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Rotator Cuff Related Shoulder PainNCT07053566

Latissimus Dorsi Strengthening Exercises in Rotator Cuff Tendinopathy

A study testing Rotator Cuff Strengthening Exercises and Latissimus Dorsi Strengthening Exercises in people with Rotator Cuff Related Shoulder Pain and Rotator Cuff Tendinopathy, run by Hacettepe University at 1 site in Turkey (Türkiye).

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Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record

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Trial summary

The aim of this study is to investigate the effects of strengthening exercises targeting the latissimus dorsi muscle on acromiohumeral distance, shoulder function, and pain levels in individuals with rotator cuff tendinopathy. Read more about this study

Who is it for?
Ages 18 to 50 years
What is being tested?
Rotator Cuff Strengthening Exercises and Latissimus Dorsi Strengthening Exercises
Could I receive a placebo?
No, everyone receives an active treatment
How many people
47 participants
Where
1 siteTurkey (Türkiye)
Study dates
23 May 2025to 22 Sep 2027
Phase
Interventional

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 50 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Age between 18 and 50 years
  • At least 3 months of ongoing shoulder pain
  • At least 3 positive tests out of 5 (Neer, Hawkins-Kennedy, Jobe, Painful Arc Sign, Pain on Resisted External Rotation)
  • Ultrasound diagnosis of rotator cuff tendinopathy
  • Shoulder pain during activity rated greater than 3 out of 10 on the Numeric Pain Scale
  • Central Sensitization Inventory score below 40

Who cannot join

  • Bilateral shoulder pain
  • History of surgery or dislocation in the symptomatic shoulder
  • Acromioclavicular degeneration
  • Presence of shoulder capsulitis (restriction in passive glenohumeral range of motion in 2 or more directions)
  • Full-thickness rotator cuff tear
  • Shoulder osteoarthritis, rheumatoid arthritis, systemic inflammatory or neurological disease
Show all 9Show fewer
  • Any injection to the symptomatic shoulder within the past 6 weeks
  • BMI greater than 30 kg/m2
  • Refusal to participate in the study

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Kubra Caylan Gurses, Msc contact

+905304790996

caylankubra@gmail.com

Irem Duzgun, Prof. Dr. contact

+905324774000

iremduzgun@yahoo.com

Turkey (Türkiye)1 site, 1 recruiting
  • Hacettepe University Faculty of Physical Therapy and Rehabilitation

    Ankara, 06000

    ırem Duzgun, Prof. Dr., +905324774000, iremduzgun@yahoo.com

    Kubra Caylan Gurses, Msc

    Recruiting

Other trials in Turkey (Türkiye)

About this study

Official title: Effects of Latissimus Dorsi Exercises on Acromiohumeral Interval, Pain, and Function in Rotator Cuff Tendinopathy

The aim of this study is to investigate the effects of strengthening exercises targeting the latissimus dorsi muscle on acromiohumeral distance, shoulder function, and pain levels in individuals with rotator cuff tendinopathy. By increasing the activation of the latissimus dorsi, one of the shoulder adductor muscles, the exercises are expected to facilitate inferior gliding of the humeral head and improve subacromial distance.

Individuals aged between 18 and 50 years with a diagnosis of rotator cuff tendinopathy will be included in the study. A total of 47 participants will be enrolled and randomly assigned to one of three groups:

Read more

A group performing exercises targeting only the rotator cuff muscles, A group performing exercises targeting the latissimus dorsi muscle, A group performing a combination of both rotator cuff and latissimus dorsi exercises.

The exercise interventions will be applied over a 12-week period. Before and after the intervention, the following outcomes will be assessed:

Acromiohumeral distance (via ultrasound), Range of motion, Shoulder function and pain using the SPADI and WORC questionnaires, and Avoidance behavior using the Adap-Tr questionnaire.

Read the detailed description

Subacromial pain syndrome, also referred to as rotator cuff-related shoulder pain (RCS), is characterized by pain localized to the proximal lateral aspect of the upper arm arising from the rotator cuff and other subacromial structures. Although the etiology of RCS is multifactorial, dynamic narrowing of the subacromial space due to impingement of soft tissues within this region has been proposed as a leading cause of chronic rotator cuff pathology. A lack of coordination between the rotator cuff and scapulothoracic muscles may impair shoulder neuromuscular control, leading to varying degrees of microtrauma and degenerative pathophysiological changes in the rotator cuff muscles and surrounding tissues. This dysfunction can result in further narrowing of the subacromial space. Specifically, inadequate superior rotation and posterior tilt of the scapula, combined with the inability of the rotator cuff muscles to resist the superior translation of the humeral head caused by deltoid contraction, may cause impingement of the subacromial soft tissues during overhead dynamic activities. In healthy shoulders, the acromiohumeral distance (AHD) is reported to range between 8 and 15 mm, whereas narrowing of the subacromial space (AHD < 7 mm) is considered a significant indicator of large rotator cuff tears. Moreover, in patients with rotator cuff tears, proximal migration of the humeral head is associated with tear size and decreased acromiohumeral distance.

In a young and healthy shoulder, the cranially directed forces generated during abduction are balanced by the coordinated contraction of the rotator cuff muscles. This mechanism prevents superior migration of the humerus toward the acromion and subsequent impingement of the subacromial tissues. When the contribution of the rotator cuff muscles to the abduction movement decreases, the deltoid muscle compensates for this deficit. However, this compensatory mechanism results in a force vector that is more cranially oriented rather than mediocranial. The reduction in the stabilizing force of the rotator cuff muscles may impair the ability to counteract the superior forces generated by the deltoid. Both of these changes can lead to superior migration of the humerus and pain in the subacromial tissues.

Insufficient depression of the humeral head during the abduction movement has been associated with pain patterns. During arm abduction, the rotator cuff muscles continue to be the focus of both research and clinical practice. However, several studies have demonstrated that the arm adductors-particularly the latissimus dorsi, teres major, and to a lesser extent the pectoralis major-contribute significantly to humeral head depression during abduction. Activation of these adductor muscles may reduce the mechanical load on subacromial structures during abduction. Elevation movements performed at various angles combined with adductor muscle activity may lead to a physiological increase in the subacromial space. This finding suggests the possibility of conservative treatment in patients with rotator cuff tears (RCT) by strengthening the adductor muscles.

OInvestigation of arm adductor contraction patterns during abduction has shown decreased adductor activation in individuals with rotator cuff tendinopathy. Reduced adductor activation may result in insufficient caudal forces on the humerus, leading to overload of subacromial tissues and persistence of symptoms.Therefore, adductor muscle training programs may be clinically effective in patients with rotator cuff tears. The application of neuromuscular electrical stimulation to increase activation of the teres major and pectoralis major muscles has been associated with a short-term increase in acromiohumeral distance in elderly individuals with rotator cuff tears.

The aim of this study is to increase the activation of the latissimus dorsi muscle, one of the adductor muscles, through targeted exercises, thereby increasing the acromiohumeral distance and facilitating inferior gliding of the humeral head.

Being tested
Rotator Cuff Strengthening Exercises, Latissimus Dorsi Strengthening Exercises
Keywords
Exercise Theraphy, Shoulder Rehabilitation, Rotator Cuff, Latissimus Dorsi
Medical subject headings
Shoulder Impingement Syndrome

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Rotator Cuff Strengthening ExercisesBehavioural

    Progressive exercise program focused on rotator cuff muscles

  • Latissimus Dorsi Strengthening ExercisesBehavioural

    Progressive exercise program targeting the latissimus dorsi muscle

Study groups in NCT07053566
Study groupRoleWhat they receive
Rotator Cuff Exercise Group (RCEG)ExperimentalProgressive strengthening program for rotator cuff muscles.
Receives: Behavioral: Rotator Cuff Strengthening Exercises
Latissimus Dorsi Exercise Group (LDEG)ExperimentalProgressive strengthening program for latissimus dorsi muscle.
Receives: Behavioral: Latissimus Dorsi Strengthening Exercises
Combined Exercise Group (CEG)ExperimentalCombined strengthening program for rotator cuff and latissimus dorsi muscles
Receives: Behavioral: Rotator Cuff Strengthening Exercises; Behavioral: Latissimus Dorsi Strengthening Exercises

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Acromio-humeral distance

    The acromiohumeral distance will be assessed using ultrasonography. Measurements will be performed by a physician blinded to the participants' group assignments, ensuring assessor blinding.

    Ultrasonographic measurement of the acromiohumeral distance has been shown to be reliable (intraclass correlation coefficient > 0.90), and the minimal detectable change has been reported as 1.2 mm

    Measured: Measurements will be performed at baseline and at the end of the 12th week

  2. Pain İntensity

    Pain intensity will be assessed using the Visual Analog Scale (VAS) at rest, during activity, and at night. On the VAS, a score of 0 indicates no pain, while a score of 10 represents unbearable pain. Higher scores reflect greater pain intensity.he scale will be explained to the patient in a face-to-face setting, and they will be asked to mark their pain levels at rest, during activity, and at night on a 100-millimeter horizontal line.

    Measured: Baseline and weekly up to 12 weeks

  3. Shoulder Range of Motion

    ll measurements will be performed with the patient in the supine position. For shoulder flexion ROM, the patient will be asked to raise their arm upward in the sagittal plane. For shoulder abduction ROM, the patient will be instructed to move their arm laterally in the scapular plane.For external and internal rotation ROM measurements, the shoulder will be positioned at 90° of abduction and the elbow at 90° of flexion.For external rotation, the patient will be asked to move the forearm upward in the sagittal plane, with the palm facing toward themselves and in the direction of the thumb. For internal rotation, the patient will be asked to move the forearm downward in the sagittal plane, in the direction of the index finger.

    Measured: Baseline and weekly up to 12 weeks

Secondary outcomes (3)
  1. ADAP-Shoulder Scale (Avoidance Behavior)

    The ADAP-Shoulder Scale (Avoidance of Daily Activities due to Pain - Shoulder Scale) was developed to assess pain-related avoidance behaviors in individuals with shoulder pain (29). The ADAP-Shoulder Scale consists of 15 photographs and a questionnaire corresponding to 15 ICF activity items. It targets individuals with unilateral or bilateral shoulder pain and focuses on daily life activities while evaluating pain-related avoidance behaviors. The items are categorized into three domains: free movement (5 items), high effort (7 items), and self-care (3 items).

    Each item is rated on a scale from 0 to 10, with higher scores indicating greater avoidance behavior due to pain. The total score is calculated by multiplying the sum of the item scores by 10 and dividing by the number of items (15). The total score ranges from 0 (no avoidance) to 100 (maximum avoidance). The Turkish version of the scale has been validated (21). The minimal clinically important difference (MCID) is 5.12 points (

    Measured: Measurements will be performed at baseline and at the end of the 12th week.

  2. Shoulder Pain and Disability Index (SPADI)

    SPADI is a self-reported questionnaire designed to measure pain and disability associated with the shoulder. It consists of 13 items divided into two subscales: pain (5 items) and disability (8 items). Each item is scored using a visual analog scale ranging from 0 (no pain or no difficulty) to 10 (worst imaginable pain or so difficult that help is required). The total score is calculated by dividing the sum of all items by 130 and multiplying by 100. Scores range from 0 (best functional status) to 100 (worst functional status). The Turkish version of the SPADI has been validated.

    Measured: At baseline and at the end of Week 12

  3. Western Ontario Rotator Cuff Index (WORC)

    Western Ontario Rotator Cuff Index (WORC): The WORC is a self-assessment tool developed to measure quality of life in patients with rotator cuff pathology. It includes 21 items representing five domains that cover all aspects of health defined by the World Health Organization: physical symptoms (6 items), sports and recreation (4 items), work (4 items), lifestyle (4 items), and emotions (3 items). The total sc

    Measured: Measurements will be performed at baseline and at the end of the 12th week.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted8 Jul 2025
  2. Study start23 May 2025
  3. Primary completion22 May 2027 (estimated)
  4. Study completion22 Sep 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Model description
Randomized Controlled Trial
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
47 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07053566
Sponsor's protocol ID
LDRCT
Status last verified
Sep 2026
First submitted
18 Jun 2025
Last updated
22 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No: IPD will not be shared due to privacy and ethical considerations.

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