Body Mass IndexNCT07046598
Is The Level of Muscle Damage After The Drop Jump Protocol Affected By Body Weight and BMI?
A study testing Drop Jump Protocol in people with Body Mass Index and Physical Exertion, run by Melike Nur Eroğlu at 1 site in Turkey (Türkiye).
Trial summary
This study investigated whether muscle damage induced by a drop jump protocol varies based on participants' body weight and BMI. Fifty healthy adults were divided into normal-weight and overweight groups. Read more about this study
- Who is it for?
- Ages 18 to 30 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Body Mass Index, Physical Exertion, Muscle Damage
- What is being tested?
- Drop Jump Protocol
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Oct 2024to 22 Nov 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy adults aged 18-30
- Normal or overweight BMI (18-35 kg/m²)
- At least 2 days/week of physical activity
- No regular jump training
Who cannot join
- Use of medications or supplements
- History of musculoskeletal injury
- Smoking or alcohol consumption during study period
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Sakarya University of Applied Sciences, Faculty of Sport Sciences, Exercise and Sports Sciences Education, Application and Research Centre
Serdivan, Sakarya
About this study
This study investigated whether muscle damage induced by a drop jump protocol varies based on participants' body weight and BMI. Fifty healthy adults were divided into normal-weight and overweight groups. All participants completed a standardized drop jump protocol, and blood samples were collected before, immediately after, and 24 hours after exercise. Creatine kinase (CK) and lactate dehydrogenase (LDH) levels were analyzed as biomarkers of muscle damage.
- Conditions
- Body Mass Index, Physical Exertion, Muscle Damage, Creatine Kinase, Lactate Dehydrogenases
- Being tested
- Drop Jump Protocol
- Keywords
- drop jump, muscle damage, creatine kinase, lactate dehydrogenase, body mass index, plyometric exercise
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Drop Jump ProtocolBehavioural
A standardized drop jump (DJ) protocol involving 100 total jumps from a 60 cm platform. Participants performed five sets of 20 jumps, with a 10-second rest between jumps and a 2-minute rest between sets. The protocol was designed to induce muscle damage through eccentric loading.
| Study group | Role | What they receive |
|---|---|---|
| Normal Weight Group | Experimental | Participants with a Body Mass Index (BMI) between 18 and 24 kg/m². Subjects in this group performed a standardized drop jump (DJ) protocol consisting of 100 total jumps from a 60 cm platform. Muscle damage markers (Creatine Kinase and Lactate Dehydrogenase) were measured pre-exercise, immediately post-exercise, and 24 hours post-exercise. Receives: Behavioral: Drop Jump Protocol |
| Overweight Group | Experimental | Participants with a Body Mass Index (BMI) between 25 and 35 kg/m². Subjects in this group performed the same standardized drop jump (DJ) protocol as the normal weight group. Blood samples were collected at three time points to evaluate changes in muscle damage markers (Creatine Kinase and Lactate Dehydrogenase). Receives: Behavioral: Drop Jump Protocol |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Creatine Kinase (CK) Levels
Serum creatine kinase (CK) concentrations measured at three time points: before the exercise protocol, immediately after the protocol, and 24 hours post-exercise. CK is a biomarker of muscle damage. Blood samples were analyzed using a standard biochemical analyzer.
Measured: Baseline (pre-exercise), immediately post-exercise, and 24 hours post-exercise
Change in Lactate Dehydrogenase (LDH) Levels
Serum lactate dehydrogenase (LDH) concentrations measured at three time points: before the exercise protocol, immediately after the protocol, and 24 hours post-exercise. LDH is used to evaluate exercise-induced muscle damage. Blood samples were centrifuged and analyzed using standardized laboratory techniques.
Measured: Baseline (pre-exercise), immediately post-exercise, and 24 hours post-exercise
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jul 2025
- Study start15 Oct 2024
- Primary completion8 Nov 2024
- Study completion22 Nov 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Body Mass IndexStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Melike Nur Eroğlu
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Melike Nur Eroğlu, Sakarya Applied Sciences University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07046598
- Sponsor's protocol ID
- SakaryaAppliedSciencesU
- Status last verified
- Jun 2025
- First submitted
- 14 Jun 2025
- Last updated
- 1 Jul 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Yeniyol B, Pancar S, Soylu Y, Birinci YZ, Eroglu MN, Fernandez-Elias VE. The overlooked risk in drop jump protocols: higher body weight as a catalyst for increased muscle damage. BMC Sports Sci Med Rehabil. 2025 Sep 29;17(1):278. doi: 10.1186/s13102-025-01330-z.
PubMed 41024229
Study at a glance
From the registry record, last updated by the sponsor on 1 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Is The Level of Muscle Damage After The Drop Jump Protocol Affected By Body Weight and BMI?
- ClinicalTrials.gov ID
- NCT07046598
- Acronym / sponsor ID
- SakaryaAppliedSciencesU
- Conditions
- Body Mass Index, Physical Exertion, Muscle Damage, Creatine Kinase, Lactate Dehydrogenases
- Keywords
- drop jump, muscle damage, creatine kinase, lactate dehydrogenase, body mass index, plyometric exercise
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Melike Nur EroğluUniversity, hospital or other
- Study start
- 15 Oct 2024 (actual)
- Primary completion
- 8 Nov 2024 (actual)
- Study completion
- 22 Nov 2024 (actual)
- First posted
- 1 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigated whether muscle damage induced by a drop jump protocol varies based on participants' body weight and BMI. Fifty healthy adults were divided into normal-weight and overweight groups. All participants completed a standardized drop jump protocol, and blood samples were collected before, immediately after, and 24 hours after exercise. Creatine kinase (CK) and lactate dehydrogenase (LDH) levels were analyzed as biomarkers of muscle damage.
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Normal Weight Group | Experimental | Behavioral: Drop Jump ProtocolParticipants with a Body Mass Index (BMI) between 18 and 24 kg/m². Subjects in this group performed a standardized drop jump (DJ) protocol consisting of 100 total jumps from a 60 cm platform. Muscle damage markers (Creatine Kinase and Lactate Dehydrogenase) were measured pre-exercise, immediately post-exercise, and 24 hours post-exercise. |
| Overweight Group | Experimental | Behavioral: Drop Jump ProtocolParticipants with a Body Mass Index (BMI) between 25 and 35 kg/m². Subjects in this group performed the same standardized drop jump (DJ) protocol as the normal weight group. Blood samples were collected at three time points to evaluate changes in muscle damage markers (Creatine Kinase and Lactate Dehydrogenase). |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Healthy adults aged 18-30
- Normal or overweight BMI (18-35 kg/m²)
- At least 2 days/week of physical activity
- No regular jump training
Key exclusion criteria (3 listed)
- Use of medications or supplements
- History of musculoskeletal injury
- Smoking or alcohol consumption during study period
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Drop Jump ProtocolA standardized drop jump (DJ) protocol involving 100 total jumps from a 60 cm platform. Participants performed five sets of 20 jumps, with a 10-second rest between jumps and a 2-minute rest between sets. The protocol was designed to induce muscle damage through eccentric loading. | Behavioural | Normal Weight Group, Overweight Group |
Primary outcome
Change in Creatine Kinase (CK) Levels
Time frame: Baseline (pre-exercise), immediately post-exercise, and 24 hours post-exercise
Serum creatine kinase (CK) concentrations measured at three time points: before the exercise protocol, immediately after the protocol, and 24 hours post-exercise. CK is a biomarker of muscle damage. Blood samples were analyzed using a standard biochemical analyzer.
Change in Lactate Dehydrogenase (LDH) Levels
Time frame: Baseline (pre-exercise), immediately post-exercise, and 24 hours post-exercise
Serum lactate dehydrogenase (LDH) concentrations measured at three time points: before the exercise protocol, immediately after the protocol, and 24 hours post-exercise. LDH is used to evaluate exercise-induced muscle damage. Blood samples were centrifuged and analyzed using standardized laboratory techniques.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Jul 2025.
- Derived from this study: PubMed 41024229Yeniyol B, Pancar S, Soylu Y, Birinci YZ, Eroglu MN, Fernandez-Elias VE. The overlooked risk in drop jump protocols: higher body weight as a catalyst for increased muscle damage. BMC Sports Sci Med Rehabil. 2025 Sep 29;17(1):278. doi: 10.1186/s13102-025-01330-z.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Drop Jump Protocol in people with Body Mass Index and Physical Exertion, run by Melike Nur Eroğlu at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Creatine Kinase (CK) Levels (time frame: Baseline (pre-exercise), immediately post-exercise, and 24 hours post-exercise). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07046598, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Jul 2025.