PneumoniaNCT07070271
Effect of Neurophysiological Facilitation of Respiration on Blood Gases and Hospital Stay in Children With Pneumonia
A study testing Respiratory neurophysiological facilitation techniques and conventional chest physical therapy in people with Pneumonia, run by Asmaa Ahmed Abd El-samad at 1 site in Egypt.
Trial summary
The goal of this clinical trial is to investigate the effect of respiratory neurophysiological facilitation techniques on arterial blood gases, the severity of respiratory distress and duration of hospital stay in hospitalized children with pneumonia. Read more about this study
- Who is it for?
- Ages 6 months to 2 years
- Conditions the study is for
- Pneumonia
- What is being tested?
- Respiratory neurophysiological facilitation techniques and conventional chest physical therapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Aug 2025to 31 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 6 months to 2 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- Children of both sexes, with age ranged from 6 months to 2 years old.
- All children diagnosed with pneumonia.
- All children should be vitally stable during the study period.
Who cannot join
- Medically unstable children.
- Children with uncontrolled convulsions.
- Children with Osteopenia.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Neurophysiological Facilitation of Respiration on Blood Gases and Duration of Hospitalization in Children With Pneumonia
The goal of this clinical trial is to investigate the effect of respiratory neurophysiological facilitation techniques on arterial blood gases, the severity of respiratory distress and duration of hospital stay in hospitalized children with pneumonia.
Read the detailed description
Children who were hospitalized with a clinically and radiologically confirmed diagnosis of pneumonia will participate in this study. Selected Patients will be randomly assigned into two groups of equal number.
One group will only receive conventional chest physical therapy program in form of (postural drainage, chest percussion, vibration and suction if needed). The other group will receive conventional chest physical therapy program along with respiratory neurophysiological facilitation techniques in form of (anterior basal lift, intercostal stretch, abdominal co-contraction).
All patients will receive the treatment program once a day throughout the hospitalization period until discharge.
- Conditions
- Pneumonia
- Being tested
- Respiratory neurophysiological facilitation techniques, conventional chest physical therapy
- Keywords
- Pneumonia, Neurophysiological facilitation, Chest physical therapy, Blood gases
- Medical subject headings
- Pneumonia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Respiratory neurophysiological facilitation techniquesOther
The respiratory neurophysiological facilitation techniques in form of (anterior basal lift, intercostal stretch, abdominal co-contraction) once a day throughout the hospitalization period until discharge.
conventional chest physical therapyOther
conventional chest physical therapy program in form of (postural drainage, chest percussion, vibration and suction if needed) once a day throughout the hospitalization period until discharge.
| Study group | Role | What they receive |
|---|---|---|
| Conventional chest physical therapy | Active comparator | Children in this group will only receive conventional chest physical therapy program in form of (postural drainage, chest percussion, vibration and suction if needed). Receives: Other: conventional chest physical therapy |
| Conventional chest physical therapy + Neurophysiological facilitation techniques | Experimental | Children in this group will receive conventional chest physical therapy program along with respiratory neurophysiological facilitation techniques in form of (anterior basal lift, intercostal stretch, abdominal co-contraction). Receives: Other: Respiratory neurophysiological facilitation techniques; Other: conventional chest physical therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Arterial blood gases
Blood gas analysis is a commonly used diagnostic tool to evaluate the partial pressures of gas in blood and acid-base content.
The blood sample is collected from the radial artery or the femoral artery.
Measured: At baseline (after enrollment and before the first chest physiotherapy session) and on day 5 after completing the fifth session, assessed within 5 days of enrollment
Duration of hospitalization
Measured: From the date of hospital admission until the date of discharge, up to 20 days
The severity of respiratory distress
Using the Pediatric Respiratory Severity Score to assess respiratory rate, wheezing, accessory muscle use, SpO2, and feeding difficulties.
Each component was given 0 or 1 point and the total score was classified as mild (0-1 points), moderate (2-3 points), or severe (4-5 points)
Measured: At baseline (after enrollment and before the first chest physiotherapy session) and on day 5 after completing the fifth session, assessed within 5 days of enrollment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jul 2025
- Study start1 Aug 2025
- Primary completion31 Dec 2025
- Study completion31 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PneumoniaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- Asmaa Ahmed Abd El-samad
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Asmaa Ahmed Abd El-samad, Cairo University
- Investigators
- Asmaa Ahmed Abd El-samad, master's degree, Principal investigator, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07070271
- Sponsor's protocol ID
- P.T.REC/012/005586
- Status last verified
- Sep 2026
- First submitted
- 1 Jul 2025
- Last updated
- 17 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Neurophysiological Facilitation of Respiration on Blood Gases and Duration of Hospitalization in Children With Pneumonia
- ClinicalTrials.gov ID
- NCT07070271
- Acronym / sponsor ID
- P.T.REC/012/005586
- Conditions
- Pneumonia
- Keywords
- Pneumonia, Neurophysiological facilitation, Chest physical therapy, Blood gases
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- Asmaa Ahmed Abd El-samadUniversity, hospital or other
- Study start
- 1 Aug 2025 (actual)
- Primary completion
- 31 Dec 2025 (actual)
- Study completion
- 31 Dec 2025 (actual)
- First posted
- 17 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to investigate the effect of respiratory neurophysiological facilitation techniques on arterial blood gases, the severity of respiratory distress and duration of hospital stay in hospitalized children with pneumonia.
Detailed description
Children who were hospitalized with a clinically and radiologically confirmed diagnosis of pneumonia will participate in this study. Selected Patients will be randomly assigned into two groups of equal number.
One group will only receive conventional chest physical therapy program in form of (postural drainage, chest percussion, vibration and suction if needed). The other group will receive conventional chest physical therapy program along with respiratory neurophysiological facilitation techniques in form of (anterior basal lift, intercostal stretch, abdominal co-contraction).
All patients will receive the treatment program once a day throughout the hospitalization period until discharge.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Conventional chest physical therapy | Active comparator | Other: conventional chest physical therapyChildren in this group will only receive conventional chest physical therapy program in form of (postural drainage, chest percussion, vibration and suction if needed). |
| Conventional chest physical therapy + Neurophysiological facilitation techniques | Experimental | Other: Respiratory neurophysiological facilitation techniques, Other: conventional chest physical therapyChildren in this group will receive conventional chest physical therapy program along with respiratory neurophysiological facilitation techniques in form of (anterior basal lift, intercostal stretch, abdominal co-contraction). |
Who may qualify
- Ages
- 6 months to 2 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (3 listed)
- Children of both sexes, with age ranged from 6 months to 2 years old.
- All children diagnosed with pneumonia.
- All children should be vitally stable during the study period.
Key exclusion criteria (3 listed)
- Medically unstable children.
- Children with uncontrolled convulsions.
- Children with Osteopenia.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Respiratory neurophysiological facilitation techniquesThe respiratory neurophysiological facilitation techniques in form of (anterior basal lift, intercostal stretch, abdominal co-contraction) once a day throughout the hospitalization period until discharge. | Other | Conventional chest physical therapy + Neurophysiological facilitation techniques |
| conventional chest physical therapyconventional chest physical therapy program in form of (postural drainage, chest percussion, vibration and suction if needed) once a day throughout the hospitalization period until discharge. | Other | Conventional chest physical therapy, Conventional chest physical therapy + Neurophysiological facilitation techniques |
Primary outcome
Arterial blood gases
Time frame: At baseline (after enrollment and before the first chest physiotherapy session) and on day 5 after completing the fifth session, assessed within 5 days of enrollment
Blood gas analysis is a commonly used diagnostic tool to evaluate the partial pressures of gas in blood and acid-base content. The blood sample is collected from the radial artery or the femoral artery.
Duration of hospitalization
Time frame: From the date of hospital admission until the date of discharge, up to 20 days
The severity of respiratory distress
Time frame: At baseline (after enrollment and before the first chest physiotherapy session) and on day 5 after completing the fifth session, assessed within 5 days of enrollment
Using the Pediatric Respiratory Severity Score to assess respiratory rate, wheezing, accessory muscle use, SpO2, and feeding difficulties. Each component was given 0 or 1 point and the total score was classified as mild (0-1 points), moderate (2-3 points), or severe (4-5 points)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Sep 2026.
- Individual participant dataSharing planned: No
Related trials for Pneumonia
Not yet recruitingPhase 1
Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)
Post-Acute COVID-19 Syndrome
Not yet recruitingPhase 2/3
A Pivotal Safety and Immunogenicity GBS-NN/NN2 Vaccine Maternal Immunisation Trial
Streptococcus Agalactiae Infection, Neonatal Sepsis
Active, not recruitingPhase 1
A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults
COVID-19
Enrolling by invitation
Personalized Ventilator Settings for Patients on ECMO
Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation
Not yet recruiting
Expanded Diagnostic Strategy in Older Adults Hospitalized With Community-Acquired Acute Respiratory Infection
Acute Respiratory Infection
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Asmaa Ahmed Abd El-samad, master's degree principal investigator
Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Respiratory neurophysiological facilitation techniques and conventional chest physical therapy in people with Pneumonia, run by Asmaa Ahmed Abd El-samad at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Arterial blood gases (time frame: At baseline (after enrollment and before the first chest physiotherapy session) and on day 5 after completing the fifth session, assessed within 5 days of enrollment). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Sep 2026.