AzTrials
AzTrials

Breast CancerPhase 3NCT07062965

A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

A Phase 3 study testing PF-07248144, Fulvestrant and Everolimus in people with Breast Cancer, run by Pfizer at 433 sites in 31 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

The purpose of this study is to learn about the safety and effects of the study medicine PF-07248144 when given along with fulvestrant for the possible treatment of HR-positive, HER2-negative advanced or metastatic breast cancer. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Breast Cancer
What is being tested?
PF-07248144, Fulvestrant and Everolimus
Type of treatment
Pill or oral medicine
Could I receive a placebo?
No, everyone receives an active treatment
How many people
400 participants
Where
433 sitesin 31 countries
Study dates
5 Aug 2025to 4 Nov 2030
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Confirmed diagnosis of HR-positive HER2-negative breast cancer with evidence of locally advanced or metastatic disease, which is not amenable to surgical resection or radiation therapy with curative intent.
  • Prior CDK4/6 inhibitor therapy in combination with endocrine therapy in advance metastatic setting or in adjuvant setting with documented progression during or within 12 months after the last dose of CDK4/6i.
  • Participants are eligible if they previously received CDK4/6i or ET as a monotherapy, or in combination for rechallenge therapy in the advance or metastatic setting; have received prior therapy targeting estrogen receptor 1 (ESR1) or breast cancer gene (BRCA)1/2.
  • Measurable disease evaluable per Response Evaluation Criterion in Solid Tumors (RECIST) v.1.1 or non-measurable bone-only disease
  • Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0 or 1.

Who cannot join

  • Documented detectable PIK3CA/AKT1/PTEN alterations in tissue
  • Received greater than two prior lines of systemic therapy in the advance or metastatic setting
  • Had received any prior chemotherapy, including antibody drug conjugates (ADCs), in advance or metastatic setting. Participants who have previously received chemotherapy in the (neo)adjuvant setting are not excluded from the study.
  • Any medical or psychiatric condition that may increase the risk of study participation or make the participant inappropriate for the study.
  • Renal impairment, hepatic dysfunction, or hematologic abnormalities.

Trial locations and contacts

433 sites in 31 countries. Contact the study team or a site near you to ask about taking part.

Pfizer CT.gov Call Center contact

1-800-718-1021

ClinicalTrials.gov_Inquiries@pfizer.com

433 sites in 31 countries

United States215 sites, 215 recruiting

  • Providence Regional Cancer System - Aberdeen

    Aberdeen, Washington, 98520

    Recruiting

  • Texas Oncology-West Texas

    Abilene, Texas, 79606

    Recruiting

  • Texas Oncology-Northeast Texas

    Allen, Texas, 75013

    Recruiting

  • Texas Oncology-West Texas

    Amarillo, Texas, 79124

    Recruiting

  • Oncura Health - Anaheim

    Anaheim, California, 92805

    Recruiting

  • Alaska Oncology and Hematology, LLC

    Anchorage, Alaska, 99508

    Recruiting

  • Maryland Oncology Hematology P.A.

    Annapolis, Maryland, 21401

    Recruiting

  • Virginia Cancer Specialists, PC

    Arlington, Virginia, 22201

    Recruiting

  • Emory University Hospital Midtown

    Atlanta, Georgia, 30308

    Recruiting

  • Emory University Hospital

    Atlanta, Georgia, 30322

    Recruiting

  • Investigational Drug Service Emory University Clinic

    Atlanta, Georgia, 30322

    Recruiting

  • Winship Cancer Institute

    Atlanta, Georgia, 30322

    Recruiting

  • Emory Saint Joseph's Hospital

    Atlanta, Georgia, 30342

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Aurora, Colorado, 80012

    Recruiting

  • Texas Oncology - Central/South Texas

    Austin, Texas, 78705

    Recruiting

  • Texas Oncology - Central South (Balcones Dr)

    Austin, Texas, 78731

    Recruiting

  • Texas Oncology - Central South (James Casey)

    Austin, Texas, 78745

    Recruiting

  • Texas Oncology - Central South (Renfert Way)

    Austin, Texas, 78758

    Recruiting

  • Mercy Medical Center - Baltimore

    Baltimore, Maryland, 21202

    Recruiting

  • Mfsmc-Hjwci

    Baltimore, Maryland, 21237

    Recruiting

  • MedStar Franklin Square Cancer Center at Loch Raven

    Baltimore, Maryland, 21239

    Recruiting

  • Maryland Oncology Hematology P.A.

    Bethesda, Maryland, 20817

    Recruiting

  • The Cancer & Hematology Centers

    Big Rapids, Michigan, 49307

    Recruiting

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115

    Recruiting

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Boulder, Colorado, 80303

    Recruiting

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana, 59715

    Recruiting

  • Maryland Oncology Hematology P.A.

    Brandywine, Maryland, 20613

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Burnsville, Minnesota, 55337

    Recruiting

  • Ventura County Hematology Oncology Specialists

    Camarillo, California, 93010

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Centennial, Colorado, 80112

    Recruiting

  • Providence Regional Cancer System - Centralia

    Centralia, Washington, 98531

    Recruiting

  • Ironwood Cancer & Research Centers

    Chandler, Arizona, 85224

    Recruiting

  • Roper Hospital

    Charleston, South Carolina, 29401

    Recruiting

  • Bon Secours St. Francis Hospital

    Charleston, South Carolina, 29414

    Recruiting

  • Charleston Oncology, A Department of Bon Secours St. Francis Hospital

    Charleston, South Carolina, 29414

    Recruiting

  • Roper St. Francis Healthcare, Clinical Biotechnology Research Institute (CBRI)

    Charleston, South Carolina, 29414

    Recruiting

  • St. Francis Hospital Breast Care - Medical Plaza

    Charleston, South Carolina, 29414

    Recruiting

  • Virginia Oncology Associates

    Chesapeake, Virginia, 23320

    Recruiting

  • Siteman Cancer Center - St Peters

    City of Saint Peters, Missouri, 63376

    Recruiting

  • Wake Forest Baptist Hematology and Oncology - Clemmons

    Clemmons, North Carolina, 27012

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Colorado Springs, Colorado, 80907

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Colorado Springs, Colorado, 80923

    Recruiting

  • Maryland Oncology Hematology P.A.

    Columbia, Maryland, 21044

    Recruiting

  • Missouri Cancer Associates

    Columbia, Missouri, 65201

    Recruiting

  • MD Anderson The Woodlands

    Conroe, Texas, 77384

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Coon Rapids, Minnesota, 55433

    Recruiting

  • Siteman Cancer Center - West County

    Creve Coeur, Missouri, 63141

    Recruiting

  • Texas Oncology-Northeast Texas

    Denison, Texas, 75020

    Recruiting

  • Texas Oncology-Northeast Texas

    Denton, Texas, 76201

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Denver, Colorado, 80220

    Recruiting

  • Smilow Cancer Hospital - Derby

    Derby, Connecticut, 06418

    Recruiting

  • Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion)

    Detroit, Michigan, 48202

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Edina, Minnesota, 55435

    Recruiting

  • Texas Oncology-West Texas

    El Paso, Texas, 79902

    Recruiting

  • Texas Oncology-West Texas

    El Paso, Texas, 79915

    Recruiting

  • Texas Oncology-West Texas

    El Paso, Texas, 79938

    Recruiting

  • Endeavor Health Cancer Institute at Swedish Hospital, Nancy W. Knowles Cancer Center

    Elmhurst, Illinois, 60126

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Englewood, Colorado, 80113

    Recruiting

  • Prime Saint Francis-Infusion Services Evanston

    Evanston, Illinois, 60202

    Recruiting

  • Virginia Cancer Specialists

    Fairfax, Virginia, 22031

    Recruiting

  • Smilow Cancer Hospital - Fairfield

    Fairfield, Connecticut, 06824

    Recruiting

  • Highlands Oncology Group, PA

    Fayetteville, Arkansas, 72703

    Recruiting

  • Siteman Cancer Center - North County

    Florissant, Missouri, 63031

    Recruiting

  • Texas Oncology-Northeast Texas

    Flower Mound, Texas, 75028

    Recruiting

  • Oncura Health - Fountain Valley

    Fountain Valley, California, 92708

    Recruiting

  • Texas Oncology - San Antonio

    Fredericksburg, Texas, 78624

    Recruiting

  • Maryland Oncology Hematology P.A.

    Germantown, Maryland, 20876

    Recruiting

  • The West Clinic, PLLC dba West Cancer Center

    Germantown, Tennessee, 38138

    Recruiting

  • Banner Gateway Medical Center

    Gilbert, Arizona, 85234

    Recruiting

  • Banner MD Anderson Cancer Center

    Gilbert, Arizona, 85234

    Recruiting

  • Ironwood Cancer & Research Centers

    Gilbert, Arizona, 85297

    Recruiting

  • Smilow Cancer Hospital - Glastonbury

    Glastonbury, Connecticut, 06033

    Recruiting

  • Ironwood Cancer & Research Centers

    Glendale, Arizona, 85306

    Recruiting

  • Oncura Health - Corporate (Central IDS & Regulatory Only)

    Glendale, California, 91204

    Recruiting

  • Ironwood Cancer & Research Centers

    Goodyear, Arizona, 85395

    Recruiting

  • The Cancer & Hematology Centers

    Grand Rapids, Michigan, 49503

    Recruiting

  • The Cancer & Hematology Centers

    Grand Rapids, Michigan, 49546

    Recruiting

  • Aurora BayCare Medical Center

    Green Bay, Wisconsin, 54311

    Recruiting

  • Smilow Cancer Hospital - Greenwich

    Greenwich, Connecticut, 06830

    Recruiting

  • Smilow Cancer Hospital - Guilford

    Guilford, Connecticut, 06437

    Recruiting

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601

    Recruiting

  • John Theurer Cancer Center at Hackensack University Medical Center

    Hackensack, New Jersey, 07601

    Recruiting

  • Texas Oncology - Central South (Pease)

    Harlingen, Texas, 78550

    Recruiting

  • Smilow Cancer Hospital at Saint Francis

    Hartford, Connecticut, 06105

    Recruiting

  • Comprehensive Cancer Centers of Nevada

    Henderson, Nevada, 89052

    Recruiting

  • Comprehensive Cancer Centers of Nevada

    Henderson, Nevada, 89074

    Recruiting

  • Hope and Healing Clinical Research LLC

    Hinsdale, Illinois, 60521

    Recruiting

  • The Cancer & Hematology Centers

    Holland, Michigan, 49424

    Recruiting

  • The University of Texas M. D. Anderson Cancer Center

    Houston, Texas, 77030

    Recruiting

  • University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030

    Recruiting

  • MD Anderson West Houston

    Houston, Texas, 77079

    Recruiting

  • US Oncology Investigation Products Center(IPC)

    Irving, Texas, 75063

    Recruiting

  • US Oncology Investigational Product Center (IPC)

    Irving, Texas, 75063

    Recruiting

  • US Oncology Investigational Products Center

    Irving, Texas, 75063

    Recruiting

  • Saint Luke's Cancer Institute

    Kansas City, Missouri, 64111

    Recruiting

  • Saint Luke's Hospital of Kansas City

    Kansas City, Missouri, 64111

    Recruiting

  • Providence Regional Cancer System - Lacey

    Lacey, Washington, 98503

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Lakewood, Colorado, 80228

    Recruiting

  • Maryland Oncology Hematology P.A.

    Largo, Maryland, 20774

    Recruiting

  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada, 89106

    Recruiting

  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada, 89128

    Recruiting

  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada, 89144

    Recruiting

  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada, 89148

    Recruiting

  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada, 89169

    Recruiting

  • MD Anderson League City

    League City, Texas, 77573

    Recruiting

  • Texas Oncology-Northeast Texas

    Lewisville, Texas, 75056

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Littleton, Colorado, 80120

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Lone Tree, Colorado, 80124

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Longmont, Colorado, 80504

    Recruiting

  • Texas Oncology-Northeast Texas

    Longview, Texas, 75601

    Recruiting

  • Oncura Health - Good Samaritan

    Los Angeles, California, 90017

    Recruiting

  • University Medical Center, Inc. ; DBA UofL Health - UofL Hospital/Brown Cancer Center

    Louisville, Kentucky, 40202

    Recruiting

  • UofL Health Brown Cancer Center Medical Center Northeast

    Louisville, Kentucky, 40245

    Recruiting

  • Virginia Cancer Specialists

    Manassas, Virginia, 20110

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Maple Grove, Minnesota, 55369

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Maplewood, Minnesota, 55109

    Recruiting

  • Texas Oncology - Central South (South 2nd)

    McAllen, Texas, 78503

    Recruiting

  • Texas Oncology-Northeast Texas

    McKinney, Texas, 75071

    Recruiting

  • Bon Secours Cancer Institute at Memorial Regional Medical Center

    Mechanicsville, Virginia, 23116

    Recruiting

  • Ironwood Cancer & Research Centers

    Mesa, Arizona, 85202

    Recruiting

  • Ironwood Cancer & Research Centers

    Mesa, Arizona, 85206

    Recruiting

  • Texas Oncology-West Texas

    Midland, Texas, 79701

    Recruiting

  • Bon Secours St. Francis Medical Center

    Midlothian, Virginia, 23114

    Recruiting

  • Aurora St Luke's Medical Center

    Milwaukee, Wisconsin, 53215

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Minneapolis, Minnesota, 55404

    Recruiting

  • Roper St Francis Mount Pleasant Hospital

    Mt. Pleasant, South Carolina, 29466

    Recruiting

  • Endeavor Health Cancer Institute at Swedish Hospital

    Naperville, Illinois, 60540

    Recruiting

  • Sarah Cannon Research Institute - Pharmacy

    Nashville, Tennessee, 37203

    Recruiting

  • SCRI Oncology Partners

    Nashville, Tennessee, 37203

    Recruiting

  • Vanderbilt Breast Center at One Hundred Oaks

    Nashville, Tennessee, 37204

    Recruiting

  • Henry-Joyce Cancer Clinic

    Nashville, Tennessee, 37232

    Recruiting

  • Texas Oncology - San Antonio

    New Braunfels, Texas, 78130

    Recruiting

  • Smilow Cancer Hospital - Yale New Haven Health

    New Haven, Connecticut, 06510

    Recruiting

  • Yale-New Haven Hospital

    New Haven, Connecticut, 06510

    Recruiting

  • Hope and Healing Clinical Research

    New Lenox, Illinois, 60451

    Recruiting

  • University Medical Center New Orleans

    New Orleans, Louisiana, 70112

    Recruiting

  • Dana-Farber Cancer Institute - Chestnut Hill

    Newton, Massachusetts, 02467

    Recruiting

  • Virginia Oncology Associates

    Norfolk, Virginia, 23502

    Recruiting

  • Charleston Oncology - A Department of Bon Secours St. Francis Hospital

    North Charleston, South Carolina, 29406

    Recruiting

  • Smilow Cancer Hospital - North Haven

    North Haven, Connecticut, 06473

    Recruiting

  • The Cancer & Hematology Centers

    Norton Shores, Michigan, 49444

    Recruiting

  • Advocate Christ Medical Center

    Oak Lawn, Illinois, 60453

    Recruiting

  • Texas Oncology-West Texas

    Odessa, Texas, 79761

    Recruiting

  • Dr. Karandeep Singh MD

    Oxnard, California, 93030

    Recruiting

  • Rolling Oaks Radiology - Oxnard

    Oxnard, California, 93030

    Recruiting

  • Ventura County Hematology Oncology Specialists

    Oxnard, California, 93030

    Recruiting

  • Rolling Oaks Radiology North Solar

    Oxnard, California, 93036

    Recruiting

  • Texas Oncology-Northeast Texas

    Palestine, Texas, 75801

    Recruiting

  • Clinical and Translational Research Unit (CTRU)

    Palo Alto, California, 94304

    Recruiting

  • Stanford Cancer Center

    Palo Alto, California, 94304

    Recruiting

  • Stanford Women's Cancer Center

    Palo Alto, California, 94304

    Recruiting

  • Texas Oncology-Northeast Texas

    Paris, Texas, 75460

    Recruiting

  • Advocate Medical Group-Park Ridge, Luther Lane-Oncology

    Park Ridge, Illinois, 60068

    Recruiting

  • Ironwood Cancer & Research Centers

    Phoenix, Arizona, 85028

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Plymouth, Minnesota, 55441

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Pueblo, Colorado, 81003

    Recruiting

  • Renown Health Medical Oncology

    Reno, Nevada, 89502

    Recruiting

  • Renown Office of Clinical Research

    Reno, Nevada, 89502

    Recruiting

  • Renown Regional Medical Center

    Reno, Nevada, 89502

    Recruiting

  • Renown Health Conrad Breast Center

    Reno, Nevada, 89521

    Recruiting

  • Renown Office of Clinical Research South Meadows

    Reno, Nevada, 89521

    Recruiting

  • Virginia Cancer Specialists, PC

    Reston, Virginia, 20190

    Recruiting

  • Bon Secours Cancer Institute at St. Mary's Hospital

    Richmond, Virginia, 23226

    Recruiting

  • University of Rochester Cancer Center Pharmacy

    Rochester, New York, 14642

    Recruiting

  • University of Rochester Medical Center

    Rochester, New York, 14642

    Recruiting

  • Maryland Oncology Hematology P.A.

    Rockville, Maryland, 20850

    Recruiting

  • Highlands Oncology Group, PA

    Rogers, Arkansas, 72758

    Recruiting

  • Huntsman Cancer Institute

    Salt Lake City, Utah, 84112

    Recruiting

  • Texas Oncology - San Antonio

    San Antonio, Texas, 78217

    Recruiting

  • Texas Oncology - San Antonio

    San Antonio, Texas, 78240

    Recruiting

  • Texas Oncology - San Antonio

    San Antonio, Texas, 78258

    Recruiting

  • Sansum Clinic

    Santa Barbara, California, 93105

    Recruiting

  • Summit Cancer Care, PC

    Savannah, Georgia, 31405

    Recruiting

  • Summit Cancer Care

    Savannah, Georgia, 31405

    Recruiting

  • Ironwood Cancer & Research Centers

    Scottsdale, Arizona, 85260

    Recruiting

  • Harborview Medical Center

    Seattle, Washington, 98104

    Recruiting

  • Fred Hutchinson Cancer Center

    Seattle, Washington, 98109

    Recruiting

  • University of Washington Medical Center

    Seattle, Washington, 98195

    Recruiting

  • Memorial Hospital.

    Shiloh, Illinois, 62269

    Recruiting

  • Siteman Cancer Center - Shiloh

    Shiloh, Illinois, 62269

    Recruiting

  • Maryland Oncology Hematology P.A.

    Silver Spring, Maryland, 20904

    Recruiting

  • Orchard Healthcare Research Inc.

    Skokie, Illinois, 60077

    Recruiting

  • Prime Saint Francis-Infusion Services Skokie

    Skokie, Illinois, 60077

    Recruiting

  • Sansum Clinic

    Solvang, California, 93463

    Recruiting

  • Highlands Oncology Group, PA

    Springdale, Arkansas, 72762

    Recruiting

  • Siteman Cancer Center

    St Louis, Missouri, 63108

    Recruiting

  • Barnes-Jewish Hospital

    St Louis, Missouri, 63110

    Recruiting

  • Washington University School of Medicine - Siteman Cancer Center

    St Louis, Missouri, 63110

    Recruiting

  • Siteman Cancer Center - South County

    St Louis, Missouri, 63129

    Recruiting

  • David C. Pratt Cancer Center

    St Louis, Missouri, 63141

    Recruiting

  • Smilow Cancer Hospital - Long Ridge

    Stamford, Connecticut, 06902

    Recruiting

  • MD Anderson in Sugar Land

    Sugar Land, Texas, 77478

    Recruiting

  • Roper St. Francis Hospital - Berkeley

    Summerville, South Carolina, 29486

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Thornton, Colorado, 80260

    Recruiting

  • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

    Torrance, California, 90502

    Recruiting

  • Torrance Memorial Physician Network - Cancer Care

    Torrance, California, 90505

    Recruiting

  • Torrance Memorial Physician Network-Cancer Care

    Torrance, California, 90505

    Recruiting

  • Harbor-UCLA Medical Center

    Torrance, California, 90509

    Recruiting

  • Smilow Cancer Hospital - Torrington

    Torrington, Connecticut, 06790

    Recruiting

  • Smilow Cancer Hospital - Trumbull

    Trumbull, Connecticut, 06611

    Recruiting

  • Texas Oncology-Northeast Texas

    Tyler, Texas, 75702

    Recruiting

  • Oncura Health - Valley Presbyterian

    Van Nuys, California, 91405

    Recruiting

  • Ventura County Hematology Oncology Specialists

    Ventura, California, 93003

    Recruiting

  • Virginia Oncology Associates

    Virginia Beach, Virginia, 23456

    Recruiting

  • Texas Oncology - Central South (Horizon Cir)

    Waco, Texas, 76712

    Recruiting

  • Texas Oncology - Central South

    Waco, Texas, 76712

    Recruiting

  • MedStar Washington Hospital Center

    Washington D.C., District of Columbia, 20010

    Recruiting

  • Smilow Cancer Hospital - Waterbury

    Waterbury, Connecticut, 06708

    Recruiting

  • Smilow Cancer Hospital - Waterford

    Waterford, Connecticut, 06385

    Recruiting

  • Texas Oncology - Central South (E 6th St)

    Weslaco, Texas, 78596

    Recruiting

  • Texas Oncology-West Texas

    Wichita Falls, Texas, 76310

    Recruiting

  • Virginia Oncology Associates

    Williamsburg, Virginia, 23188

    Recruiting

  • Atrium Health Wake Forest Baptist

    Winston-Salem, North Carolina, 27157

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Woodbury, Minnesota, 55125

    Recruiting

Other trials in United States

China24 sites, 24 recruiting

  • Affiliated Hospital of Hebei University

    Baoding, Hebei, 071066

    Recruiting

  • Beijing Cancer hospital

    Beijing, Beijing Municipality, 100142

    Recruiting

  • The First Hospital of Jilin University

    Changchun, Jilin, 130021

    Recruiting

  • Hunan Cancer Hospital

    Changsha, Hunan, 410013

    Recruiting

  • The 2nd Affiliated Hospital of Dalian Medical University

    Dalian, Liaoning, 116023

    Recruiting

  • Fujian Medical University Union Hospital

    Fuzhou, Fujian, 350001

    Recruiting

  • Sun Yat-sen University Cancer Center

    Guangzhou, Guangdong, 510060

    Recruiting

  • Guangdong Provincial People's Hospital

    Guangzhou, Guangdong, 510080

    Recruiting

  • Southern Medical University Nanfang Hospital

    Guangzhou, Guangdong, 510515

    Recruiting

  • Sir Run Run Shaw Hospital of Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310016

    Recruiting

  • The Second Affiliated hospital of Zhejiang University school of medicine

    Hangzhou, Zhejiang, 310017

    Recruiting

  • Zhejiang Cancer Hospital

    Hangzhou, Zhejiang, 310022

    Recruiting

  • Harbin Medical University Cancer Hospital

    Harbin, Heilongjiang, 150081

    Recruiting

  • Anhui Provincial Cancer Hospital

    Hefei, Anhui, 230031

    Recruiting

  • Shandong Cancer Hospital

    Jinan, Shandong, 250117

    Recruiting

  • Nanchang People's Hospital

    Nanchang, Jiangxi, 330025

    Recruiting

  • Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

    Nanjing, Jiangsu, 210008

    Recruiting

  • Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

    Nanjing, Jiangsu, 210031

    Recruiting

  • Guangxi Medical University Affiliated Tumor Hospital

    Nanning, Guangxi, 530020

    Recruiting

  • Fudan University Shanghai Cancer Center

    Shanghai, Shanghai Municipality, 200032

    Recruiting

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, Zhejiang, 325000

    Recruiting

  • Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology

    Wuhan, Hubei, 430030

    Recruiting

  • Hubei Cancer Hospital

    Wuhan, Hubei, 430079

    Recruiting

  • The Second Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, Shaanxi, 710004

    Recruiting

Other trials in China

Japan16 sites, 16 recruiting

  • Juntendo University Hospital

    Bunkyo-ku, Tokyo, 113-8431

    Recruiting

  • Chiba cancer center

    Chiba, Chiba, 260-8717

    Recruiting

  • National Cancer Center Hospital

    Chuo-ku, Tokyo, 104-0045

    Recruiting

  • St. Luke's International Hospital

    Chuo-ku, Tokyo, 104-8560

    Recruiting

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, 811-1395

    Recruiting

  • Hiroshima City Hospital

    Hiroshima, 730-8518

    Recruiting

  • Tokai University Hospital

    Isehara, Kanagawa, 259-1193

    Recruiting

  • National Cancer Center Hospital East

    Kashiwa, Chiba, 277-8577

    Recruiting

  • The Cancer Institute Hospital of JFCR

    Koto, Tokyo, 135-8550

    Recruiting

  • National Hospital Organization Shikoku Cancer Center

    Matsuyama, Ehime, 791-0280

    Recruiting

  • Okayama University Hospital

    Okayama, 700-8558

    Recruiting

  • Gunma Prefectural Cancer Center

    Otashi, Gunma, 373-8550

    Recruiting

  • Japan Institute for Health Security National Center for Global Health and Medicine

    Shinjuku-ku, Tokyo, 162-8655

    Recruiting

  • The University of Osaka Hospital

    Suita, Osaka, 565-0871

    Recruiting

  • Showa Medical University Hospital

    Tokyo, 142-8666

    Recruiting

  • Kanagawa cancer center

    Yokohama, Kanagawa, 2418515

    Recruiting

Other trials in Japan

France13 sites, 13 recruiting

  • CHU Besançon

    Besançon, 25000

    Recruiting

  • Institut Bergonié

    Bordeaux, 33076

    Recruiting

  • CHU de Brest - Hôpital de la Cavale Blanch

    Brest, Finistère, 29200

    Recruiting

  • Hôpital Femme Mère Enfant

    Bron, Rhône, 69500

    Recruiting

  • Centre François Baclesse

    Caen, 14076

    Recruiting

  • Hôpital de la Croix-Rousse

    Lyon, Rhône, 69004

    Recruiting

  • Institut Paoli-Calmettes

    Marseille, 13009

    Recruiting

  • Institut Régional du Cancer Montpellier

    Montpellier, Hérault, 34298

    Recruiting

  • Centre Hospitalier Lyon Sud

    Pierre-Bénite, Rhône, 69310

    Recruiting

  • Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer

    Rennes, Brittany Region, 35042

    Recruiting

  • Institut Curie - site Saint-Cloud

    Saint-Cloud, Hauts-de-seine, 92210

    Recruiting

  • Institut de Cancérologie de Lorraine Alexis Vautrin

    Vandœuvre-lès-Nancy, Lorraine, 54519

    Recruiting

  • Institut Gustave Roussy

    Villejuif, 94800

    Recruiting

Other trials in France

South Korea11 sites, 11 recruiting

  • Kyungpook National University Chilgok Hospital

    Deagu, Taegu-kwangyǒkshi, 41404

    Recruiting

  • Gangnam Severance Hospital, Yonsei University Health System

    Gangnam-gu, Seoul-teukbyeolsi [seoul], 06273

    Recruiting

  • National Cancer Center

    Goyang-si, Kyǒnggi-do, 10408

    Recruiting

  • Seoul National University Bundang Hospital

    Seongnam-si, Kyǒnggi-do, 13620

    Recruiting

  • Korea University Anam Hospital

    Seoul, Seoul-teukbyeolsi [seoul], 02841

    Recruiting

  • Seoul National University Hospital

    Seoul, Seoul-teukbyeolsi [seoul], 03080

    Recruiting

  • Severance Hospital, Yonsei University Health System

    Seoul, Seoul-teukbyeolsi [seoul], 03722

    Recruiting

  • Asan Medical Center

    Seoul, Seoul-teukbyeolsi [seoul], 05505

    Recruiting

  • Samsung Medical Center

    Seoul, Seoul-teukbyeolsi [seoul], 06351

    Recruiting

  • The Catholic Univ. of Korea Seoul St. Mary's Hospital

    Seoul, Seoul-teukbyeolsi [seoul], 06591

    Recruiting

  • Korea University Guro Hospital

    Seoul, Seoul-teukbyeolsi [seoul], 08308

    Recruiting

Other trials in South Korea

Germany10 sites, 10 recruiting

  • Hämatologie-onkologie im Zentrum MVZ GmbH

    Augsburg, Bavaria, 86150

    Recruiting

  • Charité Universitaetsmedizin Berlin - Campus Mitte

    Berlin, 10117

    Recruiting

  • Praxisklinik Krebsheilkunde fur Frauen

    Berlin, 10367

    Recruiting

  • Praxisklinik Krebsheilkunde fur Frauen

    Berlin, 13597

    Recruiting

  • Universitaetsklinikum Erlangen

    Erlangen, Bavaria, 91054

    Recruiting

  • Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung

    Essen, North Rhine-Westphalia, 45136

    Recruiting

  • Mammazentrum HH am Krankenhaus Jerusalem

    Hamburg, 20357

    Recruiting

  • Otto-von-Guericke-Universität, Medizinische Fakultät Universitätsklinikum Magdeburg A.ö.R.

    Magdeburg, Saxony-Anhalt, 39108

    Recruiting

  • MVZ für Hämatologie und Onkologie Ravensburg GmbH - Studienzentrum

    Ravensburg, Baden-Wurttemberg, 88212

    Recruiting

  • Universitätsklinik Ulm

    Ulm, Baden-Wurttemberg, 89075

    Recruiting

Other trials in Germany

India10 sites, 10 recruiting

  • Spandana Oncology Centre (SOC)

    Bengaluru, Karnataka, 560069

    Recruiting

  • Institute of Medical Sciences and Sum Hospital

    Bhubaneswar, Odisha, 751003

    Recruiting

  • Artemis hospital

    Gurugram, Haryana, 122001

    Recruiting

  • Sawai Man Singh Medical College Hospital (SMS Hospital)

    Jaipur, Rajasthan, 302004

    Recruiting

  • Tata Memorial Hospital

    Mumbai, Maharashtra, 400012

    Recruiting

  • HCG Manavata Cancer Centre

    Nashik, Maharashtra, 422002

    Recruiting

  • Apex Wellness Hospital

    Nashik, Maharashtra, 422009

    Recruiting

  • Sahyadri Super Speciality Hospital

    Pune, Maharashtra, 411004

    Recruiting

  • Nirmal Hospital Pvt Ltd.

    Surat, Gujarat, 395002

    Recruiting

  • Bhakti Vedanta Hospital and Research Institute

    Thane, Maharashtra, 401107

    Recruiting

Other trials in India

Belgium9 sites, 9 recruiting

  • Institut Jules Bordet

    Anderlecht, Bruxelles-capitale, Région de, 1070

    Recruiting

  • Algemeen Ziekenhuis klina

    Brasschaat, Antwerpen, 2930

    Recruiting

  • Cliniques universitaires Saint-Luc

    Brussels, Bruxelles-capitale, Région de, 1200

    Recruiting

  • Grand Hôpital de Charleroi

    Charleroi, Hainaut, 6060

    Recruiting

  • Jessa Ziekenhuis

    Hasselt, Limburg, 3500

    Recruiting

  • AZ Groeninge Campus Kennedylaan

    Kortrijk, West-vlaanderen, 8500

    Recruiting

  • UZ Leuven

    Leuven, Vlaams-brabant, 3000

    Recruiting

  • Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman

    Liège, 4000

    Recruiting

  • Clinique Saint Pierre

    Ottignies-Louvain-la-Neuve, Brabant Wallon, 1340

    Recruiting

Other trials in Belgium

Brazil9 sites, 9 recruiting

  • ONCOSITE - Centro de Pesquisa Clinica em Oncologia

    Ijuí, Rio Grande do Sul, 98700-000

    Recruiting

  • ANIMI - Unidade de Tratamento Oncologico

    Lages, Santa Catarina, 88501001

    Recruiting

  • Hospital de Cancer de Londrina

    Londrina, Paraná, 86015-520

    Recruiting

  • Hospital Moinhos de Vento

    Porto Alegre, Rio Grande do Sul, 90560032

    Recruiting

  • Hospital São Lucas da PUCRS

    Porto Alegre, Rio Grande do Sul, 90610-000

    Recruiting

  • Centro de Oncologia - CEON+ - Unidade São Caetano do Sul

    São Caetano do Sul, São Paulo, 09541-270

    Recruiting

  • Icesp - Instituto Do Câncer Do Estado de São Paulo

    São Paulo, 01246-000

    Recruiting

  • IBCC - Núcleo de Pesquisa e Ensino

    São Paulo, 04014-002

    Recruiting

  • Afecc Associacao Feminina Educacao Combate Cancer

    Vitória, Espírito Santo, 29043-260

    Recruiting

Other trials in Brazil

Italy9 sites, 9 recruiting

  • IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola

    Bologna, Emilia-Romagna, 40138

    Recruiting

  • Azienda USL Toscana Nord Ovest_Ospedale Civile di Livorno

    Livorno, Tuscany, 57124

    Recruiting

  • IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"

    Meldola, Emilia-Romagna, 47014

    Recruiting

  • Ospedale San Raffaele

    Milan, 20132

    Recruiting

  • Istituto Europeo di Oncologia IRCCS

    Milan, 20141

    Recruiting

  • Azienda Ospedaliero-Universitaria Policlinico di Modena

    Modena, 41124

    Recruiting

  • Fondazione IRCCS San Gerardo dei Tintori

    Monza, Lombardy, 20900

    Recruiting

  • Istituto Nazionale dei Tumori IRCCS Fondazione G Pascale

    Naples, Naples, 80131

    Recruiting

  • Istituto Nazionale Tumori Regina Elena

    Rome, ROMA, 00144

    Recruiting

Other trials in Italy

Spain9 sites, 9 recruiting

  • CHUAC-Complejo Hospitalario Universitario A Coruña

    A Coruña, A Coruña [LA Coruña], 15006

    Recruiting

  • Hospital Universitari Vall d'Hebron

    Barcelona, Barcelona [barcelona], 08035

    Recruiting

  • Hospital Clínic de Barcelona

    Barcelona, Catalunya [cataluña], 08036

    Recruiting

  • Osi Bilbao-Basurto

    Bilbao, Basque Country, 48013

    Recruiting

  • Hospital Universitario San Cecilio

    Granada, 18016

    Recruiting

  • Hospital Universitario de Jaen

    Jaén, 23007

    Recruiting

  • Hospital Universitario HM Sanchinarro

    Madrid, 28050

    Recruiting

  • Hospital Universitario Virgen de la Victoria

    Málaga, Málaga, 29010

    Recruiting

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009

    Recruiting

Other trials in Spain

Canada8 sites, 8 recruiting

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2

    Recruiting

  • Centre Hospitalier de l'Université de Montréal

    Montreal, Quebec, H2X 3E4

    Recruiting

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2

    Recruiting

  • McGill University Health Centre

    Montreal, Quebec, H4A 3J1

    Recruiting

  • The Ottawa Hospital Cancer Centre

    Ottawa, Ontario, K1H 8L6

    Recruiting

  • CHU de Québec-Université Laval, Hôpital du Saint-Sacrement

    Québec, Quebec, G1S 4L8

    Recruiting

  • CHU de Québec-Université Laval

    Québec, G1R 2J6

    Recruiting

  • Sunnybrook Research Institute

    Toronto, Ontario, M4N 3M5

    Recruiting

Other trials in Canada

Bulgaria7 sites, 7 recruiting

  • Complex Oncology Center - Burgas

    Burgas, 8000

    Recruiting

  • Specialized Hospital for Active Treatment of Oncology - Haskovo

    Haskovo, 6300

    Recruiting

  • Complex Oncology Center - Plovdiv EOOD

    Plovdiv, 4004

    Recruiting

  • Complex Oncology Center - Shumen

    Shumen, 9700

    Recruiting

  • Multiprofile Hospital for Active Treatment Serdikamed EOOD

    Sofia, Sofia (stolitsa), 1632

    Recruiting

  • MHAT for Women's Health Nadezhda

    Sofia, 1330

    Recruiting

  • "University Specialized Hospital for Active Treatment of Oncology Prof. Ivan Chernozemski" EAD

    Sofia, 1756

    Recruiting

Other trials in Bulgaria

Greece7 sites, 7 recruiting

  • University General Hospital of Alexandroupoli

    Alexandroupoli, East Macedonia and Thrace, 68100

    Recruiting

  • IASO General Clinic

    Athens, Attica, 151 23

    Recruiting

  • Aretaieio Hospital

    Athens, 11528

    Recruiting

  • University General Hospital of Heraklion

    Heraklion, Irakleío, 71500

    Recruiting

  • University General Hospital of Larissa

    Larissa, Thessalía, 411 10

    Recruiting

  • Hygeia Hospital

    Marousi, Attikí, 151 23

    Recruiting

  • European Interbalkan Medical Center

    Thessaloniki, Thessaloníki, 570 01

    Recruiting

Other trials in Greece

Slovakia7 sites, 7 recruiting

  • Onkologicky Ustav sv. Alzbety

    Bratislava, Bratislava Region, 812 50

    Recruiting

  • Narodny onkologicky ustav

    Bratislava, 833 10

    Recruiting

  • Nemocnica AGEL Komarno

    Komárno, Nitra Region, 945 05

    Recruiting

  • Vychodoslovensky Onkologicky ustav a.s.

    Košice, Košice Region, 041 91

    Recruiting

  • Nemocnica s poliklinikou Stefana Kukuru Michalovce a.s.

    Michalovce, Košice Region, 071 01

    Recruiting

  • Fakultna nemocnica s poliklinikou Nove Zamky

    Nové Zámky, 940 34

    Recruiting

  • Fakultna nemocnica Trnava

    Trnava, 917 75

    Recruiting

Other trials in Slovakia

Taiwan7 sites, 7 recruiting

  • Chi Mei Medical Center

    Tainan, Tainan, 71004

    Recruiting

  • National Cheng Kung University Hospital

    Tainan, 704

    Recruiting

  • National Taiwan University Hospital

    Taipei, 10002

    Recruiting

  • Mackay Memorial Hospital

    Taipei, 104217

    Recruiting

  • Koo Foundation Sun Yat-Sen Cancer Center

    Taipei, 112019

    Recruiting

  • Taipei Veterans General Hospital

    Taipei, 11217

    Recruiting

  • Chang Gung Medical Foundation-Linkou Branch

    Taoyuan, 333

    Recruiting

Other trials in Taiwan

Turkey (Türkiye)7 sites, 7 recruiting

  • Hacettepe Universite Hastaneleri

    Ankara, 06230

    Recruiting

  • Memorial Ankara Hastanesi

    Ankara, 06520

    Recruiting

  • Ankara Bilkent Şehir Hastanesi

    Ankara, 06800

    Recruiting

  • Dicle Üniversitesi

    Diyarbakır, 21200

    Recruiting

  • Medipol Mega Universite Hastanesi

    Istanbul, İ̇stanbul, 34214

    Recruiting

  • İ.A.Ü VM Medical Park Florya Hastanesi

    Küçükçekmece, İ̇stanbul, 34295

    Recruiting

  • Samsun Medical Park Hastanesi

    Samsun, 55200

    Recruiting

Other trials in Turkey (Türkiye)

Czechia6 sites, 6 recruiting

  • Nemocnice AGEL Novy Jicin a.s.

    Nový Jičín, 741 01

    Recruiting

  • Fakultni Thomayerova nemocnice

    Prague, Praha 4, 14059

    Recruiting

  • Fakultni nemocnice Bulovka

    Prague, Praha 8, 180 81

    Recruiting

  • Fakultni nemocnice Kralovske Vinohrady

    Prague, 100 34

    Recruiting

  • Vseobecna fakultni nemocnice v Praze

    Prague, 128 08

    Recruiting

  • Fakultni nemocnice Motol a Homolka

    Prague, 150 00

    Recruiting

Other trials in Czechia

Israel6 sites, 6 recruiting

  • Rambam Health Care Campus

    Haifa, Northern District, 3109601

    Recruiting

  • Shaare Zedek Medical Center

    Jerusalem, Jerusalem, 9013102

    Recruiting

  • Hadassah Medical Center

    Jerusalem, Jerusalem, 9112001

    Recruiting

  • Rabin Medical Center

    Petah Tikva, Central District, 4941492

    Recruiting

  • Sheba Medical Center

    Ramat Gan, Central District, 5265601

    Recruiting

  • Sourasky Medical Center

    Tel Aviv, TELL ABĪB, 6423906

    Recruiting

Other trials in Israel

United Kingdom6 sites, 6 recruiting

  • University Hospital Coventry & Warwickshire

    Coventry, Warwickshire, CV2 2DX

    Recruiting

  • The Royal Marsden NHS Foundation Trust

    London, SW3 6JJ

    Recruiting

  • Maidstone & Tunbridge Wells NHS Trust

    Maidstone, KENT, ME16 9QQ

    Recruiting

  • Peterborough City Hospital

    Peterborough, PE3 9GZ

    Recruiting

  • The Royal Marsden NHS Foundation Trust

    Sutton, Surrey, SM2 5PT

    Recruiting

  • Musgrove Park Hospital

    Taunton, Somerset, TA1 5DA

    Recruiting

Other trials in United Kingdom

Argentina5 sites, 5 recruiting

  • IADT - Instituto Argentino de diagnóstico y Tratamiento

    Buenos Aires, Buenos Aires F.D., C1122AAL

    Recruiting

  • Centro Medico Fleischer

    Buenos Aires, 1414

    Recruiting

  • Organizacion Medica de Investigacion

    CABA, Buenos Aires F.D., C1015ABO

    Recruiting

  • Fundación Respirar

    Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ABP

    Recruiting

  • Fundación CORI para la Investigación y Prevención del Cáncer

    La Rioja, F5300COE

    Recruiting

Other trials in Argentina

Australia5 sites, 5 recruiting

  • Cancer Research SA Pty Ltd

    Adelaide, South Australia, 5000

    Recruiting

  • ICON Cancer Centre - Kurralta Park

    Kurralta Park, South Australia, 5037

    Recruiting

  • Peter MacCallum Cancer Centre

    Melbourne, Victoria, 3000

    Recruiting

  • Western Health-Sunshine & Footscray Hospitals

    St Albans, Victoria, 3021

    Recruiting

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102

    Recruiting

Other trials in Australia

Mexico5 sites, 5 recruiting

  • Sitio Clínico UIS Chihuahua

    Chihuahua City, 31203

    Recruiting

  • COI Centro Oncologico Internacional S.A.P.I. de C.V.

    Mexico City, 04700

    Recruiting

  • Centro de Investigacion Clinica de Oaxaca

    Oaxaca City, Oaxaca, 68020

    Recruiting

  • Fundación Santos y de la Garza Evia I.B.P

    San Pedro Garza García, 66278

    Recruiting

  • COI/ CENTRO ONCOLOGICO INTERNACIONAL SAPI de CV

    Tlajomulco de Zuñiga, Jalisco, 45640

    Recruiting

Other trials in Mexico

Poland5 sites, 5 recruiting

  • Centrum Onkologii im. Prof. Franciszka Lukaszczyka

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796

    Recruiting

  • Centrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o.

    Krakow, Lesser Poland Voivodeship, 30-348

    Recruiting

  • SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu

    Opole, 45-061

    Recruiting

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy

    Warsaw, Masovian Voivodeship, 02-781

    Recruiting

  • Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii

    Wroclaw, Lower Silesian Voivodeship, 53-413

    Recruiting

Other trials in Poland

Finland4 sites, 4 recruiting

  • Docrates Syöpäsairaala

    Helsinki, Uusimaa, 00180

    Recruiting

  • Kuopion Yliopistollinen Sairaala

    Kuopio, Northern Savonia, 70210

    Recruiting

  • Tampereen yliopistollinen sairaala

    Tampere, Pirkanmaa, 33520

    Recruiting

  • Vaasan Keskussairaala

    Vaasa, Pohjanmaa, 65130

    Recruiting

Other trials in Finland

Hungary3 sites, 3 recruiting

  • Semmelweis Egyetem

    Budapest, 1082

    Recruiting

  • Országos Onkológiai Intézet Mellkasi es Hasuregi Daganatok es Klinikai Farmakologiai Osztaly

    Budapest, 1122

    Recruiting

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032

    Recruiting

Other trials in Hungary

New Zealand3 sites, 3 recruiting

  • Auckland City Hospital

    Auckland, 1023

    Recruiting

  • Christchurch Hospital

    Christchurch, Canterbury, 8011

    Recruiting

  • Capital, Coast and Hutt Valley District - Wellington Regional Hospital

    Wellington, 6021

    Recruiting

Other trials in New Zealand

Netherlands2 sites, 2 recruiting

  • Tergooi MC

    Hilversum, North Holland, 1212 VG

    Recruiting

  • Franciscus Vlietland Ziekenhuis

    Schiedam, South Holland, 3118 JH

    Recruiting

Other trials in Netherlands

South Africa2 sites, 2 recruiting

  • The Oncology Centre

    Durban, KwaZulu-Natal, 4091

    Recruiting

  • The Medical Oncology Centre of Rosebank

    Johannesburg, Gauteng, 2196

    Recruiting

Other trials in South Africa

Sweden2 sites, 2 recruiting

  • Sahlgrenska Universitetssjukhuset

    Gothenburg, SE-41345

    Recruiting

  • Södersjukhuset

    Stockholm, Stockholms LÄN [se-01], 11883

    Recruiting

Other trials in Sweden

Puerto Rico1 site, 1 recruiting

  • Ad-Vance Medical Research

    Ponce, 00717

    Recruiting

Other trials in Puerto Rico

About this study

Official title: An Interventional, Open-Label, Randomized, Multicenter, Phase 3 Study of PF-07248144 Plus Fulvestrant Compared to Investigator's Choice of Therapy in Adult Participants With Hormone Receptor-Positive, HER2-Negative Advanced/Metastatic Breast Cancer Whose Disease Progressed After Prior CDK4/6 Inhibitor-based Therapy

The purpose of this study is to learn about the safety and effects of the study medicine PF-07248144 when given along with fulvestrant for the possible treatment of HR-positive, HER2-negative advanced or metastatic breast cancer.

HR-positive breast cancer cells have proteins on their surface called receptors that bind to hormones like estrogen and progesterone (female sex hormones). These hormones can promote the growth of cancer cells.

Read more

HER2-negative describes cells that have a small amount or none of a protein called HER2 on their surface. In normal cells, HER2 helps control cell growth. Cancer cells that are HER2-negative may grow more slowly and are less likely to recur (come back) or spread to other parts of the body than cancer cells that have a large amount of HER2 on their surface.

Advanced cancer is a term that is often used to describe cancer that is unlikely to be cured.

Metastatic cancer is the type where the cancer cells spread from one part of the body to another.

This study is seeking for participants whose breast cancer has gotten worsen after receiving cyclin dependent kinase (CDK) 4/6 inhibitor-based therapy.

Half of participants in this study will receive their usual study treatment, everolimus with endocrine therapy (either exemestane or fulvestrant) for HR-positive/HER2-negative advanced or metastatic breast cancer (A/mBC). The study doctor will discuss which hormone therapy is right for the participant before treatment begins.

PF-07248144 is a tablet that will be taken by mouth at home every day in a 28-day cycle. Fulvestrant will be given as two injections (one injection in the buttock) at visits to the study clinic. Everolimus and exemestane are also tablets and will be taken by mouth at home every day in a 28-day cycle.

The study will compare the experiences of people receiving PF-07248144 in combination with fulvestrant to those of the people who do not. This will help see if PF-07248144 in combination with fulvestrant is safe and effective.

Conditions
Breast Cancer
Being tested
PF-07248144, Fulvestrant, Everolimus, Exemestane
Keywords
Locally advanced or metastatic breast cancer, Estrogen receptor positive [ER(+)], Progesterone receptor positive [PR(+)], Human epidermal growth factor receptor 2 negative [HER2(-)], ER(+)/HER2(-), PR(+)/HER2(-), HR(+)/HER2(-), Advanced Breast Cancer, Breast tumor, Breast cancer, Everolimus, Exemestane, Fulvestrant, Metastatic breast cancer, Endocrine Therapy, Hormone Therapy, Hormone positive breast cancer, Recurrent breast cancer, HR+, HER2-negative
Medical subject headings
Breast Neoplasms, Recurrence, Unilateral Breast Neoplasms

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • PF-07248144Drug

    KAT6 inhibitor

  • FulvestrantDrug

    Endocrine therapy

  • EverolimusDrug

    mTOR inhibitor

  • ExemestaneDrug

    Endocrine therapy

Study groups in NCT07062965
Study groupRoleWhat they receive
Arm A: PF-07248144 plus fulvestrantOtherPF-07248144 tablet taken by mouth plus fulvestrant taken as a shot into the muscle.
Receives: Drug: PF-07248144; Drug: Fulvestrant
Arm B: everolimus plus ETActive comparatorEverolimus tablet taken by mouth plus investigator's choice of endocrine therapy of exemestane tablet taken by mouth or fulvestrant taken as a shot into the muscle.
Receives: Drug: Fulvestrant; Drug: Everolimus; Drug: Exemestane

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Progression Free Survival (PFS) as determined by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1

    Measured: From the date of randomization until disease progression or death due to any cause (up to approximately 2 years)

Secondary outcomes (12)

  1. Overall Survival (OS)

    Measured: From the date of randomization until death due to any cause (up to approximately 5 years).

  2. Number of Participants with Objective Response (OR) by BICR

    Measured: From the date of randomization until disease progression or death due to any cause (up to approximately 2 years)

  3. Duration of Response (DoR) as defined by BICR

    Measured: From the date of the first objective (PR or CR) response (every 8 weeks during the first 48 weeks and then every 12 week) up to approximately 2 years.

  4. Number of Participants With Clinical Benefit Response (CBR) by BICR

    Measured: From randomization date (every 8 weeks during the first 48 weeks and then every 12 weeks) up to approximately 2 years.

  5. Number or Patients with Adverse Events (AEs) by Type

    Measured: From screening until 28 days after the last dose, to approximately 5 years

  6. Number or Patients with AEs by Incidence

    Measured: From screening until 28 days after the last dose, to approximately 5 years

  7. Number or Patients with AEs by Seriousness

    Measured: From screening until 28 days after the last dose, to approximately 5 years

  8. Number or Patients with AEs by relationship to study interventions

    Measured: From screening until 28 days after the last dose, to approximately 5 years

  9. Number of Participants With Abnormal Electrocardiogram (ECG; Arm A and B)

    Measured: From screening until 28 days after the last dose, to approximately 5 years

  10. Number of Participants With Increase From Baseline in Corrected QT (QTc) Interval (Arm A only)

    The study includes a QTc sub-study in approximately 40 participants in Arm A enrolled at selected sites which will evaluate the effect of PF-07248144 on QTc interval via collection of triplicate ECGs (central reading) time-matched with pharmacokinetic (PK) draws.

    Measured: 0h pre-dose on Cycle 1 Day 1, Cycle 1 Day 15, Cycle 2 Day 1, and Cycle 3 Day 1; additional 4 hrs post dose on Cycle 1 Day 15 and Cycle 2 Day 1

  11. Number of Participants With Laboratory Test Abnormalities

    Measured: From screening until 28 days after the last dose, to approximately 5 years

  12. Ctrough of PF-07248144

    Ctrough was defined as pre-dose serum concentration during multiple dosing and observed directly from data.

    Measured: Cycle 1 (Day 1), Cycle 1 (Day 15), Cycle 2 (Day 1), and Cycles 3, 5, and 7 (Day 1) only. Each Cycle is 28 days

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted14 Jul 2025
  2. Study start5 Aug 2025
  3. Primary completion22 Jul 2027 (estimated)
  4. Study completion4 Nov 2030 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Model description
Study participants will be randomly assigned into 1 of 2 groups in parallel for the entire duration of the study. The experimental arm will receive PF-07248144 and fulvestrant (Arm A) while the comparator arm will receive everolimus in combination with the study doctor's choice of endocrine therapy (exemestane or fulvestrant; Arm B).
Masking
None (open label)
Enrolment
400 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07062965
Sponsor's protocol ID
C4551002
Other IDs
2025-520566-22-00, 2025
Status last verified
Oct 2026
First submitted
3 Jul 2025
Last updated
19 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical\_trials/trial\_data\_and\_results/data\_requests.

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing PF-07248144, Fulvestrant and Everolimus in people with Breast Cancer, run by Pfizer at 433 sites in 31 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 19 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 433 sites in United States, China, Japan, France, South Korea and 26 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Pfizer CT.gov Call Center (1-800-718-1021, ClinicalTrials.gov_Inquiries@pfizer.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Progression Free Survival (PFS) as determined by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 (time frame: From the date of randomization until disease progression or death due to any cause (up to approximately 2 years)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07062965.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Oct 2026.

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Clinical Trial NCT07062965 | AzTrials