AzTrials
AzTrials

Shoulder Arthroscopic SurgeryPENGNCT07057947

Is Pericapsular Nerve Group Block Better Than Interscalene Nerve Block Regarding Effect on Hand Movement in Shoulder Scope Surgeries?

A study testing Pericapsular Nerve Group (PENG) Block, Interscalene Nerve Block and Acuson X300 ultrasound,Siemens medical solution INC, Germany in people with Shoulder Arthroscopic Surgery, run by Sherin Refaat at 1 site in Egypt.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The goal of this clinical trial is to learn if pericapsular nerve group block (PENG) in shoulder scope surgery provides adequate analgesia with less affection of muscle power compared to interscalene block. Read more about this study

Who is it for?
Ages 22 to 60 years
Conditions the study is for
Shoulder Arthroscopic Surgery
What is being tested?
Pericapsular Nerve Group (PENG) Block, Interscalene Nerve Block and Acuson X300 ultrasound,Siemens medical solution INC, Germany
Could I receive a placebo?
No, everyone receives an active treatment
How many people
60 participants
Where
1 siteEgypt
Study dates
25 Aug 2025to 2 Dec 2025
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 22 to 60 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Adult patients of the specified age range
  • Any gender
  • American Society of Anaesthesiologists physical status grades 1 and 2
  • Body mass index less than 35
  • Duration of surgery between 90 to 120 minutes

Who cannot join

  • American Society of Anaesthesiologists physical status grades 3 and 4
  • Allergy to local anesthetics
  • Coagulation disorder (INR >1.2, Platelets <100,000), or recent intake of clopidogrel or warfarin within 1 week
  • Active infection at site of injection

Trial locations and contacts

1 site in 1 country.

Egypt1 site

  • Cairo University

    Cairo, 11562

Other trials in Egypt

About this study

Official title: Is Pericapsular Nerve Group (PENG) Block Superior to Interscalene Nerve Block Regarding Motor Power Affection in Shoulder Scope Surgeries? A Randomised Comparative Study.

The goal of this clinical trial is to learn if pericapsular nerve group block (PENG) in shoulder scope surgery provides adequate analgesia with less affection of muscle power compared to interscalene block. The main questions it aims to answer are:

Does PENG block provide analgesia similar to interscalene block? Does PENG block have less or no effect on muscle power compared to interscalene block? Researchers will compare PENG block with interscalene block

Participants will:

Receive either PENG or interscalene block before shoulder scope surgery Be evaluated for their motor power after receiving the block and after the surgery Be evaluated for pain after the surgery

Being tested
Pericapsular Nerve Group (PENG) Block, Interscalene Nerve Block, Acuson X300 ultrasound,Siemens medical solution INC, Germany

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Pericapsular Nerve Group (PENG) BlockProcedure or surgery

    Injection of local anesthetic between deltoid muscle and subcapsularis tendon

  • Interscalene Nerve BlockProcedure or surgery

    Injection of local anesthetic between anterior and middle scalene muscles around the roots of brachial plexus

  • Acuson X300 ultrasound,Siemens medical solution INC, GermanyDevice

    high frequency linear probe

Study groups in NCT07057947
Study groupRoleWhat they receive
Group PActive comparatorThis arm will receive PENG block
Receives: Procedure: Pericapsular Nerve Group (PENG) Block; Device: Acuson X300 ultrasound,Siemens medical solution INC, Germany
Group IActive comparatorThis arm will receive interscalene block
Receives: Procedure: Interscalene Nerve Block; Device: Acuson X300 ultrasound,Siemens medical solution INC, Germany

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Time for full recovery of hand motor power

    Time from start of block activation till time of achieving grip strength similar to patient's baseline

    Measured: Starting from block activation until the achieves preoperative grip strength ( 24 hours)

Secondary outcomes (4)

  1. Hand grip power after surgery

    The measured hand grip power using a digital dynamometer

    Measured: 2,4,6,12,24 hours

  2. Visual analogue scale assessment

    Assessing postoperative pain, scale from 0 to 10 where 0 is no pain and 10 is worst pain

    Measured: 2,4,6,12 hours

  3. Time to first analgesia request

    Time from end of the surgery till the participant asks for additional analgesia

    Measured: 24 hours

  4. Patient satisfaction score

    Assessing the participant satisfaction after the postoperative period regarding overall experience with the block given on a scale of 1 to 5, where 1 is the least satisfaction and 5 is the greatest.

    Measured: 24 hours

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted10 Jul 2025
  2. Study start25 Aug 2025
  3. Primary completion19 Nov 2025
  4. Study completion2 Dec 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Single blind
Who is masked
Outcomes assessor
Enrolment
60 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07057947
Sponsor's protocol ID
MD-323-2024
Acronym
PENG
Status last verified
Jun 2026
First submitted
11 Mar 2025
Last updated
30 Jun 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No

Publications

  • Mosaffa F, Taheri M, Manafi Rasi A, Samadpour H, Memary E, Mirkheshti A. Comparison of pericapsular nerve group (PENG) block with fascia iliaca compartment block (FICB) for pain control in hip fractures: A double-blind prospective randomized controlled clinical trial. Orthop Traumatol Surg Res. 2022 Feb;108(1):103135. doi: 10.1016/j.otsr.2021.103135. Epub 2021 Oct 29.

    PubMed 34715388

  • Giron-Arango L, Peng PWH, Chin KJ, Brull R, Perlas A. Pericapsular Nerve Group (PENG) Block for Hip Fracture. Reg Anesth Pain Med. 2018 Nov;43(8):859-863. doi: 10.1097/AAP.0000000000000847.

    PubMed 30063657

  • Kupeli I, Yazici Kara M. Anesthesia or analgesia? New block for shoulder surgery: pericapsular nerve group block. Braz J Anesthesiol. 2022 Sep-Oct;72(5):669-672. doi: 10.1016/j.bjane.2021.05.009. Epub 2021 Jun 9.

    PubMed 34118263

  • Hussain N, Goldar G, Ragina N, Banfield L, Laffey JG, Abdallah FW. Suprascapular and Interscalene Nerve Block for Shoulder Surgery: A Systematic Review and Meta-analysis. Anesthesiology. 2017 Dec;127(6):998-1013. doi: 10.1097/ALN.0000000000001894.

    PubMed 28968280

  • Stasiowski M, Zuber M, Marciniak R, Kolny M, Chabierska E, Jalowiecki P, Pluta A, Missir A. Risk factors for the development of Horner's syndrome following interscalene brachial plexus block using ropivacaine for shoulder arthroscopy: a randomised trial. Anaesthesiol Intensive Ther. 2018;50(3):215-220. doi: 10.5603/AIT.a2018.0013. Epub 2018 Jun 22.

    PubMed 29931665

  • Bergmann L, Martini S, Kesselmeier M, Armbruster W, Notheisen T, Adamzik M, Eichholz R. Phrenic nerve block caused by interscalene brachial plexus block: breathing effects of different sites of injection. BMC Anesthesiol. 2016 Jul 29;16(1):45. doi: 10.1186/s12871-016-0218-x.

    PubMed 27473162

  • Paul RW, Szukics PF, Brutico J, Tjoumakaris FP, Freedman KB. Postoperative Multimodal Pain Management and Opioid Consumption in Arthroscopy Clinical Trials: A Systematic Review. Arthrosc Sports Med Rehabil. 2021 Dec 17;4(2):e721-e746. doi: 10.1016/j.asmr.2021.09.011. eCollection 2022 Apr.

    PubMed 35494281

  • Guity MR, Sobhani Eraghi A, Hosseini-Baharanchi FS. Early postoperative pain as a risk factor of shoulder stiffness after arthroscopic rotator cuff repair. J Orthop Traumatol. 2021 Jun 26;22(1):25. doi: 10.1186/s10195-021-00585-9.

    PubMed 34173872

  • Calvo E, Torres MD, Morcillo D, Leal V. Rotator cuff repair is more painful than other arthroscopic shoulder procedures. Arch Orthop Trauma Surg. 2019 May;139(5):669-674. doi: 10.1007/s00402-018-3100-0. Epub 2018 Dec 17.

    PubMed 30560289

  • Zong LZ, Duan MM, Yuan WW, Lu HD. Efficacy of shoulder arthroscopic surgery for the treatment of rotator cuff injury: A protocol of systematic review and meta-analysis. Medicine (Baltimore). 2020 Jun 26;99(26):e20591. doi: 10.1097/MD.0000000000020591.

    PubMed 32590734

  • Farmer KW, Wright TW. Shoulder arthroscopy: the basics. J Hand Surg Am. 2015 Apr;40(4):817-21. doi: 10.1016/j.jhsa.2015.01.002. Epub 2015 Feb 26.

    PubMed 25726045

Questions about this trial

What is this clinical trial studying?

A study testing Pericapsular Nerve Group (PENG) Block, Interscalene Nerve Block and Acuson X300 ultrasound,Siemens medical solution INC, Germany in people with Shoulder Arthroscopic Surgery, run by Sherin Refaat at 1 site in Egypt.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 30 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Time for full recovery of hand motor power (time frame: Starting from block activation until the achieves preoperative grip strength ( 24 hours)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07057947, which also lists 11 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jun 2026.

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