MYOCARD INFARCTUSMINSNCT07098468
Myocardial Injury After Noncardiac Surgery (MINS) in Patients Undergoing Knee and Hip Arthroplasty
An observational study of MYOCARD INFARCTUS and Non Cardiac Surgery, run by Ankara City Hospital Bilkent at 1 site in Turkey (Türkiye).
Trial summary
The aim of this study is to determine the incidence of myocardial injury after noncardiac surgery (MINS) in patients undergoing elective total knee or hip arthroplasty, and to identify the demographic, clinical, laboratory, and surgical risk factors that may contribute to its development. Read more about this study
- Who is it for?
- Ages 45 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- MYOCARD INFARCTUS, Non Cardiac Surgery, ARTHROPLASTY, REPLACEMENT; ANESTHESIA
- How many people
- 323 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 3 Aug 2025to 1 Feb 2026
- How long will I take part?
- 30 Days
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: The study is planned to include 314 patients aged 45 and older undergoing elective hip or knee arthroplasty. Participants will be accepted for participation with physician approval and a voluntary consent form.
Who may be able to join
- Age over 45
- Elective total knee or hip replacement
Who cannot join
- Those undergoing cardiac surgery
- History of acute MI (<30 days)
- Chronic elevation of troponin
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Evaluation of the Incidence and Risk Factors of Myocardial Injury After Noncardiac Surgery (MINS) in Patients Undergoing Knee and Hip Arthroplasty
The aim of this study is to determine the incidence of myocardial injury after noncardiac surgery (MINS) in patients undergoing elective total knee or hip arthroplasty, and to identify the demographic, clinical, laboratory, and surgical risk factors that may contribute to its development.
Read the detailed description
Cardiovascular complications that develop during the perioperative period stand out as a significant cause of morbidity and mortality in patients after surgery. Especially myocardial injury (MINS) occurring after non-cardiac surgeries often progresses without clinical symptoms and signs, and therefore its diagnosis can be missed. The early detection of this silent damage is of great importance for patient safety and treatment management. It is reported that 5% to 25% of patients after non-cardiac surgery have elevated cardiac troponin (cTn) levels, and most of these patients are asymptomatic. This situation suggests that many patients are exposed to undetected myocardial damage. In patients who have experienced myocardial infarction (MI) or myocardial injury, morbidity and mortality rates are high not only before surgery but also on the 30th day and even up to the 1st year. MINS is typically detected during the perioperative period through measurements of cardiac troponin I (cTnI) or cardiac troponin T (cTnT).
These proteins are the fundamental regulatory proteins of the myocardium and are sensitive and specific biomarkers for myocardial damage. Elevations in troponin levels should be identified within the first 30 days, but these elevations typically occur within the first 2 days of the postoperative period. When high-sensitivity troponin T (hs-cTnT) measurements are used, an increase of 5 ng/L or more over the previous value has been independently associated with 30-day mortality in a major international study. The aim of this study is to determine the incidence of myocardial injury after non-cardiac surgery (MINS) in patients undergoing elective total knee or hip arthroplasty and to identify the demographic, clinical, laboratory, and surgical risk factors that may contribute to it.
- Keywords
- Myocardial injury, noncardiac surgery
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Mins positivity | Patients with high sensitive troponin positivity after surgery | |
| Mins Negative | Patients with negative high sensitive troponin after surgery |
What is being measured
The primary outcome is the main question the study is designed to answer.
Ischemia-related myocardial damage after noncardiac surgery
Diagnostic Biochemical Criteria for MINS:
Myocardial Injury after Non-Cardiac Surgery (MINS) is defined when at least one of the following high-sensitivity cardiac troponin T (hs-cTnT) criteria is met:
A postoperative hs-cTnT level of at least 20 ng/L combined with a minimum absolute increase of 5 ng/L from the preoperative value, or
An absolute postoperative hs-cTnT concentration of ≥ 65 ng/L, regardless of baseline values.
These threshold values are used to detect subclinical myocardial injury due to ischemia that occurs after surgery, even in the absence of ischemic symptoms or electrocardiographic changes.
In this study, patients meeting at least one of the above criteria within 30 days postoperatively will be classified as having MINS.
Measured: After surgery 30 days
Secondary outcomes (1)
Causes of myocardial damage due to ischemia following noncardiac surgery
In this study, a secondary outcome is to investigate the causes of myocardial injury due to ischemia following non-cardiac surgery. Factors such as perioperative hemodynamic instability, type and duration of surgery, pre-existing cardiovascular comorbidities, and intraoperative events will be evaluated to identify potential contributors to ischemic myocardial damage
Measured: 30 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Aug 2025
- Study start3 Aug 2025
- Primary completion1 Feb 2026
- Study completion1 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MYOCARD INFARCTUSStudies of the same condition, open and under way.
- More trials run by Ankara City Hospital BilkentThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 323 participants (actual)
- Target duration
- 30 Days
Sponsor and investigators
- Lead sponsor
- Ankara City Hospital Bilkent
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mehmet sahap, Ankara City Hospital Bilkent
- Investigators
- Mehmet Şahap, Study director, Sahap
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07098468
- Sponsor's protocol ID
- MINS
- Acronym
- MINS
- Status last verified
- Feb 2026
- First submitted
- 14 Jul 2025
- Last updated
- 13 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Due to the inadequate database network, patient information will not be shared with third parties. Patient data may be shared with journals upon request.
Study at a glance
From the registry record, last updated by the sponsor on 13 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Incidence and Risk Factors of Myocardial Injury After Noncardiac Surgery (MINS) in Patients Undergoing Knee and Hip Arthroplasty
- ClinicalTrials.gov ID
- NCT07098468
- Acronym / sponsor ID
- MINS / MINS
- Keywords
- Myocardial injury, noncardiac surgery
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 323 participants (actual)
- Lead sponsor
- Ankara City Hospital BilkentUniversity, hospital or other
- Study start
- 3 Aug 2025 (actual)
- Primary completion
- 1 Feb 2026 (actual)
- Study completion
- 1 Feb 2026 (actual)
- First posted
- 1 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to determine the incidence of myocardial injury after noncardiac surgery (MINS) in patients undergoing elective total knee or hip arthroplasty, and to identify the demographic, clinical, laboratory, and surgical risk factors that may contribute to its development.
Detailed description
Cardiovascular complications that develop during the perioperative period stand out as a significant cause of morbidity and mortality in patients after surgery. Especially myocardial injury (MINS) occurring after non-cardiac surgeries often progresses without clinical symptoms and signs, and therefore its diagnosis can be missed. The early detection of this silent damage is of great importance for patient safety and treatment management. It is reported that 5% to 25% of patients after non-cardiac surgery have elevated cardiac troponin (cTn) levels, and most of these patients are asymptomatic. This situation suggests that many patients are exposed to undetected myocardial damage. In patients who have experienced myocardial infarction (MI) or myocardial injury, morbidity and mortality rates are high not only before surgery but also on the 30th day and even up to the 1st year. MINS is typically detected during the perioperative period through measurements of cardiac troponin I (cTnI) or cardiac troponin T (cTnT).
These proteins are the fundamental regulatory proteins of the myocardium and are sensitive and specific biomarkers for myocardial damage. Elevations in troponin levels should be identified within the first 30 days, but these elevations typically occur within the first 2 days of the postoperative period. When high-sensitivity troponin T (hs-cTnT) measurements are used, an increase of 5 ng/L or more over the previous value has been independently associated with 30-day mortality in a major international study. The aim of this study is to determine the incidence of myocardial injury after non-cardiac surgery (MINS) in patients undergoing elective total knee or hip arthroplasty and to identify the demographic, clinical, laboratory, and surgical risk factors that may contribute to it.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 30 Days
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Mins positivity | – | –Patients with high sensitive troponin positivity after surgery |
| Mins Negative | – | –Patients with negative high sensitive troponin after surgery |
Who may qualify
- Ages
- 45 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- The study is planned to include 314 patients aged 45 and older undergoing elective hip or knee arthroplasty. Participants will be accepted for participation with physician approval and a voluntary consent form.
Key inclusion criteria (2 listed)
- Age over 45
- Elective total knee or hip replacement
Key exclusion criteria (3 listed)
- Those undergoing cardiac surgery
- History of acute MI (<30 days)
- Chronic elevation of troponin
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Ischemia-related myocardial damage after noncardiac surgery
Time frame: After surgery 30 days
Diagnostic Biochemical Criteria for MINS: Myocardial Injury after Non-Cardiac Surgery (MINS) is defined when at least one of the following high-sensitivity cardiac troponin T (hs-cTnT) criteria is met: A postoperative hs-cTnT level of at least 20 ng/L combined with a minimum absolute increase of 5 ng/L from the preoperative value, or An absolute postoperative hs-cTnT concentration of ≥ 65 ng/L, regardless of baseline values. These threshold values are used to detect subclinical myocardial injury due to ischemia that occurs after surgery, even in the absence of ischemic symptoms or electrocardiographic changes. In this study, patients meeting at least one of the above criteria within 30 days postoperatively will be classified as having MINS.
1 secondary outcome
Causes of myocardial damage due to ischemia following noncardiac surgery
Time frame: 30 days
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Feb 2026.
- Individual participant dataSharing planned: No. Due to the inadequate database network, patient information will not be shared with third parties. Patient data may be shared with journals upon request.
Related trials for MYOCARD INFARCTUS
RecruitingObservational study
Myocardial Injury After Noncardiac Surgery (MINS) in Lumbar Surgery Patients
MYOCARD INFARCTUS, Non Cardiac Surgery
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mehmet Şahap study director
Sahap
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of MYOCARD INFARCTUS and Non Cardiac Surgery, run by Ankara City Hospital Bilkent at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Ischemia-related myocardial damage after noncardiac surgery (time frame: After surgery 30 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Feb 2026.