Cardiovascular HealthNCT07095504
A Study of Cardiac Rehabilitation Intervention to Improve Cardiovascular Health and Outcomes
A study testing Virtual World-based Cardiac Rehabilitation (VWCR) program in people with Cardiovascular Health, run by Mayo Clinic at 3 sites in United States.
Trial summary
A single-group, multi-center, non-randomized clinical trial will be conducted to assess the feasibility of implementing an enhanced virtual world-based cardiac rehabilitation (VWCR) program within a muti-site clinical trial. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiovascular Health
- What is being tested?
- Virtual World-based Cardiac Rehabilitation (VWCR) program
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 8 participants
- Where
- 3 sitesUnited States
- Study dates
- 8 Dec 2025to 1 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Indication for CR according to Centers for Medicare \& Medicaid Services (CMS) guidelines (diagnosed within the preceding 12 months) to include one or more of the following:
- Myocardial infarction
- Coronary artery bypass surgery
- Current stable angina (chest pain)
- Heart valve repair or replacement
- Percutaneous transluminal coronary angioplasty (PTCA) or coronary stenting
Show all 13Show fewer
- Heart or heart-lung transplant
- Stable chronic heart failure
- Receiving care at one of the participating CR centers
- Age ≥18 years
- Basic Internet navigation skills
- Active email address
- Access to Internet at home or public access (church, library, etc) for 3 virtual visits per week
Who cannot join
- High risk patients according to the AACVPR risk stratification44 given safety concern of unsupervised exercise
- Patients receiving continuous inotropic support
- Recent receipt of a mechanical support device
- Presence of hemodynamically unstable dysrhythmias (e.g., ventricular tachycardia)
- Decompensated heart failure
- Symptomatic valvular heart disease
Show all 17Show fewer
- Uncontrolled angina
- Pregnancy (due to associated hormonal and weight changes) per patient report
- Receiving continuous inotropic support
- Presence of a mechanical circulatory support device
- Decompensated heart failure
- Symptomatic valvular heart disease
- Uncontrolled angina
- Presence of hemodynamically unstable dysrhythmias (e.g., ventricular tachycardia) given safety concern of unsupervised exercise
- Visual/hearing impairment or mental disability that would preclude independent use of the VW platform
- Non-English-speaking patients due to logistical challenges with real time translation over a virtual platform
- Currently participating in a cardiac rehab program
Trial locations and contacts
3 sites in 1 country.
United States3 sites
University of California (UCI), Irvine
Irvine, California, 92617
Mayo Clinic
Jacksonville, Florida, 32224
Mayo Clinic
Rochester, Minnesota, 55905
About this study
Official title: Destination Cardiac Rehab: A Multicenter Feasibility Clinical Trial of an Enhanced Virtual World-based Cardiac Rehabilitation Intervention to Improve Cardiovascular Health and Outcomes Among Cardiac Patients
A single-group, multi-center, non-randomized clinical trial will be conducted to assess the feasibility of implementing an enhanced virtual world-based cardiac rehabilitation (VWCR) program within a muti-site clinical trial.
- Conditions
- Cardiovascular Health
- Being tested
- Virtual World-based Cardiac Rehabilitation (VWCR) program
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Virtual World-based Cardiac Rehabilitation (VWCR) programBehavioural
24 Virtual World-based Cardiac Rehabilitation sessions over the course of 8 weeks (3 sessions/week). Weekly visits include 1:1 video visit with Exercise Physiologist, 1:1 video visit with Nurse Coach, and virtual group education session followed by social discussion.
| Study group | Role | What they receive |
|---|---|---|
| Virtual World-Based Cardiac Rehab | Experimental | Not described Receives: Behavioral: Virtual World-based Cardiac Rehabilitation (VWCR) program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Cardiovascular health score
Cardiovascular health score will be determined by the American Heart Association's (AHA) Life's Essential 8 (LS8). The scale is 0-100 pts (low to high), with LE8 categories as low (0-49), moderate (50-79) and high (80-100). A higher score indicates higher cardiovascular health.
Measured: Baseline, 2 Months, 5 Months
Percent of Virtual world-based cardiac rehabilitation attended
Virtual world-based cardiac rehabilitation attended will be determined by the number of sessions prescribed vs the number of sessions attended (reported as a percent).
Measured: Baseline, 6 Months
Secondary outcomes (2)
Number of cardiovascular hospital readmissions
Cardiovascular Hospital readmissions will be determined by the number of times a patient is admitted to the hospital after initial admission.
Measured: Baseline, 6 Months
All-cause mortality
All-cause mortality will be determined by the number of patient deaths no matter the cause.
Measured: 6 Months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Jul 2025
- Study start8 Dec 2025
- Primary completion1 Jun 2026
- Study completion1 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiovascular HealthStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 8 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, LaPrincess C. Brewer, Mayo Clinic
- Investigators
- LaPrincess Brewer, M.P.H., Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07095504
- Sponsor's protocol ID
- 25-002186
- Other IDs
- 23SCISA1144689
- Status last verified
- Jul 2026
- First submitted
- 24 Jul 2025
- Last updated
- 31 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 31 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Destination Cardiac Rehab: A Multicenter Feasibility Clinical Trial of an Enhanced Virtual World-based Cardiac Rehabilitation Intervention to Improve Cardiovascular Health and Outcomes Among Cardiac Patients
- ClinicalTrials.gov ID
- NCT07095504
- Acronym / sponsor ID
- 25-002186
- Conditions
- Cardiovascular Health
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 8 participants (actual)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Study start
- 8 Dec 2025 (actual)
- Primary completion
- 1 Jun 2026 (actual)
- Study completion
- 1 Jun 2026 (actual)
- First posted
- 31 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
A single-group, multi-center, non-randomized clinical trial will be conducted to assess the feasibility of implementing an enhanced virtual world-based cardiac rehabilitation (VWCR) program within a muti-site clinical trial.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Virtual World-Based Cardiac Rehab | Experimental | Behavioral: Virtual World-based Cardiac Rehabilitation (VWCR) program |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (13 listed)
- Indication for CR according to Centers for Medicare \& Medicaid Services (CMS) guidelines (diagnosed within the preceding 12 months) to include one or more of the following:
- Receiving care at one of the participating CR centers
- Age ≥18 years
- Basic Internet navigation skills
- Active email address
Key exclusion criteria (17 listed)
- High risk patients according to the AACVPR risk stratification44 given safety concern of unsupervised exercise
- Pregnancy (due to associated hormonal and weight changes) per patient report
- Receiving continuous inotropic support
- Presence of a mechanical circulatory support device
- Decompensated heart failure
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Virtual World-based Cardiac Rehabilitation (VWCR) program24 Virtual World-based Cardiac Rehabilitation sessions over the course of 8 weeks (3 sessions/week). Weekly visits include 1:1 video visit with Exercise Physiologist, 1:1 video visit with Nurse Coach, and virtual group education session followed by social discussion. | Behavioural | Virtual World-Based Cardiac Rehab |
Primary outcome
Change in Cardiovascular health score
Time frame: Baseline, 2 Months, 5 Months
Cardiovascular health score will be determined by the American Heart Association's (AHA) Life's Essential 8 (LS8). The scale is 0-100 pts (low to high), with LE8 categories as low (0-49), moderate (50-79) and high (80-100). A higher score indicates higher cardiovascular health.
Percent of Virtual world-based cardiac rehabilitation attended
Time frame: Baseline, 6 Months
Virtual world-based cardiac rehabilitation attended will be determined by the number of sessions prescribed vs the number of sessions attended (reported as a percent).
2 secondary outcomes
Number of cardiovascular hospital readmissions
Time frame: Baseline, 6 Months
All-cause mortality
Time frame: 6 Months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
LaPrincess Brewer, M.P.H. principal investigator
Mayo Clinic
3 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Virtual World-based Cardiac Rehabilitation (VWCR) program in people with Cardiovascular Health, run by Mayo Clinic at 3 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 13 inclusion and 17 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 31 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 3 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Cardiovascular health score (time frame: Baseline, 2 Months, 5 Months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Jul 2026.