Dynamic WrinklesNCT07067073
ANTI-DYNAMIC LINE Test for Cream
A study testing Anti-Dynamic Line Cream in people with Dynamic Wrinkles, run by ChinaNorm at 1 site in China.
Trial summary
The goal of this clinical trial is to find out whether a new cream (Formula# 899675 44A) can help reduce dynamic facial and neck wrinkles in young Chinese women. The main questions it aims to answer are: Does the cream lower the appearance of forehead wrinkles, crow's feet, under-eye wrinkles, and nasolabial folds… Read more about this study
- Who is it for?
- Ages 18 to 35 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Dynamic Wrinkles
- What is being tested?
- Anti-Dynamic Line Cream
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteChina
- Study dates
- 29 Oct 2024to 12 Jan 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Chinese female aged 18-35 years old.
- All skin types will be contained, including 50% sensitive skin.
- Regular users of cleanser, anti-aging cream and sunscreen product.
- Self-claim having concerns of wrinkles problems.
- Presenting with obvious dynamic wrinkles while making smiling/raising eyebrow expression ( expression reach max condition) evaluated by Dermatologist：
- Raise eyebrow: Forehead wrinkles (Loreal Atlas, 1<grade≤4)
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- Smile: Underneath eye wrinkles (Loreal Atlas, grade≥3)
- Smile: Crow's feet wrinkles (Loreal Atlas, grade≥3)
- Smile: Nasolabial folds (Loreal Atlas, grade>1)
- Did not participate in any clinical test or cosmetic product test on skin within 3 months.
- Did not participate any chemical procedures for previous 2 months; and willing to not participate any procedures during the whole study.
- No disagreement of dermatologist because of other reasons that exclude the participation of the Subject.
- In general, good health at the time of the study.
- Willing and able to participate as evidenced by signing of informed consent and photorelease form.
- Must be willing to comply with all study protocol requirements (pay attention to not take topical or oral treatment like retinol, hormone, antioxidant health-care products which may affect the efficacy of test products).
Who cannot join
- Intending to get pregnant, pregnant, lactating or within 6 months of delivery.
- Subject deprived of rights by a court or administrative order.
- Major subject to a guardianship order.
- Subject residing in a health or social care establishment.
- Patient in an emergency setting.
- Subject with a skin disease in the test areas (particularly e.g., acne, rosacea, eczema).
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- Subject presenting a stable or progressive serious disease (per investigator's assessment).
- Immuno-compromised subject.
- Subject with history of allergy to cosmetic or personal care products or ingredients.
- Subject presenting excessive exposure to sunlight or UV radiation (investigator's assessment).
- Subjects regularly practicing aquatic or nautical sports.
- Subjects regularly attending a sauna.
- Subject with cardiovascular or circulatory history.
- Subject with a history of skin cancer or malignant melanoma.
- Intake of antihistamines, antibiotics, corticosteroids, non-steroidal anti-inflammatories or immune-suppressants in the last 6 months before study
Trial locations and contacts
1 site in 1 country.
China1 site
Shanghai China-norm Quality Technical Service Co., Ltd., Shanghai, Shanghai 200072
Shanghai
About this study
Official title: ANTI-DYNAMIC LINE Test for Cream: A Mono-centric 8-week Clinical Evaluation on Facial and Neck Dynamic Wrinkles in Chinese Female Subjects Aged 18-35
The goal of this clinical trial is to find out whether a new cream (Formula# 899675 44A) can help reduce dynamic facial and neck wrinkles in young Chinese women. The main questions it aims to answer are:
- Does the cream lower the appearance of forehead wrinkles, crow's feet, under-eye wrinkles, and nasolabial folds when participants smile or raise their eyebrows?
- Does the cream help reduce horizontal neck folds when participants lower their heads?
Read more
About 45 healthy women between the ages of 18 and 35 will take part in this 10-week study. They will:
- Stop using other anti-aging products for 2 weeks (wash-out period)
- Apply the study cream on their face and neck twice a day for 8 weeks
- Visit the clinic 4 times for facial and neck photo collection and clinical assessments
- Learn to make standard facial expressions for photo comparisons
Researchers will compare wrinkle changes using dermatologist scores and photo grading at different time points.
- Conditions
- Dynamic Wrinkles
- Being tested
- Anti-Dynamic Line Cream
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Anti-Dynamic Line CreamOther
Topical cream (Formula# 899675 44A) applied to the full face and neck twice daily for 8 weeks. Participants apply 1 g each time in the morning and evening after cleansing, with massage on wrinkle-prone areas. Used after a 2-week wash-out period with standard skincare.
| Study group | Role | What they receive |
|---|---|---|
| Investigational Cream Arm | Experimental | Participants apply the investigational cream (Formula# 899675 44A) on the entire face and neck twice daily for 8 weeks following a 2-week wash-out period. Application is supervised on-site at baseline and self-administered at home thereafter. Clinical assessments and facial/neck image capture are conducted at baseline, week 4, and week 8. Receives: Other: Anti-Dynamic Line Cream |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time effect of facial and neck wrinkles (Dermatologist-assessed)
Clinical scoring of dynamic wrinkles in five facial and neck areas: forehead wrinkles (raising eyebrow), crow's feet wrinkles, underneath eye wrinkles, nasolabial folds (smiling), and horizontal neck folds (lowering head), as assessed by dermatologist at T0, T4wk, and T8wk using the Skin Aging Atlas. Assessment is based on facial expression photos and in-person evaluation. Wilcoxon Signed Rank Test will be used to analyze changes from baseline.
Measured: Baseline (T0) to Week 8 (T8wk)
Secondary outcomes (3)
Time effect of facial wrinkles (Expression image-based)
Dermatologist-assessed wrinkle severity based on a series of 10 expression photos captured at baseline, week 4, and week 8. Areas include forehead wrinkles (raising eyebrow), crow's feet wrinkles, underneath eye wrinkles, nasolabial folds (smiling), and horizontal neck folds (lowering head). Images were taken using DEEP 1.0 and iPhone 15 Pro Max, and graded with the Skin Aging Atlas without referencing prior scores. Statistical analysis used Wilcoxon Signed Rank Test.
Measured: Baseline (T0) to Week 8 (T8wk)
Time effect of adverse events and intolerance reactions
Any reported adverse events (AEs) and local intolerance reactions collected through participant diaries and on-site monitoring at each visit (T0, T4wk, T8wk). All events evaluated for severity, duration, and relation to the test product, and reported within 24 hours per protocol guidelines.
Measured: Baseline (T0) to Week 8 (T8wk)
Time effect of product compliance (Twice-daily usage)
Participant adherence to the instructed regimen of twice-daily application of the investigational cream, assessed by product weight tracking and daily log review at week 4 and week 8 visits.
Measured: Baseline (T0) to Week 8 (T8wk)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jul 2025
- Study start29 Oct 2024
- Primary completion24 Dec 2024
- Study completion12 Jan 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dynamic WrinklesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 45 participants (actual)
Sponsor and investigators
- Lead sponsor
- ChinaNorm
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07067073
- Sponsor's protocol ID
- C24005075
- Status last verified
- Jul 2025
- First submitted
- 4 Jul 2025
- Last updated
- 15 Jul 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: This Data Sharing Plan (DSP) aims to promote the open exchange and reuse of de-identified individual participant data (IPD) from cosmetic clinical research, including study protocols, case report forms (CRFs), and statistical analysis plans (SAPs). The shared data will be made available through compliant platforms to eligible researchers in dermatology, cosmetic science, and related fields, following ethical principles and data protection regulations. Users must sign a Data Use Agreement (DUA) to ensure data security, privacy protection, and compliance with research purposes.
Study at a glance
From the registry record, last updated by the sponsor on 15 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- ANTI-DYNAMIC LINE Test for Cream: A Mono-centric 8-week Clinical Evaluation on Facial and Neck Dynamic Wrinkles in Chinese Female Subjects Aged 18-35
- ClinicalTrials.gov ID
- NCT07067073
- Acronym / sponsor ID
- C24005075
- Conditions
- Dynamic Wrinkles
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 45 participants (actual)
- Lead sponsor
- ChinaNormIndustry (pharma, biotech, devices)
- Study start
- 29 Oct 2024 (actual)
- Primary completion
- 24 Dec 2024 (actual)
- Study completion
- 12 Jan 2025 (actual)
- First posted
- 15 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to find out whether a new cream (Formula# 899675 44A) can help reduce dynamic facial and neck wrinkles in young Chinese women. The main questions it aims to answer are:
- Does the cream lower the appearance of forehead wrinkles, crow's feet, under-eye wrinkles, and nasolabial folds when participants smile or raise their eyebrows?
- Does the cream help reduce horizontal neck folds when participants lower their heads?
About 45 healthy women between the ages of 18 and 35 will take part in this 10-week study. They will:
- Stop using other anti-aging products for 2 weeks (wash-out period)
- Apply the study cream on their face and neck twice a day for 8 weeks
- Visit the clinic 4 times for facial and neck photo collection and clinical assessments
- Learn to make standard facial expressions for photo comparisons
Researchers will compare wrinkle changes using dermatologist scores and photo grading at different time points.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Investigational Cream Arm | Experimental | Other: Anti-Dynamic Line CreamParticipants apply the investigational cream (Formula# 899675 44A) on the entire face and neck twice daily for 8 weeks following a 2-week wash-out period. Application is supervised on-site at baseline and self-administered at home thereafter. Clinical assessments and facial/neck image capture are conducted at baseline, week 4, and week 8. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (15 listed)
- Chinese female aged 18-35 years old.
- All skin types will be contained, including 50% sensitive skin.
- Regular users of cleanser, anti-aging cream and sunscreen product.
- Self-claim having concerns of wrinkles problems.
- Presenting with obvious dynamic wrinkles while making smiling/raising eyebrow expression ( expression reach max condition) evaluated by Dermatologist：
Key exclusion criteria (15 listed)
- Intending to get pregnant, pregnant, lactating or within 6 months of delivery.
- Subject deprived of rights by a court or administrative order.
- Major subject to a guardianship order.
- Subject residing in a health or social care establishment.
- Patient in an emergency setting.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Anti-Dynamic Line CreamTopical cream (Formula# 899675 44A) applied to the full face and neck twice daily for 8 weeks. Participants apply 1 g each time in the morning and evening after cleansing, with massage on wrinkle-prone areas. Used after a 2-week wash-out period with standard skincare. | Other | Investigational Cream Arm |
Primary outcome
Time effect of facial and neck wrinkles (Dermatologist-assessed)
Time frame: Baseline (T0) to Week 8 (T8wk)
Clinical scoring of dynamic wrinkles in five facial and neck areas: forehead wrinkles (raising eyebrow), crow's feet wrinkles, underneath eye wrinkles, nasolabial folds (smiling), and horizontal neck folds (lowering head), as assessed by dermatologist at T0, T4wk, and T8wk using the Skin Aging Atlas. Assessment is based on facial expression photos and in-person evaluation. Wilcoxon Signed Rank Test will be used to analyze changes from baseline.
3 secondary outcomes
Time effect of facial wrinkles (Expression image-based)
Time frame: Baseline (T0) to Week 8 (T8wk)
Time effect of adverse events and intolerance reactions
Time frame: Baseline (T0) to Week 8 (T8wk)
Time effect of product compliance (Twice-daily usage)
Time frame: Baseline (T0) to Week 8 (T8wk)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Jul 2025.
- Individual participant dataSharing planned: Yes. This Data Sharing Plan (DSP) aims to promote the open exchange and reuse of de-identified individual participant data (IPD) from cosmetic clinical research, including study protocols, case report forms (CRFs), and statistical analysis plans (SAPs). The shared data will be made available through compliant platforms to eligible researchers in dermatology, cosmetic science, and related fields, following ethical principles and data protection regulations. Users must sign a Data Use Agreement (DUA) to ensure data security, privacy protection, and compliance with research purposes.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Anti-Dynamic Line Cream in people with Dynamic Wrinkles, run by ChinaNorm at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 15 inclusion and 15 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time effect of facial and neck wrinkles (Dermatologist-assessed) (time frame: Baseline (T0) to Week 8 (T8wk)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Jul 2025.