AzTrials
AzTrials

Heart Failure With Preserved Ejection FractionPhase 3MARITIME-HFNCT07037459

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

A Phase 3 study testing Maridebart cafraglutide in people with Heart Failure With Preserved Ejection Fraction and Heart Failure With Mildly Reduced Ejection Fraction, run by Amgen at 686 sites in 35 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

This trial will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascular (CV) deaths and improvement in HF symptoms in participants with HF with preserved ejection fraction (HFpEF) and HF… Read more about this study

Who is it for?
Ages 18 to 99 years
What is being tested?
Maridebart cafraglutide
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
5,056 participants
Where
686 sitesin 35 countries
Study dates
25 Jun 2025to 29 Sep 2030
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 99 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Age ≥ 18 years at the time of informed consent.
  • BMI ≥ 30.0 kg/m^2 at randomization.
  • HF diagnosed for at least 30 days with New York Heart Association (NYHA) Class II-IV at the time of informed consent.
  • Managed with HF standard of care therapies.
  • Left ventricular ejection fraction (LVEF) of > 40% within 12 months before randomization.

Who cannot join

  • History of any of the following within 60 days prior to or during screening: Type I (spontaneous) MI, valvular replacement or repair, coronary revascularization, coronary artery bypass graft surgery or other major cardiovascular surgery, stroke.
  • HF due to: hypertrophic cardiomyopathy, infiltrative cardiomyopathy, active or chronic myocarditis, constrictive pericarditis, cardiac tamponade, arrhythmogenic right ventricular or left ventricular cardiomyopathy/dysplasia, uncorrected primary valvular heart disease, clinically significant congenital heart disease.
  • Hospitalized with acute decompensated HF at the time of or during the screening period.
  • Type 1 diabetes mellitus, or any type of diabetes with the exception of T2DM or history of gestational diabetes.
  • For participants with a prior diagnosis of T2DM (including those diagnosed during screening):
  • HbA1c > 10.0% (86 mmol/mol) at screening
Show all 22Show fewer
  • Uncontrolled diabetes requiring immediate therapy
  • History of diabetic ketoacidosis or hyperosmolar state/coma within 12 months before randomization
  • One or more episodes of severe hypoglycemia within 6 months before randomization and/or history of hypoglycemia unawareness
  • History or presence of either proliferative diabetic retinopathy, or diabetic maculopathy, or severe non-proliferative diabetic retinopathy; or currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema.
  • SBP ≥ 180 mmHg during the screening period, or on three or more blood pressure-lowering drugs with a SBP > 160 mmHg during the screening period (including day 1 prior to randomization).
  • History of chronic pancreatitis or acute pancreatitis in the 180 days before screening or during the screening period.
  • Any personal lifetime history of, or family history(first-degree relative[s]) of medullary thyroid carcinoma or MEN-2.
  • eGFR < 20 mL/min/1.73 m^2 (CKD-EPI creatinine (Cr)-cystatin C equation) or receiving dialysis at screening.
  • Calcitonin ≥ 50 ng/L (pg/mL) at screening.
  • Acute or chronic hepatitis.
  • Any of the following psychiatric history:
  • History of unstable major depressive disorder or other severe psychiatric disorder within 2 years prior to screening or during the screening period
  • Lifetime history of suicide attempt
  • History of non-suicidal self-injury within 5 years prior to screening or during the screening period.
  • History of any other condition that, in the opinion of the investigator, may preclude the participant from following the protocol and completing the trial.
  • Use of any glucagon-like peptide 1 receptor agonist (GLP-1 RA), glucose-dependent insulinotropic polypeptide (GIP) agonists or antagonists, or amylin analogs within 90 days prior to or during the screening period or planned use during the conduct of the trial.

Trial locations and contacts

686 sites in 35 countries. Contact the study team or a site near you to ask about taking part.

Amgen Call Center contact

866-572-6436

medinfo@amgen.com

686 sites in 35 countries

United States123 sites, 116 recruiting

  • Capital Cardiology Associates

    Albany, New York, 12211

    Recruiting

  • Orlando Heart and Vascular Institute

    Altamonte Springs, Florida, 32714

    Recruiting

  • PharmaTex Research, LLC

    Amarillo, Texas, 79106

    Recruiting

  • University of Michigan Health System, Dominos Farms

    Ann Arbor, Michigan, 48109-5853

    Recruiting

  • Conquest Research, LLC

    Arlington, Virginia, 22205

    Recruiting

  • Asheville Cardiology Associates

    Asheville, North Carolina, 28803

    Recruiting

  • Piedmont Heart Institute

    Atlanta, Georgia, 30309

    Recruiting

  • Austin Heart

    Austin, Texas, 78705

    Recruiting

  • D and H Tamarac Research Center

    Aventura, Florida, 33180

    Recruiting

  • Ascension Saint Agnes Heart Care

    Baltimore, Maryland, 21229

    Recruiting

  • Johns Hopkins University

    Baltimore, Maryland, 21287

    Recruiting

  • Our Lady of the Lake Medical Center

    Baton Rouge, Louisiana, 70808

    Terminated

  • Metropolitan Cardiovascular Consultants LLC

    Beltsville, Maryland, 20705

    Recruiting

  • National Heart Institute

    Beverly Hills, California, 90211

    Recruiting

  • University of Alabama Saint Vincent's Birmingham

    Birmingham, Alabama, 35205

    Recruiting

  • Embassy Research Network

    Bloomfield Township, Michigan, 48302

    Recruiting

  • Excel Medical Clinical Trials

    Boca Raton, Florida, 33434

    Recruiting

  • Flourish Bowie

    Bowie, Maryland, 20715

    Recruiting

  • South Palm Cardiovascular Associates

    Boynton Beach, Florida, 33426

    Recruiting

  • Cardiovascular and Vein Center of Florida

    Bradenton, Florida, 34209

    Terminated

  • Advanced Heart Care LLC

    Bridgewater, New Jersey, 08807

    Completed

  • Javara Research

    Conroe, Texas, 77384

    Recruiting

  • Millennium Medical Research

    Coral Gables, Florida, 33134

    Recruiting

  • Valley Clinical Trials, LLC dba Flourish Research

    Covina, California, 91723

    Recruiting

  • Louisiana Heart Center - Hammond

    Covington, Louisiana, 70433

    Recruiting

  • Cedar Health Research, LLC

    Dallas, Texas, 75251

    Recruiting

  • Henry Ford Health System

    Detroit, Michigan, 48202

    Recruiting

  • SEC Clinical Research

    Dothan, Alabama, 36305

    Recruiting

  • Dallas Heart and Vascular Consultants

    Duncanville, Texas, 75137

    Recruiting

  • Duke University Health System

    Durham, North Carolina, 27719

    Recruiting

  • David Turbay, MD

    El Paso, Texas, 79905

    Recruiting

  • Midwest Cardiovascular Research And Education Foundation

    Elkhart, Indiana, 46514

    Recruiting

  • Eastern Shore Research Institute

    Fairhope, Alabama, 36532

    Recruiting

  • Virginia Heart

    Falls Church, Virginia, 22042

    Recruiting

  • Healthy Heart Cardiology

    Grand Rapids, Michigan, 49546

    Recruiting

  • Heart Clinic of Hammond

    Hammond, Louisiana, 70403

    Recruiting

  • Chicago Medical Research LLC

    Hazel Crest, Illinois, 60429

    Recruiting

  • Elite Cardiac Research Center LLC

    Hialeah, Florida, 33013

    Recruiting

  • Encore Medical Research LLC

    Hollywood, Florida, 33024

    Recruiting

  • Abington Medical Specialists

    Horsham, Pennsylvania, 19044

    Recruiting

  • East Texas Cardiology PA

    Houston, Texas, 77002

    Recruiting

  • Biopharma Informatic

    Houston, Texas, 77025

    Recruiting

  • Orion Medical

    Houston, Texas, 77034

    Recruiting

  • Biopharma Informatic, LLC

    Houston, Texas, 77043

    Recruiting

  • Biopharma Informatic

    Houston, Texas, 77084

    Recruiting

  • Vital Heart and Vein

    Humble, Texas, 77338

    Recruiting

  • National Institute of Clinical Research

    Huntington Beach, California, 92648

    Recruiting

  • Huntsville Clinical Research, LLC

    Huntsville, Alabama, 35801-4317

    Recruiting

  • Ascension Medical Group

    Indianapolis, Indiana, 46260

    Recruiting

  • 310 Clinical Research

    Inglewood, California, 90301

    Recruiting

  • Nature Coast Clinical Research

    Inverness, Florida, 34452

    Recruiting

  • Apex Research Foundation, LLC

    Jackson, Tennessee, 38301

    Recruiting

  • The Jackson Clinic PA

    Jackson, Tennessee, 38305

    Recruiting

  • East Coast Institute for Research

    Jacksonville, Florida, 32216

    Recruiting

  • First Coast Cardiovascular Institute PA

    Jacksonville, Florida, 32216

    Recruiting

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216

    Recruiting

  • Kalispell Regional Medical Center

    Kalispell, Montana, 59901

    Recruiting

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160

    Recruiting

  • Saint Luke's Hospital of Kansas City

    Kansas City, Missouri, 64111

    Recruiting

  • Clearwater Cardiovascular Consultants

    Largo, Florida, 33777

    Recruiting

  • Johnson County Clintrials

    Lenexa, Kansas, 66219

    Recruiting

  • Ima Clinical Research - Lenoir

    Lenoir, North Carolina, 28645

    Recruiting

  • The Research Group of Lexington LLC

    Lexington, Kentucky, 40503

    Recruiting

  • Bryan Heart

    Lincoln, Nebraska, 68506

    Recruiting

  • Arkansas Cardiology

    Little Rock, Arkansas, 72205

    Recruiting

  • Carient Heart and Vascular

    Manassas, Virginia, 20109

    Recruiting

  • Northshore Heart and Vascular LLC

    Mandeville, Louisiana, 70448

    Recruiting

  • Mankato Clinic

    Mankato, Minnesota, 56001

    Recruiting

  • Fairview Health Services M Health Fairview St Johns Hospital

    Maplewood, Minnesota, 55109

    Recruiting

  • Virtua Health Incorporated

    Marlton, New Jersey, 08053

    Completed

  • North Dallas Research Associates

    McKinney, Texas, 75069

    Recruiting

  • Texas Institute of Cardiology

    McKinney, Texas, 75071

    Recruiting

  • High Desert Heart and Vascular

    Meridian, Idaho, 83642

    Recruiting

  • Advocate Aurora Saint Lukes Medical Center

    Milwaukee, Wisconsin, 53215

    Recruiting

  • University of Minnesota

    Minneapolis, Minnesota, 55455

    Recruiting

  • Cardiovascular Research of Northwest Indiana LLC

    Munster, Indiana, 46321

    Recruiting

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10019

    Recruiting

  • Saint Michaels Medical Center

    Newark, New Jersey, 07102

    Recruiting

  • Radin Cardiovascular Medical Group

    Newport Beach, California, 92663

    Recruiting

  • Valley Clinical Trials

    Northridge, California, 91325

    Recruiting

  • Parkway Cardiology Associates

    Oak Ridge, Tennessee, 37830

    Recruiting

  • Ocala Cardiovascular Research

    Ocala, Florida, 34471

    Recruiting

  • South Oklahoma Heart Research

    Oklahoma City, Oklahoma, 73135

    Recruiting

  • Methodist Physicians Clinic Heart Consultants

    Omaha, Nebraska, 68114

    Terminated

  • University of California Irvine

    Orange, California, 92868

    Recruiting

  • AdventHealth Orlando

    Orlando, Florida, 32803

    Recruiting

  • Orlando Health Heart Institute

    Orlando, Florida, 32806

    Recruiting

  • Ormond Beach Clinical Research

    Ormond Beach, Florida, 32174

    Recruiting

  • Privia Medical Group Georgia LLC

    Peachtree City, Georgia, 30269

    Recruiting

  • Broward Research Center

    Pembroke Pines, Florida, 33024

    Recruiting

  • Ascension Sacred Heart

    Pensacola, Florida, 32504

    Recruiting

  • HonorHealth

    Phoenix, Arizona, 85006

    Terminated

  • Medical Advancement Centers of Arizona

    Phoenix, Arizona, 85044

    Recruiting

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213

    Recruiting

  • Stryde Research - Pioneer Primary Care and Cardiology Clinic

    Plano, Texas, 75093

    Recruiting

  • Empire Clinical Research

    Pomona, California, 91767

    Recruiting

  • Hudson Valley Cardiovascular Practice PC

    Poughkeepsie, New York, 12601

    Recruiting

  • Cardiovascular Research of Knoxville North Knoxville Medical Center

    Powell, Tennessee, 37849

    Recruiting

  • Pulse Heart Institute

    Puyallup, Washington, 98372

    Recruiting

  • Monument Health Clinical Research

    Rapid City, South Dakota, 57701

    Recruiting

  • Reid Physician Associates

    Richmond, Indiana, 47374

    Recruiting

  • Roanoke Heart Institute PLC

    Roanoke, Virginia, 24014

    Recruiting

  • Advanced Cardiology Associates

    Rochester Hills, Michigan, 48307

    Recruiting

  • Salem VA Medical Center

    Salem, Virginia, 24153

    Recruiting

  • San Diego Cardiac Center

    San Diego, California, 92123

    Recruiting

  • Kaiser Permanente

    San Francisco, California, 94118

    Recruiting

  • NorthBay Clinical Research LLC

    Santa Rosa, California, 95405

    Recruiting

  • Cardiovascular Center of Sarasota

    Sarasota, Florida, 34239

    Recruiting

  • Sherman Clinical Research

    Sherman, Texas, 75092

    Recruiting

  • CardioMetabolic Collaborative Clinic

    Somerset, New Jersey, 08873

    Recruiting

  • Revival Research Institute

    Southfield, Michigan, 48034

    Recruiting

  • Cardiology Associates of Fairfield County PC

    Stamford, Connecticut, 06905

    Recruiting

  • Richmond University Medical Center

    Staten Island, New York, 10310

    Recruiting

  • Accellacare of Piedmont Healthcare

    Statesville, North Carolina, 28625

    Recruiting

  • Manshadi Heart Institute

    Stockton, California, 95204

    Recruiting

  • Northwest Houston Clinical Research PLLC

    Tomball, Texas, 77375

    Recruiting

  • Pima Heart and Vascular Clinical Research

    Tucson, Arizona, 85704

    Recruiting

  • Tennessee Center for Clinical Trials

    Tullahoma, Tennessee, 37388

    Recruiting

  • Cardiology Partners Clinical Research Institute

    Wellington, Florida, 33449

    Recruiting

  • Kansas Nephrology Research Institute LLC

    Wichita, Kansas, 67214

    Terminated

  • Accellacare of Wilmington

    Wilmington, North Carolina, 28401

    Recruiting

  • Guardian Research Organization LLC

    Winter Park, Florida, 32792

    Recruiting

  • Yuma Clinical Trials

    Yuma, Arizona, 85365

    Recruiting

Other trials in United States

China55 sites, 49 recruiting

  • First Affiliated Hospital of Baotou Hospital, Inner

    Baotou, Inner Mongolia, 014010

    Recruiting

  • Beijing Hospital

    Beijing, Beijing Municipality, 100020

    Recruiting

  • Fuwai Hospital Chinese Academy of Medical Sciences

    Beijing, Beijing Municipality, 100037

    Recruiting

  • Beijing Friendship Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100050

    Recruiting

  • Peking University Third Hospital

    Beijing, Beijing Municipality, 100191

    Recruiting

  • Jilin Province Peoples Hospital

    Changchun, Jilin, 130021

    Recruiting

  • The First Bethune Hospital of Jilin University

    Changchun, Jilin, 130021

    Recruiting

  • China Japan Union Hospital of Jilin University

    Changchun, Jilin, 130033

    Recruiting

  • The Second Hospital of Jilin University

    Changchun, Jilin, 130041

    Recruiting

  • The Second Xiangya Hospital of Central South University

    Changsha, Hunan, 410011

    Recruiting

  • The Third Xiangya Hospital of Central South University

    Changsha, Hunan, 410013

    Recruiting

  • The Third Hospital of Changsha

    Changsha, Hunan, 410015

    Recruiting

  • The First Peoples Hospital of Changzhou

    Changzhou, Jiangsu, 210300

    Recruiting

  • Chengdu Fifth Peoples Hospital

    Chengdu, Sichuan, 611130

    Recruiting

  • Affiliated Hospital of Chifeng University

    Chifeng, Inner Mongolia, 024050

    Recruiting

  • The Second Affiliated Hospital of Chongqing Medical University

    Chongqing, Sichuan, 400010

    Recruiting

  • Daqing Oilfield general Hospital

    Daqing, Heilongjiang, 163000

    Recruiting

  • Guangdong Provincial Peoples Hospital

    Guangzhou, Guangdong, 519041

    Recruiting

  • The Affiliated Hospital of Inner Mongolia Medical University

    Haikou, Hainan, 570311

    Recruiting

  • The First Affiliated Hospital Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310003

    Terminated

  • Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310016

    Terminated

  • The First Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, 150001

    Recruiting

  • The Second Hospital of Anhui Medical University

    Hefei, Anhui, 230601

    Terminated

  • Hebei Petro China Central Hospital

    Hengyang, Hunan, 421001

    Recruiting

  • Qilu Hospital of Shandong University

    Jinan, Shandong, 250012

    Recruiting

  • Jinan Central Hospital

    Jinan, Shandong, 250013

    Recruiting

  • Huaihe Hospital of Henan University

    Kaifeng, Henan, 475000

    Recruiting

  • Lishui Central Hospital

    Lishui, Zhejiang, 323000

    Recruiting

  • Luoyang Third Peoples Hospital

    Luoyang, Henan, 471002

    Recruiting

  • The First Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330006

    Recruiting

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, Jiangsu, 210011

    Recruiting

  • Zhongda Hospital Southeast University

    Nanjing, Jiangsu, 211000

    Recruiting

  • Pingxiang Peoples Hospital

    Pingxiang, Jiangxi, 337000

    Recruiting

  • First Hospital of Qinhuangdao

    Qinhuangdao, Hebei, 066099

    Recruiting

  • Shanghai Tenth Peoples Hospital

    Shanghai, Shanghai Municipality, 200072

    Recruiting

  • Shanghai General Hospital

    Shanghai, Shanghai Municipality, 200080

    Recruiting

  • Shanghai East Hospital

    Shanghai, Shanghai Municipality, 200120

    Recruiting

  • Zhongshan Hospital Affiliated to Dalian University

    Shenyang, Liaoning, 110002

    Recruiting

  • The Peoples Hospital of Liaoning Province

    Shenyang, Liaoning, 110016

    Recruiting

  • The Second Hospital of Hebei Medical University

    Shijiazhuang, Hebei, 050000

    Terminated

  • The First Hospital of Hebei Medical University

    Shijiazhuang, Hebei, 300402

    Recruiting

  • Siping City Center Peoples Hospital

    Siping, Jilin, 136000

    Terminated

  • Tai'an City Central Hospital

    Tai’an, Shandong, 271099

    Recruiting

  • First Hospital of Shanxi Medical University

    Taiyuan, Shanxi, 030001

    Recruiting

  • Shanxi Cardiovascular Hospital

    Taiyuan, Shanxi, 030024

    Recruiting

  • Tianjin Peoples Hospital

    Tianjin, Tianjin Municipality, 300121

    Recruiting

  • Teda International Cardiovascular Hospital

    Tianjin, Tianjin Municipality, 300457

    Recruiting

  • The Third Peoples Hospital of Hubei Province

    Wuhan, Hubei, 430033

    Recruiting

  • Wuxi Peoples Hospital

    Wuxi, Jiangsu, 214023

    Recruiting

  • Shaanxi Provincial Peoples Hospital

    Xi'an, Shaanxi, 710068

    Recruiting

  • The First Affiliated Hospital of Xi An Medical University

    Xi'an, Shaanxi, 710077

    Terminated

  • The First Affiliated Hospital of Xi An Jiao Tong University

    Xi’an, Shanxi, 710061

    Recruiting

  • Yuncheng Central hospital

    Yuncheng, Shanxi, 044000

    Recruiting

  • Zhengzhou Central Hospital

    Zhengzhou, Henan, 450000

    Recruiting

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, 450052

    Recruiting

Other trials in China

Czechia39 sites, 39 recruiting

  • Medicus Services sro

    Brandýs nad Labem, 250 01

    Recruiting

  • MUDr Libor Nechvatal sro

    Brno, 602 00

    Recruiting

  • Univmed sro

    Brno, 602 00

    Recruiting

  • MUDr Karel Kamenik sro

    Brno, 603 00

    Recruiting

  • Kardiologicka ambulance Brno sro

    Brno, 612 00

    Recruiting

  • Fakultni nemocnice Brno

    Brno, 625 00

    Recruiting

  • Vojenska nemocnice Brno

    Brno, 636 00

    Recruiting

  • Edumed sro

    Broumov, 550 01

    Recruiting

  • CorMedico sro

    Bruntál, 792 01

    Recruiting

  • Kardio Chlumec sro

    Chlumec nad Cidlinou, 503 51

    Recruiting

  • Ordinace pro choroby srdce sro

    Chomutov, 430 02

    Recruiting

  • Dika centrum sro

    Havirov - Mesto, 736 01

    Recruiting

  • Kardio Holesov sro

    Holešov, 769 01

    Recruiting

  • Edumed sro

    Hradec Králové, 500 02

    Recruiting

  • Edumed sro

    Jaroměř, 551 01

    Recruiting

  • Kardiologie - Liberec sro

    Liberec, 460 01

    Recruiting

  • Cevni ambulance Melnik

    Mělník, 276 01

    Recruiting

  • Edumed sro

    Náchod, 547 01

    Recruiting

  • PreventaMed sro

    Olomouc, 779 00

    Recruiting

  • Ostin sro

    Ostrava, 700 30

    Recruiting

  • CCR Ostrava sro

    Ostrava, 702 00

    Recruiting

  • MUDr Miroslav Koliba sro

    Ostrava, 702 00

    Recruiting

  • Pratia Czech sro

    Pardubice, 530 02

    Recruiting

  • Nemocnice Pardubickeho kraje as

    Pardubice, 532 03

    Recruiting

  • Kardiologie a Angiologie Praha sro - Komplexni Centrum Vyzkumu, Prevence a Lecby Kardiov Nemoci

    Prague, 101 00

    Recruiting

  • Avicena - kardiologie, interna sro

    Prague, 110 00

    Recruiting

  • Kardiologie Vinohrady sro

    Prague, 110 00

    Recruiting

  • Kardiologie Vinohrady sro

    Prague, 120 00

    Recruiting

  • Pratia Czech sro

    Prague, 130 00

    Recruiting

  • Institut klinicke a experimentalni mediciny

    Prague, 140 21

    Recruiting

  • Kardiologicke centrum MUDr Janky Skrobakove sro

    Praha 5 - Smichov, 150 00

    Recruiting

  • Kardio Vaclavik sro

    Přerov, 750 02

    Recruiting

  • MUDr Jarmila Otrubova

    Prostějov, 796 01

    Recruiting

  • Nemocnice Slany

    Slaný, 274 01

    Recruiting

  • Kardiologicka ambulance MUDr Ferkl, sro

    Trutnov, 541 01

    Recruiting

  • Ansaldo sro

    Uherské Hradiště, 686 01

    Recruiting

  • Clinical Trials Service sro

    Uherské Hradiště, 686 01

    Recruiting

  • Kardiologicka Ambulance MUDr Michaela Cervinkova, sro

    Ústí nad Labem, 400 01

    Recruiting

  • Kardiologie - Usti nad Labem sro

    Ústí nad Labem, 400 01

    Recruiting

Other trials in Czechia

Germany36 sites, 34 recruiting

  • Zentralklinik Bad Berka GmbH

    Bad Berka, 99437

    Recruiting

  • Rhoehn Klinik Campus Bad Neustadt

    Bad Neustadt an der Saale, 97616

    Recruiting

  • Segeberger Kliniken GmbH

    Bad Segeberg, 23795

    Recruiting

  • policum Berlin Friedenau

    Berlin, 12157

    Recruiting

  • Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin

    Berlin, 12203

    Recruiting

  • Charite - Universitaetsmedizin Berlin, Campus Virchow

    Berlin, 13353

    Recruiting

  • Universitaetsklinikum Bonn

    Bonn, 53127

    Terminated

  • Klinikum Lippe

    Detmold, 32756

    Recruiting

  • Diabeteszentrum Dortmund

    Dortmund, 44137

    Recruiting

  • Zentrum fuer klinische Pruefungen in der Facharztzentrum Dresden-Neustadt Betriebsgesellschaft

    Dresden, 01099

    Recruiting

  • Universitaetsklinikum Dresden

    Dresden, 01307

    Recruiting

  • Universitaetsklinikum Duesseldorf

    Düsseldorf, 40225

    Recruiting

  • ClinPhenomics CVC GmbH

    Frankfurt am Main, 60596

    Recruiting

  • Universitaetsklinikum Frankfurt

    Frankfurt am Main, 60596

    Recruiting

  • Medizinisches Versorgungszentrum im Altstadt-Carree Fulda

    Fulda, 36037

    Recruiting

  • Herzzentrum der Universitaetsmedizin Goettingen

    Göttingen, 37099

    Recruiting

  • Universitaetsklinikum Hamburg Eppendorf

    Hamburg, 20251

    Recruiting

  • Cardiologicum Hamburg GbR

    Hamburg, 22041

    Recruiting

  • Kardiologische Praxis

    Haßloch, 67454

    Recruiting

  • Universitaetsklinikum Heidelberg

    Heidelberg, 69120

    Recruiting

  • Universitaetsklinikum des Saarlandes

    Homburg, 66421

    Recruiting

  • Universitaetsklinikum Jena

    Jena, 07747

    Recruiting

  • Kardiopraxis Schirmer

    Kaiserslautern, 67655

    Terminated

  • Universitaetsklinikum Leipzig

    Leipzig, 04103

    Recruiting

  • Klinikum Leverkusen

    Leverkusen, 51375

    Recruiting

  • Marienhaus Klinikum Mainz

    Mainz, 55131

    Recruiting

  • zero Praxen GbR

    Mannheim, 68165

    Recruiting

  • Johannes Wesling Klinikum Minden

    Minden, 32429

    Recruiting

  • Klinikum rechts der Isar der TUM

    München, 80809

    Recruiting

  • FutureMeds Offenbach

    Offenbach, 63065

    Recruiting

  • Kardiologische Gemeinschaftspraxis Papenburg

    Papenburg, 26871

    Recruiting

  • Universitaetsklinikum Regensburg

    Regensburg, 93053

    Recruiting

  • Kardiologische Praxis Dr Markus Knapp

    Schwäbisch Hall, 74523

    Recruiting

  • Herz- und Gefaesszentrum Praxis Dr Overhoff Dr Kraemer

    Siegen, 57072

    Recruiting

  • Cardiologicum Herzklinik Ulm

    Ulm, 89077

    Recruiting

  • Praxis Dr med Ayham Al-Zoebi Facharzt fuer Innere Medizin und Kardiologie

    Wermsdorf, 04779

    Recruiting

Other trials in Germany

Hungary30 sites, 30 recruiting

  • EUREKA-CENTER Orvosi es Szolgaltato Bt

    Baja, 6500

    Recruiting

  • Tagore Medical Center

    Balatonfüred, 8230

    Recruiting

  • Budapesti Szent Ferenc Korhaz

    Budapest, 1021

    Recruiting

  • Geomedical Orvosi Kft

    Budapest, 1066

    Recruiting

  • Bajcsy-Zsilinszky Korhaz es Rendelointezet

    Budapest, 1106

    Recruiting

  • Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika

    Budapest, 1122

    Recruiting

  • Eszak-Pesti Centrum Korhaz - Honvedkorhaz

    Budapest, 1134

    Recruiting

  • MedKontroll Egeszsegkozpont

    Budapest, 1134

    Recruiting

  • Budapesti Uzsoki Utcai Korhaz

    Budapest, 1145

    Recruiting

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032

    Recruiting

  • CRU Hungary Kft

    Encs, 3860

    Recruiting

  • Gyongyosi Bugat Pal Korhaz

    Gyöngyös, 3200

    Recruiting

  • Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktatokorhaz

    Győr, 9024

    Recruiting

  • BKS Research Kft

    Hatvan, 3000

    Recruiting

  • Bacs-Kiskun Varmegyei Oktatokorhaz

    Kecskemét, 6000

    Recruiting

  • Trial Pharma Kft

    Kecskemét, 6000

    Recruiting

  • Keszthelyi Korhaz

    Keszthely, 8360

    Recruiting

  • Kistarcsai Flor Ferenc Korhaz

    Kistarcsa, 2143

    Recruiting

  • Komaromi Selye Janos Korhaz

    Komárom, 2921

    Recruiting

  • Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz

    Nyíregyháza, 4400

    Recruiting

  • Oroshazi Dr Laszlo Elek Korhaz es Rendelointezet

    Orosháza, 5900

    Recruiting

  • COROMED-SMO Kft

    Pécs, 7623

    Recruiting

  • DaVinci Maganklinika

    Pécs, 7635

    Recruiting

  • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

    Szeged, 6725

    Recruiting

  • Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz

    Székesfehérvár, 8000

    Recruiting

  • Tolna Varmegyei Balassa Janos Korhaz

    Szekszárd, 7100

    Recruiting

  • Szegedi Tudomanyegyetem SZGYA Klinikai Kozpont Dr Bugyi Istvan Szentesi Multidiszciplinaris Centrum

    Szentes, 6600

    Recruiting

  • Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointezet

    Szolnok, 5000

    Recruiting

  • Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz

    Szombathely, 9700

    Recruiting

  • Zala Varmegyei Szent Rafael Korhaz

    Zalaegerszeg, 8900

    Recruiting

Other trials in Hungary

Poland26 sites, 25 recruiting

  • Marek Dariusz Klimkiewicz Klimed Marek Klimkiewicz

    Bialystok, 15-704

    Recruiting

  • Centrum medyczne intercore sp zoo

    Bydgoszcz, 85-605

    Recruiting

  • American Heart of Poland Spolka Akcyjna

    Chrzanów, 32-500

    Recruiting

  • Centrum Badan Klinicznych Agnieszka Mital

    Elblag, 82-300

    Recruiting

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80-214

    Recruiting

  • Pawel Miekus, NZOZ Sopockie Centrum Badan Kardiologicznych ProCordis Pawel Miekus

    Gdynia, 81-423

    Recruiting

  • Niepubliczny Zaklad Opieki Zdrowotnej Medica Jerzy Cygler

    Giżycko, 11-500

    Recruiting

  • Pro Familia Altera Sp zoo

    Katowice, 40-648

    Recruiting

  • Futuremeds spolka z ograniczona odpowiedzialnoscia

    Krakow, 31-501

    Recruiting

  • SPZOZ Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi

    Lodz, 90-549

    Recruiting

  • Futuremeds spolka z ograniczona odpowiedzialnoscia

    Lodz, 91-363

    Recruiting

  • Drelich Grzegorz Centrum Kardiologiczne Kardio-Med

    Lublin, 20-044

    Recruiting

  • Szpital Swietej Anny w Miechowie

    Miechów, 32-200

    Recruiting

  • Futuremeds spolka z ograniczona odpowiedzialnoscia

    Olsztyn, 10-165

    Recruiting

  • Medicome Spolka z Ograniczona Odpowiedzialnoscia

    Oświęcim, 32-600

    Recruiting

  • Centrum Medyczne Medyk Spolka z Ograniczona Odpowiedzialnoscia Spolka Komandytowa

    Rzeszów, 35-055

    Recruiting

  • Velocity Nova Sp zoo

    Skierniewice, 96-100

    Recruiting

  • Aidport Spolka z ograniczona odpowiedzialnoscia

    Skorzewo, 60-185

    Recruiting

  • Praktyka Lekarska Lidia Pawlowicz

    Torun, 87-100

    Recruiting

  • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca

    Tychy, 43-100

    Recruiting

  • Oha-Med Sp zoo

    Warsaw, 01-018

    Recruiting

  • Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji

    Warsaw, 02-507

    Recruiting

  • Gabinet Lekarski Maciej Karcz

    Warsaw, 02-758

    Recruiting

  • Uniwersytecki Szpital Kliniczny im Jana Mikulicza-Radeckiego we Wroclawiu

    Wroclaw, 50-556

    Recruiting

  • Futuremeds spolka z ograniczona odpowiedzialnoscia

    Wroclaw, 53-673

    Terminated

  • Halina Serafin NZOZ Centrum Medyczne "Serafin-Med"

    Żarów, 58-130

    Recruiting

Other trials in Poland

United Kingdom26 sites, 26 recruiting

  • University Hospital Monklands

    Airdrie, ML6 0JS

    Recruiting

  • North Tyneside General Hospital

    Ashington, NE63 9JJ

    Recruiting

  • Ormeau Clinical Trials Ltd

    Belfast, BT2 8BG

    Recruiting

  • Royal Bournemouth Hospital

    Bournemouth, BH7 7DW

    Recruiting

  • Princess of Wales Hospital

    Bridgend, CF31 1RQ

    Recruiting

  • Southmead Hospital

    Bristol, BS10 5NB

    Recruiting

  • St Richards Hospital

    Chichester, PO19 6SE

    Recruiting

  • Ninewells Hospital and Medicine School

    Dundee, DD1 9SY

    Recruiting

  • Royal Devon and Exeter Hospital

    Exeter, EX2 5DW

    Recruiting

  • Glasgow Royal Infirmary

    Glasgow, G31 2ER

    Recruiting

  • Monkfield Medical Practice

    Great Cambourne, CB23 6HL

    Recruiting

  • Wycombe Hospital

    High Wycombe, HP11 2TT

    Recruiting

  • Highlands Clinical Research Facility, Raigmore Hospital

    Inverness, IV2 3UJ

    Recruiting

  • University Hospital Crosshouse

    Kilmarnock, KA2 0BE

    Recruiting

  • Glenfield Hospital

    Leicester, LE3 9QP

    Recruiting

  • University College London Hospital

    London, NW1 2BU

    Recruiting

  • Kings College Hospital

    London, SE5 9RS

    Recruiting

  • St Georges Hospital

    London, SW17 0QT

    Recruiting

  • Manchester Royal Infirmary

    Manchester, M13 9WL

    Recruiting

  • Newcastle NIHR Commercial Research Delivery Centre

    Newcastle upon Tyne, NE7 7DN

    Recruiting

  • Craigavon Area Hospital

    Portadown, Craigavon, BT63 5QQ

    Recruiting

  • Ashfields Primary Care Centre

    Sandbach, CW11 1EQ

    Recruiting

  • University Hospital of North Tees

    Stockton-on-Tees, TS19 8PE

    Recruiting

  • Breckland Alliance Research

    Thetford, IP24 1JD

    Recruiting

  • Pinderfields Hospital

    Wakefield, WF1 4DG

    Recruiting

  • Marine Lake & Estuary Medical Practice

    West Kirby, CH48 5AA

    Recruiting

Other trials in United Kingdom

Japan24 sites, 22 recruiting

  • Akaicho Clinic

    Chiba, Chiba, 260-0804

    Recruiting

  • Fujinomiya City General Hospital

    Fujinomiya-shi, Shizuoka, 418-0076

    Terminated

  • Fukuoka University Hospital

    Fukuoka, Fukuoka, 814-0180

    Recruiting

  • Medical Corporation Kenshinkai Minamino Cardiovascular Hospital

    Hachioji-shi, Tokyo, 192-0918

    Recruiting

  • Japanese Red Cross Hamamatsu Hospital

    Hamamatsu, Shizuoka, 434-8533

    Recruiting

  • Affiliated Central Clinic of Higashiyamato Hospital

    Higashiyamato-shi, Tokyo, 207-0014

    Recruiting

  • Hyogo Prefectural Harima-Himeji General Medical Center

    Himeji-shi, Hyōgo, 670-8560

    Recruiting

  • Tenyoukai Central Clinic

    Kagoshima, Kagoshima-ken, 892-0822

    Recruiting

  • Ishikawa Prefectural Central Hospital

    Kanazawa, Ishikawa-ken, 920-8530

    Recruiting

  • North Alps Medical Center Azumi Hospital

    Kitaazumi-gun, Nagano, 399-8695

    Recruiting

  • Kokura Memorial Hospital

    Kitakyushu-shi, Fukuoka, 802-8555

    Recruiting

  • Kumamoto Kinoh Hospital

    Kumamoto, Kumamoto, 860-8518

    Recruiting

  • Rakuwakai Otowa Hospital

    Kyoto, Kyoto, 607-8062

    Recruiting

  • Niigata University Medical and Dental Hospital

    Niigata, Niigata, 951-8520

    Recruiting

  • Oita Red Cross Hospital

    Ōita, Oita Prefecture, 870-0033

    Terminated

  • Sagamihara Kyodo Hospital

    Sagamihara-shi, Kanagawa, 252-5188

    Recruiting

  • Miyanosawa Clinic of Internal Medicine and Cardiology

    Sapporo, Hokkaido, 063-0826

    Recruiting

  • Tokyo Shinagawa Hospital Social Medical Corporation Association Tokyokyojuno-kai

    Shinagawa-ku, Tokyo, 140-8522

    Recruiting

  • NewHeart Watanabe Institute

    Suginami-ku, Tokyo, 168-0065

    Recruiting

  • Osaka Saiseikai Suita Hospital

    Suita-shi, Osaka, 564-0013

    Recruiting

  • Takamatsu Red Cross Hospital

    Takamatsu, Kagawa-ken, 760-0017

    Recruiting

  • Higashi Takarazuka Satoh Hospital

    Takarazuka-shi, Hyōgo, 665-0873

    Recruiting

  • Fujita Health University Hospital

    Toyoake-shi, Aichi-ken, 470-1192

    Recruiting

  • Sanin Rosai Hospital

    Yonago-shi, Tottori, 683-8605

    Recruiting

Other trials in Japan

Argentina23 sites, 23 recruiting

  • Imoba Investigaciones medicas

    CABA, Buenos Aires, 1178

    Recruiting

  • Centro de Investigaciones Metabolicas Cinme

    CABA, Buenos Aires, C1056ABI

    Recruiting

  • Cemedic Centro de Especialidades Medicas

    CABA, Buenos Aires, C1407GTN

    Recruiting

  • Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada

    CABA, Buenos Aires, C1425AGC

    Recruiting

  • Fundacion Respirar - Consultorios Medicos Dr Doreski

    CABA, Buenos Aires, C1426ABP

    Recruiting

  • Cemic - Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno

    CABA, Buenos Aires, C1431FWO

    Recruiting

  • Cardiología Palermo

    Ciudad Autonoma de Buenos Aires, Buenos Aires, 1425

    Recruiting

  • Ciprec Centro de Investigacion y Prevencion Cardiovascular

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1061AAT

    Recruiting

  • Mautalen Salud e Investigacion Expertia SA-Osteo

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1128AAF

    Recruiting

  • Instituto Medico Damic

    Córdoba, X5003DCE

    Recruiting

  • Ciad - Consultorio Integral de Atencion al Diabetico

    Morón, Buenos Aires, B1708EPE

    Recruiting

  • Dim Clinica Privada

    Ramos Meija, Buenos Aires, B1704ETD

    Recruiting

  • Instituto de Investigaciones Clínicas Rosario-Sanatorio Delta

    Rosario, Santa Fe Province, S2000CVD

    Recruiting

  • Instituto CAICI - Centro de Asistencia e Investigacion Clinica Integral

    Rosario, Santa Fe Province, S2000PBJ

    Recruiting

  • INECO Neurociencias Oronio

    Rosario, S2000DSR

    Recruiting

  • Centro Modelo de Cardiologia

    San Miguel de Tucumán, Tucumán Province, 4000

    Recruiting

  • Investigaciones Clinicas Tucuman

    San Miguel de Tucumán, Tucumán Province, T4000ICL

    Recruiting

  • Go Centro Medico San Nicolas

    San Nicolás de los Arroyos, Buenos Aires, 2900

    Recruiting

  • Instituto de Investigaciones Clinicas de San Nicolas

    San Nicolás de los Arroyos, Buenos Aires, B2900DMH

    Recruiting

  • Hospital Dr Jose Maria Cullen

    Santa Fe, S3000EOZ

    Recruiting

  • Centro de Investigaciones Clinicas del Litoral

    Santa Fe, S3000FWO

    Recruiting

  • Clinica Fusavim Privada SRL

    Villa María, Córdoba Province, 5900

    Recruiting

  • Instituto de Investigaciones Clinicas Zarate

    Zárate, 2800

    Recruiting

Other trials in Argentina

Brazil21 sites, 21 recruiting

  • jmf Clinica do Coracao ltda

    Aracaju, Sergipe, 49055-530

    Recruiting

  • Ccih - Consultoria em Controle de Infecção Hospitalar

    Belo Horizonte, Minas Gerais, 30150-320

    Recruiting

  • Cardresearch Cardiologia Assistencial de Pesquisa

    Belo Horizonte, Minas Gerais, 31110-580

    Recruiting

  • Instituto de Pesquisa Clinica de Campinas - Ipecc

    Campinas, São Paulo, 13060-080

    Recruiting

  • Loema Instituto de Pesquisa Clinica e Consultores Ltda - Clinica Loema

    Campinas, São Paulo, 13092-133

    Recruiting

  • Nucleo de Pesquisa Clinica

    Curitiba, Paraná, 80730-150

    Recruiting

  • Hospital das Clinicas da Universidade Federal de Goias

    Goiânia, Goiás, 74605-020

    Recruiting

  • Instituto do Coracao de Marilia

    Marília, São Paulo, 17515-000

    Recruiting

  • Hospital de Clinicas de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90410-000

    Recruiting

  • Fz Pesquisa e Servicos em Cardiologia Clinica Ltda

    Porto Alegre, Rio Grande do Sul, 91350-280

    Recruiting

  • Clinicor Clinica Cardiologica

    Ribeirão Preto, São Paulo, 14026-900

    Recruiting

  • IBPClin Instituto Brasil de Pesquisa Clinica

    Rio de Janeiro, 20241-180

    Recruiting

  • Hospital Ana Nery

    Salvador, Estado de Bahia, 40301-155

    Recruiting

  • Pesquisare Saude Ltda

    Santo André, São Paulo, 09080-110

    Recruiting

  • Praxis Pesquisa Medica

    Santo André, São Paulo, 09090-790

    Recruiting

  • Hospital de Base de Sao Jose do Rio Preto

    São José do Rio Preto, São Paulo, 15090-000

    Recruiting

  • Centro Internacional de Pesquisa Clinica - Cipes

    São José dos Campos, São Paulo, 12230-001

    Recruiting

  • Instituto Dante Pazzanese de Cardiologia

    São Paulo, São Paulo, 04012-909

    Recruiting

  • Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo

    São Paulo, São Paulo, 05403-900

    Recruiting

  • Instituto de Molestias Cardiovasculares de Tatui

    Tatuí, São Paulo, 18270-170

    Recruiting

  • Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo

    Vitória, Espírito Santo, 29055-450

    Recruiting

Other trials in Brazil

Canada21 sites, 21 recruiting

  • Brampton Clinical Trials

    Brampton, Ontario, L6Z 4N5

    Recruiting

  • Cambridge Cardiac Care Centre

    Cambridge, Ontario, N1R 6V6

    Recruiting

  • Saul Vizel Professional Medicine Corporation - Vizel Cardiac Research

    Cambridge, Ontario, N1R 7R1

    Recruiting

  • Ecogene-21

    Chicoutimi, Quebec, G7H 7K9

    Recruiting

  • University of Alberta Hospital

    Edmonton, Alberta, T6G 2B7

    Recruiting

  • Montreal Heart Institute

    Montreal, Quebec, H1T 1C8

    Recruiting

  • Partners in Advanced Cardiac Evaluation

    Newmarket, Ontario, L3Y 2P6

    Recruiting

  • North York Diagnostic and Cardiac Centre

    North York, Ontario, M6B 3H7

    Recruiting

  • Kawartha Cardiology Clinical Trials

    Peterborough, Ontario, K9J 0B2

    Recruiting

  • CardioQuest Research Centre

    Sarnia, Ontario, N7T 4P5

    Recruiting

  • Heart Health Institute Research Incorporated

    Scarborough Village, Ontario, M1B 4Z8

    Recruiting

  • Diex Recherche Sherbrooke Est

    Sherbrooke, Quebec, J1E 0N8

    Recruiting

  • KMH Cardiology Centres Incorporated Hamilton

    Stoney Creek, Ontario, L8J 3W2

    Recruiting

  • Curans Heart Center

    Thunder Bay, Ontario, P7B 5N3

    Recruiting

  • Womens College Hospital

    Toronto, Ontario, M5S 1B2

    Recruiting

  • Diabetes Heart Research Centre

    Toronto, Ontario, M6G 1M2

    Recruiting

  • Diex Recherche Trois Rivieres

    Trois-Rivières, Quebec, G9A 4P3

    Recruiting

  • CPS Research

    Waterloo, Ontario, N2T 0C1

    Recruiting

  • Winchester District Memorial Hospital

    Winchester, Ontario, K0C 2K0

    Recruiting

  • St Boniface Hospital

    Winnipeg, Manitoba, R2H 2A6

    Recruiting

  • Cardio 1

    Winnipeg, Manitoba, R3L 1Z5

    Recruiting

Other trials in Canada

Slovakia20 sites, 20 recruiting

  • Alian, sro

    Bardejov, 085 01

    Recruiting

  • HeartCare sro

    Bardejov, 085 01

    Recruiting

  • Narodny ustav srdcovych a cievnych chorob, as

    Bratislava, 833 48

    Recruiting

  • Novate sro

    Bratislava, 841 04

    Recruiting

  • Kardio-Sanus, spol sro

    Bratislava, 841 08

    Recruiting

  • Kardiomedina sro

    Dolný Kubín, 026 01

    Recruiting

  • Nemocnica Dr Vojtecha Alexandra v Kezmarku no

    Kežmarok, 060 01

    Recruiting

  • Medical group Kosice sro

    Košice, 040 01

    Recruiting

  • Cardio D and R, sro Kosice

    Košice, 040 22

    Recruiting

  • KardioLEV sro

    Levoča, 054 01

    Recruiting

  • Kardio 1 sro

    Lučenec, 984 01

    Recruiting

  • Poliklinika Nemocnicna as

    Malacky, 901 22

    Recruiting

  • Oralek, sro

    Námestovo, 029 01

    Recruiting

  • Kardiomed NZ, sro

    Nové Zámky, 940 01

    Recruiting

  • KaCH, sro

    Nové Zámky, 940 02

    Recruiting

  • Nemocnica Poprad, as

    Poprad, 058 45

    Recruiting

  • Intermedis sro

    Prešov, 080 01

    Recruiting

  • Medispol, sro

    Prešov, 080 01

    Recruiting

  • Interna SK, sro

    Svidník, 089 01

    Recruiting

  • Pentes, sro

    Žilina, 010 01

    Recruiting

Other trials in Slovakia

Spain20 sites, 19 recruiting

  • Complexo Hospitalario Universitario A Coruña

    A Coruña, Galicia, 15006

    Recruiting

  • Hospital Universitari Germans Trias i Pujol

    Badalona, Catalonia, 08916

    Recruiting

  • Hospital Universitari Vall d Hebron

    Barcelona, Catalonia, 08035

    Recruiting

  • Hospital Clinic i Provincial de Barcelona

    Barcelona, Catalonia, 08036

    Recruiting

  • Hospital Universitario Reina Sofia

    Córdoba, Andalusia, 14004

    Recruiting

  • Hospital Marina Salud de Denia

    Denia, Valencia, 03700

    Recruiting

  • Hospital Universitario Virgen de la Arrixaca

    El Palmar, Murcia, 30120

    Recruiting

  • Hospital Universitari de Bellvitge

    L'Hospitalet de Llobregat, Catalonia, 08907

    Recruiting

  • Hospital Universitario de Gran Canaria Doctor Negrin

    Las Palmas de Gran Canaria, Canary Islands, 35010

    Recruiting

  • Hospital Universitario Arnau de Vilanova Lleida

    Lleida, Catalonia, 25198

    Recruiting

  • Hospital Clinico San Carlos

    Madrid, 28040

    Recruiting

  • Hospital Universitario 12 de Octubre

    Madrid, 28041

    Recruiting

  • Hospital Universitario La Paz

    Madrid, 28046

    Recruiting

  • Hospital Universitario Puerta de Hierro Majadahonda

    Majadahonda, Madrid, 28222

    Recruiting

  • Hospital Clinico Universitario Virgen de la Victoria

    Málaga, Andalusia, 29010

    Terminated

  • Hospital Universitario de Salamanca

    Salamanca, 37007

    Recruiting

  • Hospital Clinico Universitario de Valencia

    Valencia, Valencia, 46010

    Recruiting

  • Hospital General Universitario Valencia

    Valencia, Valencia, 46014

    Recruiting

  • Hospital Universitari i Politecnic La Fe

    Valencia, Valencia, 46026

    Recruiting

  • Hospital Vithas Valencia Turia

    Valencia, Valencia, 46026

    Recruiting

Other trials in Spain

France17 sites, 16 recruiting

  • Centre Hospitalier Universitaire Amiens Picardie - Site Sud

    Amiens, 80054

    Recruiting

  • Centre Hospitalier de Beziers

    Béziers, 34525

    Recruiting

  • Hospices Civils de Lyon Groupement Hospitalier Est - Hopital Louis Pradel

    Bron, 69677

    Recruiting

  • Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand

    Dijon, 21000

    Recruiting

  • Hopital prive Le Bois

    Lille, 59000

    Recruiting

  • Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon

    Lille, 59037

    Recruiting

  • Centre Hospitalier Universitaire de Montpellier - Hopital Arnaud de Villeneuve

    Montpellier, 34090

    Recruiting

  • Hopital prive du Confluent

    Nantes, 44277

    Recruiting

  • Centre Hospitalier Universitaire de Nice - Hopital Pasteur

    Nice, 06000

    Terminated

  • Hopital Saint Antoine

    Paris, 75012

    Recruiting

  • Hopital Pitie-Salpetriere

    Paris, 75013

    Recruiting

  • Hopital Bichat Claude Bernard

    Paris, 75877

    Recruiting

  • Centre Hospitalier Intercommunal Toulon-La Seyne-sur-Mer - Hopital Sainte Musse

    Toulon, 83056

    Recruiting

  • Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil

    Toulouse, 31059

    Recruiting

  • Centre Hospitalier de Tourcoing - Hopital Guy Chatiliez

    Tourcoing, 59208

    Recruiting

  • Centre Hospitalier Regional Universitaire de Tours - Hopital Trousseau

    Tours, 37044

    Recruiting

  • Polyclinique Vauban

    Valenciennes, 59300

    Recruiting

Other trials in France

Netherlands17 sites, 17 recruiting

  • Amsterdam Universitair Medisch Centrum

    Amsterdam, 1081 HV

    Recruiting

  • Rijnstate Ziekenhuis

    Arnhem, 6815 AD

    Recruiting

  • Amphia ziekenhuis

    Breda, 4818 CK

    Recruiting

  • Reinier de Graaf Gasthuis

    Delft, 2625 AD

    Recruiting

  • Deventer Ziekenhuis

    Deventer, 7416 SE

    Recruiting

  • Albert Schweitzer Ziekenhuis, Locatie Dordwijk

    Dordrecht, 3318 AT

    Recruiting

  • Catharina Ziekenhuis

    Eindhoven, 5623 EJ

    Recruiting

  • Treant Zorggroep, locatie Scheper ziekenhuis Emmen

    Emmen, 7824 AA

    Recruiting

  • Medisch Spectrum Twente

    Enschede, 7512 KZ

    Recruiting

  • Universitair Medisch Centrum Groningen

    Groningen, 9713 GZ

    Recruiting

  • Zuyderland Medisch Centrum

    Heerlen, 6419 PC

    Recruiting

  • Frisius Medisch Centrum, locatie Leeuwarden

    Leeuwarden, 8934 AD

    Recruiting

  • Ikazia Ziekenhuis

    Rotterdam, 3083 AN

    Recruiting

  • D and A Research and Genetics

    Sneek, 8601 ZR

    Recruiting

  • Haga Ziekenhuis

    The Hague, 2545 AA

    Recruiting

  • VieCuri Medisch Centrum

    Venlo, 5912 BL

    Recruiting

  • Zaans Medisch Centrum

    Zaandam, 1502 DV

    Recruiting

Other trials in Netherlands

Australia16 sites, 13 recruiting

  • Advara HeartCare Wesley

    Auchenflower, Queensland, 4066

    Terminated

  • Flinders Medical Centre

    Bedford Park, South Australia, 5042

    Recruiting

  • Sunshine Coast University Hospital

    Birtinya, Queensland, 4575

    Recruiting

  • Victorian Heart Hospital

    Clayton, Victoria, 3168

    Recruiting

  • Canberra Hospital

    Garran, Australian Capital Territory, 2605

    Recruiting

  • Royal Brisbane and Womens Hospital

    Herston, Queensland, 4029

    Recruiting

  • Advara HeartCare Joondalup

    Joondalup, Western Australia, 6027

    Recruiting

  • Advara HeartCare Leabrook

    Leabrook, South Australia, 5068

    Recruiting

  • Sydney Cardiometabolic Centre

    Liverpool, New South Wales, 2170

    Recruiting

  • The Alfred Hospital

    Melbourne, Victoria, 3004

    Recruiting

  • Core Research Group Pty Ltd

    Milton, Queensland, 4064

    Recruiting

  • Advara HeartCare Mulgrave

    Mulgrave, Victoria, 3170

    Recruiting

  • Fiona Stanley Hospital

    Murdoch, Western Australia, 6150

    Recruiting

  • Gold Coast Hospital and Health Service

    Southport, Queensland, 4215

    Terminated

  • Royal North Shore Hospital

    St Leonards, New South Wales, 2065

    Recruiting

  • Dr Heart Pty Ltd

    Woolloongabba, Queensland, 4102

    Terminated

Other trials in Australia

Italy16 sites, 15 recruiting

  • Azienda Ospedaliero Universitaria Consorziale Policlinico

    Bari, 70124

    Recruiting

  • Azienda Socio Sanitaria Territoriale Papa Giovanni xxiii

    Bergamo, 24127

    Recruiting

  • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

    Brescia, 25123

    Recruiting

  • Azienda Unita Sanitaria Locale Toscana sud est Ospedale S. Margherita

    Cortona AR, 52044

    Recruiting

  • Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia

    Foggia, 71122

    Terminated

  • Azienda Unita Sanitaria Locale Romagna

    Forlì, 47121

    Recruiting

  • IRCCS Ospedale San Raffaele

    Milan, 20132

    Recruiting

  • IRCCS Centro Cardiologico Monzino

    Milan, 20138

    Recruiting

  • Azienda Ospedaliera di Rilievo Nazionale Specialistica dei Colli Monaldi

    Naples, 80131

    Recruiting

  • Azienda Ospedaliera Universitaria Federico II

    Naples, 80131

    Recruiting

  • Azienda Ospedaliero Universitaria di Parma

    Parma, 43126

    Recruiting

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100

    Recruiting

  • Azienda Unita Sanitaria Locale Romagna

    Rimini, 47923

    Recruiting

  • ASL TO3 Ospedale di Rivoli

    Rivoli, 10098

    Recruiting

  • Fondazione Policlinico Universitario Campus Bio-Medico

    Roma, 00128

    Recruiting

  • Azienda Ospedaliero Universitaria di Sassari

    Sassari, 07100

    Recruiting

Other trials in Italy

Belgium15 sites, 14 recruiting

  • Azorg Campus Aalst - Moorselbaan

    Aalst, 9300

    Recruiting

  • Universitair Ziekenhuis Brussel

    Brussels, 1090

    Terminated

  • Algemeen Ziekenhuis Sint Blasius

    Dendermonde, 9200

    Recruiting

  • Ziekenhuis Oost-Limburg - Campus Sint-Jan

    Genk, 3600

    Recruiting

  • Algemeen Ziekenhuis Maria Middelares

    Ghent, 9000

    Recruiting

  • Universitair Ziekenhuis Gent

    Ghent, 9000

    Recruiting

  • Jessa Ziekenhuis - Campus Virga Jesse

    Hasselt, 3500

    Recruiting

  • AZ Herentals

    Herentals, 2200

    Recruiting

  • Algemeen Ziekenhuis Groeninge - Campus Kennedylaan

    Kortrijk, 8500

    Recruiting

  • Universitair Ziekenhuis Leuven - Campus Gasthuisberg

    Leuven, 3000

    Recruiting

  • Centre Hospitalier Regional de la Citadelle

    Liège, 4000

    Recruiting

  • Clinique Centre Hospitalier Chrétien MontLégia

    Liège, 4000

    Recruiting

  • AZ Delta Campus Rumbeke

    Roeselare, 8800

    Recruiting

  • Algemeen Ziekenhuis Turnhout

    Turnhout, 2300

    Recruiting

  • Universite Catholique de Louvain Cliniques Universitaires de Mont-Godinne

    Yvoir, 5530

    Recruiting

Other trials in Belgium

Greece15 sites, 14 recruiting

  • University Hospital of Alexandroupolis

    Alexandroupoli, 68100

    Recruiting

  • Athens Naval Hospital

    Athens, 11521

    Recruiting

  • General Hospital for Thoracic Diseases of Athens "Sotiria

    Athens, 11527

    Recruiting

  • General Hospital of Athens Georgios Gennimatas

    Athens, 11527

    Recruiting

  • General Hospital of Athens Ippokrateio

    Athens, 11527

    Recruiting

  • Alexandra Hospital

    Athens, 11528

    Recruiting

  • University General Hospital Attikon General Hospital Of West Attica H Agia Varvara

    Athens, 12462

    Recruiting

  • General Hospital Asklipieio Voulas

    Athens, 16673

    Recruiting

  • General Hospital of Chios "Skilitsion"

    Chios, 82131

    Recruiting

  • University Hospital of Larissa

    Larissa, 41110

    Recruiting

  • Hygeia Hospital

    Marousi, 15123

    Recruiting

  • Athens Medical Center - Amarousion Branch

    Marousi, Athens, 151 25

    Recruiting

  • General Hospital Of Nea Ionia Konstantopouleio Patision

    Nea Ionia, 14233

    Terminated

  • Tzaneio General Hospital

    Piraeus, 18536

    Recruiting

  • Ahepa University Hospital

    Thessaloniki, 54636

    Recruiting

Other trials in Greece

Turkey (Türkiye)14 sites, 14 recruiting

  • Adana Sehir Egitim ve Arastirma Hastanesi

    Adana, 01370

    Recruiting

  • Afyonkarahisar Saglik Bilimleri Universitesi Hastanesi

    Afyonkarahisar, 03218

    Recruiting

  • Ankara Bilkent Sehir Hastanesi

    Ankara, 06800

    Recruiting

  • Hitit Universitesi Erol Olcok Egitim ve Arastirma Hastanesi

    Çorum, 19040

    Recruiting

  • Eskisehir Sehir Hastanesi

    Eskişehir, 26080

    Recruiting

  • Istanbul Universitesi Cerrahpasa Tip Fakultesi

    Istanbul, 34096

    Recruiting

  • Bagcilar Medipol Mega Universite Hastanesi

    Istanbul, 34214

    Recruiting

  • Mehmet Akif Ersoy Gogus Kalp ve Damar Cerrahisi Egitim ve Arastirma Hastanesi

    Istanbul, 34307

    Recruiting

  • Dr Siyami Ersek Gogus Kalp ve Damar Cerrahisi Egitim ve Arastirma Hastanesi

    Istanbul, 34668

    Recruiting

  • Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi

    Istanbul, 34722

    Recruiting

  • Dokuz Eylul Universitesi Tip Fakultesi Hastanesi

    Izmir, 35340

    Recruiting

  • Erciyes Universitesi Tip Fakultesi Hastanesi

    Kayseri, 38039

    Recruiting

  • Kocaeli Universitesi Tip Fakultesi Hastanesi

    Kocaeli, 41380

    Recruiting

  • Necmettin Erbakan Universitesi Tip Fakultesi Hastanesi

    Konya

    Recruiting

Other trials in Turkey (Türkiye)

Bulgaria13 sites, 13 recruiting

  • Ambulatory for special outpatient medical aid in Cardiology-Private Practice Dr Elena Dotcheva EOOD

    Burgas, 8000

    Recruiting

  • Multiprofile Hospital for Active Treatment - Haskovo AD

    Haskovo, 6300

    Recruiting

  • University Multiprofile Hospital for Active Treatment Sveti Georgi EAD

    Plovdiv, 4001

    Recruiting

  • Medical Center Futuremeds EOOD

    Plovdiv, 4002

    Recruiting

  • Multiprofile Hospital for Active Treatment Knyaginya Klementina - Sofia EAD

    Sofia, 1233

    Recruiting

  • National Multiprofile Transport Hospital Tzar Boris III

    Sofia, 1233

    Recruiting

  • Multiprofile Hospital for Active Treatment National Hospital of Cardiology EAD

    Sofia, 1309

    Recruiting

  • Diagnostic-Consultative Center Alexandrovska EOOD

    Sofia, 1431

    Recruiting

  • Medical Center Hera EOOD

    Sofia, 1510

    Recruiting

  • Diagnostic-Consultative Center XX-Sofia EOOD

    Sofia, 1618

    Recruiting

  • Diagnostic-Consultative Center Convex OOD

    Sofia, 1680

    Recruiting

  • Multiprofile Regional Hospital for Active Treatment Dr Stefan Cherkezov AD

    Veliko Tarnovo, 5000

    Recruiting

  • Specialised Hospital for Active Cardiology Treatment EAD

    Yambol, 8600

    Recruiting

Other trials in Bulgaria

Austria12 sites, 10 recruiting

  • Krankenhaus Sankt Josef Braunau

    Braunau am Inn, 5280

    Recruiting

  • Pro Kompetenzzentrum fuer Gesundheit

    Graz, 8020

    Recruiting

  • Medizinische Universitaet Graz

    Graz, 8036

    Recruiting

  • Klinikum Klagenfurt am Woerthersee

    Klagenfurt, 9020

    Recruiting

  • Ordensklinikum Linz Elisabethinen

    Linz, 4020

    Recruiting

  • Landeskrankenhaus Salzburg

    Salzburg, 5020

    Recruiting

  • Imed Sankt Poelten

    Sankt Pölten, 3100

    Recruiting

  • Universitaetsklinikum Sankt Poelten

    Sankt Pölten, 3100

    Terminated

  • Universitaetsklinikum Allgemeines Krankenhaus Wien

    Vienna, 1090

    Recruiting

  • Herz Zentrum Waehring

    Vienna, 1180

    Recruiting

  • Ordinationszentrum imedneunzehn privat

    Vienna, 1190

    Recruiting

  • Krankenhaus Nord - Klinik Floridsdorf

    Vienna, 1210

    Terminated

Other trials in Austria

Romania11 sites, 11 recruiting

  • Cardioplus Center SRL

    Baia Mare, 430124

    Recruiting

  • cmi Cardiologie - Dr Pop Calin

    Baia Mare, 430222

    Recruiting

  • Thera Card SRL

    Brasov, 500102

    Recruiting

  • Centrul Medical de Diagnostic si Tratament Ambulator Neomed

    Brasov, 500283

    Recruiting

  • Spitalul Universitar de Urgenta Bucuresti

    Bucharest, 050098

    Recruiting

  • Matcord Biomedica Buzau

    Buzău, 120133

    Recruiting

  • Consultmed SRL

    Iași, 700544

    Recruiting

  • Sal Med SRL

    Piteşti, 110438

    Recruiting

  • Spitalul Clinic Judetean de Urgenta Targu Mures

    Târgu Mureş, 540136

    Recruiting

  • Cabinet Medical Individual Dr Podoleanu Cristian

    Târgu Mureş, 540143

    Recruiting

  • Spitalul Clinic Municipal de Urgenta Timisoara

    Timișoara, 300079

    Recruiting

Other trials in Romania

Chile10 sites, 10 recruiting

  • Fundacion Innovacion Cardiovascular Clinica Ensenada

    Independencia, Santiago Metropolitan

    Recruiting

  • Enroll SpA

    Providencia, Santiago Metropolitan, 7500587

    Recruiting

  • Biocinetic servicios medicos limitada

    Santiago, 8320000

    Recruiting

  • Pontificia Universidad Catolica de Chile

    Santiago, 8330034

    Recruiting

  • Hospital Las Higueras

    Talcahuano, Concepción, 4270918

    Recruiting

  • Centro de Investigacion Clinica del Sur

    Temuco, Cautín, 4781156

    Recruiting

  • Centro de Estudios Cardiologicos y Medicina Interna CECMI

    Temuco, Cautín, 4813299

    Recruiting

  • Clinical Research Chile SpA

    Valdivia, 5110683

    Recruiting

  • Oncocentro Apys

    Viña del Mar, Valparaiso, 2520598

    Recruiting

  • Cinvec Estudios Clinicos quinta region Limitada

    Viña del Mar, Valparaiso, 2520997

    Recruiting

Other trials in Chile

Colombia10 sites, 10 recruiting

  • Instituicion Prestadora de Salud Centro Cientifico Asistencial SAS

    Barranquilla, Atlántico, 080002

    Recruiting

  • Centro de Investigacion Clinica de la Costa SAS

    Barranquilla, Atlántico, 080020

    Recruiting

  • Corazon Institucion prestadora de Salud sas

    Barranquilla, Atlántico, 080020

    Recruiting

  • Solano y Terront Servicios Medicos SAS - Unidad Integral de Endocrinologia Uniendo

    Bogota, Cundinamarca, 110221

    Recruiting

  • Fundacion cardiovascular de Colombia

    Bucaramanga, Santander Department, 681017

    Recruiting

  • Centro de Investigaciones Clinicas SAS

    Cali, Valle del Cauca Department, 760032

    Recruiting

  • Fundacion Valle del Lili

    Cali, Valle del Cauca Department, 760032

    Recruiting

  • Instituto Neumologico De Oriente Sa

    Floridablanca, Santander Department, 681004

    Recruiting

  • Instituicion Prestadora de Salud Medicos Internistas de Caldas SAS

    Manizales, Caldas Department, 170004

    Recruiting

  • Clinica Cardio Vid

    Medellín, Antioquia, 050034

    Recruiting

Other trials in Colombia

Portugal8 sites, 7 recruiting

  • Unidade Local de Saude de Almada-Seixal, EPE - Hospital Garcia de Orta

    Almada, 2805-267

    Recruiting

  • Unidade Local de Saude de Coimbra, EPE

    Coimbra, 3000-075

    Terminated

  • Unidade Local de Saude do Alto Ave, EPE

    Guimarães, 4835-044

    Recruiting

  • Unidade Local de Saude de Lisboa Ocidental, EPE - Hospital Sao Francisco Xavier

    Lisbon, 1449-005

    Recruiting

  • Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria

    Lisbon, 1649-035

    Recruiting

  • Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano

    Matosinhos Municipality, 4464-513

    Recruiting

  • Unidade Local de Saude de Sao Joao, EPE - Hospital de Sao Joao

    Porto, 4200-319

    Recruiting

  • Unidade Local de Saude de Gaia-Espinho, EPE

    Vila Nova de Gaia, 4430-502

    Recruiting

Other trials in Portugal

Sweden8 sites, 7 recruiting

  • Falu Lasarett

    Falun, 791 82

    Recruiting

  • Carlanderska sjukhuset

    Gothenburg, 405 45

    Recruiting

  • Helsingborgs Lasarett

    Helsingborg, 251 87

    Terminated

  • Clemenstorgets Hjartmottagning

    Lund, 222 21

    Recruiting

  • Vrinnevisjukhuset i Norrkoeping

    Norrköping, 601 82

    Recruiting

  • Karolinska Universitetssjukhuset Solna

    Solna, 171 76

    Recruiting

  • Capio Saint Gorans Hospital

    Stockholm, 112 19

    Recruiting

  • Danderyds Sjukhus

    Stockholm, 182 88

    Recruiting

Other trials in Sweden

Denmark7 sites, 3 recruiting

  • Aarhus Universitetshospital

    Aarhus N, 8200

    Terminated

  • Esbjerg sygehus Syddansk universitetshospital

    Esbjerg, 6700

    Terminated

  • Frederiksberg/Bispebjerg Hospitaler

    Frederiksberg, 2000

    Recruiting

  • Herlev and Gentofte Hospital

    Herlev, 2730

    Recruiting

  • Regionshospitalet Gødstrup

    Herning, 7400

    Terminated

  • Hvidovre Hospital

    Hvidovre, 2650

    Recruiting

  • Sjaellands Universitetshospital, Roskilde

    Roskilde, 4000

    Terminated

Other trials in Denmark

Switzerland7 sites, 7 recruiting

  • Universitaetsspital Basel

    Basel, 4031

    Recruiting

  • Inselspital Bern

    Bern, 3010

    Recruiting

  • Hopitaux Universitaires de Geneve

    Geneva, 1211

    Recruiting

  • Centre hospitalier universitaire vaudois

    Lausanne, 1011

    Recruiting

  • Luzerner Kantonsspital

    Lucerne, 6000

    Recruiting

  • Istituto Cardiocentro Ticino

    Lugano, 6900

    Recruiting

  • Kantonsspital Sankt Gallen

    Sankt Gallen, 9007

    Recruiting

Other trials in Switzerland

Mexico6 sites, 6 recruiting

  • Hospital Cardiologica Aguascalientes

    Aguascalientes, 20230

    Recruiting

  • Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC

    Culiacán, Sinaloa, 80230

    Recruiting

  • Health Pharma Queretaro Sa de Cv

    Juriquilla, Querétaro, 76230

    Recruiting

  • Soluciones Terapeuticas Medico Quirurgicas

    Mexico City, Mexico City, 03650

    Recruiting

  • Cardiolink Clin Trials

    Monterrey, Nuevo León, 64060

    Recruiting

  • Centro de Estudios Clinicos de Queretaro

    Querétaro City, Querétaro, 76000

    Recruiting

Other trials in Mexico

South Korea6 sites, 6 recruiting

  • Chungnam National University Hospital

    Daejeon, 35015

    Recruiting

  • Chonnam National University Hospital

    Gwangju, 61469

    Recruiting

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620

    Recruiting

  • Seoul National University Hospital

    Seoul, 03080

    Recruiting

  • Severance Hospital Yonsei University Health System

    Seoul, 03722

    Recruiting

  • Yonsei University Wonju Severance Christian Hospital

    Wonju-si, Gangwon-do, 26426

    Recruiting

Other trials in South Korea

Taiwan6 sites, 5 recruiting

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 80756

    Recruiting

  • China Medical University Hospital

    Taichung, 40447

    Recruiting

  • National Cheng Kung University Hospital

    Tainan, 70403

    Terminated

  • National Taiwan University Hospital

    Taipei, 10002

    Recruiting

  • Taipei Medical University Hospital

    Taipei, 11031

    Recruiting

  • Taipei Veterans General Hospital

    Taipei, 11217

    Recruiting

Other trials in Taiwan

Finland5 sites, 5 recruiting

  • Helsinki University Hospital

    Helsinki, 000290

    Recruiting

  • Terveystalo Kamppi

    Helsinki, 00180

    Recruiting

  • Terveystalo Jyvaskyla

    Jyväskylä, 40100

    Recruiting

  • Health Step Finland

    Kuopio, 70600

    Recruiting

  • Turku University Hospital Tyks

    Turku, 20520

    Recruiting

Other trials in Finland

Hong Kong2 sites, 2 recruiting

  • Queen Mary Hospital, The University of Hong Kong

    Hong Kong

    Recruiting

  • Prince of Wales Hospital, Chinese University of Hong Kong

    Shatin, New Territories

    Recruiting

Other trials in Hong Kong

Puerto Rico1 site, 1 recruiting

  • Solace Clinical Research

    Bayamón, 00959

    Recruiting

Other trials in Puerto Rico

About this study

Official title: A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Maridebart Cafraglutide on Mortality and Morbidity in Participants Living With Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity (MARITIME-HF)

This trial will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascular (CV) deaths and improvement in HF symptoms in participants with HF with preserved ejection fraction (HFpEF) and HF with mildly reduced ejection fraction (HFmrEF) who are obese. This is a phase 3, global, multicenter, 2-part trial with a double-blind period and an open-label extension (OLE). The trial is event-driven, and Part 1 will conclude when approximately 850 primary endpoint events have occurred.

Being tested
Maridebart cafraglutide, Placebo
Keywords
Heart Failure, Obesity, Maridebart Cafraglutide, AMG 133, MariTide
Medical subject headings
Obesity, Heart Failure

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Maridebart cafraglutideDrug

    Also called AMG 133, MariTide

    Maridebart cafraglutide will be administered SC.

  • PlaceboDrug

    Placebo will be administered SC.

Study groups in NCT07037459
Study groupRoleWhat they receive
Maridebart CafraglutideExperimentalParticipants will receive maridebart cafraglutide subcutaneously (SC)
Receives: Drug: Maridebart cafraglutide
PlaceboPlacebo comparatorParticipants will receive placebo SC
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Time to First Occurrence of a Composite Endpoint Consisting of: CV Death or HF Events

    Heart Failure events include: hospitalization for HF or urgent HF visits.

    Measured: Up to approximately 35 months

Secondary outcomes (33)

  1. Change From Baseline in Kansas City Cardiomyopathy Questionnaire (KCCQ) Clinical Summary Score (CSS) for Participants with Baseline KCCQ-CSS Score ≤ 80

    The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life.

    Measured: Baseline and Week 48

  2. Change from Baseline in the KCCQ Total Symptom Score (TSS) for Participants with Baseline KCCQ-CSS Score ≤ 80

    The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-TSS assesses symptom frequency and burden, ranging from 0 to 100, with higher scores indicating better functioning and quality of life.

    Measured: Baseline and Week 48

  3. Total Number of HF Events Including First and Recurrent HF Events

    Measured: Up to approximately 35 months

  4. Time to First Occurrence of a Composite Endpoint Consisting of: Myocardial Infarction (MI), Ischemic Stroke, CV Death (Major Adverse Cardiac Events [MACE]), or HF Events

    Measured: Up to approximately 35 months

  5. Time to First Event of a Composite Nephropathy Endpoint

    The composite nephropathy endpoint consists of: persistent macroalbuminuria, persistent ≥ 40% reduction in estimated glomerular filtration rate (eGFR), onset of persistent eGFR < 15 mL/min/1.73 m^2, initiation of chronic renal replacement therapy (dialysis or transplantation), CV or renal death.

    Measured: Up to approximately 35 months

  6. Change in eGFR Slope (Total)

    Measured: Baseline up to approximately 35 months

  7. Change in eGFR Slope (Chronic)

    Measured: From 4 months up to approximately 35 months

  8. Time to Onset of Type 2 Diabetes Mellitus (T2DM) in Participants with Prediabetes

    Measured: Up to approximately 35 months

  9. Time to the First HF Event

    Measured: Up to approximately 35 months

  10. Change from Baseline in the Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP)

    Measured: Baseline and Week 72

  11. Change from Baseline in Body Mass Index (BMI) (kg/m^2)

    Measured: Baseline and Week 72

  12. Change from Baseline in the Waist Circumference (cm)

    Measured: Baseline and Week 72

  13. Change from Baseline in the Urine Albumin-to-creatinine Ratio (uACR)

    Measured: Baseline and Week 72

  14. Change from Baseline in the Hemoglobin A1c (HbA1c [%, mmol/mol]) and fasting plasma glucose (mg/dL)

    Measured: Baseline and Week 72

  15. Percent Change from Baseline in the High-sensitivity C Reactive Protein (hs-CRP)

    Measured: Baseline and Week 72

  16. Percent Change from Baseline in the Body Weight (kg)

    Measured: Baseline and Week 72

  17. Percent Change from Baseline in Total Cholesterol

    Measured: Baseline and Week 72

  18. Percent Change from Baseline in Non-high-density Lipoprotein Cholesterol (non-HDL-C)

    Measured: Baseline and Week 72

  19. Percent Change from Baseline in Low-density Lipoprotein Cholesterol (LDL-C), HDL-C, Triglycerides (TG), Very Low-density Lipoprotein Cholesterol (VLDL-C)

    Measured: Baseline and Week 72

  20. Total All-cause Hospitalizations (First and Recurrent Time to Event)

    Measured: Up to approximately 35 months

  21. Number of Participants Achieving ≥ 5-point Change in KCCQ-CSS Score from Baseline for Participants with Baseline KCCQ-CSS Score ≤ 80

    The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life.

    Measured: Baseline and Week 48

  22. Number of Participants Achieving ≥ 10-point Change in KCCQ-CSS Score from Baseline for Participants with Baseline KCCQ-CSS Score ≤ 80

    The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life.

    Measured: Baseline and Week 48

  23. Number of Participants Achieving an Anchor-based Change in KCCQ-CSS Score From Baseline for Participants with Baseline KCCQ-CSS Score ≤ 80

    The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life. The Patient Global Impression of Severity (PGI-S) and Patient Global Impression of Change (PGI-C) can be used as anchors to estimate within-patient change in the KCCQ-CSS score.

    Measured: Baseline and Week 48

  24. Number of Participants Achieving ≥ 5-point Change in KCCQ-TSS Score from Baseline for Participants with Baseline KCCQ-CSS Score ≤ 80

    The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-TSS assesses symptom frequency and burden, ranging from 0 to 100, with higher scores indicating better functioning and quality of life. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life.

    Measured: Baseline and Week 48

  25. Number of Participants Achieving ≥ 10-point Change in KCCQ-TSS Score from Baseline for Participants with Baseline KCCQ-CSS Score ≤ 80

    The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-TSS assesses symptom frequency and burden, ranging from 0 to 100, with higher scores indicating better functioning and quality of life. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life.

    Measured: Baseline and Week 48

  26. Number of Participants Achieving an Anchor-based Change in KCCQ-TSS Score from Baseline for Participants with Baseline KCCQ-CSS Score ≤ 80

    The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-TSS assesses symptom frequency and burden, ranging from 0 to 100, with higher scores indicating better functioning and quality of life. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life. The PGI-S and PGI-C can be used as anchors to estimate within-patient change in the KCCQ-CSS score.

    Measured: Baseline and Week 48

  27. Time to All-cause Death

    Measured: Up to approximately 35 months

  28. Time to CV Death

    Measured: Up to Approximately 35 Months

  29. Number of Participants with Treatment-emergent Adverse Events and Serious Adverse Events

    Measured: Up to approximately 35 months

  30. Plasma Concentration of Maridebart Cafraglutide

    Measured: Week 72

  31. Change from Baseline in N-terminal Pro B Type Natriuretic Peptide (NT-proBNP)

    Measured: Baseline and Week 72

  32. Time to New Onset of Atrial Fibrillation (AF) or Atrial Flutter (AFL) in Participants Without a History of AF or AFL at Baseline

    Measured: Baseline and up to approximately 35 months

  33. Time to First Event of a Composite Nephropathy Endpoint

    The composite nephropathy endpoint consisting of persistent ≥ 40% reduction in estimated glomerular filtration rate (eGFR), onset of persistent eGFR < 15 mL/min/1.73 m^2, initiation of chronic renal replacement therapy (dialysis or transplantation), or CV death.

    Measured: Up to approximately 35 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted25 Jun 2025
  2. Study start25 Jun 2025
  3. Primary completion30 Jun 2028 (estimated)
  4. Study completion29 Sep 2030 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
5,056 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07037459
Sponsor's protocol ID
20230227
Acronym
MARITIME-HF
Status last verified
Oct 2026
First submitted
16 Jun 2025
Last updated
29 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request.

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Maridebart cafraglutide in people with Heart Failure With Preserved Ejection Fraction and Heart Failure With Mildly Reduced Ejection Fraction, run by Amgen at 686 sites in 35 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 22 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 29 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 686 sites in United States, China, Czechia, Germany, Hungary and 30 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Amgen Call Center (866-572-6436, medinfo@amgen.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Time to First Occurrence of a Composite Endpoint Consisting of: CV Death or HF Events (time frame: Up to approximately 35 months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07037459.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Oct 2026.

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