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Endodontic Procedural Errors in Root Canal Treated TeethNCT07045025

Endodontic Errors Detected by CBCT in Egypt

An observational study of Endodontic Procedural Errors in Root Canal Treated Teeth, run by Cairo University.

Not yet recruiting

Opening soon. The study is approved but enrolment has not started yet. Sites may already take enquiries.

Sites and contacts
Official record
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Trial summary

This observational cross-sectional study aims to evaluate the prevalence of endodontic procedural errors in root canal-treated teeth among an Egyptian subpopulation using cone-beam computed tomography (CBCT). Read more about this study

Who is it for?
Ages 18 years and olderHealthy volunteers can take part
What is being tested?
No Clinical Intervention - Analysis of Previously Acquired CBCT Scans
How many people
379 participants
Where
No sites listed yet
Study dates
1 Aug 2025to 1 Oct 2026
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Study population: The study population consists of 379 CBCT scans obtained from Egyptian adult patients (over 18 years old) of both genders. These scans were acquired from radiology centers across Cairo, where patients were referred for various diagnostic purposes. The included scans represent cases with at least one fully endodontically treated permanent tooth and acceptable image quality

Who may be able to join

  • CBCT scans showing at least one permanent tooth that has undergone complete root canal treatment.
  • Scans showing both jaw (maxilla and mandible) .
  • Scans with good image quality and a voxel size of 0.2 mm or 0.3 mm.
  • Egyptian nationals of either gender.
  • Age over 18 years.

Who cannot join

  • CBCT scans that do not show any teeth with complete root canal treatment.
  • Completely edentulous patient.
  • Low-quality images or scans with artefacts.
  • Scans with voxel size larger than 0.3 mm.
  • Non- Egyptian patients.
  • Surgically treated endodontic cases (e.g., apicoectomy).

Trial locations and contacts

No sites are listed yet. Contact the study team or a site near you to ask about taking part.

Esbah A. Mohamed, B.D.S /2018 contact

00201094573196

esbah.adam@dentistry.cu.edu.eg

About this study

Official title: Prevalence of Endodontic Procedural Errors Using CBCT in an Egyptian Subpopulation: A Cross-Sectional Study

This observational cross-sectional study aims to evaluate the prevalence of endodontic procedural errors in root canal-treated teeth among an Egyptian subpopulation using cone-beam computed tomography (CBCT). The study will analyze CBCT scans obtained from radiology centers in Cairo to detect errors such as missed canals, short fillings, perforations, fractured instruments, and other complications. Understanding the frequency and distribution of these errors between the maxillary and mandibular arches may help improve endodontic treatment outcomes and raise awareness of common procedural challenges. The study does not involve any new treatment or drug but will rely on previously taken CBCT images.

Read the detailed description

The biological and therapeutic goals of Endodontic treatment are to prevent apical lesions or to establish ideal healing conditions by removing bacteria and infection from the root canal system and preventing reinfection. However, endodontic mishaps such as incorrect diagnosis, missed canals, perforations, instrument separation, over- or under-obturation, and vertical root fractures compromise the success of root canal therapy.

The reported success rate of endodontic treatments by general dentists ranges from 60% to 75%. Procedural errors are a significant factor contributing to the suboptimal success rate of endodontic treatments performed by general dentists. Moreover, the global prevalence of periapical lesion is approximately 52% in individuals and 5% in teeth, with higher frequency in teeth with root-filled teeth compered to non-treated teeth.

Procedural errors may be difficult to correct. Certain procedural errors could need endodontic retreatment, apicoectomy, or even tooth extraction. Root canal transportation, apical perforation, strip perforation, access cavity perforation, and instrument fracture are among the commonly occurring procedural errors. The working length of the root canal filling is a critical factor, with fillings short of the apex by 2 mm reducing success rates to 68-77% and overfills beyond the apex yielding around 75% success rates.

Endodontic treatment for molar teeth is more challenging and requires more caution than anterior and premolar teeth, and is associated with a higher rate of procedural errors. The reason for this is their difficulty in accessibility and anatomical complexity. This is reflected in the distribution of errors, were Procedural errors were more frequently observed in mandibular teeth (53.1%) than maxillary teeth (46.9%), with the highest error rate found in the right and left permanent mandibular first molars (20.2% and 14.3%, respectively).

Cone-beam computed tomography (CBCT) it delivers high-quality images and images providing three-dimensional imaging, allowing detailed views of individual teeth from any angle. This makes it an effective tool for diagnosing, planning, and monitoring endodontic treatment. CBCT can detect periapical radiolucency before they would be apparent on conventional radiographs. While traditional radiographs are less expensive and expose patients to lower radiation doses, research has demonstrated that CBCT images are better for diagnosing periapical lesions.

Rationale for conducting the research:

In Egypt, there is a lack of comprehensive data regarding the prevalence and distribution of procedural errors in endodontically treated teeth. This knowledge gap limits our understanding of how these errors differ between the maxilla and mandible and restricts the development of targeted strategies to enhance treatment quality and reduce failure rates.

Despite significant advancements in endodontic techniques and imaging modalities, procedural errors remain a critical challenge in achieving optimal treatment outcomes. These errors are particularly problematic in molar teeth due to their anatomical complexity and reduced accessibility. Although several international studies have evaluated the prevalence of endodontic procedural errors, there is limited research focusing specifically on the Egyptian subpopulation.

Understanding the patterns and frequencies of procedural errors in maxillary and mandibular teeth among Egyptians can aid clinicians in anticipating challenges, refining treatment strategies, and minimizing procedural failures. Moreover, differences in error distribution between the two jaws reported in other populations highlight the need for local investigation.

CBCT technology provides a detailed three-dimensional assessment of dental anatomy and procedural errors, offering superior diagnostic capabilities compared to two-dimensional radiography. This makes it an ideal tool for evaluating the prevalence and distribution of endodontic procedural errors.

Therefore, the aim of this study is to determine the prevalence and distribution of endodontic procedural errors in the maxilla and mandible using CBCT imaging in a selected Egyptian subpopulation.

Being tested
No Clinical Intervention - Analysis of Previously Acquired CBCT Scans
Keywords
Prevalence of Endodontic Procedural Errors

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • No Clinical Intervention - Analysis of Previously Acquired CBCT ScansOther

    This study does not involve any clinical or therapeutic intervention. It is solely based on the retrospective analysis of previously acquired CBCT scans from patients who have undergone root canal treatment. No drugs, devices, or procedures are administered or applied to participants as part of this study.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Prevalence of Procedural Errors

    Analysis of CBCT scans to detect and evaluate the prevalence of procedural errors such as instrument separation, perforations, ledges, and canal transportation in Endodontically treated teeth.

    Measured: Baseline assessment of all available cases within the study period

Secondary outcomes (1)
  1. Distribution of Procedural Errors between Maxilla and Mandible

    Analysis of CBCT scans to determine and compare the distribution of procedural errors, such as instrument separation, perforations, ledges, and canal transportation, between maxillary and mandibular teeth.

    Measured: Baseline assessment of all available cases within the study period.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted1 Jul 2025
  2. Study start1 Aug 2025 (estimated)
  3. Primary completion1 Aug 2026 (estimated)
  4. Study completion1 Oct 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Other
Time perspective
Retrospective
Enrolment
379 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07045025
Sponsor's protocol ID
New ENDO 1-1-1 n/code=7 (3/5 G
Status last verified
Jun 2025
First submitted
22 Jun 2025
Last updated
1 Jul 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No

Publications

  • Yousuf W, Khan M, Mehdi H. Endodontic Procedural Errors: Frequency, Type of Error, and the Most Frequently Treated Tooth. Int J Dent. 2015;2015:673914. doi: 10.1155/2015/673914. Epub 2015 Aug 10.

    PubMed 26347779
  • de Paula-Silva FW, Wu MK, Leonardo MR, da Silva LA, Wesselink PR. Accuracy of periapical radiography and cone-beam computed tomography scans in diagnosing apical periodontitis using histopathological findings as a gold standard. J Endod. 2009 Jul;35(7):1009-12. doi: 10.1016/j.joen.2009.04.006.

    PubMed 19567324
  • Patel S, Durack C, Abella F, Shemesh H, Roig M, Lemberg K. Cone beam computed tomography in Endodontics - a review. Int Endod J. 2015 Jan;48(1):3-15. doi: 10.1111/iej.12270. Epub 2014 Apr 2.

    PubMed 24697513
  • Nascimento EHL, Gaeta-Araujo H, Andrade MFS, Freitas DQ. Prevalence of technical errors and periapical lesions in a sample of endodontically treated teeth: a CBCT analysis. Clin Oral Investig. 2018 Sep;22(7):2495-2503. doi: 10.1007/s00784-018-2344-y. Epub 2018 Jan 21.

    PubMed 29354883

Questions about this trial

What is this clinical trial studying?

An observational study of Endodontic Procedural Errors in Root Canal Treated Teeth, run by Cairo University.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: opening soon, as of the sponsor's last update on 1 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Esbah A. Mohamed, B.D.S /2018 (00201094573196, esbah.adam@dentistry.cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Prevalence of Procedural Errors (time frame: Baseline assessment of all available cases within the study period). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07045025, which also lists 4 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Jul 2025.

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