Alzheimer's Disease (AD)NCT07086261
Using SRT to Improve The Drinking Problem Behavior of Elderly People With Dementia During The Care of Day Care
A study testing Spaced Retrieval Training in people with Alzheimer's Disease (AD), run by National Taipei University of Nursing and Health Sciences at 1 site in Taiwan.
Trial summary
Objective: To explore the effects of intermittent retrieval training on cognitive function, daily water intake, body weight, total body water, drinking problem behaviors in day care centers, and caregiver distress in day care centers for elderly people with dementia. Read more about this study
- Who is it for?
- Ages 65 years and olderHealthy volunteers can take part
- Conditions the study is for
- Alzheimer's Disease (AD)
- What is being tested?
- Spaced Retrieval Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 70 participants
- Where
- 1 siteTaiwan
- Study dates
- 6 Aug 2025to 30 Nov 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- Healthy volunteers accepted
- Older adult
Who may be able to join
- Elderly people with dementia aged 65 years or above who are receiving care in day care centers.
- Clear consciousness and able to communicate in Mandarin and Taiwanese.
- Clinical Dementia Rating Scale (CDR) should be 1-2 points.
- Brain Health Test (BHT) should be less than 9 points.
- Pass the SRT training screening test, indicating that the trainer's name can be remembered for 20-30 seconds.
- Agree to participate in this study.
Who cannot join
- Patients diagnosed with severe cognitive impairment according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) after evaluation by psychiatrists.
- Patients with chronic heart disease and renal failure.
- Patients with upper and lower limb dysfunction.
- Patients with hearing impairment and dysphagia.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effectiveness of Using Spaced Retrieval Training to Improve The Drinking Problem Behavior of Elderly People With Dementia During The Care of Day Care Centers in Taoyuan, Taiwan
Objective: To explore the effects of intermittent retrieval training on cognitive function, daily water intake, body weight, total body water, drinking problem behaviors in day care centers, and caregiver distress in day care centers for elderly people with dementia.
Methods: This study adopted a quasi-experimental research design with two groups of pre- and post-tests. The sample was recruited by convenient sampling. The experimental group was intervened with the intermittent retrieval training program to perform relevant drinking training, 40 minutes each time, 3 times a week, for a total of 8 weeks of intervention measures, while the control group was carried out with routine care for general drinking. Both groups collected pre-test data before the intermittent retrieval training intervention program in the first week, and conducted post-test data tracking and analysis in the 4th and 8th weeks after the intervention activities. The research tools included basic attribute data sheet, Chinese version of cognitive ability screening test (CASI), daily water intake, average daily water intake and drinking problem behaviors in the past week, body fat scale for measuring weight and total body water content, and day care center caregiver burden assessment scale. It is expected that this research intervention measure can improve the behavior of elderly people with dementia to drink water independently.
Read the detailed description
Background: Elderly people with dementia have impaired semantic and episodic memory, which significantly affects the difficulties of caregivers in day care centers and the burden of primary caregivers. During their internship in nursing care for the elderly at graduate school, researchers found that many elderly people with dementia have drinking problems. Some elderly people did not drink enough water, which caused their skin to be dry and flaky. They also forgot to replenish water after many dynamic activities in the course, which caused them to sweat too much. Many female elderly people also suffered from urinary tract infections. Therefore, if a training program can be designed for each elderly person to use time retrieval training as drinking behavior training, it will not only improve the memory of elderly people with mild cognitive impairment and dementia, but also enhance the training of the elderly in daily life functions, so as to increase the daily water intake to improve the physical burden and the occurrence of diseases and the burden on day care centers or family caregivers.
- Conditions
- Alzheimer's Disease (AD)
- Being tested
- Spaced Retrieval Training
- Keywords
- Alzheimer's Disease, Spaced Retrieval Training, Water, drinking, Memory, Fluid intake
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Spaced Retrieval TrainingOther
This study adopted a quasi-experimental research design with two groups of pre- and post-tests. The sample was recruited by convenient sampling. The experimental group used the time extraction training program to intervene and perform relevant water drinking training, 40 minutes each time, 3 times a week, for a total of 8 weeks of intervention measures, while the control group used routine care for general water drinking. Both groups collected pre-test data before the time extraction training intervention program activities in the first week, and conducted post-test data tracking and analysis in the 4th and 8th weeks after the intervention activities.
| Study group | Role | What they receive |
|---|---|---|
| Experimental Group | Experimental | Intervention of timed retrieval training program to implement relevant water drinking training Receives: Other: Spaced Retrieval Training |
| Drink water as usual | No intervention | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cognitive function (CASI)
Total number of questions: 25, The higher the score, the better, with a full score of 100, indicating better cognitive function. Taking high school graduates as an example, a score of 82 or more is considered normal, 78-81 is suspected of mild cognitive impairment, and less than 77 is considered suspected of dementia.
Measured: 10-20minute
Daily water intake and Drinking Problem Behavior
Calculate the water requirement of the elderly according to the recommended daily water requirement per person by multiplying 30 mL per kilogram of body weight (e.g., if the elderly weigh 60 kg, 60 kg × 30 ml = 1800 ml, 1800 ml/day). While the elderly are at the day care center, researchers and staff will monitor their water intake. When they return home from the center, researchers will give each person a 600ml bottle of mineral water (the bottle will be marked with the total amount of water the elderly need to drink in a day). Elderly people are asked to take it home, and family members are asked to help monitor the elderly's water intake at home. Family members are asked to deduct the amount of water they drink and record the remaining amount of water in the "Elderly Drinking Water Good Health Plan Water Drinking Registration Form"and"Daily Water Intake Registration Form for Elderly People"
Measured: From intervention to end of 8 weeks
Distress of caregivers in day care centers
There are 10 questions in total, used in the questionnaire on the concerns of caregivers about drinking water problems of elderly people with dementia.The scale is a Likert scale with a 0-4 point scale, with a total of 40 points.The higher the score, the more trouble the caregiver has with the subject's drinking behavior.
Measured: From intervention to end of 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Jul 2025
- Study start6 Aug 2025
- Primary completion1 Nov 2025 (estimated)
- Study completion30 Nov 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Alzheimer's Disease (AD)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 70 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Taipei University of Nursing and Health Sciences
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Wu Chia Jung, National Taipei University of Nursing and Health Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07086261
- Sponsor's protocol ID
- 202501EM036
- Status last verified
- Aug 2025
- First submitted
- 17 Jul 2025
- Last updated
- 28 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Publications
Han JW, Son KL, Byun HJ, Ko JW, Kim K, Hong JW, Kim TH, Kim KW. Efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (USMART) program among patients with mild cognitive impairment: a randomized controlled crossover trial. Alzheimers Res Ther. 2017 Jun 6;9(1):39. doi: 10.1186/s13195-017-0264-8.
PubMed 28587629Kao CC, Lin LC, Wu SC, Lin KN, Liu CK. Effectiveness of different memory training programs on improving hyperphagic behaviors of residents with dementia: a longitudinal single-blind study. Clin Interv Aging. 2016 May 23;11:707-20. doi: 10.2147/CIA.S102027. eCollection 2016.
PubMed 27307717Bunn DK, Abdelhamid A, Copley M, Cowap V, Dickinson A, Howe A, Killett A, Poland F, Potter JF, Richardson K, Smithard D, Fox C, Hooper L. Effectiveness of interventions to indirectly support food and drink intake in people with dementia: Eating and Drinking Well IN dementiA (EDWINA) systematic review. BMC Geriatr. 2016 May 4;16:89. doi: 10.1186/s12877-016-0256-8.
PubMed 27142469Wu HS, Lin LC, Wu SC, Lin KN, Liu HC. The effectiveness of spaced retrieval combined with Montessori-based activities in improving the eating ability of residents with dementia. J Adv Nurs. 2014 Aug;70(8):1891-901. doi: 10.1111/jan.12352. Epub 2014 Jan 20.
PubMed 24444172Wu HS, Lin LC, Su SC, Wu SC. The effects of spaced retrieval combined with errorless learning in institutionalized elders with dementia: recall performance, cognitive status, and food intake. Alzheimer Dis Assoc Disord. 2014 Oct-Dec;28(4):333-9. doi: 10.1097/WAD.0000000000000028.
PubMed 24632986
Study at a glance
From the registry record, last updated by the sponsor on 28 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effectiveness of Using Spaced Retrieval Training to Improve The Drinking Problem Behavior of Elderly People With Dementia During The Care of Day Care Centers in Taoyuan, Taiwan
- ClinicalTrials.gov ID
- NCT07086261
- Acronym / sponsor ID
- 202501EM036
- Conditions
- Alzheimer's Disease (AD)
- Keywords
- Alzheimer's Disease, Spaced Retrieval Training, Water, drinking, Memory, Fluid intake
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 70 participants (estimated)
- Lead sponsor
- National Taipei University of Nursing and Health SciencesUniversity, hospital or other
- Study start
- 6 Aug 2025 (actual)
- Primary completion
- 1 Nov 2025 (estimated)
- Study completion
- 30 Nov 2025 (estimated)
- First posted
- 25 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Objective: To explore the effects of intermittent retrieval training on cognitive function, daily water intake, body weight, total body water, drinking problem behaviors in day care centers, and caregiver distress in day care centers for elderly people with dementia.
Methods: This study adopted a quasi-experimental research design with two groups of pre- and post-tests. The sample was recruited by convenient sampling. The experimental group was intervened with the intermittent retrieval training program to perform relevant drinking training, 40 minutes each time, 3 times a week, for a total of 8 weeks of intervention measures, while the control group was carried out with routine care for general drinking. Both groups collected pre-test data before the intermittent retrieval training intervention program in the first week, and conducted post-test data tracking and analysis in the 4th and 8th weeks after the intervention activities. The research tools included basic attribute data sheet, Chinese version of cognitive ability screening test (CASI), daily water intake, average daily water intake and drinking problem behaviors in the past week, body fat scale for measuring weight and total body water content, and day care center caregiver burden assessment scale. It is expected that this research intervention measure can improve the behavior of elderly people with dementia to drink water independently.
Detailed description
Background: Elderly people with dementia have impaired semantic and episodic memory, which significantly affects the difficulties of caregivers in day care centers and the burden of primary caregivers. During their internship in nursing care for the elderly at graduate school, researchers found that many elderly people with dementia have drinking problems. Some elderly people did not drink enough water, which caused their skin to be dry and flaky. They also forgot to replenish water after many dynamic activities in the course, which caused them to sweat too much. Many female elderly people also suffered from urinary tract infections. Therefore, if a training program can be designed for each elderly person to use time retrieval training as drinking behavior training, it will not only improve the memory of elderly people with mild cognitive impairment and dementia, but also enhance the training of the elderly in daily life functions, so as to increase the daily water intake to improve the physical burden and the occurrence of diseases and the burden on day care centers or family caregivers.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Experimental Group | Experimental | Other: Spaced Retrieval TrainingIntervention of timed retrieval training program to implement relevant water drinking training |
| Drink water as usual | No intervention | – |
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Older adult
Key inclusion criteria (6 listed)
- Elderly people with dementia aged 65 years or above who are receiving care in day care centers.
- Clear consciousness and able to communicate in Mandarin and Taiwanese.
- Clinical Dementia Rating Scale (CDR) should be 1-2 points.
- Brain Health Test (BHT) should be less than 9 points.
- Pass the SRT training screening test, indicating that the trainer's name can be remembered for 20-30 seconds.
Key exclusion criteria (4 listed)
- Patients diagnosed with severe cognitive impairment according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) after evaluation by psychiatrists.
- Patients with chronic heart disease and renal failure.
- Patients with upper and lower limb dysfunction.
- Patients with hearing impairment and dysphagia.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Spaced Retrieval TrainingThis study adopted a quasi-experimental research design with two groups of pre- and post-tests. The sample was recruited by convenient sampling. The experimental group used the time extraction training program to intervene and perform relevant water drinking training, 40 minutes each time, 3 times a week, for a total of 8 weeks of intervention measures, while the control group used routine care for general water drinking. Both groups collected pre-test data before the time extraction training intervention program activities in the first week, and conducted post-test data tracking and analysis in the 4th and 8th weeks after the intervention activities. | Other | Experimental Group |
Primary outcome
Cognitive function (CASI)
Time frame: 10-20minute
Total number of questions: 25, The higher the score, the better, with a full score of 100, indicating better cognitive function. Taking high school graduates as an example, a score of 82 or more is considered normal, 78-81 is suspected of mild cognitive impairment, and less than 77 is considered suspected of dementia.
Daily water intake and Drinking Problem Behavior
Time frame: From intervention to end of 8 weeks
Calculate the water requirement of the elderly according to the recommended daily water requirement per person by multiplying 30 mL per kilogram of body weight (e.g., if the elderly weigh 60 kg, 60 kg × 30 ml = 1800 ml, 1800 ml/day). While the elderly are at the day care center, researchers and staff will monitor their water intake. When they return home from the center, researchers will give each person a 600ml bottle of mineral water (the bottle will be marked with the total amount of water the elderly need to drink in a day). Elderly people are asked to take it home, and family members are asked to help monitor the elderly's water intake at home. Family members are asked to deduct the amount of water they drink and record the remaining amount of water in the "Elderly Drinking Water Good Health Plan Water Drinking Registration Form"and"Daily Water Intake Registration Form for Elderly People"
Distress of caregivers in day care centers
Time frame: From intervention to end of 8 weeks
There are 10 questions in total, used in the questionnaire on the concerns of caregivers about drinking water problems of elderly people with dementia.The scale is a Likert scale with a 0-4 point scale, with a total of 40 points.The higher the score, the more trouble the caregiver has with the subject's drinking behavior.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Aug 2025.
- Results publication: PubMed 28587629Han JW, Son KL, Byun HJ, Ko JW, Kim K, Hong JW, Kim TH, Kim KW. Efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (USMART) program among patients with mild cognitive impairment: a randomized controlled crossover trial. Alzheimers Res Ther. 2017 Jun 6;9(1):39. doi: 10.1186/s13195-017-0264-8.
- Results publication: PubMed 27307717Kao CC, Lin LC, Wu SC, Lin KN, Liu CK. Effectiveness of different memory training programs on improving hyperphagic behaviors of residents with dementia: a longitudinal single-blind study. Clin Interv Aging. 2016 May 23;11:707-20. doi: 10.2147/CIA.S102027. eCollection 2016.
- Results publication: PubMed 27142469Bunn DK, Abdelhamid A, Copley M, Cowap V, Dickinson A, Howe A, Killett A, Poland F, Potter JF, Richardson K, Smithard D, Fox C, Hooper L. Effectiveness of interventions to indirectly support food and drink intake in people with dementia: Eating and Drinking Well IN dementiA (EDWINA) systematic review. BMC Geriatr. 2016 May 4;16:89. doi: 10.1186/s12877-016-0256-8.
- Results publication: PubMed 24444172Wu HS, Lin LC, Wu SC, Lin KN, Liu HC. The effectiveness of spaced retrieval combined with Montessori-based activities in improving the eating ability of residents with dementia. J Adv Nurs. 2014 Aug;70(8):1891-901. doi: 10.1111/jan.12352. Epub 2014 Jan 20.
- Results publication: PubMed 24632986Wu HS, Lin LC, Su SC, Wu SC. The effects of spaced retrieval combined with errorless learning in institutionalized elders with dementia: recall performance, cognitive status, and food intake. Alzheimer Dis Assoc Disord. 2014 Oct-Dec;28(4):333-9. doi: 10.1097/WAD.0000000000000028.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Spaced Retrieval Training in people with Alzheimer's Disease (AD), run by National Taipei University of Nursing and Health Sciences at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 28 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cognitive function (CASI) (time frame: 10-20minute). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07086261, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Aug 2025.