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Left Ventricular Ejection FractionHVGLDNCT07061821

Evaluation of Left Ventricular Ejection Fraction Using an Accelerated Cardiac Cine-MRI Sequence With Deep Learning-based Image Reconstructions

A study testing accelerated cardiac cine-MRI sequence in people with Left Ventricular Ejection Fraction and Cardiac Magnetic Resonance Imaging, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

Left ventricular hypertrophy (LVH) is a common condition that may result from hypertension, hypertrophic cardiomyopathy, aortic valve stenosis, or certain metabolic disorders. Cardiac imaging is essential for diagnosis, prognostic assessment, and quantification of cardiac function. Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
accelerated cardiac cine-MRI sequence
How many people
61 participants
Where
1 siteFrance
Study dates
5 Aug 2025to Sep 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Patient referred for cardiac MRI as part of the assessment or follow-up of left ventricular hypertrophy
  • Age ≥ 18 years old
  • Ability of the subject to understand and express his consent
  • Affiliation to the social security scheme

Who cannot join

  • Severe obesity (>140 kg) preventing the patient from entering the scanner bore, which has a diameter of less than 70 cm
  • Age ≥ 18 years old
  • Person under guardianship or curators, or deprived of liberty
  • Pregnant or breastfeeding woman
  • Known allergy to gadolinium chelates
  • Claustrophobia
Show all 9Show fewer
  • Any contraindication to MRI
  • Arrhythmia
  • Inability to hold breath for more than 10 seconds

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Cédric Renard, MD contact

33+3 22 08 75 37

renard.cedric@chu-amiens.fr

France1 site, 1 recruiting

  • CHRU Amiens

    Amiens, 80480

    Cedric Renard, MD, 33+3 22 08 75 37, renard.cedric@chu-amiens.fr

    Recruiting

Other trials in France

About this study

Official title: Evaluation of Left Ventricular Ejection Fraction Using an Accelerated Cardiac Cine-MRI Sequence With Deep Learning-based Image Reconstructions Compared to the Reference Cine-MRI Sequence in the Assessment or Follow-up of Left Ventricular Hypertrophy

Left ventricular hypertrophy (LVH) is a common condition that may result from hypertension, hypertrophic cardiomyopathy, aortic valve stenosis, or certain metabolic disorders. Cardiac imaging is essential for diagnosis, prognostic assessment, and quantification of cardiac function. While transthoracic echocardiography remains widely used, it is limited by acoustic window dependence and inter-observer variability. Cardiovascular Magnetic Resonance (CMR) imaging currently serves as the reference standard for measuring left ventricular ejection fraction (LVEF), cardiac volumes, and tissue characterization. However, conventional cine-CMR sequences require repeated breath-holds, which are often challenging for elderly or dyspneic patients, generating respiratory motion artifacts that compromise image quality. Accelerated cine-CMR sequences with deep learning-based image reconstructions offer a promising alternative by significantly reducing acquisition time while preserving image quality. This study aims to evaluate whether these accelerated cine-CMR sequences provide LVEF measurements concordant with conventional cine-CMR sequences, with potential to improve patient comfort and reduce examination time.

Being tested
accelerated cardiac cine-MRI sequence
Keywords
Left Ventricular Hypertrophy, Left Ventricular Ejection Fraction, Cardiac Magnetic Resonance Imaging, Deep Learning, Image Reconstruction
Medical subject headings
Hypertrophy, Left Ventricular

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • accelerated cardiac cine-MRI sequenceOther

    Addition of an accelerated cardiac cine-MRI sequence with deep learning-based image reconstruction to the standard cardiac MRI protocol, performed during the same session

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. LVEF Difference between both sequences

    Value of the difference between the measurement of left ventricular ejection fraction (LVEF) obtained using the accelerated cardiac cine-MRI sequence with Deep Learning-based image reconstruction compared to the conventional cine-MRI sequence.

    Measured: day 1

Secondary outcomes (6)

  1. difference of end-diastolic volume of the left ventricle between both sequences

    Value of the difference between the measurements of end-diastolic volumes of the left ventricle obtained using the accelerated cardiac cine-MRI sequence with Deep Learning-based image reconstruction compared to the conventional cine-MRI sequence.

    Measured: day 1

  2. difference of end-systolic volume of the left ventricle between both sequences

    Value of the difference between the measurements of end-systolic volumes of the left ventricle obtained using the accelerated cardiac cine-MRI sequence with Deep Learning-based image reconstruction compared to the conventional cine-MRI sequence.

    Measured: day 1

  3. Differnce of measurement of the global longitudinal strain of the left ventricle between both sequences

    Value of the difference between the measurement of global longitudinal strain of the left ventricle obtained using the accelerated cardiac cine-MRI sequence with Deep Learning-based image reconstruction compared to the conventional cine-MRI sequence.

    Measured: day 1

  4. Difference of the left ventricular mass between both sequences

    Value of the difference between the measurement of left ventricular mass obtained using the accelerated cardiac cine-MRI sequence with Deep Learning-based image reconstruction compared to the conventional cine-MRI sequence.

    Measured: day 1

  5. diffrence of the maximal thickness of the left ventricle between both sequences

    Value of the difference between the measurement of maximal thickness of the left ventricle obtained using the accelerated cardiac cine-MRI sequence with Deep Learning-based image reconstruction compared to the conventional cine-MRI sequence.

    Measured: day 1

  6. Difference of the acquisition time between both sequences

    Value of the difference in acquisition time between the accelerated cardiac cine-MRI sequence with Deep Learning-based image reconstruction and the conventional cine-MRI sequence

    Measured: day 1

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted11 Jul 2025
  2. Study start5 Aug 2025
  3. Primary completionSep 2026 (estimated)
  4. Study completionSep 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Diagnosis
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrolment
61 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07061821
Sponsor's protocol ID
PI2025_843_0122
Acronym
HVGLD
Status last verified
Jan 2026
First submitted
1 Jul 2025
Last updated
16 Jan 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A study testing accelerated cardiac cine-MRI sequence in people with Left Ventricular Ejection Fraction and Cardiac Magnetic Resonance Imaging, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 16 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Cédric Renard, MD (33+3 22 08 75 37, renard.cedric@chu-amiens.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

LVEF Difference between both sequences (time frame: day 1). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07061821.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jan 2026.

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