Primary Knee OsteoarthritisNCT07066215
Effects of Balance and Muscle Strength in Knee Osteoarthritis
An observational study of Primary Knee Osteoarthritis, run by Bezmialem Vakif University at 1 site in Turkey (Türkiye).
Trial summary
Knee osteoarthritis (OA) is a chronic and progressive joint disease characterized by the degeneration of articular cartilage, subchondral bone sclerosis, and the formation of osteophytes. This condition leads to joint pain and stiffness, negatively affecting individuals' quality of life. Read more about this study
- Who is it for?
- Ages 45 to 75 years, women only
- Conditions the study is for
- Primary Knee Osteoarthritis
- How many people
- 64 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Aug 2025to 13 Mar 2026
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 75 years
- Women only
- No healthy volunteers
- Adult, Older adult
Study population: Patients who have diagnosed primary knee osteoarthritis will be included
Who may be able to join
- Primary knee osteoarthritis
Who cannot join
- Previous surgery in the lower extremity
- Neuromuscular disease
- Vestibular pathology
- Physiotherapy intervention or intra-articular injection within the last 6 months
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Balance and Muscle Strength on Functional Capacity in Knee Osteoarthritis
Knee osteoarthritis (OA) is a chronic and progressive joint disease characterized by the degeneration of articular cartilage, subchondral bone sclerosis, and the formation of osteophytes. This condition leads to joint pain and stiffness, negatively affecting individuals' quality of life. Joint stiffness, decreased quadriceps strength, and impaired proprioceptive sensation result in functional limitations. Due to these symptoms, individuals experience difficulties in performing daily activities such as rising from a chair, walking, and climbing stairs. The aim of this study is to evaluate the effects of balance, and muscle strength on functional capacity in patients with knee osteoarthritis.
Read the detailed description
In knee OA, structural changes in the cartilage and the formation of peripheral osteophytes contribute to joint stiffness and a reduction in the range of motion, which adversely affects physical function, particularly in older adults. Activities such as stair climbing, sitting and standing, and walking require the contribution of core muscles as well as lower extremity muscles, particularly the knee extensors. In knee OA, there is a reported decrease in lower extremity muscle strength, especially in the quadriceps femoris muscle, which further impairs functional activities in the advanced stages of the disease.
Arthritic damage to joint mechanoreceptors in osteoarthritis leads to a decline in motor control and proprioceptive sensitivity. These sensorimotor deficits result in decreased stability and impaired balance function. Additionally, reduced muscle strength can hinder neuromuscular control, leading to postural instability and an increased risk of falls, especially in older patients.
Identifying the factors that contribute to the decline in functional capacity is crucial for planning appropriate exercise programs. The aim of this study is to evaluate the effects of balance, and muscle strength on functional capacity in patients with knee osteoarthritis.
- Conditions
- Primary Knee Osteoarthritis
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscle strength
Muscles strength measurement with 5 time sit-to-stand test
Measured: Baseline
Balance
Biodex Balance System will be used for postural stability evaluation. Lower scores indicate better stability and higher scores mean poor balance.
Measured: Baseline
6-minute walk test
Walking distance will be measured
Measured: Baseline
Stair climb test
Test completion time will be evaluated
Measured: Baseline
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
Function subscale consisting of 17 items will be used for evaluation. Higher scores indicate greater functional limitation.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jul 2025
- Study start1 Aug 2025
- Primary completion28 Feb 2026
- Study completion13 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Primary Knee OsteoarthritisStudies of the same condition, open and under way.
- More trials run by Bezmialem Vakif UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 64 participants (actual)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Bezmialem Vakif University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Kübra Alpay, Bezmialem Vakif University
- Investigators
- Kubra Alpay, PhD, Principal investigator, Bezmialem Vakif University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07066215
- Sponsor's protocol ID
- KA25-1
- Status last verified
- Apr 2026
- First submitted
- 14 Jul 2025
- Last updated
- 28 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Balance and Muscle Strength on Functional Capacity in Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT07066215
- Acronym / sponsor ID
- KA25-1
- Conditions
- Primary Knee Osteoarthritis
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 64 participants (actual)
- Lead sponsor
- Bezmialem Vakif UniversityUniversity, hospital or other
- Study start
- 1 Aug 2025 (actual)
- Primary completion
- 28 Feb 2026 (actual)
- Study completion
- 13 Mar 2026 (actual)
- First posted
- 15 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Knee osteoarthritis (OA) is a chronic and progressive joint disease characterized by the degeneration of articular cartilage, subchondral bone sclerosis, and the formation of osteophytes. This condition leads to joint pain and stiffness, negatively affecting individuals' quality of life. Joint stiffness, decreased quadriceps strength, and impaired proprioceptive sensation result in functional limitations. Due to these symptoms, individuals experience difficulties in performing daily activities such as rising from a chair, walking, and climbing stairs. The aim of this study is to evaluate the effects of balance, and muscle strength on functional capacity in patients with knee osteoarthritis.
Detailed description
In knee OA, structural changes in the cartilage and the formation of peripheral osteophytes contribute to joint stiffness and a reduction in the range of motion, which adversely affects physical function, particularly in older adults. Activities such as stair climbing, sitting and standing, and walking require the contribution of core muscles as well as lower extremity muscles, particularly the knee extensors. In knee OA, there is a reported decrease in lower extremity muscle strength, especially in the quadriceps femoris muscle, which further impairs functional activities in the advanced stages of the disease.
Arthritic damage to joint mechanoreceptors in osteoarthritis leads to a decline in motor control and proprioceptive sensitivity. These sensorimotor deficits result in decreased stability and impaired balance function. Additionally, reduced muscle strength can hinder neuromuscular control, leading to postural instability and an increased risk of falls, especially in older patients.
Identifying the factors that contribute to the decline in functional capacity is crucial for planning appropriate exercise programs. The aim of this study is to evaluate the effects of balance, and muscle strength on functional capacity in patients with knee osteoarthritis.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Target follow-up
- 1 Day
Who may qualify
- Ages
- 45 to 75 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients who have diagnosed primary knee osteoarthritis will be included
Key inclusion criteria (1 listed)
- Primary knee osteoarthritis
Key exclusion criteria (4 listed)
- Previous surgery in the lower extremity
- Neuromuscular disease
- Vestibular pathology
- Physiotherapy intervention or intra-articular injection within the last 6 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Muscle strength
Time frame: Baseline
Muscles strength measurement with 5 time sit-to-stand test
Balance
Time frame: Baseline
Biodex Balance System will be used for postural stability evaluation. Lower scores indicate better stability and higher scores mean poor balance.
6-minute walk test
Time frame: Baseline
Walking distance will be measured
Stair climb test
Time frame: Baseline
Test completion time will be evaluated
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
Time frame: Baseline
Function subscale consisting of 17 items will be used for evaluation. Higher scores indicate greater functional limitation.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Apr 2026.
Related trials for Primary Knee Osteoarthritis
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Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty
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Survivorship of Attune Primary Total Knee Prosthesis
Noninflammatory Degenerative Joint Disease
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Study Comparing Osteoarthritis Programs
Osteoarthritis
Active, not recruitingObservational study
Condylar Offset and Outcomes in Primary Total Knee Arthroplasty
Knee Arthritis Osteoarthritis
Not yet recruiting
A Randomized Comparison of the Efficacy of the IPACK Block Versus the Popliteal Plexus Block for Posterior Knee Analgesia, in Patients Undergoing a Total Knee Arthroplasty and Receiving a Continuous Distal Femoral Triangle Block
Osteoarthritis, Knee, Postoperative Pain
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Kubra Alpay, PhD principal investigator
Bezmialem Vakif University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Primary Knee Osteoarthritis, run by Bezmialem Vakif University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Muscle strength (time frame: Baseline). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Apr 2026.