Mortality, Perioperative Blood Transfusion, Propensity Score, Retrospective Study, SurgeryNCT07094295
Perioperative Blood Transfusion and Increased One-year Mortality
An observational study of Mortality, Perioperative Blood Transfusion, Propensity Score, Retrospective Study, Surgery, run by Changhai Hospital.
Trial summary
The goal of this retrospective observational study is to explore the association of perioperative blood transfusion with increased one-year mortality in patients undergoing surgeries. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Mortality, Perioperative Blood Transfusion, Propensity Score, Retrospective Study, Surgery
- What is being tested?
- perioperative blood transfusion
- How many people
- 97,443 participants
- Where
- No sites listed yet
- Study dates
- 1 Jan 2012to 31 Oct 2016
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Adult, Older adult
Study population: Adult patients who underwent surgery at Singapore General Hospital between 1 January 2012 and 31 October 2016
Who may be able to join
- ≥18 years
- Patients undergoing first-time cardiothoracic surgery, orthopedics, obstetrics and gynecology, general surgery, otolaryngology, hand surgery, neurosurgery, colorectal surgery, urology, plastic surgery, and oral and maxillofacial surgery were included.
Who cannot join
- Patients with missing values for the American Society of Anesthesiologists (ASA) physical status, revised cardiac risk index (RCRI), degree of preoperative anemia, kidney disease, or race were excluded.
About this study
Official title: Association of Perioperative Blood Transfusion With Increased One-year Mortality After Surgery: a Retrospective Propensity Score-Matched Cohort Study
The goal of this retrospective observational study is to explore the association of perioperative blood transfusion with increased one-year mortality in patients undergoing surgeries. The main question it aims to answer perioperative blood transfusion is associated with increased one-year mortality across various surgical settings. We will retrospectively collect the clinical data (including one-year mortality) in patients with perioperative blood transfusion or not and analysis the association between perioperative blood transfusion and one-year mortality after surgery.
- Conditions
- Mortality, Perioperative Blood Transfusion, Propensity Score, Retrospective Study, Surgery
- Being tested
- perioperative blood transfusion
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
perioperative blood transfusionOther
The PBT group received the red blood cell concentrate units during surgery and up to one month postoperatively.
| Study group | Role | What they receive |
|---|---|---|
| PBT group | Patients in PBT group received red blood cell concentrate units during surgery and up to one month postoperatively. Receives: Other: perioperative blood transfusion | |
| No-PBT group | Patients in No-PBT group did not receive red blood cell concentrate units during surgery and up to one month postoperatively. |
What is being measured
The primary outcome is the main question the study is designed to answer.
one-year mortality after surgery
Measured: one year after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Jul 2025
- Study start1 Jan 2012
- Primary completion31 Oct 2016
- Study completion31 Oct 2016
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Mortality, Perioperative Blood Transfusion, Propensity Score, Retrospective Study, SurgeryStudies of the same condition, open and under way.
- More trials run by Changhai HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 97,443 participants (actual)
Sponsor and investigators
- Lead sponsor
- Changhai Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Wen-bin Lu, MD, Changhai Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07094295
- Sponsor's protocol ID
- PBTOM
- Status last verified
- Jul 2025
- First submitted
- 23 Jul 2025
- Last updated
- 30 Jul 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Association of Perioperative Blood Transfusion With Increased One-year Mortality After Surgery: a Retrospective Propensity Score-Matched Cohort Study
- ClinicalTrials.gov ID
- NCT07094295
- Acronym / sponsor ID
- PBTOM
- Conditions
- Mortality, Perioperative Blood Transfusion, Propensity Score, Retrospective Study, Surgery
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 97,443 participants (actual)
- Lead sponsor
- Changhai HospitalUniversity, hospital or other
- Study start
- 1 Jan 2012 (actual)
- Primary completion
- 31 Oct 2016 (actual)
- Study completion
- 31 Oct 2016 (actual)
- First posted
- 30 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this retrospective observational study is to explore the association of perioperative blood transfusion with increased one-year mortality in patients undergoing surgeries. The main question it aims to answer perioperative blood transfusion is associated with increased one-year mortality across various surgical settings. We will retrospectively collect the clinical data (including one-year mortality) in patients with perioperative blood transfusion or not and analysis the association between perioperative blood transfusion and one-year mortality after surgery.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| PBT group | – | Other: perioperative blood transfusionPatients in PBT group received red blood cell concentrate units during surgery and up to one month postoperatively. |
| No-PBT group | – | –Patients in No-PBT group did not receive red blood cell concentrate units during surgery and up to one month postoperatively. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- Adult patients who underwent surgery at Singapore General Hospital between 1 January 2012 and 31 October 2016
Key inclusion criteria (2 listed)
- ≥18 years
- Patients undergoing first-time cardiothoracic surgery, orthopedics, obstetrics and gynecology, general surgery, otolaryngology, hand surgery, neurosurgery, colorectal surgery, urology, plastic surgery, and oral and maxillofacial surgery were included.
Key exclusion criteria (1 listed)
- Patients with missing values for the American Society of Anesthesiologists (ASA) physical status, revised cardiac risk index (RCRI), degree of preoperative anemia, kidney disease, or race were excluded.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| perioperative blood transfusionThe PBT group received the red blood cell concentrate units during surgery and up to one month postoperatively. | Other | PBT group |
Primary outcome
one-year mortality after surgery
Time frame: one year after surgery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Jul 2025.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Mortality, Perioperative Blood Transfusion, Propensity Score, Retrospective Study, Surgery, run by Changhai Hospital.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
one-year mortality after surgery (time frame: one year after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jul 2025.