Aerobic Exercise Phoenix Seed, Antioxidant PotentialNCT07073716
TAC, SOD and MDA Responses to Aerobic Exercise Versus Phoenix Seed in Obese Sedentary Females
A study testing aerobic exercise, phoenix seed and aerobic exercise+ phoenix seed in people with Aerobic Exercise Phoenix Seed, Antioxidant Potential, run by Cairo University.
Trial summary
the aim of this study is To assess the antioxidant potential by measuring TAC, SOD and MDA responses to aerobic exercise versus phoenix seed in 60 obese sedentary females with symptoms of systemic inflammation. Read more about this study
- Who is it for?
- Ages 35 to 55 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Aerobic Exercise Phoenix Seed, Antioxidant Potential
- What is being tested?
- aerobic exercise, phoenix seed and aerobic exercise+ phoenix seed
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- No sites listed yet
- Study dates
- 10 Jul 2025to 10 Nov 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 35 to 55 years
- Women only
- Healthy volunteers accepted
- Adult
Inclusion Criteria: sedentary obese female aged 35-55 years old with BMI of 30-39.9 and some symptoms of systemic inflammation (˃75 score at the inflammatory questionnaire) and had none of the exclusion criteria could be included in this study.
-
Exclusion Criteria: patients with orthopaedic or cardiac or any health condition that could interfere the ability to walk or exercise
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
Zainab Saeed Aly, lecturer at Horus university contact
About this study
the aim of this study is To assess the antioxidant potential by measuring TAC, SOD and MDA responses to aerobic exercise versus phoenix seed in 60 obese sedentary females with symptoms of systemic inflammation. • All subjects will follow the given instructions strictly during the study duration, regarding the assessment and the treatment procedure, all participants will be evaluated under the same environmental conditions
Read the detailed description
reactive oxygen species (ROS) are generated as metabolic by-products by biological systems during Processes like protein phosphorylation, activation of several transcriptional factors, apoptosis, immunity, and differentiation. When ROS production increases, they start showing harmful effects on important cellular structures like proteins, lipids, and nucleic acids. A large body of evidences shows that oxidative stress can be responsible, with different degrees of importance in the onset and/or progression of several diseases as cancer, diabetes, metabolic disorders, atherosclerosis, and cardiovascular diseases.
Date seed is a waste product that is high in polyphenolics (a mjor antioxidant compounds), phenolicacid (allergic, epicatechin, catechol,chlorogenic), carotenoids, total dietary fiber (such as pectin, β-glucan, and arabinoxylan), fat, protein, minerals, and various other nutrients and functional elements Phytosterols as β-sitosterol, campesterol, and Δ5-avenasterol are The major components of date seed oil sterols (contents varied between 4.70 and 8.45 mg/g) are important micronutrients and essential structural components of the cellular membrane.they serve crucial functions, such as modulating membrane permeability and fluidity, antioxidant activity , cholesterol-lowering effects and anti-inflammatory properties in addition to their putative contribution to reducing the risk of cardiovascular diseases and affording benefits to the immune system.
Physical activity improves antioxidant defences, lowers lipid peroxidation levels and involved in the protection from cardiovascular disorders, type II diabetes, metabolic syndrome and neurodegenerative diseases like Alzheimer's disease both in adult and in aged individuals. Thus emphasizing the importance of regular physical activity to decelerate the aging-associated impairment process.
Myokines,the bioactive peptides released by skeletal muscle following exercise as acrucial regulator of metabolic and protective pathways in peripheral tissues, particularly in combating oxidative stress and inflammation through activating intracellular signalling pathways within the liver that are involved in the liver's antioxidant defences.
this study aims to compare between aerobic exercise and phoenix seed in their antioxidant potential.
- Being tested
- aerobic exercise, phoenix seed, aerobic exercise+ phoenix seed
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
aerobic exerciseOther
the exercise protocol was applied following these characteristics
- frequency: 3-5 times /week along the whole study period
- intensity: 70% of the maximal heart rate (220- age x 70/100)
- duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers and the researcher. The researcher controlled the heartbeat 2 times through carotid pulse and At the end in order to restore the body to its initial state. all the patients could drink water during their training.
phoenix seedDietary supplement
consuming 2 grams of phoenix seed powder dissolved in about 100 ml water 3 times/day
aerobic exercise+ phoenix seedCombination product
a specialized programme of aerobic exercise.the exercise protocol follow these characteristics
- frequency: 3-5 times /week along the whole study period
- intensity: 70% of the maximal heart rate (220- age x 70/100)
- duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers and the researcher. The researcher controlled the heartbeat 2 times through carotid pulse and At the end in order to restore the body to its initial state. all the patients could drink water during their training. the specialized program of phoenix seed consumption (consuming 2 grams of phoenix seed powder dissolved in about 100 ml water 3 times/day)
| Study group | Role | What they receive |
|---|---|---|
| Aerobic exercise | Experimental | 20 subjects performed a specialized program of aerobic exercise with frequency of 3-5 times /week Receives: Other: aerobic exercise |
| phoenix seed | Experimental | 20 subjects performed specialized program of phoenix seed consumption Receives: Dietary Supplement: phoenix seed |
| Aerobic exercise and phoenix seed | Experimental | 20 subjects performed the same program of aerobic exercise with same frequency of 3-5 times /weeks combined with the same program of phoenix seed consumption Receives: Combination Product: aerobic exercise+ phoenix seed |
What is being measured
The primary outcome is the main question the study is designed to answer.
TAC or total antioxidant capacity (blood test)
TAC: Determines the total antioxidant capacity of biological samples as a valuable approach to measuring health status under oxidative stress conditions,
Measured: test applied before and after 2 months of the intervention protocol
SOD (superoxide dismutase)
a blood test to determine the amount of SOD in blood and giving a good idea of the overall superoxide detoxifying capacity of a cell or tissue
Measured: Pre- intervention and after 8 weeks of treatment
MDA (malondialdehyde)
blood test that measures Malondialdehyde (MDA) level as a marker of oxidative stress and a contributor to all major diseases by determining the impact of oxidation in normal and cancer cells.
Measured: Pre- intervention and after 8 weeks of treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Jul 2025
- Study start10 Jul 2025 (estimated)
- Primary completion10 Oct 2025 (estimated)
- Study completion10 Nov 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Aerobic Exercise Phoenix Seed, Antioxidant PotentialStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Zainab Saeed Aly, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07073716
- Sponsor's protocol ID
- R.T.REC/012/005432
- Status last verified
- Jul 2025
- First submitted
- 10 Jul 2025
- Last updated
- 18 Jul 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 18 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- TAC, SOD and MDA Responses to Aerobic Exercise Versus Phoenix Seed in Obese Sedentary Females
- ClinicalTrials.gov ID
- NCT07073716
- Acronym / sponsor ID
- R.T.REC/012/005432
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 10 Jul 2025 (estimated)
- Primary completion
- 10 Oct 2025 (estimated)
- Study completion
- 10 Nov 2025 (estimated)
- First posted
- 18 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
the aim of this study is To assess the antioxidant potential by measuring TAC, SOD and MDA responses to aerobic exercise versus phoenix seed in 60 obese sedentary females with symptoms of systemic inflammation. • All subjects will follow the given instructions strictly during the study duration, regarding the assessment and the treatment procedure, all participants will be evaluated under the same environmental conditions
Detailed description
reactive oxygen species (ROS) are generated as metabolic by-products by biological systems during Processes like protein phosphorylation, activation of several transcriptional factors, apoptosis, immunity, and differentiation. When ROS production increases, they start showing harmful effects on important cellular structures like proteins, lipids, and nucleic acids. A large body of evidences shows that oxidative stress can be responsible, with different degrees of importance in the onset and/or progression of several diseases as cancer, diabetes, metabolic disorders, atherosclerosis, and cardiovascular diseases.
Date seed is a waste product that is high in polyphenolics (a mjor antioxidant compounds), phenolicacid (allergic, epicatechin, catechol,chlorogenic), carotenoids, total dietary fiber (such as pectin, β-glucan, and arabinoxylan), fat, protein, minerals, and various other nutrients and functional elements Phytosterols as β-sitosterol, campesterol, and Δ5-avenasterol are The major components of date seed oil sterols (contents varied between 4.70 and 8.45 mg/g) are important micronutrients and essential structural components of the cellular membrane.they serve crucial functions, such as modulating membrane permeability and fluidity, antioxidant activity , cholesterol-lowering effects and anti-inflammatory properties in addition to their putative contribution to reducing the risk of cardiovascular diseases and affording benefits to the immune system.
Physical activity improves antioxidant defences, lowers lipid peroxidation levels and involved in the protection from cardiovascular disorders, type II diabetes, metabolic syndrome and neurodegenerative diseases like Alzheimer's disease both in adult and in aged individuals. Thus emphasizing the importance of regular physical activity to decelerate the aging-associated impairment process.
Myokines,the bioactive peptides released by skeletal muscle following exercise as acrucial regulator of metabolic and protective pathways in peripheral tissues, particularly in combating oxidative stress and inflammation through activating intracellular signalling pathways within the liver that are involved in the liver's antioxidant defences.
this study aims to compare between aerobic exercise and phoenix seed in their antioxidant potential.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Aerobic exercise | Experimental | Other: aerobic exercise20 subjects performed a specialized program of aerobic exercise with frequency of 3-5 times /week |
| phoenix seed | Experimental | Dietary Supplement: phoenix seed20 subjects performed specialized program of phoenix seed consumption |
| Aerobic exercise and phoenix seed | Experimental | Combination Product: aerobic exercise+ phoenix seed20 subjects performed the same program of aerobic exercise with same frequency of 3-5 times /weeks combined with the same program of phoenix seed consumption |
Who may qualify
- Ages
- 35 to 55 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| aerobic exercisethe exercise protocol was applied following these characteristics * frequency: 3-5 times /week along the whole study period * intensity: 70% of the maximal heart rate (220- age x 70/100) * duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers and the researcher. The researcher controlled the heartbeat 2 times through carotid pulse and At the end in order to restore the body to its initial state. all the patients could drink water during their training. | Other | Aerobic exercise |
| phoenix seedconsuming 2 grams of phoenix seed powder dissolved in about 100 ml water 3 times/day | Dietary supplement | phoenix seed |
| aerobic exercise+ phoenix seeda specialized programme of aerobic exercise.the exercise protocol follow these characteristics * frequency: 3-5 times /week along the whole study period * intensity: 70% of the maximal heart rate (220- age x 70/100) * duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers and the researcher. The researcher controlled the heartbeat 2 times through carotid pulse and At the end in order to restore the body to its initial state. all the patients could drink water during their training. the specialized program of phoenix seed consumption (consuming 2 grams of phoenix seed powder dissolved in about 100 ml water 3 times/day) | Combination product | Aerobic exercise and phoenix seed |
Primary outcome
TAC or total antioxidant capacity (blood test)
Time frame: test applied before and after 2 months of the intervention protocol
TAC: Determines the total antioxidant capacity of biological samples as a valuable approach to measuring health status under oxidative stress conditions,
SOD (superoxide dismutase)
Time frame: Pre- intervention and after 8 weeks of treatment
a blood test to determine the amount of SOD in blood and giving a good idea of the overall superoxide detoxifying capacity of a cell or tissue
MDA (malondialdehyde)
Time frame: Pre- intervention and after 8 weeks of treatment
blood test that measures Malondialdehyde (MDA) level as a marker of oxidative stress and a contributor to all major diseases by determining the impact of oxidation in normal and cancer cells.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Jul 2025.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Zainab Saeed Aly, lecturer at Horus university contact
Questions about this trial
What is this clinical trial studying?
A study testing aerobic exercise, phoenix seed and aerobic exercise+ phoenix seed in people with Aerobic Exercise Phoenix Seed, Antioxidant Potential, run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 18 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Zainab Saeed Aly, lecturer at Horus university (+201003859679 ext. 01285512452, zaly@horus.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
TAC or total antioxidant capacity (blood test) (time frame: test applied before and after 2 months of the intervention protocol). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Jul 2025.