Endodontic Procedural Errors in Root Canal Treated TeethNCT07045025
Endodontic Errors Detected by CBCT in Egypt
An observational study of Endodontic Procedural Errors in Root Canal Treated Teeth, run by Cairo University.
Trial summary
This observational cross-sectional study aims to evaluate the prevalence of endodontic procedural errors in root canal-treated teeth among an Egyptian subpopulation using cone-beam computed tomography (CBCT). Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Endodontic Procedural Errors in Root Canal Treated Teeth
- What is being tested?
- No Clinical Intervention - Analysis of Previously Acquired CBCT Scans
- How many people
- 379 participants
- Where
- No sites listed yet
- Study dates
- 1 Aug 2025to 1 Oct 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: The study population consists of 379 CBCT scans obtained from Egyptian adult patients (over 18 years old) of both genders. These scans were acquired from radiology centers across Cairo, where patients were referred for various diagnostic purposes. The included scans represent cases with at least one fully endodontically treated permanent tooth and acceptable image quality
Who may be able to join
- CBCT scans showing at least one permanent tooth that has undergone complete root canal treatment.
- Scans showing both jaw (maxilla and mandible) .
- Scans with good image quality and a voxel size of 0.2 mm or 0.3 mm.
- Egyptian nationals of either gender.
- Age over 18 years.
Who cannot join
- CBCT scans that do not show any teeth with complete root canal treatment.
- Completely edentulous patient.
- Low-quality images or scans with artefacts.
- Scans with voxel size larger than 0.3 mm.
- Non- Egyptian patients.
- Surgically treated endodontic cases (e.g., apicoectomy).
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Prevalence of Endodontic Procedural Errors Using CBCT in an Egyptian Subpopulation: A Cross-Sectional Study
This observational cross-sectional study aims to evaluate the prevalence of endodontic procedural errors in root canal-treated teeth among an Egyptian subpopulation using cone-beam computed tomography (CBCT). The study will analyze CBCT scans obtained from radiology centers in Cairo to detect errors such as missed canals, short fillings, perforations, fractured instruments, and other complications. Understanding the frequency and distribution of these errors between the maxillary and mandibular arches may help improve endodontic treatment outcomes and raise awareness of common procedural challenges. The study does not involve any new treatment or drug but will rely on previously taken CBCT images.
Read the detailed description
The biological and therapeutic goals of Endodontic treatment are to prevent apical lesions or to establish ideal healing conditions by removing bacteria and infection from the root canal system and preventing reinfection. However, endodontic mishaps such as incorrect diagnosis, missed canals, perforations, instrument separation, over- or under-obturation, and vertical root fractures compromise the success of root canal therapy.
The reported success rate of endodontic treatments by general dentists ranges from 60% to 75%. Procedural errors are a significant factor contributing to the suboptimal success rate of endodontic treatments performed by general dentists. Moreover, the global prevalence of periapical lesion is approximately 52% in individuals and 5% in teeth, with higher frequency in teeth with root-filled teeth compered to non-treated teeth.
Procedural errors may be difficult to correct. Certain procedural errors could need endodontic retreatment, apicoectomy, or even tooth extraction. Root canal transportation, apical perforation, strip perforation, access cavity perforation, and instrument fracture are among the commonly occurring procedural errors. The working length of the root canal filling is a critical factor, with fillings short of the apex by 2 mm reducing success rates to 68-77% and overfills beyond the apex yielding around 75% success rates.
Endodontic treatment for molar teeth is more challenging and requires more caution than anterior and premolar teeth, and is associated with a higher rate of procedural errors. The reason for this is their difficulty in accessibility and anatomical complexity. This is reflected in the distribution of errors, were Procedural errors were more frequently observed in mandibular teeth (53.1%) than maxillary teeth (46.9%), with the highest error rate found in the right and left permanent mandibular first molars (20.2% and 14.3%, respectively).
Cone-beam computed tomography (CBCT) it delivers high-quality images and images providing three-dimensional imaging, allowing detailed views of individual teeth from any angle. This makes it an effective tool for diagnosing, planning, and monitoring endodontic treatment. CBCT can detect periapical radiolucency before they would be apparent on conventional radiographs. While traditional radiographs are less expensive and expose patients to lower radiation doses, research has demonstrated that CBCT images are better for diagnosing periapical lesions.
Rationale for conducting the research:
In Egypt, there is a lack of comprehensive data regarding the prevalence and distribution of procedural errors in endodontically treated teeth. This knowledge gap limits our understanding of how these errors differ between the maxilla and mandible and restricts the development of targeted strategies to enhance treatment quality and reduce failure rates.
Despite significant advancements in endodontic techniques and imaging modalities, procedural errors remain a critical challenge in achieving optimal treatment outcomes. These errors are particularly problematic in molar teeth due to their anatomical complexity and reduced accessibility. Although several international studies have evaluated the prevalence of endodontic procedural errors, there is limited research focusing specifically on the Egyptian subpopulation.
Understanding the patterns and frequencies of procedural errors in maxillary and mandibular teeth among Egyptians can aid clinicians in anticipating challenges, refining treatment strategies, and minimizing procedural failures. Moreover, differences in error distribution between the two jaws reported in other populations highlight the need for local investigation.
CBCT technology provides a detailed three-dimensional assessment of dental anatomy and procedural errors, offering superior diagnostic capabilities compared to two-dimensional radiography. This makes it an ideal tool for evaluating the prevalence and distribution of endodontic procedural errors.
Therefore, the aim of this study is to determine the prevalence and distribution of endodontic procedural errors in the maxilla and mandible using CBCT imaging in a selected Egyptian subpopulation.
- Being tested
- No Clinical Intervention - Analysis of Previously Acquired CBCT Scans
- Keywords
- Prevalence of Endodontic Procedural Errors
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
No Clinical Intervention - Analysis of Previously Acquired CBCT ScansOther
This study does not involve any clinical or therapeutic intervention. It is solely based on the retrospective analysis of previously acquired CBCT scans from patients who have undergone root canal treatment. No drugs, devices, or procedures are administered or applied to participants as part of this study.
What is being measured
The primary outcome is the main question the study is designed to answer.
Prevalence of Procedural Errors
Analysis of CBCT scans to detect and evaluate the prevalence of procedural errors such as instrument separation, perforations, ledges, and canal transportation in Endodontically treated teeth.
Measured: Baseline assessment of all available cases within the study period
Secondary outcomes (1)
Distribution of Procedural Errors between Maxilla and Mandible
Analysis of CBCT scans to determine and compare the distribution of procedural errors, such as instrument separation, perforations, ledges, and canal transportation, between maxillary and mandibular teeth.
Measured: Baseline assessment of all available cases within the study period.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jul 2025
- Study start1 Aug 2025 (estimated)
- Primary completion1 Aug 2026 (estimated)
- Study completion1 Oct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Endodontic Procedural Errors in Root Canal Treated TeethStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Retrospective
- Enrolment
- 379 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Esbah Adam Ahmed Mohamed, Cairo University
- Investigators
- Nehal N. Roshdy, Professor of Endodontics, Principal investigator, Cairo UniversityDr.sara, Lecturer in Endodontics, Study chair, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07045025
- Sponsor's protocol ID
- New ENDO 1-1-1 n/code=7 (3/5 G
- Status last verified
- Jun 2025
- First submitted
- 22 Jun 2025
- Last updated
- 1 Jul 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Yousuf W, Khan M, Mehdi H. Endodontic Procedural Errors: Frequency, Type of Error, and the Most Frequently Treated Tooth. Int J Dent. 2015;2015:673914. doi: 10.1155/2015/673914. Epub 2015 Aug 10.
PubMed 26347779de Paula-Silva FW, Wu MK, Leonardo MR, da Silva LA, Wesselink PR. Accuracy of periapical radiography and cone-beam computed tomography scans in diagnosing apical periodontitis using histopathological findings as a gold standard. J Endod. 2009 Jul;35(7):1009-12. doi: 10.1016/j.joen.2009.04.006.
PubMed 19567324Patel S, Durack C, Abella F, Shemesh H, Roig M, Lemberg K. Cone beam computed tomography in Endodontics - a review. Int Endod J. 2015 Jan;48(1):3-15. doi: 10.1111/iej.12270. Epub 2014 Apr 2.
PubMed 24697513Nascimento EHL, Gaeta-Araujo H, Andrade MFS, Freitas DQ. Prevalence of technical errors and periapical lesions in a sample of endodontically treated teeth: a CBCT analysis. Clin Oral Investig. 2018 Sep;22(7):2495-2503. doi: 10.1007/s00784-018-2344-y. Epub 2018 Jan 21.
PubMed 29354883
Study at a glance
From the registry record, last updated by the sponsor on 1 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prevalence of Endodontic Procedural Errors Using CBCT in an Egyptian Subpopulation: A Cross-Sectional Study
- ClinicalTrials.gov ID
- NCT07045025
- Acronym / sponsor ID
- New ENDO 1-1-1 n/code=7 (3/5 G
- Keywords
- Prevalence of Endodontic Procedural Errors
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 379 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Aug 2025 (estimated)
- Primary completion
- 1 Aug 2026 (estimated)
- Study completion
- 1 Oct 2026 (estimated)
- First posted
- 1 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This observational cross-sectional study aims to evaluate the prevalence of endodontic procedural errors in root canal-treated teeth among an Egyptian subpopulation using cone-beam computed tomography (CBCT). The study will analyze CBCT scans obtained from radiology centers in Cairo to detect errors such as missed canals, short fillings, perforations, fractured instruments, and other complications. Understanding the frequency and distribution of these errors between the maxillary and mandibular arches may help improve endodontic treatment outcomes and raise awareness of common procedural challenges. The study does not involve any new treatment or drug but will rely on previously taken CBCT images.
Detailed description
The biological and therapeutic goals of Endodontic treatment are to prevent apical lesions or to establish ideal healing conditions by removing bacteria and infection from the root canal system and preventing reinfection. However, endodontic mishaps such as incorrect diagnosis, missed canals, perforations, instrument separation, over- or under-obturation, and vertical root fractures compromise the success of root canal therapy.
The reported success rate of endodontic treatments by general dentists ranges from 60% to 75%. Procedural errors are a significant factor contributing to the suboptimal success rate of endodontic treatments performed by general dentists. Moreover, the global prevalence of periapical lesion is approximately 52% in individuals and 5% in teeth, with higher frequency in teeth with root-filled teeth compered to non-treated teeth.
Procedural errors may be difficult to correct. Certain procedural errors could need endodontic retreatment, apicoectomy, or even tooth extraction. Root canal transportation, apical perforation, strip perforation, access cavity perforation, and instrument fracture are among the commonly occurring procedural errors. The working length of the root canal filling is a critical factor, with fillings short of the apex by 2 mm reducing success rates to 68-77% and overfills beyond the apex yielding around 75% success rates.
Endodontic treatment for molar teeth is more challenging and requires more caution than anterior and premolar teeth, and is associated with a higher rate of procedural errors. The reason for this is their difficulty in accessibility and anatomical complexity. This is reflected in the distribution of errors, were Procedural errors were more frequently observed in mandibular teeth (53.1%) than maxillary teeth (46.9%), with the highest error rate found in the right and left permanent mandibular first molars (20.2% and 14.3%, respectively).
Cone-beam computed tomography (CBCT) it delivers high-quality images and images providing three-dimensional imaging, allowing detailed views of individual teeth from any angle. This makes it an effective tool for diagnosing, planning, and monitoring endodontic treatment. CBCT can detect periapical radiolucency before they would be apparent on conventional radiographs. While traditional radiographs are less expensive and expose patients to lower radiation doses, research has demonstrated that CBCT images are better for diagnosing periapical lesions.
Rationale for conducting the research:
In Egypt, there is a lack of comprehensive data regarding the prevalence and distribution of procedural errors in endodontically treated teeth. This knowledge gap limits our understanding of how these errors differ between the maxilla and mandible and restricts the development of targeted strategies to enhance treatment quality and reduce failure rates.
Despite significant advancements in endodontic techniques and imaging modalities, procedural errors remain a critical challenge in achieving optimal treatment outcomes. These errors are particularly problematic in molar teeth due to their anatomical complexity and reduced accessibility. Although several international studies have evaluated the prevalence of endodontic procedural errors, there is limited research focusing specifically on the Egyptian subpopulation.
Understanding the patterns and frequencies of procedural errors in maxillary and mandibular teeth among Egyptians can aid clinicians in anticipating challenges, refining treatment strategies, and minimizing procedural failures. Moreover, differences in error distribution between the two jaws reported in other populations highlight the need for local investigation.
CBCT technology provides a detailed three-dimensional assessment of dental anatomy and procedural errors, offering superior diagnostic capabilities compared to two-dimensional radiography. This makes it an ideal tool for evaluating the prevalence and distribution of endodontic procedural errors.
Therefore, the aim of this study is to determine the prevalence and distribution of endodontic procedural errors in the maxilla and mandible using CBCT imaging in a selected Egyptian subpopulation.
Study design
- Observational model
- Other
- Time perspective
- Retrospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of 379 CBCT scans obtained from Egyptian adult patients (over 18 years old) of both genders. These scans were acquired from radiology centers across Cairo, where patients were referred for various diagnostic purposes. The included scans represent cases with at least one fully endodontically treated permanent tooth and acceptable image quality
Key inclusion criteria (5 listed)
- CBCT scans showing at least one permanent tooth that has undergone complete root canal treatment.
- Scans showing both jaw (maxilla and mandible) .
- Scans with good image quality and a voxel size of 0.2 mm or 0.3 mm.
- Egyptian nationals of either gender.
- Age over 18 years.
Key exclusion criteria (6 listed)
- CBCT scans that do not show any teeth with complete root canal treatment.
- Completely edentulous patient.
- Low-quality images or scans with artefacts.
- Scans with voxel size larger than 0.3 mm.
- Non- Egyptian patients.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| No Clinical Intervention - Analysis of Previously Acquired CBCT ScansThis study does not involve any clinical or therapeutic intervention. It is solely based on the retrospective analysis of previously acquired CBCT scans from patients who have undergone root canal treatment. No drugs, devices, or procedures are administered or applied to participants as part of this study. | Other | – |
Primary outcome
Prevalence of Procedural Errors
Time frame: Baseline assessment of all available cases within the study period
Analysis of CBCT scans to detect and evaluate the prevalence of procedural errors such as instrument separation, perforations, ledges, and canal transportation in Endodontically treated teeth.
1 secondary outcome
Distribution of Procedural Errors between Maxilla and Mandible
Time frame: Baseline assessment of all available cases within the study period.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Jul 2025.
- Background: PubMed 26347779Yousuf W, Khan M, Mehdi H. Endodontic Procedural Errors: Frequency, Type of Error, and the Most Frequently Treated Tooth. Int J Dent. 2015;2015:673914. doi: 10.1155/2015/673914. Epub 2015 Aug 10.
- Background: PubMed 19567324de Paula-Silva FW, Wu MK, Leonardo MR, da Silva LA, Wesselink PR. Accuracy of periapical radiography and cone-beam computed tomography scans in diagnosing apical periodontitis using histopathological findings as a gold standard. J Endod. 2009 Jul;35(7):1009-12. doi: 10.1016/j.joen.2009.04.006.
- Background: PubMed 24697513Patel S, Durack C, Abella F, Shemesh H, Roig M, Lemberg K. Cone beam computed tomography in Endodontics - a review. Int Endod J. 2015 Jan;48(1):3-15. doi: 10.1111/iej.12270. Epub 2014 Apr 2.
- Background: PubMed 29354883Nascimento EHL, Gaeta-Araujo H, Andrade MFS, Freitas DQ. Prevalence of technical errors and periapical lesions in a sample of endodontically treated teeth: a CBCT analysis. Clin Oral Investig. 2018 Sep;22(7):2495-2503. doi: 10.1007/s00784-018-2344-y. Epub 2018 Jan 21.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Nehal N. Roshdy, Professor of Endodontics principal investigator
Cairo University
Dr.sara, Lecturer in Endodontics study chair
Cairo University
Questions about this trial
What is this clinical trial studying?
An observational study of Endodontic Procedural Errors in Root Canal Treated Teeth, run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 1 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Esbah A. Mohamed, B.D.S /2018 (00201094573196, esbah.adam@dentistry.cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Prevalence of Procedural Errors (time frame: Baseline assessment of all available cases within the study period). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07045025, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Jul 2025.