Implant FailureNCT07078890
Effect of Bone Augmentation Simultaneous to Implant Removal on the Prognosis of Reimplantation at the Same Site
A study testing bone augmentation simultaneous to implant removal in people with Implant Failure and Bone Augmentation, run by The Dental Hospital of Zhejiang University School of Medicine at 3 sites in China.
Trial summary
The aim of this study was to investigate the effect of bone augmentation simultaneous to implant removal on the prognosis of reimplantation at the same sites, providing recommendations for management strategies after failed implant removal. Read more about this study
- Who is it for?
- Ages 18 to 90 years
- Conditions the study is for
- Implant Failure, Bone Augmentation, Prognosis
- What is being tested?
- bone augmentation simultaneous to implant removal
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 3 sitesChina
- Study dates
- 12 Mar 2025to Aug 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 90 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- 1. Age greater than 18 years 2. Implant failure requiring removal 3. Plan to reimplant in the same site 4. Periodontal health, or stabilized periodontitis after treatment
Who cannot join
- 1. Uncontrolled metabolic diseases 2. Taking medications that have an effect on bone metabolism 3. The implant has detached at the time of consultation 4. Do not consent to reimplant in the same site 5. Unwillingness to participate in the follow-up of this study 6. Other conditions that do not qualify for implant therapy
Trial locations and contacts
3 sites in 1 country. Contact the study team or a site near you to ask about taking part.
China3 sites, 3 recruiting
- Recruiting
The Affiliated Stomatology Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310000
Misi Si, +86 18605712858, misi_si@zju.edu.cn
- Recruiting
Shanghai Stomatological Hospital
Shanghai, 200001
Chenghui Qian, +86 13818062933, chenghui_qian@fudan.edu.cn
- Recruiting
Hospital of Stomatology, Wuhan University
Wuhan, Hubei, 430079
Qi Yan, +86 13995544537, yanqi@whu.edu.cn
About this study
The aim of this study was to investigate the effect of bone augmentation simultaneous to implant removal on the prognosis of reimplantation at the same sites, providing recommendations for management strategies after failed implant removal.
Read the detailed description
The study aims to compare the radiographic and clinical indicators between bone augmentation simultaneous to implant removal and natural healing after implant removal, thus evaluate the effect on the prognosis of reimplantation. At the same time, patients with implant failure were also retrospectively collected to investigate the factors influencing the prognosis of bone healing and reimplantation after implant failure.
- Conditions
- Implant Failure, Bone Augmentation, Prognosis
- Being tested
- bone augmentation simultaneous to implant removal
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
bone augmentation simultaneous to implant removalProcedure or surgery
Placement of bone substitutes in the socket simultaneous to implant removal, and reimplantation is performed after 6 months of healing.
| Study group | Role | What they receive |
|---|---|---|
| Bone augmentation simultaneous to implant removal | Experimental | Placement of bone substitutes in the socket simultaneous to implant removal, and reimplantation is performed after 6 months of healing. Receives: Procedure: bone augmentation simultaneous to implant removal |
| Natural healing after implant removal | No intervention | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Ridge Height (RH)
Two reference lines were established for the radiological analysis: the longitudinal axis of the implant and a line perpendicular to this axis and tangential to a reference point (sinus floor in the maxilla and mandibular base in the mandible).Ridge height (RH) in mm, defined as the distance between the tangential reference line and the most coronal point of the bone crest, assessed buccal (B-RH) and lingual (L-RH).
Measured: Before implant removal and 6 months after implant removal
Secondary outcomes (8)
Ridge Width (RW)
Two reference lines were established for the radiological analysis: the longitudinal axis of the implant and a line perpendicular to this axis and tangential to a reference point (sinus floor in the maxilla and mandibular base in the mandible).Ridge width (RW) in mm, recorded at 1, 3, and 5 mm from the bone crest. In the event of discrepancy between the buccal and lingual bone crests, the most apical one was chosen as reference.
Measured: Before implant removal and 6 months after implant removal
Bone Plate Thickness (BPT)
Two reference lines were established for the radiological analysis: the longitudinal axis of the implant and a line perpendicular to this axis and tangential to a reference point (sinus floor in the maxilla and mandibular base in the mandible).Bone plate thickness (BPT) in mm, assessed at 1, 3, 5, and 7 mm below the crest and measured buccal and lingual.
Measured: Before implant removal and 6 months after implant removal
Bone Mineral Density(BMD)
Bone density in the socket 6 months after implant removal
Measured: 6 months after implant removal
Inserting Torque(IT)
Measured: Replantation surgery
Implant Survival Rate(SVR)
Measured: 6 months and 12 months after restoration
Probing Depth
Measured: 6 months and 12 months after restoration
Bleeding On Probing（BOP）
Measured: 6 months and 12 months after restoration
Marginal Bone Loss(MBL)
MBL was defined as the linear distance (in mm) measured at both the proximal and distal mesial planes from the most coronal point of the surrounding bone to the cervical plane of the implant.
Measured: 6 months and 12 months after restoration
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jul 2025
- Study start12 Mar 2025
- Primary completionMar 2027 (estimated)
- Study completionAug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Implant FailureStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- The Dental Hospital of Zhejiang University School of Medicine
- Sponsor type
- University, hospital or other
- Collaborators
- Hospital of Stomatology, Wuhan University, Shanghai Stomotological Hospital
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07078890
- Sponsor's protocol ID
- 2025-025
- Status last verified
- Jul 2025
- First submitted
- 13 Jul 2025
- Last updated
- 22 Jul 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Bone Augmentation Simultaneous to Implant Removal on the Prognosis of Reimplantation at the Same Site
- ClinicalTrials.gov ID
- NCT07078890
- Acronym / sponsor ID
- 2025-025
- Conditions
- Implant Failure, Bone Augmentation, Prognosis
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- The Dental Hospital of Zhejiang University School of MedicineUniversity, hospital or other
- Collaborators
- Hospital of Stomatology, Wuhan University, Shanghai Stomotological Hospital
- Study start
- 12 Mar 2025 (actual)
- Primary completion
- Mar 2027 (estimated)
- Study completion
- Aug 2027 (estimated)
- First posted
- 22 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study was to investigate the effect of bone augmentation simultaneous to implant removal on the prognosis of reimplantation at the same sites, providing recommendations for management strategies after failed implant removal.
Detailed description
The study aims to compare the radiographic and clinical indicators between bone augmentation simultaneous to implant removal and natural healing after implant removal, thus evaluate the effect on the prognosis of reimplantation. At the same time, patients with implant failure were also retrospectively collected to investigate the factors influencing the prognosis of bone healing and reimplantation after implant failure.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Bone augmentation simultaneous to implant removal | Experimental | Procedure: bone augmentation simultaneous to implant removalPlacement of bone substitutes in the socket simultaneous to implant removal, and reimplantation is performed after 6 months of healing. |
| Natural healing after implant removal | No intervention | – |
Who may qualify
- Ages
- 18 to 90 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- 1. Age greater than 18 years 2. Implant failure requiring removal 3. Plan to reimplant in the same site 4. Periodontal health, or stabilized periodontitis after treatment
Key exclusion criteria (1 listed)
- 1. Uncontrolled metabolic diseases 2. Taking medications that have an effect on bone metabolism 3. The implant has detached at the time of consultation 4. Do not consent to reimplant in the same site 5. Unwillingness to participate in the follow-up of this study 6. Other conditions that do not qualify for implant therapy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| bone augmentation simultaneous to implant removalPlacement of bone substitutes in the socket simultaneous to implant removal, and reimplantation is performed after 6 months of healing. | Procedure or surgery | Bone augmentation simultaneous to implant removal |
Primary outcome
Ridge Height (RH)
Time frame: Before implant removal and 6 months after implant removal
Two reference lines were established for the radiological analysis: the longitudinal axis of the implant and a line perpendicular to this axis and tangential to a reference point (sinus floor in the maxilla and mandibular base in the mandible).Ridge height (RH) in mm, defined as the distance between the tangential reference line and the most coronal point of the bone crest, assessed buccal (B-RH) and lingual (L-RH).
8 secondary outcomes
Ridge Width (RW)
Time frame: Before implant removal and 6 months after implant removal
Bone Plate Thickness (BPT)
Time frame: Before implant removal and 6 months after implant removal
Bone Mineral Density(BMD)
Time frame: 6 months after implant removal
Inserting Torque(IT)
Time frame: Replantation surgery
Implant Survival Rate(SVR)
Time frame: 6 months and 12 months after restoration
Probing Depth
Time frame: 6 months and 12 months after restoration
Bleeding On Probing（BOP）
Time frame: 6 months and 12 months after restoration
Marginal Bone Loss(MBL)
Time frame: 6 months and 12 months after restoration
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jul 2025.
Related trials for Implant Failure
Active, not recruiting
Assessment of Combined CCM and ICD Device in HFrEF
Heart Failure, Heart Failure With Reduced Ejection Fraction
Not yet recruiting
Safety Assessment of Placing a Single Dental Implant Without Antibiotic Prophylaxis in Simple Cases: A Pilot Study
Tooth Loss and Rehabillitation, Dental Implant Failure
RecruitingObservational study
dPmax for Predicting Right Ventricular Failure After Left Ventricular Assist Device Implantation
Ventricular Dysfunction, Right
RecruitingObservational study
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
Arrhythmia, Bradycardia
Recruiting
Post Market Study for VasQ, an External Support Implant for Arteriovenous Fistula
End Stage Renal Disease
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
3 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing bone augmentation simultaneous to implant removal in people with Implant Failure and Bone Augmentation, run by The Dental Hospital of Zhejiang University School of Medicine at 3 sites in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 22 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 3 sites in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Misi Si (+86 18605712858, misi_si@zju.edu.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Ridge Height (RH) (time frame: Before implant removal and 6 months after implant removal). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jul 2025.