Knee Arthroscopic SurgeryNCT07046390
TIPS Block vs. IV Analgesia for Postoperative Pain After Knee Arthroscopy
A study testing nerve block with bupivacaine 0.25% in people with Knee Arthroscopic Surgery and Nerve Block, run by Ain Shams University at 1 site in Egypt.
Trial summary
In this study participants are aiming to compare triple injection peri-sartorius (TIPS) block versus intravenous analgesia for postoperative analgesia after knee arthroscopy regarding efficacy of pain relief and early ambulation Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Knee Arthroscopic Surgery, Nerve Block
- What is being tested?
- nerve block with bupivacaine 0.25%
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 52 participants
- Where
- 1 siteEgypt
- Study dates
- 20 Jul 2025to 20 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- .Age 18-40 years undergoing knee arthroscopy. .Sex: Both sexes.
- .American Society of Anaesthesiologists (ASA) Physical Status Class I and II
Who cannot join
- .Declining to give written informed consent. .History of allergy to the medications used in the study. .Contraindications to regional anesthesia (including patient refusal, coagulopathy and local infection).
- Psychiatric disorder. .American Society of Anesthesiologists (ASA) Physical Status Class III and IV.
- Patients with body mass index (BMI) >35 kg/m2 .Neurological deficits or mobility-related disorders of the non-operated limb .
- Moderate to severe hepatic , renal diseases and cardiac disease.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparative Study Between Triple Injection Peri-Sartorius (TIPS) Block Versus Intravenous Analgesia for Postoperative Analgesia After Knee Arthroscopy
In this study participants are aiming to compare triple injection peri-sartorius (TIPS) block versus intravenous analgesia for postoperative analgesia after knee arthroscopy regarding efficacy of pain relief and early ambulation
Read the detailed description
Arthroscopic knee surgery is a commonly performed orthopedic procedure due to being minimally invasive and providing early recovery. A significant number of patients have severe postoperative pain despite using small incisions leading to poor quality of postoperative recovery. Currently, multimodal analgesia is a widely used method of pain relief and also to improve patient functionality and satisfaction scores. Systemic opioids and non-steroidal anti-inflammatory drugs (NSAIDs) have been the mainstay for treating postoperative pain after knee surgery. The traditional high-dose opioid approach is associated with increased opioid-related side effects eg: (Nausea ,vomiting and delayed recovery ).NSAIDs are effective as part of a multimodal analgesic approach, but their use can be limited due to concerns regarding coagulopathy or impairment of renal function and GIT side effects.Ultrasound guidance in regional anaesthesia is increasingly being used leading to approaches to the sciatic nerve block, femoral nerve block (FNB), adductor canal block (ACB) and obturator nerve block increasingly motivated as an element of multimodal analgesia regimen in many operations, including knee arthroscopy.Sub sartorial block has been studied for its efficacy in providing analgesia following knee surgeries while preserving quadriceps muscle power. However, misnomers have been prescribed at different locations for different block approaches. TIPS block targets motor-sparing analgesia through injection at three planes ultrsound guided.Study Procedures: Patients will be enrolled in this randomly allocated using computer-based randomization into two groups with (26) patients in each group
- Group 1 (study group number 1) will receive triple injection peri-sartorius (TIPS) block. The block will be done after induction of general anesthesia before skin incision
- Group 2 (study group number 2) (control group )will receive conventional analgesic regimen without having a regional block.
- Conditions
- Knee Arthroscopic Surgery, Nerve Block
- Being tested
- nerve block with bupivacaine 0.25%, No intervention
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
nerve block with bupivacaine 0.25%Drug
0.25% bupivacaine
No interventionDrug
No intervention
| Study group | Role | What they receive |
|---|---|---|
| tips block group | Active comparator | this group will receive triple injection peri-sartorius (TIPS) block. The block will be done after induction of general anesthesia before skin incision Receives: Drug: nerve block with bupivacaine 0.25%; Drug: No intervention |
| control group | No intervention | control group will receive conventional analgesic regimen without having a regional block. |
What is being measured
The primary outcome is the main question the study is designed to answer.
postoperative analgesics
Measured: 24 hours postoperative
Secondary outcomes (1)
The secondary outcomes will be the total morphine consumption in mg , ambulation distances during the first 24 hours postoperative in meters
Measured: 24 hours postoperative
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jul 2025
- Study start20 Jul 2025
- Primary completion20 Jul 2026
- Study completion20 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Knee Arthroscopic SurgeryStudies of the same condition, open and under way.
- More trials run by Ain Shams UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 52 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ain Shams University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07046390
- Sponsor's protocol ID
- FMASU MD24/2024
- Status last verified
- Mar 2025
- First submitted
- 6 Apr 2025
- Last updated
- 30 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Study Between Triple Injection Peri-Sartorius (TIPS) Block Versus Intravenous Analgesia for Postoperative Analgesia After Knee Arthroscopy
- ClinicalTrials.gov ID
- NCT07046390
- Acronym / sponsor ID
- FMASU MD24/2024
- Conditions
- Knee Arthroscopic Surgery, Nerve Block
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 52 participants (actual)
- Lead sponsor
- Ain Shams UniversityUniversity, hospital or other
- Study start
- 20 Jul 2025 (actual)
- Primary completion
- 20 Jul 2026 (actual)
- Study completion
- 20 Aug 2026 (actual)
- First posted
- 1 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In this study participants are aiming to compare triple injection peri-sartorius (TIPS) block versus intravenous analgesia for postoperative analgesia after knee arthroscopy regarding efficacy of pain relief and early ambulation
Detailed description
Arthroscopic knee surgery is a commonly performed orthopedic procedure due to being minimally invasive and providing early recovery. A significant number of patients have severe postoperative pain despite using small incisions leading to poor quality of postoperative recovery. Currently, multimodal analgesia is a widely used method of pain relief and also to improve patient functionality and satisfaction scores. Systemic opioids and non-steroidal anti-inflammatory drugs (NSAIDs) have been the mainstay for treating postoperative pain after knee surgery. The traditional high-dose opioid approach is associated with increased opioid-related side effects eg: (Nausea ,vomiting and delayed recovery ).NSAIDs are effective as part of a multimodal analgesic approach, but their use can be limited due to concerns regarding coagulopathy or impairment of renal function and GIT side effects.Ultrasound guidance in regional anaesthesia is increasingly being used leading to approaches to the sciatic nerve block, femoral nerve block (FNB), adductor canal block (ACB) and obturator nerve block increasingly motivated as an element of multimodal analgesia regimen in many operations, including knee arthroscopy.Sub sartorial block has been studied for its efficacy in providing analgesia following knee surgeries while preserving quadriceps muscle power. However, misnomers have been prescribed at different locations for different block approaches. TIPS block targets motor-sparing analgesia through injection at three planes ultrsound guided.Study Procedures: Patients will be enrolled in this randomly allocated using computer-based randomization into two groups with (26) patients in each group
- Group 1 (study group number 1) will receive triple injection peri-sartorius (TIPS) block. The block will be done after induction of general anesthesia before skin incision
- Group 2 (study group number 2) (control group )will receive conventional analgesic regimen without having a regional block.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| tips block group | Active comparator | Drug: nerve block with bupivacaine 0.25%, Drug: No interventionthis group will receive triple injection peri-sartorius (TIPS) block. The block will be done after induction of general anesthesia before skin incision |
| control group | No intervention | –control group will receive conventional analgesic regimen without having a regional block. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- .Age 18-40 years undergoing knee arthroscopy. .Sex: Both sexes.
- .American Society of Anaesthesiologists (ASA) Physical Status Class I and II
Key exclusion criteria (4 listed)
- .Declining to give written informed consent. .History of allergy to the medications used in the study. .Contraindications to regional anesthesia (including patient refusal, coagulopathy and local infection).
- Psychiatric disorder. .American Society of Anesthesiologists (ASA) Physical Status Class III and IV.
- Patients with body mass index (BMI) >35 kg/m2 .Neurological deficits or mobility-related disorders of the non-operated limb .
- Moderate to severe hepatic , renal diseases and cardiac disease.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| nerve block with bupivacaine 0.25%0.25% bupivacaine | Drug | tips block group |
| No interventionNo intervention | Drug | tips block group |
Primary outcome
postoperative analgesics
Time frame: 24 hours postoperative
1 secondary outcome
The secondary outcomes will be the total morphine consumption in mg , ambulation distances during the first 24 hours postoperative in meters
Time frame: 24 hours postoperative
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing nerve block with bupivacaine 0.25% in people with Knee Arthroscopic Surgery and Nerve Block, run by Ain Shams University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
postoperative analgesics (time frame: 24 hours postoperative). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Oct 2026.