HemodialysisNCT07076888
Aerobic Exercises and Hemodialysis Patients
A study testing Aerobic Exercises and Conventional Program in people with Hemodialysis, run by Cairo University at 1 site in Egypt.
Trial summary
Patients undergoing hemodialysis (HD) frequently exhibit elevated serum uric acid (SUA) levels, which are associated with cardiovascular risks, joint issues, and diminished quality of life (QoL). Read more about this study
- Who is it for?
- Ages 40 to 60 years
- Conditions the study is for
- Hemodialysis
- What is being tested?
- Aerobic Exercises and Conventional Program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 32 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Aug 2025to 20 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Hemodialysis patients aged 40-60years
- Patients are medically stable and able to participate in physical activity.
- Participants are able to understand the commands.
- Participants must be stable on hemodialysis for at least 3 months.
Who cannot join
- Patients with significant cardiovascular or respiratory diseases, or other conditions that could impair their ability to exercise.
- Severe cognitive impairment or psychiatric conditions that could interfere with study participation.
- patients with acute medical conditions.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Impact of Aerobic Exercises on Serum Uric Acid Levels in Hemodialysis Patients
Patients undergoing hemodialysis (HD) frequently exhibit elevated serum uric acid (SUA) levels, which are associated with cardiovascular risks, joint issues, and diminished quality of life (QoL). Aerobic exercise has been shown to improve cardiovascular health and reduce SUA levels in various populations, suggesting potential benefits for HD patients.
Objective: This study aimed to investigate the impact of aerobic exercise on serum uric acid (SUA) levels, functional capacity, and quality of life (QoL) in patients undergoing hemodialysis (HD).
Methods: This randomized controlled trial will recruit 32 participants, aged 40-60, undergoing HD. The intervention group (Group A) will participate in a structured 6-week aerobic exercise program, while the control group (Group B) will receive only conventional physical therapy. Pre- and post-intervention assessments included SUA levels, the Six-Minute Walk Test (6MWT), and the Kidney Disease Quality of Life Short Form (KDQOL-SF™)
Read the detailed description
32 Subjects of both genders will participate in this study at El-khazendara Hospitals with age ranged between (40-60) years old. They will receive a comprehensive verbal and written explanation of the study, including its objectives, procedures, and potential benefits.
participants will randomly assigned into two equal groups using a sealed-envelope randomization method to ensure unbiased allocation.
- Group A (study Group): 16 HD patients receiving a conventional physical therapy program (breathing, stretching, and lower limb circulatory exercises) plus the aerobic exercise program.
- Group B (Control Group): 16 HD patients receiving only the conventional physical therapy program. 6-weeks of aerobic exercise program (3 sessions per week, 20-45 minutes each session)
Outcome measures include:
- Serum Uric Acid: Measured using an automated biochemistry analyzer, with results reported in mg/dL.
- Functional Capacity: Assessed using the Six-Minute Walk Test (6MWT), a validated tool used to evaluate exercise tolerance and endurance in clinical populations.
- Quality of Life:Measured using the Kidney Disease Quality of Life Short Form (KDQOL-SF™) Arabic Version, which assesses various domains related to both physical and mental health.
- Conditions
- Hemodialysis
- Being tested
- Aerobic Exercises, Conventional Program
- Keywords
- Aerobic exercise, hemodialysis, serum uric acid, quality of life
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Aerobic ExercisesOther
- Timing of Exercise: Aerobic exercises were performed on non-dialysis days. This scheduling avoids post-dialysis fatigue and hypotensive effects, optimizing patient safety and performance.
- Frequency: Patients was engaged in aerobic exercise 3 times per week on non-consecutive days, to allow sufficient recovery time between sessions.
- Duration of Each Session:
- Total Duration: Each exercise session was last between 20 to 45 minutes.
- Warm-Up: 5-10 minutes of low-intensity activity (e.g., slow walking).
- Main Exercise: 15-30 minutes of moderate-intensity aerobic exercise.
- Cool-Down:*5-10 minutes of gradual reduction in intensity.
- Exercise Modality:
- Options: Patients may choose between treadmill walking or using a stationary bike, depending on their preference, physical condition.
- Variety: To maintain engagement and reduce monotony, patients can alternate between treadmill and bike exercises.
- Intensity:
Use moderate-intensity exercise, aiming for 60-70% of the p
Conventional ProgramOther
- Breathing Exercises
- Diaphragmatic Breathing: Instruct patients to place one hand on their chest and the other on their abdomen. They should inhale deeply through their nose, allowing the abdomen to rise, and then exhale slowly through their mouth. This breathing technique has been shown to reduce stress, improve respiratory efficiency, and enhance relaxation . For optimal benefits, patients should practice this for 5-10 minutes, 2-3 times a day.
Stretching Exercises Hamstring Stretch: Instruct patients to sit with one leg extended straight out in front of them and the other leg bent. They should reach towards the toes of the extended leg while keeping their back straight. Hold the stretch for 20-30 seconds and repeat the stretch 2-3 times per leg.
Lower Limb Circulatory Exercises Ankle Pumps: While lying down or seated, instruct patients to alternately point and flex their feet to stimulate circulation and improve lower leg mobility. Perform 20-30 pumps per foot, 2-3 times a day
| Study group | Role | What they receive |
|---|---|---|
| Group A | Experimental | Group A (study Group): 16 HD patients received a conventional physical therapy program (breathing, stretching, and lower limb circulatory exercises) combined with the aerobic exercise program. Receives: Other: Aerobic Exercises; Other: Conventional Program |
| Group B | Active comparator | Group B (Control Group): 16 HD patients received only the conventional physical therapy program. Receives: Other: Conventional Program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Serum Uric Acid
Measured: from enrollment to the end of 6 weeks of treatment
Secondary outcomes (2)
Change in Functional ability of the patient
Assessed by using the Six-Minute Walk Test (6MWT), a validated tool used to evaluate exercise tolerance and endurance in clinical populations.
Measured: from enrollment to the end of 6 weeks of treatment
Change in Quality of life
Kidney Disease Quality of Life Short Form (KDQOL-SF™): The KDQOL-SF™ is a key tool used to assess the quality of life in patients with chronic kidney disease, particularly those undergoing hemodialysis. This version of the questionnaire measures multiple domains, including physical functioning, emotional well-being, and social roles, with a focus on issues specific to kidney disease such as symptoms, work status, and patient satisfaction. The scores are transformed into a scale from 0 to 100, with higher scores indicating a better quality of life
Measured: from enrollment to the end of 6 weeks of treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jul 2025
- Study start1 Aug 2025
- Primary completion1 Dec 2025
- Study completion20 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HemodialysisStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 32 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Doaa Rafat, Cairo University
- Investigators
- Heba Elfeky Lecturer of physical therapy - Cairo University, lecturer, Study director, Department of Basic sciences for physical therapy, Faculty of Physical Therapy , Cairo university, Cairo, Egypt
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07076888
- Sponsor's protocol ID
- P.T.REC/025/00123
- Status last verified
- Nov 2025
- First submitted
- 10 Jun 2025
- Last updated
- 15 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Aerobic Exercises on Serum Uric Acid Levels in Hemodialysis Patients
- ClinicalTrials.gov ID
- NCT07076888
- Acronym / sponsor ID
- P.T.REC/025/00123
- Conditions
- Hemodialysis
- Keywords
- Aerobic exercise, hemodialysis, serum uric acid, quality of life
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 32 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Aug 2025 (actual)
- Primary completion
- 1 Dec 2025 (actual)
- Study completion
- 20 Dec 2025 (actual)
- First posted
- 22 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Patients undergoing hemodialysis (HD) frequently exhibit elevated serum uric acid (SUA) levels, which are associated with cardiovascular risks, joint issues, and diminished quality of life (QoL). Aerobic exercise has been shown to improve cardiovascular health and reduce SUA levels in various populations, suggesting potential benefits for HD patients.
Objective: This study aimed to investigate the impact of aerobic exercise on serum uric acid (SUA) levels, functional capacity, and quality of life (QoL) in patients undergoing hemodialysis (HD).
Methods: This randomized controlled trial will recruit 32 participants, aged 40-60, undergoing HD. The intervention group (Group A) will participate in a structured 6-week aerobic exercise program, while the control group (Group B) will receive only conventional physical therapy. Pre- and post-intervention assessments included SUA levels, the Six-Minute Walk Test (6MWT), and the Kidney Disease Quality of Life Short Form (KDQOL-SF™)
Detailed description
32 Subjects of both genders will participate in this study at El-khazendara Hospitals with age ranged between (40-60) years old. They will receive a comprehensive verbal and written explanation of the study, including its objectives, procedures, and potential benefits.
participants will randomly assigned into two equal groups using a sealed-envelope randomization method to ensure unbiased allocation.
- Group A (study Group): 16 HD patients receiving a conventional physical therapy program (breathing, stretching, and lower limb circulatory exercises) plus the aerobic exercise program.
- Group B (Control Group): 16 HD patients receiving only the conventional physical therapy program. 6-weeks of aerobic exercise program (3 sessions per week, 20-45 minutes each session)
Outcome measures include:
- Serum Uric Acid: Measured using an automated biochemistry analyzer, with results reported in mg/dL.
- Functional Capacity: Assessed using the Six-Minute Walk Test (6MWT), a validated tool used to evaluate exercise tolerance and endurance in clinical populations.
- Quality of Life:Measured using the Kidney Disease Quality of Life Short Form (KDQOL-SF™) Arabic Version, which assesses various domains related to both physical and mental health.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A | Experimental | Other: Aerobic Exercises, Other: Conventional ProgramGroup A (study Group): 16 HD patients received a conventional physical therapy program (breathing, stretching, and lower limb circulatory exercises) combined with the aerobic exercise program. |
| Group B | Active comparator | Other: Conventional ProgramGroup B (Control Group): 16 HD patients received only the conventional physical therapy program. |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Hemodialysis patients aged 40-60years
- Patients are medically stable and able to participate in physical activity.
- Participants are able to understand the commands.
- Participants must be stable on hemodialysis for at least 3 months.
Key exclusion criteria (3 listed)
- Patients with significant cardiovascular or respiratory diseases, or other conditions that could impair their ability to exercise.
- Severe cognitive impairment or psychiatric conditions that could interfere with study participation.
- patients with acute medical conditions.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Aerobic Exercises1. Timing of Exercise: Aerobic exercises were performed on non-dialysis days. This scheduling avoids post-dialysis fatigue and hypotensive effects, optimizing patient safety and performance. 2. Frequency: Patients was engaged in aerobic exercise 3 times per week on non-consecutive days, to allow sufficient recovery time between sessions. 3. Duration of Each Session: * Total Duration: Each exercise session was last between 20 to 45 minutes. * Warm-Up: 5-10 minutes of low-intensity activity (e.g., slow walking). * Main Exercise: 15-30 minutes of moderate-intensity aerobic exercise. * Cool-Down:*5-10 minutes of gradual reduction in intensity. 4. Exercise Modality: * Options: Patients may choose between treadmill walking or using a stationary bike, depending on their preference, physical condition. * Variety: To maintain engagement and reduce monotony, patients can alternate between treadmill and bike exercises. 5. Intensity: Use moderate-intensity exercise, aiming for 60-70% of the p | Other | Group A |
| Conventional Program1. Breathing Exercises - Diaphragmatic Breathing: Instruct patients to place one hand on their chest and the other on their abdomen. They should inhale deeply through their nose, allowing the abdomen to rise, and then exhale slowly through their mouth. This breathing technique has been shown to reduce stress, improve respiratory efficiency, and enhance relaxation . For optimal benefits, patients should practice this for 5-10 minutes, 2-3 times a day. Stretching Exercises Hamstring Stretch: Instruct patients to sit with one leg extended straight out in front of them and the other leg bent. They should reach towards the toes of the extended leg while keeping their back straight. Hold the stretch for 20-30 seconds and repeat the stretch 2-3 times per leg. Lower Limb Circulatory Exercises Ankle Pumps: While lying down or seated, instruct patients to alternately point and flex their feet to stimulate circulation and improve lower leg mobility. Perform 20-30 pumps per foot, 2-3 times a day | Other | Group A, Group B |
Primary outcome
Serum Uric Acid
Time frame: from enrollment to the end of 6 weeks of treatment
2 secondary outcomes
Change in Functional ability of the patient
Time frame: from enrollment to the end of 6 weeks of treatment
Change in Quality of life
Time frame: from enrollment to the end of 6 weeks of treatment
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Heba Elfeky Lecturer of physical therapy - Cairo University, lecturer study director
Department of Basic sciences for physical therapy, Faculty of Physical Therapy , Cairo university, Cairo, Egypt
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Aerobic Exercises and Conventional Program in people with Hemodialysis, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Serum Uric Acid (time frame: from enrollment to the end of 6 weeks of treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Sep 2026.