hospital

    Athens, 15123

  • General Hospital Asklipieio Voulas

    Athens, 16673

  • University Hospital of Ioannina

    Ioannina, 45500

  • Ahepa University Hospital

    Thessaloniki, 54636

  • University General Hospital of Thessaloniki Ahepa

    Thessaloniki, 54636

  • Papageorgiou General Hospital of Thessaloniki

    Thessaloniki, 56403

Other trials in Greece

South Korea14 sites

  • Daegu Catholic University Medical Center

    Daegu, 42472

  • Keimyung University Dongsan Medical Center

    Daegu, 42601

  • Myongji Hospital

    Goyang-si, Gyeonggi-do, 10475

  • Gachon University Gil Medical Center

    Incheon, 21565

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620

  • Kyung Hee University Hospital

    Seoul, 02447

  • Korea University Anam Hospital

    Seoul, 02841

  • Seoul National University Hospital

    Seoul, 03080

  • Kangbuk Samsung Hospital

    Seoul, 03181

  • Severance Hospital Yonsei University Health System

    Seoul, 03722

  • Kyung Hee University Hospital at Gangdong

    Seoul, 05278

  • The Catholic University of Korea Seoul St Marys Hospital

    Seoul, 06591

  • Ulsan University Hospital

    Ulsan, 44033

  • Yonsei University Wonju Severance Christian Hospital

    Wonju-si, Gangwon-do, 26426

Other trials in South Korea

Denmark13 sites

  • Aalborg Universitetshospital

    Aalborg, 9000

  • Aarhus Universitetshospital

    Aarhus N, 8200

  • Esbjerg sygehus Syddansk universitetshospital

    Esbjerg, 6700

  • Sanos Gandrup

    Gandrup, DK-9362

  • Steno Diabetes Center Copenhagen

    Herlev, 2730

  • Regionshospitalet Gødstrup

    Herning, 7400

  • Holbaek Sygehus

    Holbæk, 4300

  • Hvidovre Hospital

    Hvidovre, 2650

  • Frederiksberg Hospital

    København NV, 2400

  • Amager Hospital

    København S, 2300

  • Sjaellands Universitetshospital, Roskilde

    Roskilde, 4000

  • Svendborg Sygehus

    Svendborg, 5700

  • Sanos Vejle

    Vejle, 7100

Other trials in Denmark

Italy13 sites

  • Azienda Unita Locale Socio Sanitaria Berica 8 Ospedale Cazzavillan

    Arzignano, 36071

  • Azienda Ospedaliera Sant Anna e San Sebastiano

    Caserta, 81100

  • Casa della salute Ceccano Ospedale

    Ceccano, 03023

  • Ospedale Santissima Annunziata

    Chieti, 66100

  • Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia

    Foggia, 71122

  • Azienda Sanitaria Locale Abruzzo 1 Avezzano, Sulmona e L'Aquila - Ospedale regionale San Salvatore

    L’Aquila, 67100

  • IRCCS Ospedale San Raffaele

    Milan, 20132

  • IRCCS Centro Cardiologico Monzino

    Milan, 20138

  • Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

    Milan, 20162

  • Azienda Ospedale - Università Padova

    Padova, 35128

  • Azienda Unita Sanitaria Locale Romagna

    Rimini, 47923

  • Policlinico Universitario Campus Biomedico

    Roma, 00128

  • Azienda Ospedaliera Ordine Mauriziano di Torino

    Torino, 10128

Other trials in Italy

Belgium12 sites

  • Azorg Campus Aalst - Moorselbaan

    Aalst, 9300

  • Imelda Ziekenhuis vzw

    Bonheiden, 2820

  • Algemeen Ziekenhuis Sint-Jan Brugge

    Bruges, 8000

  • Cliniques universitaires de Bruxelles Hopital Erasme

    Brussels, 1070

  • Universitair Ziekenhuis Antwerpen

    Edegem, 2650

  • Ziekenhuis Oost-Limburg - Campus Sint-Jan

    Genk, 3600

  • Algemeen Ziekenhuis Sint Lucas

    Ghent, 9000

  • Centres Hospitaliers Universitaires - Helora - Hopital de La Louviere - Site Jolimont

    La Louvière, 7100

  • Universitair Ziekenhuis Leuven - Campus Gasthuisberg

    Leuven, 3000

  • Centre Hospitalier Universitaire de Liege - Sart Tilman

    Liège, 4000

  • AZ Oostende - Damiaan

    Ostend, 8400

  • Universite Catholique de Louvain Cliniques Universitaires de Mont-Godinne

    Yvoir, 5530

Other trials in Belgium

Mexico11 sites

  • Centro Medico Nacional Siglo XXI

    Cuauhtémoc, 06720

  • Instituto de Diabetes Obesidad y Nutricion

    Cuernavaca, Morelos, 62250

  • Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC

    Culiacán, Sinaloa, 80230

  • Private Practice Dr. Francisco Padilla Padilla

    Guadalajara, Jalisco, 44670

  • Medical Care and Research Sociedad Anonima

    Mérida, Yucatán, 97070

  • Soluciones Terapeuticas Medico Quirurgicas

    Mexico City, Mexico City, 03650

  • Cardiolink Clin Trials

    Monterrey, Nuevo León, 64060

  • Unidad Biomedica Avanzada Monterrey

    Monterrey, Nuevo León, 64460

  • Centro de Estudios Clinicos de Queretaro

    Querétaro, 76000

  • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares SC

    Tampico, Tamaulipas, 89000

  • Sociedad de Metabolismo y Corazon

    Veracruz, 91855

Other trials in Mexico

Bulgaria10 sites

  • Multiprofile Hospital for Active Treatment Puls AD

    Blagoevgrad, 2700

  • Medical Center Doctor Staikov EOOD

    Burgas, 8008

  • Medical Center Medconsult Pleven OOD

    Pleven, 5800

  • Multiprofile Hospital for Active Treatment Heart and Brain EAD

    Pleven, 5804

  • Multiprofile Hospital for Active Treatment Sveta Karidad EAD

    Plovdiv, 4004

  • National Multiprofile Transport Hospital Tzar Boris III

    Sofia, 1233

  • University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD

    Sofia, 1527

  • Military Medical Academy - Multiprofile Hospital for Active Treatment Sofia

    Sofia, 1606

  • University Multiprofile Hospital for Active Treatment and Emergency Medicine N I Pirogov EAD

    Sofia, 1606

  • Medical Center Dr Kalchev OOD

    Sofia, 1700

Other trials in Bulgaria

Portugal10 sites

  • Unidade Local de Saude de Braga, EPE

    Braga, 4710-243

  • Unidade Local de Saude de Lisboa Ocidental, EPE - Hospital de Santa Cruz

    Carnaxide, 2790-134

  • Unidade Local de Saude de Coimbra, EPE

    Coimbra, 3000-075

  • Unidade Local de Saude do Alto Ave, EPE

    Guimarães, 4835-044

  • Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria

    Lisbon, 1649-035

  • Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano

    Matosinhos Municipality, 4464-513

  • Cardiolima - Centro de Diagnóstico Cardiopulmonar

    Ponte de Lima, 4990-029

  • Ucardio - Centro Clinico Cardiovascular

    Riachos, Torres Novas, 2350-325

  • Unidade Local de Saude de Entre Douro e Vouga, EPE - Hospital de Sao Sebastiao

    Santa Maria da Feira, 4520-211

  • Unidade Local de Saude de Gaia-Espinho, EPE

    Vila Nova de Gaia, 4430-502

Other trials in Portugal

Austria9 sites

  • Landeskrankenhaus Feldkirch

    Feldkirch, 6800

  • Medizinische Universitaet Graz

    Graz, 8036

  • Klinikum Klagenfurt am Woerthersee

    Klagenfurt, 9020

  • Krankenhaus der Barmherzigen Brueder Linz

    Linz, 4021

  • CardioMetabolicCentre

    Mattersburg, 7210

  • Klinik Landstrasse

    Vienna, 1030

  • Zentrum fuer klinische Studien - Dr Hanusch GmbH

    Vienna, 1060

  • Universitaetsklinikum Allgemeines Krankenhaus Wien

    Vienna, 1090

  • Klinik Hietzing

    Vienna, 1130

Other trials in Austria

Taiwan8 sites

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 80756

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung City, 83301

  • Taichung Veterans General Hospital

    Taichung, 40705

  • National Taiwan University Hospital

    Taipei, 10002

  • Taipei Medical University Hospital

    Taipei, 11031

  • Shin Kong Wu Ho-Su Memorial Hospital

    Taipei, 11101

  • Taipei Veterans General Hospital

    Taipei, 11217

  • Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation

    Taoyuan, 33305

Other trials in Taiwan

Chile7 sites

  • Fundacion Innovacion Cardiovascular Clinica Ensenada

    Independencia, Santiago Metropolitan

  • Enroll SpA

    Providencia, Santiago Metropolitan, 7500587

  • Biocinetic servicios medicos limitada

    Santiago, 8320000

  • Hospital Las Higueras

    Talcahuano, Biobio, 4260000

  • Centro de Investigacion Clinica del Sur

    Temuco, Cautín, 4781156

  • Clinical Research Chile SpA

    Valdivia, 5110683

  • Cinvec Estudios Clinicos quinta region Limitada

    Viña del Mar, Valparaiso, 2520997

Other trials in Chile

Sweden7 sites

  • Falu Lasarett

    Falun, 791 82

  • Sahlgrenska Universitetssjukhus

    Gothenburg, 413 45

  • Helsingborgs Lasarett

    Helsingborg, 251 87

  • Linkopings Universitetssjukhus

    Linköping, 581 85

  • Clemenstorgets Hjartmottagning

    Lund, 222 21

  • Orebros Universitetssjukhus

    Örebro, 703 62

  • Karolinska Universitetssjukhuset Solna

    Stockholm, 171 64

Other trials in Sweden

Colombia6 sites

  • Institucion Prestadora de Salud Centro Científico Asistencia

    Barranquilla, Atlántico, 080002

  • Fundacion del Caribe para la Investigacion Biomedica

    Barranquilla, Atlántico, 080020

  • Salud Sura Calle 100

    Bogota, Cundinamarca, 110231

  • Rodrigo Botero SAS

    Medellín, Antioquia, 050012

  • Instituto Cardiovascular del Cesa SA Cardiocesar

    Valledupar, Cesar Department, 200001

  • Healthy Medical Center sas

    Zipaquirá, Cundinamarca, 250251

Other trials in Colombia

Finland6 sites

  • Helsinki University Hospital

    Helsinki, 000290

  • Helsinki University Hospital

    Helsinki, 00029

  • Studycor Oy

    Jyväskylä, 40620

  • Health Step Finland

    Kuopio, 70600

  • Oulu University Hospital

    OYS, 90029

  • Tays sydankeskus oy

    Tampere, 33520

Other trials in Finland

Singapore6 sites

  • Ng Teng Fong General Hospital

    Singapore, Jurong East, 609606

  • Sengkang General Hospital

    Singapore, Sengkang, 544886

  • National University Hospital

    Singapore, 119074

  • National Heart Centre Singapore

    Singapore, 169609

  • Tan Tock Seng Hospital

    Singapore, 308433

  • Changi General Hospital

    Singapore, 529889

Other trials in Singapore

Switzerland6 sites

  • Universitaetsspital Basel

    Basel, 4031

  • Inselspital Bern

    Bern, 3010

  • Hopitaux Universitaires de Geneve

    Geneva, 1211

  • Centre hospitalier universitaire vaudois

    Lausanne, 1011

  • Istituto Cardiocentro Ticino

    Lugano, 6900

  • Universitaetsspital Zuerich

    Zurich, 8091

Other trials in Switzerland

Hong Kong2 sites

  • Queen Mary Hospital, The University of Hong Kong

    Hong Kong

  • Prince of Wales Hospital, Chinese University of Hong Kong

    Shatin, New Territories

Other trials in Hong Kong

Puerto Rico1 site

  • Research and Cardiovascular

    Ponce, 00717

Other trials in Puerto Rico

About this study

Official title: A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

The primary objective of this trial is to demonstrate that maridebart cafraglutide is superior to placebo when given as an adjunct to standard of care with respect to reducing cardiovascular (CV) morbidity and mortality.

Being tested
Maridebart Cafraglutide, Placebo
Keywords
Atherosclerotic Cardiovascular Disease, Overweight, Obesity, Maridebart cafraglutide, AMG 133, MariTide
Medical subject headings
Atherosclerosis, Overweight, Obesity

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Maridebart CafraglutideDrug

    Also called AMG 133, MariTide

    Maridebart cafraglutide will be administered SC.

  • PlaceboDrug

    Placebo will be administered SC.

Study groups in NCT07037433
Study groupRoleWhat they receive
Maridebart CafraglutideExperimentalParticipants will receive maridebart cafraglutide subcutaneously (SC).
Receives: Drug: Maridebart Cafraglutide
PlaceboPlacebo comparatorParticipants will receive placebo SC.
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Time to First Occurrence of a Composite Endpoint Consisting of: CV Death, Myocardial Infarction (MI), or Ischemic Stroke (3-point Major Adverse Cardiac Events [3-P MACE])

    Measured: Up to approximately 35 months

  2. Time to First Occurrence of a Composite Endpoint Consisting of: All-cause Death, MI, Ischemic Stroke, Coronary Revascularization, or Heart Failure (HF) Event (5-point MACE)

    Measured: Up to approximately 35 months

Secondary outcomes (48)

  1. Time to First Occurrence of a Composite Endpoint Consisting of: CV Death, MI, Ischemic Stroke, or HF Event

    Measured: Up to approximately 35 months

  2. Time to First Occurrence of a Composite Endpoint Consisting of: CV Death, MI, Ischemic Stroke or Coronary Revascularization

    Measured: Up to approximately 35 months

  3. Time to First MI

    Measured: Up to approximately 35 months

  4. Time to First Ischemic Stroke

    Measured: Up to approximately 35 months

  5. Time to CV Death

    Measured: Up to approximately 35 months

  6. Time to All-cause Death

    Measured: Up to approximately 35 months

  7. Time to First Coronary Revascularization

    Measured: Up to approximately 35 months

  8. Time to First HF Event

    Measured: Up to approximately 35 months

  9. Time to First HF Event or CV Death

    Measured: Up to approximately 35 months

  10. Time to First Unstable Angina Requiring Hospitalization

    Measured: Up to approximately 35 months

  11. Time to First Occurrence of MI or CV Death

    Measured: Up to approximately 35 months

  12. Time to First Occurrence of MI, Ischemic Stroke or All-cause Death

    Measured: Up to approximately 35 months

  13. Total Major Ischemic Events (Time to First and Recurrent MI or Ischemic Stroke)

    Measured: Up to approximately 35 months

  14. Total All-cause Hospitalizations (Time to First and Recurrent Event)

    Measured: Up to approximately 35 months

  15. Time to Onset of Type 2 Diabetes Mellitus (T2DM) in Participants with Prediabetes at Baseline

    Measured: Up to approximately 35 months

  16. Time to Onset of T2DM in Participants without T2DM at Baseline

    Measured: Up to approximately 35 months

  17. Change from Baseline in Systolic Blood Pressure (SBP) at Week 72

    Measured: Baseline and Week 72

  18. Change from Baseline in Diastolic Blood Pressure (DBP) at Week 72

    Measured: Baseline and Week 72

  19. Change from Baseline in Body Mass Index (BMI) at Week 72

    Measured: Baseline and Week 72

  20. Change from Baseline in Waist Circumference at Week 72

    Measured: Baseline and Week 72

  21. Change from Baseline in Urine Albumin-to-creatinine Ratio (uACR) at Week 72

    Measured: Baseline and Week 72

  22. Change from Baseline in Hemoglobin A1c (HbA1c) at Week 72

    Measured: Baseline and Week 72

  23. Change from Baseline in Fasting Plasma Glucose at Week 72

    Measured: Baseline and Week 72

  24. Percent Change from Baseline in High-sensitivity C-reactive protein (hs-CRP) at Week 72

    Measured: Baseline and Week 72

  25. Percent Change from Baseline in Body Weight at Week 72

    Measured: Baseline and Week 72

  26. Percent Change from Baseline in Total Cholesterol at Week 72

    Measured: Baseline and Week 72

  27. Percent Change from Baseline in High-density Lipoprotein Cholesterol (HDL-C) at Week 72

    Measured: Baseline and Week 72

  28. Percent Change from Baseline in Low-density Lipoprotein Cholesterol (LDL-C) at Week 72

    Measured: Baseline and Week 72

  29. Percent Change from Baseline in Triglycerides (TG) at Week 72

    Measured: Baseline and Week 72

  30. Number of Participants at Week 72 with HbA1c < 6.5% (48 mmol/mol) in Participants with T2DM at Baseline

    Measured: Baseline and Week 72

  31. Number of Participants at Week 72 with HbA1c < 6.0% (42 mmol/mol) in Participants with T2DM at Baseline

    Measured: Baseline and Week 72

  32. Number of Participants at Week 72 with HbA1c < 5.7% (39 mmol/mol) in Participants with T2DM at Baseline

    Measured: Baseline and Week 72

  33. Number of Participants at Week 72 with HbA1c < 6.5% (48 mmol/mol) in Participants Without T2DM at Baseline

    Measured: Baseline and Week 72

  34. Number of Participants at Week 72 with HbA1c < 6.0% (42 mmol/mol) in Participants Without T2DM at Baseline

    Measured: Baseline and Week 72

  35. Number of Participants at Week 72 with HbA1c < 5.7% (39 mmol/mol) in Participants Without T2DM at Baseline

    Measured: Baseline and Week 72

  36. Number of Participants at Week 72 with HbA1c < 5.7% (39 mmol/mol) in Participants with HbA1c ≥ 5.7% and < 6.5% at Baseline

    Measured: Baseline and Week 72

  37. Change from Baseline in Short Form 36 Health Survey Acute Version 2 (SF-36 v2) Physical Function Domain Score at Week 48

    Measured: Baseline and Week 48

  38. Time to First Event of a Composite Nephropathy Endpoint

    Composite endpoint consists of onset of persistent macroalbuminuria, persistent ≥ 40% reduction in estimated glomerular filtration rate (eGFR), onset of persistent eGFR < 15 mL/min/1.73 m^2, initiation of chronic renal replacement therapy (dialysis or transplantation), CV or renal death.

    Measured: Up to approximately 35 months

  39. Change in eGFR (total slope) for the period from baseline to the final follow up visit

    Measured: Baseline up to approximately 35 months

  40. Change in eGFR (chronic slope) for the period from 4 months to the final follow-up visit

    Measured: From 4 months up to approximately 35 months

  41. Time to First Occurrence of a Major Adverse Limb Event (MALE) Defined as Acute Limb Ischemia, Urgent Peripheral Revascularization, Major Amputation Due to a Vascular Etiology or Chronic Limb-threatening Ischemia Requiring Revascularization

    Measured: Up to approximately 35 months

  42. Total Arterial (Coronary, Cerebrovascular, and Peripheral) Revascularization Procedures (Time to First and Recurrent Event)

    Measured: Up to approximately 35 months

  43. Time to First Occurrence of a Composite Endpoint Consisting of: CV Death, MI, Ischemic Stroke, MALE, or Arterial Revascularization

    Measured: Up to approximately 35 months

  44. Time to First Occurrence of a Composite Endpoint Consisting of: CV Death, MI, Ischemic Stroke, or Acute Limb Ischemia

    Measured: Up to approximately 35 months

  45. Time to First Occurrence of a Composite Endpoint Consisting of CV Death, MI, Ischemic Stroke, Acute Limb Ischemia, or Urgent Arterial Revascularization Procedure (Coronary, Cerebrovascular or Peripheral)

    Measured: Up to approximately 35 months

  46. Number of Participants with Treatment-emergent Adverse Events

    Measured: Up to approximately 35 months

  47. Number of Participants with Serious Adverse Events

    Measured: Up to approximately 35 months

  48. Plasma Concentration of Maridebart Cafraglutide at Week 72

    Measured: Week 72

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted25 Jun 2025
  2. Study start25 Jul 2025
  3. Primary completion30 Jun 2028 (estimated)
  4. Study completion29 Sep 2030 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
12,800 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07037433
Sponsor's protocol ID
20220196
Acronym
MARITIME-CV
Status last verified
Oct 2026
First submitted
16 Jun 2025
Last updated
29 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request.

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Maridebart Cafraglutide in people with Atherosclerotic Cardiovascular Disease and Overweight, run by Amgen at 783 sites in 36 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 15 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 29 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 783 sites in United States, Czechia, China, Germany, Poland and 31 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Time to First Occurrence of a Composite Endpoint Consisting of: CV Death, Myocardial Infarction (MI), or Ischemic Stroke (3-point Major Adverse Cardiac Events [3-P MACE]) (time frame: Up to approximately 35 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07037433.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Oct 2026; AzTrials last refreshed its copy on 7 Nov 2026.

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