CARDIOMYOPATHYNCT07062874
Combined Effect of Aerobic and Resistance Exercise in Non Ischemic Dilated Cardiomyopathy Patients
A study testing Combined Aerobic and Resistance Exercise and Aerobic Exercise Only in people with CARDIOMYOPATHY, run by Riphah International University at 1 site in Pakistan.
Trial summary
This study explores the effects of combined aerobic and resistance exercise in patients with non-ischemic dilated cardiomyopathy (NIDCM). In a six-week randomized clinical trial with 66 participants, both exercise groups-combined and aerobic-only-showed significant improvements in exercise capacity, functional… Read more about this study
- Who is it for?
- Ages 40 to 60 years
- Conditions the study is for
- CARDIOMYOPATHY
- What is being tested?
- Combined Aerobic and Resistance Exercise and Aerobic Exercise Only
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 66 participants
- Where
- 1 sitePakistan
- Study dates
- 28 Jul 2025to 10 Oct 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Both male and female Age 40 to 60
- Left ventricular ejection fraction <50%
Who cannot join
- Patients diagnosed with valvular heart disease, supraventricular arrhythmias, congenital heart disease were excluded.
- Neuromuscular diseases such as stroke, Parkinson.
- Underlying pulmonary disease
- Impaired cognitive function (14)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site
Arjumand
Lahore, Punjab Province, 40100
Arjumand Bano, MS-CPPT, 03059551883, arjumand.bano@riphah.edu.pk
Arooj Fatima, MS-CPPT
About this study
This study explores the effects of combined aerobic and resistance exercise in patients with non-ischemic dilated cardiomyopathy (NIDCM). In a six-week randomized clinical trial with 66 participants, both exercise groups-combined and aerobic-only-showed significant improvements in exercise capacity, functional independence, dyspnea, and blood pressure. However, no significant difference was found between the two groups. The study concludes that both exercise approaches are effective, but longer studies are needed to determine if combined training offers added benefits.
Read the detailed description
The study titled "Combined Effect of Aerobic and Resistance Exercise in Non-Ischemic Dilated Cardiomyopathy Patients" by Arooj Fatima investigates how integrating both aerobic and resistance exercises impacts patients suffering from NIDCM, a condition marked by left ventricular dysfunction and reduced exercise tolerance. Through a randomized clinical trial involving 66 patients divided into two groups-one receiving both aerobic and resistance training and the other only aerobic training-the study evaluated changes in ejection fraction, VO₂ max, dyspnea, and functional independence over six weeks. Significant improvements were observed within both groups across all measured outcomes, including increased exercise capacity, better functional independence, and reduced blood pressure and dyspnea levels. However, no statistically significant difference was found between the two groups, indicating that while both exercise regimens are beneficial, the combined approach did not yield superior results within the study's timeframe. The research highlights the value of structured exercise in improving cardiovascular and functional outcomes in NIDCM patients and recommends longer, more varied studies to further explore these benefits.
- Conditions
- CARDIOMYOPATHY
- Being tested
- Combined Aerobic and Resistance Exercise, Aerobic Exercise Only
- Keywords
- Cardiomyopathy, Dyspnea, Exercise, Functional Independence, NIDCM.
- Medical subject headings
- Cardiomyopathies, Dyspnea, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Combined Aerobic and Resistance ExerciseBehavioural
Also called Resistance training
Participants received supervised exercise training 3 times per week for 6 weeks. Each session included a 10-minute warm-up (walking at 1.5 km/h), a 30-minute aerobic phase at 60-85% heart rate reserve (calculated using the Karvonen formula), and a 10-minute cool-down (walking at 1 km/h). In addition, participants performed resistance training for upper and lower extremities using TheraBands, with 8-10 sets targeting major muscle groups.
Aerobic Exercise OnlyBehavioural
Participants followed the same aerobic training protocol as the experimental group-3 sessions per week for 6 weeks, with 10-minute warm-up, 30-minute aerobic exercise (60-85% HRR), and 10-minute cool-down. No resistance training was provided.
| Study group | Role | What they receive |
|---|---|---|
| Combined Aerobic and Resistance Exercise: | Experimental | Participants performed aerobic training three times a week for six weeks.
Each session included a 10-minute warm-up, 30-minute main aerobic activity (60-85% of heart rate reserve using the Karvonen formula), and 10-minute cool-down.
Additionally, they performed resistance exercises for upper and lower extremities using TheraBands, 8-10 sets covering major muscle groups, three times a week. Receives: Behavioral: Combined Aerobic and Resistance Exercise; Behavioral: Aerobic Exercise Only |
| Aerobic Exercise Only | Active comparator | Participants followed the same aerobic training protocol as Group A.
No resistance training was included.
Sessions also occurred three times a week for six weeks, with similar warm-up, active, and cool-down phases. Receives: Behavioral: Aerobic Exercise Only |
What is being measured
The primary outcome is the main question the study is designed to answer.
Functional Independence Measure (FIM) questionnaire
Assesses level of functional independence across self-care, mobility, communication, and social cognition.
Measured: Baseline and 6 weeks
VO₂ Max (Maximum Oxygen Consumption)
Measured using Graded Exercise Test (GXT) to assess cardiovascular fitness.
Measured: Baseline and 6 weeks.
Secondary outcomes (2)
Modified Borg Dyspnea Scale
Rates severity of dyspnea (shortness of breath) from 0 (none) to 10 (maximum).
Measured: Baseline and 6 weeks.
Blood Pressure (Systolic and Diastolic)
Measured via Transthoracic Echocardiogram and standard BP monitor.
Measured: Baseline and 6 weeks.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2025
- Study start28 Jul 2025 (estimated)
- Primary completion28 Sep 2025 (estimated)
- Study completion10 Oct 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for CARDIOMYOPATHYStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 66 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Arjumand Bano, MS-CPPT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07062874
- Sponsor's protocol ID
- REC/RCR&AHS/24/0359
- Status last verified
- Jul 2025
- First submitted
- 3 Jul 2025
- Last updated
- 14 Jul 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Combined Effect of Aerobic and Resistance Exercise in Non Ischemic Dilated Cardiomyopathy Patients
- ClinicalTrials.gov ID
- NCT07062874
- Acronym / sponsor ID
- REC/RCR&AHS/24/0359
- Conditions
- CARDIOMYOPATHY
- Keywords
- Cardiomyopathy, Dyspnea, Exercise, Functional Independence, NIDCM.
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 66 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 28 Jul 2025 (estimated)
- Primary completion
- 28 Sep 2025 (estimated)
- Study completion
- 10 Oct 2025 (estimated)
- First posted
- 14 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study explores the effects of combined aerobic and resistance exercise in patients with non-ischemic dilated cardiomyopathy (NIDCM). In a six-week randomized clinical trial with 66 participants, both exercise groups-combined and aerobic-only-showed significant improvements in exercise capacity, functional independence, dyspnea, and blood pressure. However, no significant difference was found between the two groups. The study concludes that both exercise approaches are effective, but longer studies are needed to determine if combined training offers added benefits.
Detailed description
The study titled "Combined Effect of Aerobic and Resistance Exercise in Non-Ischemic Dilated Cardiomyopathy Patients" by Arooj Fatima investigates how integrating both aerobic and resistance exercises impacts patients suffering from NIDCM, a condition marked by left ventricular dysfunction and reduced exercise tolerance. Through a randomized clinical trial involving 66 patients divided into two groups-one receiving both aerobic and resistance training and the other only aerobic training-the study evaluated changes in ejection fraction, VO₂ max, dyspnea, and functional independence over six weeks. Significant improvements were observed within both groups across all measured outcomes, including increased exercise capacity, better functional independence, and reduced blood pressure and dyspnea levels. However, no statistically significant difference was found between the two groups, indicating that while both exercise regimens are beneficial, the combined approach did not yield superior results within the study's timeframe. The research highlights the value of structured exercise in improving cardiovascular and functional outcomes in NIDCM patients and recommends longer, more varied studies to further explore these benefits.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Combined Aerobic and Resistance Exercise: | Experimental | Behavioral: Combined Aerobic and Resistance Exercise, Behavioral: Aerobic Exercise OnlyParticipants performed aerobic training three times a week for six weeks. Each session included a 10-minute warm-up, 30-minute main aerobic activity (60-85% of heart rate reserve using the Karvonen formula), and 10-minute cool-down. Additionally, they performed resistance exercises for upper and lower extremities using TheraBands, 8-10 sets covering major muscle groups, three times a week. |
| Aerobic Exercise Only | Active comparator | Behavioral: Aerobic Exercise OnlyParticipants followed the same aerobic training protocol as Group A. No resistance training was included. Sessions also occurred three times a week for six weeks, with similar warm-up, active, and cool-down phases. |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Both male and female Age 40 to 60
- Left ventricular ejection fraction <50%
Key exclusion criteria (4 listed)
- Patients diagnosed with valvular heart disease, supraventricular arrhythmias, congenital heart disease were excluded.
- Neuromuscular diseases such as stroke, Parkinson.
- Underlying pulmonary disease
- Impaired cognitive function (14)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Combined Aerobic and Resistance ExerciseAlso: Resistance trainingParticipants received supervised exercise training 3 times per week for 6 weeks. Each session included a 10-minute warm-up (walking at 1.5 km/h), a 30-minute aerobic phase at 60-85% heart rate reserve (calculated using the Karvonen formula), and a 10-minute cool-down (walking at 1 km/h). In addition, participants performed resistance training for upper and lower extremities using TheraBands, with 8-10 sets targeting major muscle groups. | Behavioural | Combined Aerobic and Resistance Exercise: |
| Aerobic Exercise OnlyParticipants followed the same aerobic training protocol as the experimental group-3 sessions per week for 6 weeks, with 10-minute warm-up, 30-minute aerobic exercise (60-85% HRR), and 10-minute cool-down. No resistance training was provided. | Behavioural | Aerobic Exercise Only, Combined Aerobic and Resistance Exercise: |
Primary outcome
Functional Independence Measure (FIM) questionnaire
Time frame: Baseline and 6 weeks
Assesses level of functional independence across self-care, mobility, communication, and social cognition.
VO₂ Max (Maximum Oxygen Consumption)
Time frame: Baseline and 6 weeks.
Measured using Graded Exercise Test (GXT) to assess cardiovascular fitness.
2 secondary outcomes
Modified Borg Dyspnea Scale
Time frame: Baseline and 6 weeks.
Blood Pressure (Systolic and Diastolic)
Time frame: Baseline and 6 weeks.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Jul 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Arjumand Bano, MS-CPPT principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Combined Aerobic and Resistance Exercise and Aerobic Exercise Only in people with CARDIOMYOPATHY, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 14 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact imran amjad, phd (03324390125, imran.amjad@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Functional Independence Measure (FIM) questionnaire (time frame: Baseline and 6 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Jul 2025.