Eccentric Exercise TrainingNCT07042750
Eccentric Cycling Exercise During Pulmonary Rehabilitation in Patients With Cardiopulmonary Diseases
A study testing Eccentric cycling exercise in people with Eccentric Exercise Training, run by Silvia Ulrich Somaini at 2 sites in Switzerland.
Trial summary
Eccentric cycling exercise (ECC) allows training at low metabolic costs and may therefore be valuable for patients with pulmonary vascular disease (PVD). For these patients, regular exercise training has an evidence level 1A recommendation in the current guidelines. Read more about this study
- Who is it for?
- Ages 18 to 85 years
- Conditions the study is for
- Eccentric Exercise Training
- What is being tested?
- Eccentric cycling exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 22 participants
- Where
- 2 sitesSwitzerland
- Study dates
- 2 May 2025to 1 Jul 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Diagnosed with PVD, either PAH or CTEPH via right heart catheterization, according to recent guidelines [9]
- Diagnosed with a cardiopulmonary disease as indication for a pulmonary rehabilitation
- Stable medication for at least 1 month
- Age 18years to 85 years
- No resting hypoxemia (PaO2 >7.3 kPa)
- Medical indication to prescibe a pulmonary rehabilitation
Who cannot join
- Any co-morbidity that limits the patient to participate the full rehabilitation
- Enrollments in other trials with active treatments
- Language barriers that limits the patient to participate in the rehabilitation
Trial locations and contacts
2 sites in 1 country.
Switzerland2 sites
Klinik Barmelweid
Barmelweid, 5017
Universitätsspital Zürich
Zurich, 8092
About this study
Eccentric cycling exercise (ECC) allows training at low metabolic costs and may therefore be valuable for patients with pulmonary vascular disease (PVD). For these patients, regular exercise training has an evidence level 1A recommendation in the current guidelines. Exercise training during longer and regular periods provides chronic adaptation, for which ECC was recently found to have a greater effectiveness than CON by increasing muscle strength, hypertrophy, six-minute walking distance and furthermore, by increasing maximum oxygen uptake (V'O2max) especially in patients with chronic obstructive pulmonary disease (COPD), chronic left heart failure or coronary heart disease. Furthermore, we conducted an RCT in which we exposed patients with PVD to ECC and concluded that ECC is a feasible and well-tolerated exercise modality for PVD patients with severely lower O2 demand and load to the right ventricle. The study in patients with PVD was started (EccRehab), and the great potential was recognized. Therefore there was an indication to open the inclusion criteria to all cardiopulmonary patients with indication for pulmonary rehabilitation (EccRehab2).
For this purpose, the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with cardiopulmonary diseases.
- Conditions
- Eccentric Exercise Training
- Being tested
- Eccentric cycling exercise, Standard Care Arm
- Keywords
- Eccentric cycling exercise, Pulmonary rehabilitation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Eccentric cycling exerciseOther
Patients perform eccentric cycling exercise instead of normal cycling exercise in addition to standard car during a cardiopulmonary rehabilitation
Standard Care ArmOther
Patients perform cardiopulmonary rehabilitation according to standard care
| Study group | Role | What they receive |
|---|---|---|
| Eccentric cycling | Experimental | Patients perform eccentric cycling exercise instead of normal cycling exercise in addition to standard car during a cardiopulmonary rehabilitation Receives: Other: Eccentric cycling exercise |
| Standard care | Active comparator | Patients perform cardiopulmonary rehabilitation according to standard care Receives: Other: Standard Care Arm |
What is being measured
The primary outcome is the main question the study is designed to answer.
Peak exercise performance [Watts]
Peak exercise performance is measured during cardiopulmonary exercise tests on a cycle ergometer. The Unit of the measurement is watts.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Secondary outcomes (14)
Peak oxygen uptake [L/min]
Peak oxygen uptake is measured during cardiopulmonary exercise tests on a cycle ergometer. The Unit of the measurement is liters per minute.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Ventilatory equivalents for carbon dioxide (Minute ventilation / carbon dioxide output)
Ventilatory equivalents for carbon dioxide is measured during cardiopulmonary exercise tests on a cycle ergometer. The measurement is a ratio without a unit (VE/VCO2).
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Six minute walk distance [meters]
The maximal distance that a patient is able to walk within six minutes. The unit of the measurement is meters.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Knee extension test [repetitions]
The patients has to stad up from a chair and sit down as often the patient is able to do this within 1 minute. The unit of the measurement is repetitions.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Systolic pulmonary arterial pressure [mmHg]
The sytolic pulmonary arterial pressure is measured by echocardiography using continuous wave doppler at the tricuspid valve. The unit of the measurement is mmHg.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Total pulmonary reistance [Wood units]
The total pulmonary resistance is measured by echocardiography by dividing the systolic pulmonary arterial pressure by the cardiac output. The unit of the measurement is woos units.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Right ventricular to arterial coupling [mm/mmHg]
The right ventricular arterial coupling is measured by echocardiography dividing the tricuspid annular plane systolic excursion by the systolic arterial pressure. the unit is mm/mmHg.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Cardiac output [L/min]
The cardiac output is measured by echocardiography using the left ventricular outflow tract velocity time integral assessed by pulse wave doppler. The unit of the measurement is L/min.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Arterial partial pressure for oxygen [kPa]
The arterial partial pressure for oxygen is measured by taking a arterial blood sample from the arteria radialis at peak exercise and analyze it in a radiometer. The unit of the measurement is kPa.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Arterial partial pressure for carbon dioxide [kPa]
The arterial partial pressure for carbon dioxide is measured by taking a arterial blood sample from the arteria radialis at peak exercise and analyze it in a radiometer. The unit of the measurement is kPa.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Arterial oxygen saturation [%]
The arterial oxygen saturation is measured by taking a arterial blood sample from the arteria radialis at peak exercise and analyze it in a radiometer. The unit of the measurement is %.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Patient reported leg fatigue [scale from 1 to 10]
Patients perceived leg fatigue is assessed at peak exercise on the Borg CR 10 scale. The unit of the measurement is a scale from 1 to 10.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Patient reported dyspnea [scale from 1 to 10]
Patients perceived dyspnea is assessed at peak exercise on the Borg CR 10 scale. The unit of the measurement is a scale from 1 to 10.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Patient reported quality of life [cm]
The patient reported quality of life is assessed by the visual analogue scale, where the patient has to draw on a 10 cm long line where left is "bad" and right is "very good". The unit of the measurement is cm.
Measured: At baseline pre-intervention and immediately after three weeks of rehabilitation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Jun 2025
- Study start2 May 2025
- Primary completion30 Jun 2026
- Study completion1 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Eccentric Exercise TrainingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Intervention: Eccentric cycling (instead of usual cycling) + standard care Control: Standard care
- Masking
- None (open label)
- Enrolment
- 22 participants (actual)
Sponsor and investigators
- Lead sponsor
- Silvia Ulrich Somaini
- Sponsor type
- University, hospital or other
- Collaborators
- Klinik Barmelweid
- Responsible party
- Sponsor-investigator, Silvia Ulrich Somaini, University of Zurich
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07042750
- Sponsor's protocol ID
- EccRehab2
- Status last verified
- Jul 2026
- First submitted
- 10 Jun 2025
- Last updated
- 7 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 7 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Eccentric Cycling Exercise During Pulmonary Rehabilitation in Patients With Cardiopulmonary Diseases
- ClinicalTrials.gov ID
- NCT07042750
- Acronym / sponsor ID
- EccRehab2
- Conditions
- Eccentric Exercise Training
- Keywords
- Eccentric cycling exercise, Pulmonary rehabilitation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 22 participants (actual)
- Lead sponsor
- Silvia Ulrich SomainiUniversity, hospital or other
- Collaborators
- Klinik Barmelweid
- Study start
- 2 May 2025 (actual)
- Primary completion
- 30 Jun 2026 (actual)
- Study completion
- 1 Jul 2026 (actual)
- First posted
- 29 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Eccentric cycling exercise (ECC) allows training at low metabolic costs and may therefore be valuable for patients with pulmonary vascular disease (PVD). For these patients, regular exercise training has an evidence level 1A recommendation in the current guidelines. Exercise training during longer and regular periods provides chronic adaptation, for which ECC was recently found to have a greater effectiveness than CON by increasing muscle strength, hypertrophy, six-minute walking distance and furthermore, by increasing maximum oxygen uptake (V'O2max) especially in patients with chronic obstructive pulmonary disease (COPD), chronic left heart failure or coronary heart disease. Furthermore, we conducted an RCT in which we exposed patients with PVD to ECC and concluded that ECC is a feasible and well-tolerated exercise modality for PVD patients with severely lower O2 demand and load to the right ventricle. The study in patients with PVD was started (EccRehab), and the great potential was recognized. Therefore there was an indication to open the inclusion criteria to all cardiopulmonary patients with indication for pulmonary rehabilitation (EccRehab2).
For this purpose, the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with cardiopulmonary diseases.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Intervention: Eccentric cycling (instead of usual cycling) + standard care Control: Standard care
| Arm | Type | Receives |
|---|---|---|
| Eccentric cycling | Experimental | Other: Eccentric cycling exercisePatients perform eccentric cycling exercise instead of normal cycling exercise in addition to standard car during a cardiopulmonary rehabilitation |
| Standard care | Active comparator | Other: Standard Care ArmPatients perform cardiopulmonary rehabilitation according to standard care |
Who may qualify
- Ages
- 18 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Diagnosed with PVD, either PAH or CTEPH via right heart catheterization, according to recent guidelines [9]
- Diagnosed with a cardiopulmonary disease as indication for a pulmonary rehabilitation
- Stable medication for at least 1 month
- Age 18years to 85 years
- No resting hypoxemia (PaO2 >7.3 kPa)
Key exclusion criteria (3 listed)
- Any co-morbidity that limits the patient to participate the full rehabilitation
- Enrollments in other trials with active treatments
- Language barriers that limits the patient to participate in the rehabilitation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Eccentric cycling exercisePatients perform eccentric cycling exercise instead of normal cycling exercise in addition to standard car during a cardiopulmonary rehabilitation | Other | Eccentric cycling |
| Standard Care ArmPatients perform cardiopulmonary rehabilitation according to standard care | Other | Standard care |
Primary outcome
Peak exercise performance [Watts]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Peak exercise performance is measured during cardiopulmonary exercise tests on a cycle ergometer. The Unit of the measurement is watts.
14 secondary outcomes
Peak oxygen uptake [L/min]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Ventilatory equivalents for carbon dioxide (Minute ventilation / carbon dioxide output)
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Six minute walk distance [meters]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Knee extension test [repetitions]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Systolic pulmonary arterial pressure [mmHg]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Total pulmonary reistance [Wood units]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Right ventricular to arterial coupling [mm/mmHg]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Cardiac output [L/min]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Arterial partial pressure for oxygen [kPa]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Arterial partial pressure for carbon dioxide [kPa]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Arterial oxygen saturation [%]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Patient reported leg fatigue [scale from 1 to 10]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Patient reported dyspnea [scale from 1 to 10]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Patient reported quality of life [cm]
Time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jul 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Eccentric Exercise Training
Not yet recruiting
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Chronic Respiratory Disease, Chronic Obstructive Pulmonary Disease
Not yet recruiting
Comparison Between Eccentric Hamstring Training and Sprint-Specific Training
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Recruiting
Effects of the Tyler Twist Versus Eccentric Exercises
Lateral Epicondylalgia
Enrolling by invitation
Effectiveness of Eccentric Cycling Exercise in Ambulatory Rehabilitation for Patients With Cardiopulmonary Diseases: A Pragmatic Randomized Controlled Trial
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Enrolling by invitation
Concentric vs Eccentric Exercise in Blood Flow Restriction Training
Exercise
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Eccentric cycling exercise in people with Eccentric Exercise Training, run by Silvia Ulrich Somaini at 2 sites in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Peak exercise performance [Watts] (time frame: At baseline pre-intervention and immediately after three weeks of rehabilitation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026.