Dual Subsartorial BlockNCT07082374
Dual Subsartorial Versus Adductor Canal Block Versus Femoral Nerve Block for Postoperative Analgesia in Patients Undergoing Total Knee Arthroplasty
A study testing Dual subsartorial block, Adductor canal block and Femoral nerve block in people with Dual Subsartorial Block and Adductor Canal Block, run by Tanta University at 1 site in Egypt.
Trial summary
This study aims to compare the effect of dual subsartorial block (DSB), adductor canal block (ACB), and femoral nerve block (FNB) for postoperative analgesia in patients undergoing total knee arthroplasty (TKA). Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Dual Subsartorial Block, Adductor Canal Block, Femoral Nerve Block
- What is being tested?
- Dual subsartorial block, Adductor canal block and Femoral nerve block
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteEgypt
- Study dates
- 24 Jul 2025to 1 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age from 18 to 75 years.
- Both sexes.
- American Society of Anesthesiology (ASA) physical status I-II.
- Undergoing total knee arthroplasty (TKA) under general anesthesia.
Who cannot join
- Severe valgus deformity.
- Acute/chronic kidney disease.
- Neurological deficit.
- Cognitive dysfunction.
- Local infection at the site of injection.
- Coagulopathy.
Show all 9Show fewer
- Hypersensitivity and/or allergies to local anesthetic (LA) or any of the study medications.
- Chronic opioid consumption (daily or almost daily use of opioids for > three months).
- Operative limb neuropathy.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Dual Subsartorial Block Versus Adductor Canal Block Versus Femoral Nerve Block for Postoperative Analgesia in Patients Undergoing Total Knee Arthroplasty: A Randomized Clinical Trial
This study aims to compare the effect of dual subsartorial block (DSB), adductor canal block (ACB), and femoral nerve block (FNB) for postoperative analgesia in patients undergoing total knee arthroplasty (TKA).
Read the detailed description
Total knee arthroplasty (TKA) offers increased joint mobility and painless ambulation to patients. Femoral nerve block (FNB) is commonly used to relieve postoperative pain and opioid consumption.
Adductor canal block (ACB) is a common analgesic intervention for postoperative pain control following TKA. The dual subsartorial block (DSB) is a novel procedure-specific and motor-sparing regional analgesia (RA) technique that may reduce overall postoperative opioid consumption when used in conjunction with multimodal analgesia.
- Conditions
- Dual Subsartorial Block, Adductor Canal Block, Femoral Nerve Block, Postoperative Analgesia, Total Knee Arthroplasty
- Being tested
- Dual subsartorial block, Adductor canal block, Femoral nerve block
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Dual subsartorial blockOther
Patients will receive dual subsartorial block (DSB).
Adductor canal blockOther
Patients will receive an adductor canal block (ACB).
Femoral nerve blockOther
Patients will receive a femoral nerve block (FNB).
| Study group | Role | What they receive |
|---|---|---|
| DSB group | Experimental | Patients will receive dual subsartorial block (DSB). Receives: Other: Dual subsartorial block |
| ACB group | Experimental | Patients will receive an adductor canal block (ACB). Receives: Other: Adductor canal block |
| FNB group | Experimental | Patients will receive a femoral nerve block (FNB). Receives: Other: Femoral nerve block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to the 1st rescue analgesia
Time to the first request for the rescue analgesia (time from the end of surgery to first dose of morphine administrated).
Measured: 24 hours postoperatively
Secondary outcomes (4)
Intraoperative fentanyl consumption
Additional fentanyl bolus dosages of 1 µg/kg IV will be administered if heart rate or mean arterial blood pressure elevated more than 20% of the baseline (after exclusion of other causes than pain).
Measured: Intraoperatively
Degree of pain
Each patient will be instructed about postoperative pain assessment with the visual analog scale (VAS). VAS (0 represents "no pain" while 10 represents "the worst pain imaginable"). VAS will be assessed at PACU, 2, 4, 6, 8, 12, 18 and 24 h postoperatively.
Measured: 24 hours postoperatively
Degree of patient satisfaction
Degree of patient satisfaction will be assessed on a 5-point Likert scale patient satisfaction (1, extremely dissatisfied; 2, unsatisfied; 3, neutral; 4, satisfied; 5, extremely satisfied).
Measured: 24 hours postoperatively
Incidence of adverse events
Incidence of adverse events such as bradycardia, hypotension, nausea, vomiting, respiratory depression, pruritus, or any other complication.
Measured: 24 hours postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jul 2025
- Study start24 Jul 2025
- Primary completion1 Jun 2026
- Study completion1 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dual Subsartorial BlockStudies of the same condition, open and under way.
- More trials run by Tanta UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Tanta University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mohammed Said ElSharkawy, Tanta University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07082374
- Sponsor's protocol ID
- 36264PR1260/6/25
- Status last verified
- Jun 2026
- First submitted
- 16 Jul 2025
- Last updated
- 22 Jun 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Study at a glance
From the registry record, last updated by the sponsor on 22 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Dual Subsartorial Block Versus Adductor Canal Block Versus Femoral Nerve Block for Postoperative Analgesia in Patients Undergoing Total Knee Arthroplasty: A Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT07082374
- Acronym / sponsor ID
- 36264PR1260/6/25
- Conditions
- Dual Subsartorial Block, Adductor Canal Block, Femoral Nerve Block, Postoperative Analgesia, Total Knee Arthroplasty
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Tanta UniversityUniversity, hospital or other
- Study start
- 24 Jul 2025 (actual)
- Primary completion
- 1 Jun 2026 (actual)
- Study completion
- 1 Jun 2026 (actual)
- First posted
- 24 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to compare the effect of dual subsartorial block (DSB), adductor canal block (ACB), and femoral nerve block (FNB) for postoperative analgesia in patients undergoing total knee arthroplasty (TKA).
Detailed description
Total knee arthroplasty (TKA) offers increased joint mobility and painless ambulation to patients. Femoral nerve block (FNB) is commonly used to relieve postoperative pain and opioid consumption.
Adductor canal block (ACB) is a common analgesic intervention for postoperative pain control following TKA. The dual subsartorial block (DSB) is a novel procedure-specific and motor-sparing regional analgesia (RA) technique that may reduce overall postoperative opioid consumption when used in conjunction with multimodal analgesia.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| DSB group | Experimental | Other: Dual subsartorial blockPatients will receive dual subsartorial block (DSB). |
| ACB group | Experimental | Other: Adductor canal blockPatients will receive an adductor canal block (ACB). |
| FNB group | Experimental | Other: Femoral nerve blockPatients will receive a femoral nerve block (FNB). |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age from 18 to 75 years.
- Both sexes.
- American Society of Anesthesiology (ASA) physical status I-II.
- Undergoing total knee arthroplasty (TKA) under general anesthesia.
Key exclusion criteria (9 listed)
- Severe valgus deformity.
- Acute/chronic kidney disease.
- Neurological deficit.
- Cognitive dysfunction.
- Local infection at the site of injection.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Dual subsartorial blockPatients will receive dual subsartorial block (DSB). | Other | DSB group |
| Adductor canal blockPatients will receive an adductor canal block (ACB). | Other | ACB group |
| Femoral nerve blockPatients will receive a femoral nerve block (FNB). | Other | FNB group |
Primary outcome
Time to the 1st rescue analgesia
Time frame: 24 hours postoperatively
Time to the first request for the rescue analgesia (time from the end of surgery to first dose of morphine administrated).
4 secondary outcomes
Intraoperative fentanyl consumption
Time frame: Intraoperatively
Degree of pain
Time frame: 24 hours postoperatively
Degree of patient satisfaction
Time frame: 24 hours postoperatively
Incidence of adverse events
Time frame: 24 hours postoperatively
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jun 2026.
- Individual participant dataSharing planned: Yes. The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Dual subsartorial block, Adductor canal block and Femoral nerve block in people with Dual Subsartorial Block and Adductor Canal Block, run by Tanta University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time to the 1st rescue analgesia (time frame: 24 hours postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jun 2026.