Virtual Reality Pain Distraction8baanNCT07042178
The Influence of Virtual Reality on Blood Parameters
A study testing Meditation video at the beach and Rollercoaster video in people with Virtual Reality Pain Distraction and Endocrinology, run by Van Creveldkliniek at 1 site in Netherlands.
Trial summary
The goal of this study is to learn what the impact of exposure to virtual reality content is on the levels of stress-related blood values in healthy volunteers. The main question it aims to answer is: To compare the levels of stress-related biomarkers before and after relaxing VR-content (Relax Visit); To compare the… Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Virtual Reality Pain Distraction, Endocrinology, Haematology
- What is being tested?
- Meditation video at the beach and Rollercoaster video
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteNetherlands
- Study dates
- 27 Aug 2025to 20 Feb 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age between 18 and 45 years old;
- Willing and able to provide written informed consent.
Who cannot join
- A history of motion- or cybersickness;
- Fear of needles;
- Any of the following haematological disorders:
- Congenital or acquired haemophilia A;
- Von Willebrand Disease.
- Any of the following endocrinological disorders:
Show all 15Show fewer
- Thyroid disorders (e.g. hypo/hyperthyroidism);
- Cushing syndrome;
- Adrenal insufficiency;
- Diabetes mellitus type 1 or 2;
- Central or nephrogenic AVP deficiency.
- A confirmed cardiac disorder;
- All types of epilepsy;
- Every form of medication, except for intermittent use of pain killers but not in the last week (e.g. paracetamol) and an intra-uterine device with or without contraceptive;
- Pregnancy.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Influence of Stress-inducing and Relaxing VR Content on Haematologic and Endocrinologic Blood Parameters in Healthy Participants - the 8baan Study
The goal of this study is to learn what the impact of exposure to virtual reality content is on the levels of stress-related blood values in healthy volunteers. The main question it aims to answer is:
- To compare the levels of stress-related biomarkers before and after relaxing VR-content (Relax Visit);
- To compare the levels of stress-related biomarkers before and after stress-inducing VR-content (Rollercoaster Visit).
Read more
Researchers will compare the Relax and Rollercoaster Visit to see if there is a relationship between the relaxing and stress-inducing VR content on stress-related blood values.
Participants will be asked to watch relaxing or stress-inducing VR content for approximately five minutes. Blood will be withdrawn before and after intervention. After 3-5 weeks the study visit will be repeated using the other VR content.
Read the detailed description
Rationale: In recent years virtual reality (VR) has become increasingly popular in clinical setting, especially during blood sampling to enhance patient comfort and reduce anxiety. The immersion in a 360° fantasy world contributes to an effective way of distraction. During a medical procedure the patient is allowed to choose a VR interface that corresponds his liking. This can consist in relaxing content, like meditation video's or swimming with dolphins, or stress-inducing content, like a rollercoaster ride. The latter might be problematic due to its potential influence on stress levels. Many laboratory tests, like haematologic and endocrinologic markers can be influenced during an acute stress response. Normally, this physiological process ensures an effective energy metabolism when most needed. However, during a blood withdrawal using stress-inducing VR this is inconvenient as it could theoretically result in elevated or inaccurate laboratory tests. This might lead to additional blood draws, misdiagnoses and potential over- or undertreatment of patients. To the best of our knowledge, no previous research has assessed the accuracy of laboratory tests conducted on blood samples drawn during a VR rollercoaster experience.
Objective: To assess the impact of exposure to relaxing and stress-inducing virtual reality content on the levels of stress-related biomarkers in healthy individuals.
Study design: This is a monocentre pilot cross-over clinical trial. Study participants will be randomly assigned to one of the two arms. These arms determine the order of VR content exposure. The first arm will be exposed to relaxing VR content during the first study visit, during which blood will be drawn before and after the VR experience. Then, after an interval of 3-5 weeks, they will be exposed to stress-inducing VR content and blood will be drawn before and after. The second arm will do the study visits in the opposite order.
Study population: Healthy volunteers between the ages of 18 and 45 years with no medical history on haematologic, endocrinologic or cardiac disorders.
Intervention:
Participants will be exposed to stress-inducing and relaxing VR content during two separate study visits, the Relax Visit and the Rollercoaster Visit. Blood samples will be collected immediately before and after each VR session to measure changes in stress-related biomarkers. Additionally, objective stress levels measured by vital functions (e.g. heart rate, blood pressure) and subjective stress levels measured using a visual analogue scale (VAS) will be collected immediately pre- and post- VR exposure.
Main study parameters/endpoints:
The correlation between stress-related biomarkers (factor VIII activity, vWF ristocetin co-factor activity, copeptin (AVP), prolactin, thyroid stimulating hormone (TSH), cortisol and glucose) before and after relaxing and stress-inducing VR-content.
Nature and extent of the burden and risks associated with participation, benefit and group relatedness:
Participation includes two site visits, with an interval of 3 to 5 weeks. In both visits blood samples will be collected immediately before and after each VR session to measure changes in biomarkers. Additionally, objective stress levels measured by vital functions and subjective stress levels measured using a visual analogue scale will be collected immediately pre- and post- VR exposure. There are no benefits for participants. However, the results of this study may possibly benefit patients with haematological and endocrinological disorders regarding their comfort and anxiety during blood sampling and by reducing unnecessary extra sampling. Furthermore, it may benefit their treatment by optimizing the diagnostic process. Potential risks are the experience of motion-sickness during the VR experience and a blood withdrawal might be experienced as minimally painful for a very short amount of time. However, to minimalize this pain participants will apply a numbing cream one hour before the start of a study visit.
- Conditions
- Virtual Reality Pain Distraction, Endocrinology, Haematology
- Being tested
- Meditation video at the beach, Rollercoaster video
- Keywords
- Virtual reality, Stress-related biomarkers, Rollercoaster
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Meditation video at the beachOther
A virtual reality video consisting of a 5 minute meditation video at te beach.
Rollercoaster videoOther
A virtual reality video consisting of a five minute rollercoaster ride.
| Study group | Role | What they receive |
|---|---|---|
| Arm A | Experimental | Arm A receives the Relax visit first and 3-5 weeks later the Rollercoaster Visit. Receives: Other: Meditation video at the beach; Other: Rollercoaster video |
| Arm B | Experimental | Arm B receives the Rollercoaster Visit first and 3-5 weeks later the Relax Visit. Receives: Other: Meditation video at the beach; Other: Rollercoaster video |
What is being measured
The primary outcome is the main question the study is designed to answer.
The effect of relaxing VR content on von Willebrand ristocetin co-factor activity
The difference between von Willebrand ristocetin co-factor activity before and after relaxing VR content (beach meditation video) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on von Willebrand ristocetin co-factor activity
The difference between von Willebrand ristocetin co-factor activity before and after stress-inducing VR content (rollercoaster ride) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on von Willebrand ristocetin co-factor activity
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for von Willebrand ristocetin co-factor activity is assessed.
Measured: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on FVIII activity
The difference between FVIII activity before and after relaxing VR content (beach meditation video) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on FVIII activity
The difference between FVIII activity before and after stress-inducing VR content (rollercoaster ride) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on FVIII activity
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for FVIII activity is assessed.
Measured: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on copeptin
The difference between copeptin before and after relaxing VR content (beach meditation video) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on copeptin
The difference between copeptin before and after stress-inducing VR content (rollercoaster ride) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on copeptin
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for copeptin is assessed.
Measured: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on prolactin
The difference between prolactin before and after relaxing VR content (beach meditation video) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on prolactin
The difference between prolactin before and after stress-inducing VR content (rollercoaster ride) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on prolactin
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for prolactin is assessed.
Measured: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on thyroid stimulating hormone (TSH)
The difference between TSH before and after relaxing VR content (beach meditation video) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on TSH
The difference between TSH before and after stress-inducing VR content (rollercoaster ride) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on TSH
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for TSH is assessed.
Measured: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on cortisol
The difference between cortisol before and after relaxing VR content (beach meditation video) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on cortisol
The difference between cortisol before and after stress-inducing VR content (rollercoaster ride) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on cortisol
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for cortisol is assessed.
Measured: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on glucose
The difference between glucose before and after relaxing VR content (beach meditation video) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on glucose
The difference between glucose before and after stress-inducing VR content (rollercoaster ride) is measured.
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on glucose
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for glucose is assessed.
Measured: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
Secondary outcomes (14)
The effect of relaxing VR-content on blood pressure
The difference before and after relaxing VR-content (beach meditation video) on blood pressure
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR-content on blood pressure
The difference before and after stress-inducing VR-content (rollercoaster ride video) on blood pressure
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on blood pressure
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for blood pressure is assessed.
Measured: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR-content on temperature
The difference before and after relaxing VR-content (beach meditation video) on temperature
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR-content on temperature
The difference before and after stress-inducing VR-content (rollercoaster ride video) on temperature
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on temperature
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for temperature is assessed.
Measured: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR-content on heart rate
The difference before and after relaxing VR-content (beach meditation video) on heart rate
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR-content on heart rate
The difference before and after stress-inducing VR-content (rollercoaster ride video) on heart rate
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on heart rate
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for heart rate is assessed.
Measured: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR-content on respiratory rate
The difference before and after relaxing VR-content (beach meditation video) on respiratory rate
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR-content on respiratory rate
The difference before and after stress-inducing VR-content (rollercoaster ride video) on respiratory rate
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on respiratory rate
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for respiratory rate is assessed.
Measured: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on subjective stress reported by participant
Subjective stress, measured by a visual analogue scale (VAS) (scale 0-10 made visual using different faces; 0 being no stress, 10 being the worst stress a person can imagine), during relaxing VR content (beach meditation video).
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on subjective stress reported by participant
Subjective stress, measured by a visual analogue scale (VAS) (scale 0-10 made visual using different faces; 0 being no stress, 10 being the worst stress a person can imagine), during relaxing VR content (rollercoaster ride video).
Measured: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jun 2025
- Study start27 Aug 2025
- Primary completion20 Feb 2026
- Study completion20 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Virtual Reality Pain DistractionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Van Creveldkliniek
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Van Creveldkliniek, UMC Utrecht
- Investigators
- Corien L. Eckhardt, MD PhD, Principal investigator, UMC Utrecht
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07042178
- Sponsor's protocol ID
- 25U-0212
- Other IDs
- NL-009813
- Acronym
- 8baan
- Status last verified
- Apr 2026
- First submitted
- 11 Jun 2025
- Last updated
- 29 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: After finishing the project, the data package will be stored at the UMC Utrecht Research Folder Structure and is under the responsibility of the Principal Investigator of the research group. The metadata will be available in the UMCU repository (DataverseNL). As the data is privacy-sensitive, we publish the descriptive metadata in the data repository with a description of how a data request can be made (by sending an email to the corresponding author). In the event that peers like to reuse our data this can only be granted if the research question is in line with the original informed consent signed by the study participants. Every application therefore will be screened upon this requirement. If granted, a data usage agreement is signed by the receiving party.
Study at a glance
From the registry record, last updated by the sponsor on 29 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Influence of Stress-inducing and Relaxing VR Content on Haematologic and Endocrinologic Blood Parameters in Healthy Participants - the 8baan Study
- ClinicalTrials.gov ID
- NCT07042178
- Acronym / sponsor ID
- 8baan / 25U-0212
- Conditions
- Virtual Reality Pain Distraction, Endocrinology, Haematology
- Keywords
- Virtual reality, Stress-related biomarkers, Rollercoaster
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Van CreveldkliniekUniversity, hospital or other
- Study start
- 27 Aug 2025 (actual)
- Primary completion
- 20 Feb 2026 (actual)
- Study completion
- 20 Feb 2026 (actual)
- First posted
- 27 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to learn what the impact of exposure to virtual reality content is on the levels of stress-related blood values in healthy volunteers. The main question it aims to answer is:
- To compare the levels of stress-related biomarkers before and after relaxing VR-content (Relax Visit);
- To compare the levels of stress-related biomarkers before and after stress-inducing VR-content (Rollercoaster Visit).
Researchers will compare the Relax and Rollercoaster Visit to see if there is a relationship between the relaxing and stress-inducing VR content on stress-related blood values.
Participants will be asked to watch relaxing or stress-inducing VR content for approximately five minutes. Blood will be withdrawn before and after intervention. After 3-5 weeks the study visit will be repeated using the other VR content.
Detailed description
Rationale: In recent years virtual reality (VR) has become increasingly popular in clinical setting, especially during blood sampling to enhance patient comfort and reduce anxiety. The immersion in a 360° fantasy world contributes to an effective way of distraction. During a medical procedure the patient is allowed to choose a VR interface that corresponds his liking. This can consist in relaxing content, like meditation video's or swimming with dolphins, or stress-inducing content, like a rollercoaster ride. The latter might be problematic due to its potential influence on stress levels. Many laboratory tests, like haematologic and endocrinologic markers can be influenced during an acute stress response. Normally, this physiological process ensures an effective energy metabolism when most needed. However, during a blood withdrawal using stress-inducing VR this is inconvenient as it could theoretically result in elevated or inaccurate laboratory tests. This might lead to additional blood draws, misdiagnoses and potential over- or undertreatment of patients. To the best of our knowledge, no previous research has assessed the accuracy of laboratory tests conducted on blood samples drawn during a VR rollercoaster experience.
Objective: To assess the impact of exposure to relaxing and stress-inducing virtual reality content on the levels of stress-related biomarkers in healthy individuals.
Study design: This is a monocentre pilot cross-over clinical trial. Study participants will be randomly assigned to one of the two arms. These arms determine the order of VR content exposure. The first arm will be exposed to relaxing VR content during the first study visit, during which blood will be drawn before and after the VR experience. Then, after an interval of 3-5 weeks, they will be exposed to stress-inducing VR content and blood will be drawn before and after. The second arm will do the study visits in the opposite order.
Study population: Healthy volunteers between the ages of 18 and 45 years with no medical history on haematologic, endocrinologic or cardiac disorders.
Intervention:
Participants will be exposed to stress-inducing and relaxing VR content during two separate study visits, the Relax Visit and the Rollercoaster Visit. Blood samples will be collected immediately before and after each VR session to measure changes in stress-related biomarkers. Additionally, objective stress levels measured by vital functions (e.g. heart rate, blood pressure) and subjective stress levels measured using a visual analogue scale (VAS) will be collected immediately pre- and post- VR exposure.
Main study parameters/endpoints:
The correlation between stress-related biomarkers (factor VIII activity, vWF ristocetin co-factor activity, copeptin (AVP), prolactin, thyroid stimulating hormone (TSH), cortisol and glucose) before and after relaxing and stress-inducing VR-content.
Nature and extent of the burden and risks associated with participation, benefit and group relatedness:
Participation includes two site visits, with an interval of 3 to 5 weeks. In both visits blood samples will be collected immediately before and after each VR session to measure changes in biomarkers. Additionally, objective stress levels measured by vital functions and subjective stress levels measured using a visual analogue scale will be collected immediately pre- and post- VR exposure. There are no benefits for participants. However, the results of this study may possibly benefit patients with haematological and endocrinological disorders regarding their comfort and anxiety during blood sampling and by reducing unnecessary extra sampling. Furthermore, it may benefit their treatment by optimizing the diagnostic process. Potential risks are the experience of motion-sickness during the VR experience and a blood withdrawal might be experienced as minimally painful for a very short amount of time. However, to minimalize this pain participants will apply a numbing cream one hour before the start of a study visit.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Arm A | Experimental | Other: Meditation video at the beach, Other: Rollercoaster videoArm A receives the Relax visit first and 3-5 weeks later the Rollercoaster Visit. |
| Arm B | Experimental | Other: Meditation video at the beach, Other: Rollercoaster videoArm B receives the Rollercoaster Visit first and 3-5 weeks later the Relax Visit. |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Age between 18 and 45 years old;
- Willing and able to provide written informed consent.
Key exclusion criteria (15 listed)
- A history of motion- or cybersickness;
- Fear of needles;
- Any of the following haematological disorders:
- Any of the following endocrinological disorders:
- A confirmed cardiac disorder;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Meditation video at the beachA virtual reality video consisting of a 5 minute meditation video at te beach. | Other | Arm A, Arm B |
| Rollercoaster videoA virtual reality video consisting of a five minute rollercoaster ride. | Other | Arm A, Arm B |
Primary outcome
The effect of relaxing VR content on von Willebrand ristocetin co-factor activity
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The difference between von Willebrand ristocetin co-factor activity before and after relaxing VR content (beach meditation video) is measured.
The effect of stress-inducing VR content on von Willebrand ristocetin co-factor activity
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The difference between von Willebrand ristocetin co-factor activity before and after stress-inducing VR content (rollercoaster ride) is measured.
The correlation between relaxing and stress-inducing VR content on von Willebrand ristocetin co-factor activity
Time frame: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for von Willebrand ristocetin co-factor activity is assessed.
The effect of relaxing VR content on FVIII activity
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The difference between FVIII activity before and after relaxing VR content (beach meditation video) is measured.
The effect of stress-inducing VR content on FVIII activity
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The difference between FVIII activity before and after stress-inducing VR content (rollercoaster ride) is measured.
The correlation between relaxing and stress-inducing VR content on FVIII activity
Time frame: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for FVIII activity is assessed.
The effect of relaxing VR content on copeptin
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The difference between copeptin before and after relaxing VR content (beach meditation video) is measured.
The effect of stress-inducing VR content on copeptin
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The difference between copeptin before and after stress-inducing VR content (rollercoaster ride) is measured.
The correlation between relaxing and stress-inducing VR content on copeptin
Time frame: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for copeptin is assessed.
The effect of relaxing VR content on prolactin
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The difference between prolactin before and after relaxing VR content (beach meditation video) is measured.
The effect of stress-inducing VR content on prolactin
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The difference between prolactin before and after stress-inducing VR content (rollercoaster ride) is measured.
The correlation between relaxing and stress-inducing VR content on prolactin
Time frame: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for prolactin is assessed.
The effect of relaxing VR content on thyroid stimulating hormone (TSH)
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The difference between TSH before and after relaxing VR content (beach meditation video) is measured.
The effect of stress-inducing VR content on TSH
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The difference between TSH before and after stress-inducing VR content (rollercoaster ride) is measured.
The correlation between relaxing and stress-inducing VR content on TSH
Time frame: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for TSH is assessed.
The effect of relaxing VR content on cortisol
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The difference between cortisol before and after relaxing VR content (beach meditation video) is measured.
The effect of stress-inducing VR content on cortisol
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The difference between cortisol before and after stress-inducing VR content (rollercoaster ride) is measured.
The correlation between relaxing and stress-inducing VR content on cortisol
Time frame: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for cortisol is assessed.
The effect of relaxing VR content on glucose
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The difference between glucose before and after relaxing VR content (beach meditation video) is measured.
The effect of stress-inducing VR content on glucose
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The difference between glucose before and after stress-inducing VR content (rollercoaster ride) is measured.
The correlation between relaxing and stress-inducing VR content on glucose
Time frame: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The relationship between relaxing (beach meditation video) and stress-inducing VR content (rollercoaster video) for glucose is assessed.
14 secondary outcomes
The effect of relaxing VR-content on blood pressure
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR-content on blood pressure
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on blood pressure
Time frame: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR-content on temperature
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR-content on temperature
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on temperature
Time frame: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR-content on heart rate
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR-content on heart rate
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on heart rate
Time frame: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR-content on respiratory rate
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR-content on respiratory rate
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
The correlation between relaxing and stress-inducing VR content on respiratory rate
Time frame: From baseline to the end of the second VR video (type is depending on assigned arm) (approximately 3-5 weeks later)
The effect of relaxing VR content on subjective stress reported by participant
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)
The effect of stress-inducing VR content on subjective stress reported by participant
Time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to stress-inducing VR content (approximately 10 minutes later)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Apr 2026.
- Individual participant dataSharing planned: Yes. After finishing the project, the data package will be stored at the UMC Utrecht Research Folder Structure and is under the responsibility of the Principal Investigator of the research group. The metadata will be available in the UMCU repository (DataverseNL). As the data is privacy-sensitive, we publish the descriptive metadata in the data repository with a description of how a data request can be made (by sending an email to the corresponding author). In the event that peers like to reuse our data this can only be granted if the research question is in line with the original informed consent signed by the study participants. Every application therefore will be screened upon this requirement. If granted, a data usage agreement is signed by the receiving party.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Corien L. Eckhardt, MD PhD principal investigator
UMC Utrecht
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Meditation video at the beach and Rollercoaster video in people with Virtual Reality Pain Distraction and Endocrinology, run by Van Creveldkliniek at 1 site in Netherlands.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 15 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Netherlands. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The effect of relaxing VR content on von Willebrand ristocetin co-factor activity (time frame: From baseline (5 minutes before start of the VR content during a study visit) to the end of the exposure to relaxing VR content (approximately 10 minutes later)). The study lists 21 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Apr 2026.