NephrectomyNCT07071012
Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block
A study testing Bupivacaine, morphine and paracetamol in people with Nephrectomy and Pain Scores, run by Hacettepe University at 1 site in Turkey (Türkiye).
Trial summary
This study aims to compare the effects of external oblique intercostal block versus paravertebral block on postoperative pain and complications in patients undergoing open nephrectomy. Read more about this study
- Who is it for?
- Ages 18 to 90 years
- Conditions the study is for
- Nephrectomy, Pain Scores, Paravertebral Block
- What is being tested?
- Bupivacaine, morphine and paracetamol
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 98 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Aug 2025to 2 Feb 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 90 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged 18 to 90 years
- Scheduled for elective open radical nephrectomy for renal cell carcinoma
- ASA classification I-III
- Mini-Mental State Examination score ≥24
- Provided written informed consent
Who cannot join
- Neuropathy
- Hepatic failure
- Coagulopathy
- Local anesthetic allergy
- Mini-Mental State Examination score <24
- Refusal to participate
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Hacettepe University Faculty of Medicine Hospital
Ankara
About this study
Official title: Ultrasound-Guided Thoracic Paravertebral Block Versus External Oblique Intercostal Block for Postoperative Analgesia After Open Radical Nephrectomy: A Randomised Controlled Trial
This study aims to compare the effects of external oblique intercostal block versus paravertebral block on postoperative pain and complications in patients undergoing open nephrectomy.
- Being tested
- Bupivacaine, morphine, paracetamol, Diclofenac
- Keywords
- postoperative pain, nephrectomy, External oblique intercostal block, paravertebral block
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
BupivacaineDrug
Used for regional anesthesia during nephrectomy procedure (e.g., paravertebral or external oblique intercostal block)
morphineDrug
Used for postoperative pain control via PCA device
paracetamolDrug
Used as part of postoperative multimodal analgesia
DiclofenacDrug
Used as part of postoperative multimodal analgesia
| Study group | Role | What they receive |
|---|---|---|
| Paravertebral block | Active comparator | Patients scheduled to undergo thoracic paravertebral block will receive an injection of 20 ml of 0.25% bupivacaine hydrochloride into the paravertebral space between the parietal pleura and the costotransverse ligament using a block needle under ultrasound guidance. Receives: Drug: Bupivacaine; Drug: morphine; Drug: paracetamol; Drug: Diclofenac |
| External Oblique Intercostal Block | Active comparator | Patients scheduled to undergo an external oblique intercostal block will receive an injection of 30 ml of 0.25% bupivacaine hydrochloride between the external oblique muscle and the intercostal muscle at the level of the 6th rib, using a block needle under ultrasound guidance. Receives: Drug: Bupivacaine; Drug: morphine; Drug: paracetamol; Drug: Diclofenac |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative Pain Score
Pain intensity measured using Visual Analog Scale at rest. (Visual Analog Scale ranging from 0 = no pain to 10 = worst pain imaginable; higher scores indicate worse pain).
Measured: Up to 24 hours after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jul 2025
- Study start1 Aug 2025
- Primary completion1 Feb 2026
- Study completion2 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for NephrectomyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 98 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hacettepe University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Almıla Gulsun Pamuk, Hacettepe University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07071012
- Sponsor's protocol ID
- KA-24040
- Status last verified
- Mar 2026
- First submitted
- 6 Jul 2025
- Last updated
- 17 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Ultrasound-Guided Thoracic Paravertebral Block Versus External Oblique Intercostal Block for Postoperative Analgesia After Open Radical Nephrectomy: A Randomised Controlled Trial
- ClinicalTrials.gov ID
- NCT07071012
- Acronym / sponsor ID
- KA-24040
- Keywords
- postoperative pain, nephrectomy, External oblique intercostal block, paravertebral block
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 98 participants (actual)
- Lead sponsor
- Hacettepe UniversityUniversity, hospital or other
- Study start
- 1 Aug 2025 (actual)
- Primary completion
- 1 Feb 2026 (actual)
- Study completion
- 2 Feb 2026 (actual)
- First posted
- 17 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to compare the effects of external oblique intercostal block versus paravertebral block on postoperative pain and complications in patients undergoing open nephrectomy.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Paravertebral block | Active comparator | Drug: Bupivacaine, Drug: morphine, Drug: paracetamol, Drug: DiclofenacPatients scheduled to undergo thoracic paravertebral block will receive an injection of 20 ml of 0.25% bupivacaine hydrochloride into the paravertebral space between the parietal pleura and the costotransverse ligament using a block needle under ultrasound guidance. |
| External Oblique Intercostal Block | Active comparator | Drug: Bupivacaine, Drug: morphine, Drug: paracetamol, Drug: DiclofenacPatients scheduled to undergo an external oblique intercostal block will receive an injection of 30 ml of 0.25% bupivacaine hydrochloride between the external oblique muscle and the intercostal muscle at the level of the 6th rib, using a block needle under ultrasound guidance. |
Who may qualify
- Ages
- 18 to 90 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Aged 18 to 90 years
- Scheduled for elective open radical nephrectomy for renal cell carcinoma
- ASA classification I-III
- Mini-Mental State Examination score ≥24
- Provided written informed consent
Key exclusion criteria (6 listed)
- Neuropathy
- Hepatic failure
- Coagulopathy
- Local anesthetic allergy
- Mini-Mental State Examination score <24
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| BupivacaineUsed for regional anesthesia during nephrectomy procedure (e.g., paravertebral or external oblique intercostal block) | Drug | External Oblique Intercostal Block, Paravertebral block |
| morphineUsed for postoperative pain control via PCA device | Drug | External Oblique Intercostal Block, Paravertebral block |
| paracetamolUsed as part of postoperative multimodal analgesia | Drug | External Oblique Intercostal Block, Paravertebral block |
| DiclofenacUsed as part of postoperative multimodal analgesia | Drug | External Oblique Intercostal Block, Paravertebral block |
Primary outcome
Postoperative Pain Score
Time frame: Up to 24 hours after surgery
Pain intensity measured using Visual Analog Scale at rest. (Visual Analog Scale ranging from 0 = no pain to 10 = worst pain imaginable; higher scores indicate worse pain).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Mar 2026.
- Individual participant dataSharing planned: No
Related trials for Nephrectomy
Recruiting
Implementation of a Pain Management Plan in Major Open Abdominal Surgeries.
Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H)
Not yet recruitingObservational study
Hugo™ RAS Urology Post-Market Clinical Study
Prostatectomy, Cystectomy
Active, not recruitingPhase 2
Upfront Immune Checkpoint Inhibitors With Deferred Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma
Immune Checkpoint Inhibitors, Cytoreductive Nephrectomy
Active, not recruitingPhase 2
NSAID Use After Robotic Partial Nephrectomy
Kidney Cancer, Renal Cancer
Recruiting
Effect of Non-Clamping and Sutureless Technique on Postoperative Renal Function in Robot-Assisted Partial Nephrectomy
Renal Neoplasms, Localized Kidney Tumors
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Bupivacaine, morphine and paracetamol in people with Nephrectomy and Pain Scores, run by Hacettepe University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative Pain Score (time frame: Up to 24 hours after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Mar 2026.