AsthmaNCT07064057
Effects of Aerobic Training With and Without Sniff Maneuver
A study testing Aerobic exercise combined with the sniff maneuver technique and Aerobic exercise in people with Asthma, run by Riphah International University at 1 site in Pakistan.
Trial summary
This study was planned to assess effects of Aerobic training with and without Sniff maneuver on Dyspnea, Functional capacity and Quality of life among Asthma Patients. Results showed that when aerobic training done along with the sniff maneuver had proven to be the more effective choice of treatment in reducing… Read more about this study
- Who is it for?
- Ages 35 to 50 years
- Conditions the study is for
- Asthma
- What is being tested?
- Aerobic exercise combined with the sniff maneuver technique and Aerobic exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 28 participants
- Where
- 1 sitePakistan
- Study dates
- 3 Aug 2023to 1 Dec 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 35 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Age between 35 to 50
- Moderate to severe asthma (FE ratio: 50 to 65%, ˂50%)
Who cannot join
- Patient with Cardiovascular(5)
- Musculosketal disorders (5)
- Smokers were excluded
- Patient with foot drop
- Osteoarthritis
- Low back pain
Show all 9Show fewer
- Post traumatic history
- Patients who was suffer physical or mental illness were be excluded
- If participant engage another exercise program were be excluded Mild asthma patient
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Aerobic Training With and Without Sniff Maneuver on Dyspnea, Functional Capacity and Quality of Life Among Asthma Patients
This study was planned to assess effects of Aerobic training with and without Sniff maneuver on Dyspnea, Functional capacity and Quality of life among Asthma Patients. Results showed that when aerobic training done along with the sniff maneuver had proven to be the more effective choice of treatment in reducing severity level of asthma along with the decreased perceived dyspnea and improved quality of life and functional capacity.
Read the detailed description
This study aimed to check the effects of Aerobic training with and without Sniff maneuver on Dyspnea, Functional capacity and Quality of life among Asthma Patients. This research of randomized clinical trial checked the effects of aerobic training with and without sniff maneuver on dyspnea, functional capacity and quality of life among asthma patient. By taking sample of 28 patients through convenience sampling and randomly allocating them to two group A and B out of which A was received Aerobic training with sniff maneuver and group B was received Aerobic training up to the duration of 3 days per week for 6 weeks. Pre and Post training outcomes of functional capacity was measured through 6 min walk test, dyspnea through Borg rating perceived exertion scale and QOL through 5d euro quality of life questionnaire.
- Conditions
- Asthma
- Being tested
- Aerobic exercise combined with the sniff maneuver technique, Aerobic exercise
- Keywords
- Exercise, Dyspnea, Sniff maneuver, Functional capacity, Quality of life
- Medical subject headings
- Asthma, Motor Activity, Dyspnea
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Aerobic exercise combined with the sniff maneuver techniqueOther
Aerobic exercises on a stationary bike or electric treadmill three times a week for six week. Five minutes of stretching, concentrated on the main lower limb muscle groups, were followed by a ten-minute warm-up, twenty minutes of training during the first two weeks and thirty minutes during the third to sixth week, and finally, a five-minute cooling-down phase..
Aerobic exerciseOther
The treadmill was used for both the warm-up and cooling-down phases. Heart rate was kept between 40% and 50% of maximum heart rate for these sessions. (5) To achieve a moderate exertion (rated as 11--13 on the Borg scale) and/or a moderate dyspnea (rated as 3---4 on the modified Borg scale), the intensity of the aerobic training was progressively increased.
| Study group | Role | What they receive |
|---|---|---|
| Aerobic exercises along with sniff maneuver | Experimental | Aerobic exercises on a stationary bike or electric treadmill three times a week for six weeks. Receives: Other: Aerobic exercise combined with the sniff maneuver technique |
| Aerobic exercises only | Active comparator | The treadmill was used for both the warm-up and cooling-down phases. Receives: Other: Aerobic exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Euro QOL 5 Dimensional Questionnaire
The EQ-5D is the most often used multi attribute utility (MAU) instrument in cost effectiveness evaluations for evaluating health-related quality of life. The descriptive system is made up of five features: mobility, self-care, regular activities, pain/discomfort, and anxiety/depression. The terms "not /no problems," "slight problems," "moderate problems," "severe problems," and "unable to" (mobility, self-care, regular activities) are used to describe the five levels in each category. Other terms used are "extreme" (pain/depression) or "extremely" (anxiety/depression). The patient is questioned to rate his or her current state of health by checking the box next to the statement that most closely matches each of the five dimensions.
Measured: 6 weeks
Borg Scale
Dyspnea was checked by Borg Scale.
Measured: 6 weeks
6 Min Walk Test
Functional capacity was checked by 6 min walk test Stopwatch to calculate overall activity time
Measured: 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2025
- Study start3 Aug 2023
- Primary completion1 Oct 2023
- Study completion1 Dec 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for AsthmaStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Hira Shaukat, Mphill, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07064057
- Sponsor's protocol ID
- REC/RCR&AHS/23/0341
- Status last verified
- Jul 2025
- First submitted
- 3 Jul 2025
- Last updated
- 14 Jul 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Moraes-Ferreira R, Brandao-Rangel MAR, Gibson-Alves TG, Silva-Reis A, Souza-Palmeira VH, Aquino-Santos HC, Frison CR, Oliveira LVF, Albertini R, Vieira RP. Physical Training Reduces Chronic Airway Inflammation and Mediators of Remodeling in Asthma. Oxid Med Cell Longev. 2022 Oct 20;2022:5037553. doi: 10.1155/2022/5037553. eCollection 2022.
PubMed 36312895Hansen ESH, Pitzner-Fabricius A, Toennesen LL, Rasmusen HK, Hostrup M, Hellsten Y, Backer V, Henriksen M. Effect of aerobic exercise training on asthma in adults: a systematic review and meta-analysis. Eur Respir J. 2020 Jul 30;56(1):2000146. doi: 10.1183/13993003.00146-2020. Print 2020 Jul.
PubMed 32350100Andrade LB, Britto MC, Lucena-Silva N, Gomes RG, Figueroa JN. The efficacy of aerobic training in improving the inflammatory component of asthmatic children. Randomized trial. Respir Med. 2014 Oct;108(10):1438-45. doi: 10.1016/j.rmed.2014.07.009. Epub 2014 Aug 29.
PubMed 25231109Abdelbasset WK, Alsubaie SF, Tantawy SA, Abo Elyazed TI, Kamel DM. Evaluating pulmonary function, aerobic capacity, and pediatric quality of life following a 10-week aerobic exercise training in school-aged asthmatics: a randomized controlled trial. Patient Prefer Adherence. 2018 Jun 15;12:1015-1023. doi: 10.2147/PPA.S159622. eCollection 2018.
PubMed 29942118
Study at a glance
From the registry record, last updated by the sponsor on 14 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Aerobic Training With and Without Sniff Maneuver on Dyspnea, Functional Capacity and Quality of Life Among Asthma Patients
- ClinicalTrials.gov ID
- NCT07064057
- Acronym / sponsor ID
- REC/RCR&AHS/23/0341
- Conditions
- Asthma
- Keywords
- Exercise, Dyspnea, Sniff maneuver, Functional capacity, Quality of life
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 3 Aug 2023 (actual)
- Primary completion
- 1 Oct 2023 (actual)
- Study completion
- 1 Dec 2023 (actual)
- First posted
- 14 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study was planned to assess effects of Aerobic training with and without Sniff maneuver on Dyspnea, Functional capacity and Quality of life among Asthma Patients. Results showed that when aerobic training done along with the sniff maneuver had proven to be the more effective choice of treatment in reducing severity level of asthma along with the decreased perceived dyspnea and improved quality of life and functional capacity.
Detailed description
This study aimed to check the effects of Aerobic training with and without Sniff maneuver on Dyspnea, Functional capacity and Quality of life among Asthma Patients. This research of randomized clinical trial checked the effects of aerobic training with and without sniff maneuver on dyspnea, functional capacity and quality of life among asthma patient. By taking sample of 28 patients through convenience sampling and randomly allocating them to two group A and B out of which A was received Aerobic training with sniff maneuver and group B was received Aerobic training up to the duration of 3 days per week for 6 weeks. Pre and Post training outcomes of functional capacity was measured through 6 min walk test, dyspnea through Borg rating perceived exertion scale and QOL through 5d euro quality of life questionnaire.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Aerobic exercises along with sniff maneuver | Experimental | Other: Aerobic exercise combined with the sniff maneuver techniqueAerobic exercises on a stationary bike or electric treadmill three times a week for six weeks. |
| Aerobic exercises only | Active comparator | Other: Aerobic exerciseThe treadmill was used for both the warm-up and cooling-down phases. |
Who may qualify
- Ages
- 35 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Age between 35 to 50
- Moderate to severe asthma (FE ratio: 50 to 65%, ˂50%)
Key exclusion criteria (9 listed)
- Patient with Cardiovascular(5)
- Musculosketal disorders (5)
- Smokers were excluded
- Patient with foot drop
- Osteoarthritis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Aerobic exercise combined with the sniff maneuver techniqueAerobic exercises on a stationary bike or electric treadmill three times a week for six week. Five minutes of stretching, concentrated on the main lower limb muscle groups, were followed by a ten-minute warm-up, twenty minutes of training during the first two weeks and thirty minutes during the third to sixth week, and finally, a five-minute cooling-down phase.. | Other | Aerobic exercises along with sniff maneuver |
| Aerobic exerciseThe treadmill was used for both the warm-up and cooling-down phases. Heart rate was kept between 40% and 50% of maximum heart rate for these sessions. (5) To achieve a moderate exertion (rated as 11--13 on the Borg scale) and/or a moderate dyspnea (rated as 3---4 on the modified Borg scale), the intensity of the aerobic training was progressively increased. | Other | Aerobic exercises only |
Primary outcome
Euro QOL 5 Dimensional Questionnaire
Time frame: 6 weeks
The EQ-5D is the most often used multi attribute utility (MAU) instrument in cost effectiveness evaluations for evaluating health-related quality of life. The descriptive system is made up of five features: mobility, self-care, regular activities, pain/discomfort, and anxiety/depression. The terms "not /no problems," "slight problems," "moderate problems," "severe problems," and "unable to" (mobility, self-care, regular activities) are used to describe the five levels in each category. Other terms used are "extreme" (pain/depression) or "extremely" (anxiety/depression). The patient is questioned to rate his or her current state of health by checking the box next to the statement that most closely matches each of the five dimensions.
Borg Scale
Time frame: 6 weeks
Dyspnea was checked by Borg Scale.
6 Min Walk Test
Time frame: 6 weeks
Functional capacity was checked by 6 min walk test Stopwatch to calculate overall activity time
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Jul 2025.
- Background: PubMed 36312895Moraes-Ferreira R, Brandao-Rangel MAR, Gibson-Alves TG, Silva-Reis A, Souza-Palmeira VH, Aquino-Santos HC, Frison CR, Oliveira LVF, Albertini R, Vieira RP. Physical Training Reduces Chronic Airway Inflammation and Mediators of Remodeling in Asthma. Oxid Med Cell Longev. 2022 Oct 20;2022:5037553. doi: 10.1155/2022/5037553. eCollection 2022.
- Background: PubMed 32350100Hansen ESH, Pitzner-Fabricius A, Toennesen LL, Rasmusen HK, Hostrup M, Hellsten Y, Backer V, Henriksen M. Effect of aerobic exercise training on asthma in adults: a systematic review and meta-analysis. Eur Respir J. 2020 Jul 30;56(1):2000146. doi: 10.1183/13993003.00146-2020. Print 2020 Jul.
- Background: PubMed 25231109Andrade LB, Britto MC, Lucena-Silva N, Gomes RG, Figueroa JN. The efficacy of aerobic training in improving the inflammatory component of asthmatic children. Randomized trial. Respir Med. 2014 Oct;108(10):1438-45. doi: 10.1016/j.rmed.2014.07.009. Epub 2014 Aug 29.
- Background: PubMed 29942118Abdelbasset WK, Alsubaie SF, Tantawy SA, Abo Elyazed TI, Kamel DM. Evaluating pulmonary function, aerobic capacity, and pediatric quality of life following a 10-week aerobic exercise training in school-aged asthmatics: a randomized controlled trial. Patient Prefer Adherence. 2018 Jun 15;12:1015-1023. doi: 10.2147/PPA.S159622. eCollection 2018.
- Individual participant dataSharing planned: No
Related trials for Asthma
RecruitingPhase 1
Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation
Asthma
RecruitingPhase 1
A Study to Compare the Relative Potency of Salbutamol Administered Via Metered Dose Inhalers (MDI) Containing Propellants HFA-152a to HFA-134a in Mild Asthmatics Aged 18 to 65 Inclusive
Asthma, Mild Asthma
RecruitingPhase 3
A Study Assessing the Effect of Dupilumab on Inducing Clinical Remission in Asthma
Asthma Control
Active, not recruitingPhase 2/3
Local Antibiotic Delivery for Community Acquired Pneumonia
Community Acquired Pneumonia (CAP)
RecruitingPhase 2
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma
Asthma
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Hira Shaukat, Mphill principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Aerobic exercise combined with the sniff maneuver technique and Aerobic exercise in people with Asthma, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 14 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Euro QOL 5 Dimensional Questionnaire (time frame: 6 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07064057, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Jul 2025.