Seamless Return to SportsNCT07086209
Optimizing Hamstring Rehabilitation With Amino Acids
A study testing Branched-Chain Amino Acid Supplement and Therapeutic Exercise Program in people with Seamless Return to Sports, run by Universidad de Zaragoza.
Trial summary
Hamstring injuries are among the most prevalent and troublesome injuries in athletes, particularly those engaged in sports that require high-speed movements such as sprinting, kicking, and rapid changes in direction. Read more about this study
- Who is it for?
- Ages Up to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Seamless Return to Sports
- What is being tested?
- Branched-Chain Amino Acid Supplement and Therapeutic Exercise Program
- Type of treatment
- Pill or oral medicine, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 25 participants
- Where
- No sites listed yet
- Study dates
- 19 Sep 2025to 20 Oct 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Up to 60 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- • Male football players aged 18 to 35 years.
- Active players from eight clubs in the Iraqi Football League.
- MRI-confirmed partial hamstring muscle injury.
- No participation in other ongoing rehabilitation programs.
Who cannot join
- • History of hamstring injury in the past six months.
- Any other musculoskeletal injuries affecting lower limbs.
- Contraindications for MRI scanning (e.g., metal implants, pacemakers).
- Any existing neurological or metabolic conditions affecting muscle recovery.
About this study
Official title: Optimizing Hamstring Rehabilitation With Amino Acids: A Randomized Controlled Study for Seamless Return to Sports in Football Athletes
Hamstring injuries are among the most prevalent and troublesome injuries in athletes, particularly those engaged in sports that require high-speed movements such as sprinting, kicking, and rapid changes in direction. The hamstring muscles, which include the biceps femoris, semitendinosus, and semimembranosus, are essential for powerful lower limb actions, and thus, any injury to these muscles can significantly impact an athlete's performance and recovery. These injuries often occur during eccentric muscle contractions, such as when the muscles lengthen rapidly under tension, as seen in running and sprinting. According to epidemiological studies, hamstring strains account for a substantial portion of sports-related injuries, with hamstring strains being the most commonly reported injury in disciplines such as football, soccer, rugby, and athletics. In professional football, for instance, hamstring injuries account for approximately 12% of all injuries and represent the most frequent muscle strain, underlining their significance in the context of athletic performance.
- Conditions
- Seamless Return to Sports
- Being tested
- Branched-Chain Amino Acid Supplement, Therapeutic Exercise Program
- Keywords
- Hamstring Rehabilitation, Return to play, Amino Acids, Football
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Branched-Chain Amino Acid SupplementDietary supplement
Also called Therapeutic Exercise + Amino Acid Supplementation
Oral BCAA blend (leucine, isoleucine, valine), 10 g/day divided into two doses, pre- and post-training, for 6 weeks.
Therapeutic Exercise ProgramBehavioural
6-week structured program including isometric, eccentric, plyometric, and sprint-specific exercises.
| Study group | Role | What they receive |
|---|---|---|
| Therapeutic Exercise + Amino Acid Supplementation | Experimental | Participants in this arm will undergo a structured 6-week therapeutic exercise rehabilitation program combined with daily oral branched-chain amino acid (BCAA) supplementation (10 g per day, divided into two doses: pre-training and post-training). The exercise program includes progressive isometric, eccentric, plyometric, and sprint-specific training to optimize hamstring recovery. Receives: Dietary Supplement: Branched-Chain Amino Acid Supplement; Behavioral: Therapeutic Exercise Program |
| Therapeutic Exercise Only | Active comparator | Arm Description:
Participants in this arm will undergo the same structured 6-week therapeutic exercise rehabilitation program without any amino acid supplementation. The exercise program includes progressive isometric, eccentric, plyometric, and sprint-specific training for hamstring recovery. Receives: Dietary Supplement: Branched-Chain Amino Acid Supplement; Behavioral: Therapeutic Exercise Program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Hamstring Muscle Strength
Isometric knee flexion strength measured at 15° and 90° using the ForHealth Kit to assess change from baseline.
Measured: Baseline, Mid-Rehabilitation (Week 3), Post-Rehabilitation (Week 6)
Secondary outcomes (1)
MRI Findings
MRI assessment of muscle healing, including reduction in edema and tear resolution.
Measured: Baseline and Post-Rehabilitation (Week 6)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Jul 2025
- Study start19 Sep 2025 (estimated)
- Primary completion19 Oct 2025 (estimated)
- Study completion20 Oct 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Seamless Return to SportsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Sequential
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 25 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Universidad de Zaragoza
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Kamal Hadib Abdulridha, Universidad de Zaragoza
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07086209
- Sponsor's protocol ID
- Unizar
- Status last verified
- Jul 2025
- First submitted
- 18 Jul 2025
- Last updated
- 25 Jul 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 25 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Optimizing Hamstring Rehabilitation With Amino Acids: A Randomized Controlled Study for Seamless Return to Sports in Football Athletes
- ClinicalTrials.gov ID
- NCT07086209
- Acronym / sponsor ID
- Unizar
- Conditions
- Seamless Return to Sports
- Keywords
- Hamstring Rehabilitation, Return to play, Amino Acids, Football
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 25 participants (estimated)
- Lead sponsor
- Universidad de ZaragozaUniversity, hospital or other
- Study start
- 19 Sep 2025 (estimated)
- Primary completion
- 19 Oct 2025 (estimated)
- Study completion
- 20 Oct 2025 (estimated)
- First posted
- 25 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Hamstring injuries are among the most prevalent and troublesome injuries in athletes, particularly those engaged in sports that require high-speed movements such as sprinting, kicking, and rapid changes in direction. The hamstring muscles, which include the biceps femoris, semitendinosus, and semimembranosus, are essential for powerful lower limb actions, and thus, any injury to these muscles can significantly impact an athlete's performance and recovery. These injuries often occur during eccentric muscle contractions, such as when the muscles lengthen rapidly under tension, as seen in running and sprinting. According to epidemiological studies, hamstring strains account for a substantial portion of sports-related injuries, with hamstring strains being the most commonly reported injury in disciplines such as football, soccer, rugby, and athletics. In professional football, for instance, hamstring injuries account for approximately 12% of all injuries and represent the most frequent muscle strain, underlining their significance in the context of athletic performance.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Sequential
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Therapeutic Exercise + Amino Acid Supplementation | Experimental | Dietary Supplement: Branched-Chain Amino Acid Supplement, Behavioral: Therapeutic Exercise ProgramParticipants in this arm will undergo a structured 6-week therapeutic exercise rehabilitation program combined with daily oral branched-chain amino acid (BCAA) supplementation (10 g per day, divided into two doses: pre-training and post-training). The exercise program includes progressive isometric, eccentric, plyometric, and sprint-specific training to optimize hamstring recovery. |
| Therapeutic Exercise Only | Active comparator | Dietary Supplement: Branched-Chain Amino Acid Supplement, Behavioral: Therapeutic Exercise ProgramArm Description: Participants in this arm will undergo the same structured 6-week therapeutic exercise rehabilitation program without any amino acid supplementation. The exercise program includes progressive isometric, eccentric, plyometric, and sprint-specific training for hamstring recovery. |
Who may qualify
- Ages
- Up to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (4 listed)
- • Male football players aged 18 to 35 years.
Key exclusion criteria (4 listed)
- • History of hamstring injury in the past six months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Branched-Chain Amino Acid SupplementAlso: Therapeutic Exercise + Amino Acid SupplementationOral BCAA blend (leucine, isoleucine, valine), 10 g/day divided into two doses, pre- and post-training, for 6 weeks. | Dietary supplement | Therapeutic Exercise + Amino Acid Supplementation, Therapeutic Exercise Only |
| Therapeutic Exercise Program6-week structured program including isometric, eccentric, plyometric, and sprint-specific exercises. | Behavioural | Therapeutic Exercise + Amino Acid Supplementation, Therapeutic Exercise Only |
Primary outcome
Change in Hamstring Muscle Strength
Time frame: Baseline, Mid-Rehabilitation (Week 3), Post-Rehabilitation (Week 6)
Isometric knee flexion strength measured at 15° and 90° using the ForHealth Kit to assess change from baseline.
1 secondary outcome
MRI Findings
Time frame: Baseline and Post-Rehabilitation (Week 6)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Jul 2025.
- pubmedLink provided by the sponsor.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing Branched-Chain Amino Acid Supplement and Therapeutic Exercise Program in people with Seamless Return to Sports, run by Universidad de Zaragoza.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 25 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Hamstring Muscle Strength (time frame: Baseline, Mid-Rehabilitation (Week 3), Post-Rehabilitation (Week 6)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Jul 2025.