OsteoporosisNCT07084857
Association Between Isokinetic Lower Extremity Muscle Strength and Bone Mineral Density in Elderly Women With and Without Osteoporosis
An observational study of Osteoporosis, run by Cairo University at 1 site in Egypt.
Trial summary
bone density and muscle strength appear to be more related to each other. Examining the association between muscle strength and bone health is very important in recognizing risk factors for lower extremity muscle weakness. Read more about this study
- Who is it for?
- Ages 50 to 70 years, women only
- Conditions the study is for
- Osteoporosis
- What is being tested?
- correlational analysis between BMD and isokinetic lower extremity strength
- How many people
- 70 participants
- Where
- 1 siteEgypt
- Study dates
- 8 Feb 2025to 29 Mar 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 70 years
- Women only
- No healthy volunteers
- Adult, Older adult
Study population: Based on a sample size calculation via G Power software, a total of 70 participants will be required to participate in the study taking in consideration 20% drop out. A total 66 elderly women with ages range from 50 to 70 years will be involved in the study
Who may be able to join
- The group of OP (n=33) has femoral BMD T-scores below -2.5 diagnosed by DEXA scan according to the WHO [8] classification of BMD in 2003,
- The control group has normal BMD T-scores more than -1.
Who cannot join
- There was any neurological, musculoskeletal, rheumatologic, respiratory or cardiovascular problem.
- They were receiving medications that result in bone loss such as corticosteroids,
- They had vertigo, dizziness, or any vestibular problem,
- They had hyperthyroidism or hyperparathyroidism. 6- They actively participate in sports activities,
- They underwent previous surgery (e.g; joint replacement) or history of fractures of the lower extremity.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Association Between Isokinetic Lower Extremity Muscle Strength and Bone Mineral Density in Elderly Women With and Without Osteoporosis: A Case-Control Study
bone density and muscle strength appear to be more related to each other. Examining the association between muscle strength and bone health is very important in recognizing risk factors for lower extremity muscle weakness.
Read the detailed description
Dual Energy X-ray Absorptiometry (DEXA) scan will be used to assess hip bone mineral density (BMD) at femoral head region. Isokinetic PT of hip flexors, extensors, abductors and adductors and knee flexors and extensors will be measured using Biodex System 3 Isokinetic Dynamometer. The measured outcomes will be evaluated at an angular velocity of 60°/sec in a concentric mode of muscle contraction for five successive repetitions. Isokinetic testing will be done at the Isokinetic Laboratory, Faculty of Physical therapy, Cairo University.
- Conditions
- Osteoporosis
- Being tested
- correlational analysis between BMD and isokinetic lower extremity strength
- Keywords
- Osteoporosis, Bone Mineral Density, Isokinetic Strength;, Hip Muscles, Knee Muscles
- Medical subject headings
- Osteoporosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
correlational analysis between BMD and isokinetic lower extremity strengthOther
correlational analysis between BMD and isokinetic lower extremity strength
What is being measured
The primary outcome is the main question the study is designed to answer.
isokinetic strength of hip muscles
isokinetic hip muscle stregth will be measured using Biodex system 3 Isokinetic Dynamometer
Measured: one month
Bone mineral density
bone mineral density measured by dual energy x ray absorptiometry scan
Measured: one month
Secondary outcomes (1)
isokinetic strength of knee muscles
isokinetic hip muscle stregth will be measured using Biodex system 3 Isokinetic Dynamometer
Measured: one month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Jul 2025
- Study start8 Feb 2025
- Primary completion28 Mar 2025
- Study completion29 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for OsteoporosisStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Enrolment
- 70 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Azza Mohammed, Cairo University
- Investigators
- Azza M Abdelmohsen, professor, Principal investigator, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07084857
- Sponsor's protocol ID
- P.T.REC/012/005,927
- Other IDs
- faculty of physical therapy
- Status last verified
- Apr 2026
- First submitted
- 20 May 2025
- Last updated
- 8 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 8 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Association Between Isokinetic Lower Extremity Muscle Strength and Bone Mineral Density in Elderly Women With and Without Osteoporosis: A Case-Control Study
- ClinicalTrials.gov ID
- NCT07084857
- Acronym / sponsor ID
- P.T.REC/012/005,927
- Conditions
- Osteoporosis
- Keywords
- Osteoporosis, Bone Mineral Density, Isokinetic Strength;, Hip Muscles, Knee Muscles
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 70 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 8 Feb 2025 (actual)
- Primary completion
- 28 Mar 2025 (actual)
- Study completion
- 29 Mar 2025 (actual)
- First posted
- 25 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
bone density and muscle strength appear to be more related to each other. Examining the association between muscle strength and bone health is very important in recognizing risk factors for lower extremity muscle weakness.
Detailed description
Dual Energy X-ray Absorptiometry (DEXA) scan will be used to assess hip bone mineral density (BMD) at femoral head region. Isokinetic PT of hip flexors, extensors, abductors and adductors and knee flexors and extensors will be measured using Biodex System 3 Isokinetic Dynamometer. The measured outcomes will be evaluated at an angular velocity of 60°/sec in a concentric mode of muscle contraction for five successive repetitions. Isokinetic testing will be done at the Isokinetic Laboratory, Faculty of Physical therapy, Cairo University.
Study design
- Observational model
- Case only
- Time perspective
- Cross-sectional
Who may qualify
- Ages
- 50 to 70 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Based on a sample size calculation via G Power software, a total of 70 participants will be required to participate in the study taking in consideration 20% drop out. A total 66 elderly women with ages range from 50 to 70 years will be involved in the study
Key inclusion criteria (2 listed)
- The group of OP (n=33) has femoral BMD T-scores below -2.5 diagnosed by DEXA scan according to the WHO [8] classification of BMD in 2003,
- The control group has normal BMD T-scores more than -1.
Key exclusion criteria (5 listed)
- There was any neurological, musculoskeletal, rheumatologic, respiratory or cardiovascular problem.
- They were receiving medications that result in bone loss such as corticosteroids,
- They had vertigo, dizziness, or any vestibular problem,
- They had hyperthyroidism or hyperparathyroidism. 6- They actively participate in sports activities,
- They underwent previous surgery (e.g; joint replacement) or history of fractures of the lower extremity.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| correlational analysis between BMD and isokinetic lower extremity strengthcorrelational analysis between BMD and isokinetic lower extremity strength | Other | – |
Primary outcome
isokinetic strength of hip muscles
Time frame: one month
isokinetic hip muscle stregth will be measured using Biodex system 3 Isokinetic Dynamometer
Bone mineral density
Time frame: one month
bone mineral density measured by dual energy x ray absorptiometry scan
1 secondary outcome
isokinetic strength of knee muscles
Time frame: one month
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Apr 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Osteoporosis
RecruitingObservational study
A Clinical Study to Collect Real-wordt Data on Safety and Clinical Performance of the VCFix Spinal System for Treatment of Vertebral Compression Fractures of (Suspected) Osteoporotic Origin.
Vertebra Compression Fracture
Active, not recruitingObservational study
The Impact of Osteosarcopenia on Falls, Kinesiophobia, and Quality of Life in Postmenopausal Women
Osteosarcopenia, Sarcopenia
Active, not recruitingPhase 2
TCM Formula vs. HMB in Pre-Frail Elders: Muscle Strength and Bone Status
Pre-Frailty, Sarcopenia
Not yet recruitingPhase 4
Romosozumab and Denosumab Combination Therapy for Osteoporosis
Postmenopausal Osteoporosis
RecruitingObservational study
Assessment and Comparison of Osteoporosis Risk Factors After Stroke
Stroke, Osteoporosis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Azza M Abdelmohsen, professor principal investigator
Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Osteoporosis, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
isokinetic strength of hip muscles (time frame: one month). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Apr 2026.