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Myofascial Pain Syndrome - NeckNCT07098754

Comparing Physical Therapy Interventions on Craniovertebral Angle (CVA) in Cervical Myofascial Pain Syndrome (MPS)

A study testing Dry Needling, Trigger point therapy and Maitlands' Mobilizations in people with Myofascial Pain Syndrome - Neck, run by National Orthopedic and General Hospital at 1 site in Pakistan.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

Myofascial pain syndrome (MPS) and radiculopathy are prevalent musculoskeletal conditions that afflict a substantial portion of the population, causing significant discomfort and impairments in daily functioning. Read more about this study

Who is it for?
Ages 20 to 40 years
Conditions the study is for
Myofascial Pain Syndrome - Neck
What is being tested?
Dry Needling, Trigger point therapy and Maitlands' Mobilizations
Could I receive a placebo?
No, everyone receives an active treatment
How many people
100 participants
Where
1 sitePakistan
Study dates
15 Mar 2025to 15 Sep 2025
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 20 to 40 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Age: Participants must be between 20 and 40 years old.
  • Gender: Both genders, Male and Female have equal chance of selection as participant in the study.
  • Diagnosis: Participants must have a confirmed diagnosis of myofascial pain syndrome (MPS), altered cervical posture, restricted range of motion of cervical spine due to muscular spasm etc, altered craniovertebral angle, pain in cervical region or upper extremity and/or radiculopathy by a qualified healthcare professional, based on standardized diagnostic criteria (e.g., clinical examination, imaging studies).
  • Severity: Participants should have mild to moderate symptoms of MPS and/or radiculopathy, as determined by the assessing healthcare provider.
  • Willingness to Participate: Participants must be willing and able to comply physically and mentally with the study procedures, including attending scheduled physiotherapy sessions and completing outcome assessments.
  • Informed Consent: Participants will have to provide written informed consent mendatorily to be selected as participant in the study after receiving detailed information about the study aims, procedures, potential risks, and benefits.

Who cannot join

  • Severe Comorbidities: Participants with severe comorbidities or medical conditions that may interfere with their ability to participate in the study or confound the interpretation of results will be excluded. C1, C2 compression… vertigo
  • Surgeries: Participants who have undergone surgeries in the cervical or head region in past will be excluded due to potential confounding effects on outcomes.
  • Pregnancy: Pregnant individuals will be excluded from the study due to the potential risks associated with certain physiotherapy modalities and the need for specialized considerations in this population.
  • Contraindications: Participants with contraindications to specific physiotherapy modalities included in the study protocol (e.g., contraindications to dry needling, electrotherapy) will be excluded to ensure participant safety.
  • Inability to Attend Sessions: Participants who are unable to attend scheduled physiotherapy sessions due to logistical constraints (e.g., transportation issues, scheduling conflicts) will be excluded.
  • Cognitive Impairment: Participants with significant cognitive impairment or communication difficulties that may impede their ability to understand and follow study instructions will be excluded.
Show all 9Show fewer
  • Participation in Other Research: Participants who are currently participating in other research studies involving treatment interventions for MPS and/or radiculopathy will be excluded to avoid potential confounding effects on outcomes and treatment adherence.
  • Malignancies: participants suffering from any kind of malignancies will be excluded from the study.
  • Trauma: Participants having a history of trauma and fractures in head and neck region will also be excluded from the study.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Nasir Mehmood, MPhil contact

+923346165226

n.mehmood777@gmail.com

Mahtab AM Patafi, M.Phil contact

+923017766019

Pakistan1 site, 1 recruiting
  • National Orthopedic and General Hospital

    Bahawalpur, Punjab Province, 63100

    Saeed A Mian, +92622884580, clinic.ncpt@gmail.com

    Nasir Mehmood, Mphil

    Recruiting

Other trials in Pakistan

About this study

Official title: Comparative Analysis of Different Physiotherapy Interventions on Craniovertebral Angle in Individuals With Myofascial Pain Syndrome and Radiculopathy: a Randomized Controlled Trial

Myofascial pain syndrome (MPS) and radiculopathy are prevalent musculoskeletal conditions that afflict a substantial portion of the population, causing significant discomfort and impairments in daily functioning. MPS is characterized by localized muscle pain, trigger points, and referred pain, often accompanied by stiffness and restricted range of motion. A common feature shared by individuals with MPS and radiculopathy is the presence of postural abnormalities and balance impairments . The craniovertebral angle, which reflects the relationship between the head and neck, is often compromised in these individuals due to muscle imbalances, pain-related guarding, and structural changes in the spine. Various physiotherapy modalities, including dry needling, manual mobilization and soft tissue release, trigger point therapy, stretching, cupping therapy, and electrotherapy, have been utilized in clinical practice, but their relative efficacy in improving the craniovertebral angle and alleviating symptoms in individuals with MPS and radiculopathy has not been comprehensively compared. Understanding the underlying mechanisms and comparative effectiveness of various physiotherapy interventions is essential for guiding evidence-based clinical decision-making and optimizing treatment outcomes for individuals with MPS and radiculopathy. By elucidating the effects of different treatment modalities on the craniovertebral angle and associated outcomes, this research endeavor aims to contribute to the development of more tailored and effective physiotherapy approaches for improving the well-being of individuals affected by these debilitating musculoskeletal conditions.

Read the detailed description

Myofascial pain syndrome (MPS) and radiculopathy are prevalent musculoskeletal conditions that afflict a substantial portion of the population, causing significant discomfort and impairments in daily functioning. Myofascial pain syndrome (MPS) is characterized by localized muscle pain, trigger points, and referred pain, often accompanied by stiffness and restricted range of motion. Radiculopathy, on the other hand, involves dysfunction or compression of spinal nerve roots, resulting in symptoms such as radiating pain, numbness, and weakness along the affected nerve pathway. Both conditions can profoundly impact an individual's quality of life, leading to limitations in activities of daily living, work-related tasks, and recreational activities.

A common feature shared by individuals with Myofascial pain syndrome (MPS) and radiculopathy is the presence of postural abnormalities and balance impairments. The craniovertebral angle, which reflects the relationship between the head and neck, is often compromised in these individuals due to muscle imbalances, pain-related guarding, and structural changes in the spine. The alteration in the craniovertebral angle can exacerbate symptoms, contribute to muscle tension, and impede proper biomechanical function, further exacerbating the overall discomfort and functional limitations experienced by affected individuals.

The clinical examination of individuals with cervical spine disorders routinely encompasses assessment of posture, mobility, strength, and neuromuscular function. Among these, forward head posture (FHP)-characterized by anterior displacement of the head relative to the trunk-has been recognized as a key contributor to cervical dysfunction, neck pain, and related impairments. FHP is frequently implicated in a wide spectrum of musculoskeletal and neurological concerns, including temporomandibular disorders, headaches, visual disturbances, tinnitus, and altered electromyographic activity of craniofacial muscles, all of which can reduce sleep quality and daily function.

Anatomically, FHP involves extension of the upper cervical segments (C1-C3) and flexion of the lower cervical and upper thoracic segments, resulting in altered biomechanics and increased stress on the cervical musculature and joint. In addition, increased thoracic kyphosis is often associated with or predictive of FHP.

The craniovertebral angle (CVA), defined between a horizontal line through C7 and a line from C7 to the tragus of the ear, remains one of the most clinically accessible and valid quantitative indicators of FHP. A lower CVA represents a more pronounced forward head position, while higher angles reflect better postural alignment.

Despite these validated tools, there is limited research validating newer software platforms like MicroDiCom-commonly used in medical imaging-which may offer improved calibration, workflow integration, or measurement consistency. Each platform's unique interface and processing methodology necessitate separate psychometric evaluation.

Various physiotherapy modalities, including dry needling, manual mobilization and soft tissue release, trigger point therapy, stretching, cupping therapy, and electrotherapy, have been utilized in clinical practice, but their relative efficacy in improving the craniovertebral angle and alleviating symptoms in individuals with Myofascial pain syndrome (MPS)and radiculopathy has not been comprehensively compared.

Myofascial pain syndrome is often diagnosed in neuro-Musculo-skeletal pain patients with active Myofascial Trigger Points (MTrPs). The literature proposes many myo-fascial trigger point therapy procedures. There is a lack of credible evidence about inter and intra-efficacy among various therapy methods. One high-quality and two low-quality studies showed that conventional ultrasonography does not cure cervical and upper back myofascial trigger point pain better than placebo or no treatment. Magnet therapy may be a beneficial treatment, but more high-quality research is needed. Manual therapy trials imply that these therapies can be useful, however medium to long-term efficacy or effect more than placebo cannot be determined. Many neck region myofascial trigger point pain therapies lack proof. The variability of the included studies suggests that future high-quality trials could impact this review's conclusions. Future research must also examine perpetuating and contributory factors and the clinical efficacy of various treatment strategies.

Therefore, this research study aims to conduct a comparative analysis of these physiotherapy treatments on the craniovertebral angle in individuals diagnosed with MPS and radiculopathy. By evaluating the effects of different treatment modalities on posture, balance, pain levels, and overall quality of life, this study seeks to provide valuable insights into the optimal management of these challenging conditions.

Understanding the underlying mechanisms and comparative effectiveness of various physiotherapy interventions is essential for guiding evidence-based clinical decision-making and optimizing treatment outcomes for individuals with MPS and radiculopathy. By elucidating the effects of different treatment modalities on the craniovertebral angle and associated outcomes, this research endeavor aims to contribute to the development of more tailored and effective physiotherapy approaches for improving the well-being of individuals affected by these debilitating musculoskeletal conditions.

while there is evidence supporting the use of various physiotherapy interventions for managing pain and improving function in individuals with Myofascial pain syndrome (MPS) and radiculopathy, there is a paucity of research specifically comparative analysis of these interventions to find the most effective one as well as evaluating their effects on the craniovertebral angle. Addressing this gap in the literature is essential for developing more targeted and effective treatment approaches tailored to the unique needs of individuals with these conditions. The present study aims to fill this gap by conducting a comparative analysis of different physiotherapy treatments and their effects on the craniovertebral angle, pain levels, functional ability, and quality of life in individuals with MPS and radiculopathy.

Rationale:

Myofascial pain syndrome (MPS) and radiculopathy present complex challenges in clinical management, causing localized muscle pain, trigger points, and neurological deficits. These conditions severely impact daily functioning and quality of life, often manifesting in postural abnormalities and balance impairments. The craniovertebral angle, reflecting head-neck relationship, is frequently affected, leading to increased muscle tension and reduced mobility. Physiotherapy is pivotal in managing these conditions, yet the optimal approach targeting the craniovertebral angle remains unclear due to insufficient research. This study aims to compare various physiotherapy treatments (e.g., dry needling, manual mobilization) to improve the craniovertebral angle and alleviate symptoms. By understanding treatment effectiveness, healthcare providers can tailor interventions, ultimately improving care for MPS and radiculopathy patients. This research seeks to elucidate treatment mechanisms, guide clinical decisions, and enhance overall well-being for this challenging patient population

OBJECTIVES OF THE STUDY

Principal Objective:

To assess and compare the effects of different physiotherapy modalities, including dry needling, manual mobilization and soft tissue release, trigger point therapy, stretching, cupping therapy, and electrotherapy, on the craniovertebral angle and quality of life in individuals diagnosed with myofascial pain syndrome (MPS) and radiculopathy.

Specific Objectives:

  1. To compare improvements in pain levels, functional ability, and overall quality of life among the different treatment groups.
  2. To evaluate effects of different physiotherapy interventions on range of motion.
  3. To evaluate the effects of different physiotherapy interventions on craniovertebral angle.
  4. To evaluate the effects of different physiotherapy interventions on balance.
  5. To evaluate effects of different physiotherapy interventions on quality of life.
  6. To evaluate effects of different physiotherapy interventions on myofascial trigger points.

Research Question:

  1. Which is the most effective physiotherapy intervention to treat abnormal craniovertebral angle in patients with myofascial pain syndrome (MPS) and radiculopathy? II. Which physiotherapy intervention can bring optimal improvements in pain levels, functional ability, and overall quality of life among patients with myofascial pain syndrome (MPS) and radiculopathy? III. What is the effectiveness of different physiotherapy interventions regarding pain in patients with myofascial pain syndrome (MPS) and radiculopathy? IV. What is the effectiveness of different physiotherapy interventions in improving craniovertebral angle in patients with myofascial pain syndrome (MPS) and radiculopathy? V. What is the effectiveness of different physiotherapy interventions in improving balance in patients with myofascial pain syndrome (MPS) and radiculopathy? VI. What is the effectiveness of different physiotherapy interventions for improving range of motion in patients with myofascial pain syndrome (MPS) and radiculopathy? VII. What are the effects of different physiotherapy interventions on quality of life among patients with myofascial pain syndrome (MPS) and radiculopathy?

Conceptual Framework of Study:

With the purpose of evaluating and contrasting the effects of various physiotherapy techniques on persons who have been diagnosed with myofascial pain syndrome (MPS) and cervical radiculopathy, this research study aims to conduct an investigation. This study will include a total of one hundred participants, and it will be divided into four unique treatment groups, which are as follows: In Group A, dry needling and myofascial release will be administered, in Group B, trigger point therapy and stretching will be performed, in Group C, mobilisation grade-1 and grade-2 will be performed in conjunction with cupping therapy, and in Group D, the control group, electrotherapy (TENS and ultrasound) will be administered in conjunction with stretching and range of motion exercises. It is the primary purpose of this study to assess the efficacy of the various physiotherapy methods with regard to the craniovertebral angle (CVA) and the overall quality of life. One of the specific goals is to evaluate the effects of the therapies on range of motion, balance, and myofascial trigger points. Other specific objectives include comparing the levels of pain, functional ability, and quality of life that have improved among the treatment groups. The various physiotherapy techniques that were utilized in this investigation are the independent factors. The dependent variables, on the other hand, consist of pain levels, functional capacity, quality of life, range of motion, craniovertebral angle, balance, and the existence of myofascial trigger points. A randomized controlled trial methodology will be utilized for the research project. This methodology will comprise the utilization of pre-, mid-, and post-intervention assessments to evaluate the dependent variables. Additionally, proper statistical analysis will be utilized to compare the outcomes across the different groups. In the end, the purpose of this research is to provide valuable insights into the effectiveness of various physiotherapy modalities for the management of myofascial pain syndrome and cervical radiculopathy, as well as their effects on the craniovertebral angle (CVA). These findings have the potential to guide clinical practice and improve patient care.

Being tested
Dry Needling, Trigger point therapy, Maitlands' Mobilizations, Tens and ultrasound
Keywords
myofascial pain syndrome, dry needling in myofascial pain syndrome, cupping therapy in myofascial pain syndrome, best intervention for myofascial pain syndrome
Medical subject headings
Myofascial Pain Syndromes

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Dry NeedlingOther

    will use dry needles of different recommended sizes to intercept the trigger points

    will add on myofascial release technique manually.

  • Trigger point therapyOther

    will release trigger points by manual pressure using trigger point therapy technique protocols

    will ad on stretching techniques

  • Maitlands' MobilizationsOther

    Maitlands' Mobilizations Grade-1\& Grade-2 will be applied to upper thoracic and cervical regions

    dry cupping therapy will be applied as ad on therapy

  • Tens and ultrasoundOther

    TENS and ultrasound will be applied according to recommended dosages followed by stretching and Range of motion activities

Study groups in NCT07098754
Study groupRoleWhat they receive
Dry NeedlingExperimentalthis group will receive dry needling with myofascial release
Receives: Other: Dry Needling
Trigger Point TherapyExperimentalthis will receive trigger point therapy with stretching
Receives: Other: Trigger point therapy
Cupping TherapyExperimentalthis will receive dry cupping therapy with Mobilizations Grade-1\&2
Receives: Other: Maitlands' Mobilizations
Conventional PhysiotherapyActive comparatorWill receive electrotherapy with stretching and ROM exercises
Receives: Other: Tens and ultrasound

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Craniovertebral (CV) Angle

    Angle between horizontal line crossing spinous process of C7 and line joining the same with tragus of ear.

    it is assessed using digital photography and then calculating angle using MicroDiCom Software.

    Measured: Four Weeks

  2. Pain Severity

    Pain severity will be checked by Numeric Pain Rating Scale (NPRS). this scale consists of 0-10 values with 0 being no pain and 10 being the worst possible pain. Increasing pain scores show high severity of pain and decreasing/less scores show less severity of pain.

    Measured: Four weeks

Secondary outcomes (1)
  1. Balance

    Balance will be assessed using Y Balance Test. this test measures distance of reach on posterior side, anterolateral and anteromedial sides of one leg from keeping one foot stationary on a center point. Distance/reach is measured in cm. Higher values show better balance then lower values of reach in any direction.

    Measured: Four weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted1 Aug 2025
  2. Study start15 Mar 2025
  3. Primary completion5 Aug 2025 (estimated)
  4. Study completion15 Sep 2025 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Triple blind
Who is masked
Participant, Care provider, Outcomes assessor
Enrolment
100 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07098754
Sponsor's protocol ID
NOGH/NasirMehmoodPhD/0125/001
Status last verified
Jul 2025
First submitted
18 Jul 2025
Last updated
1 Aug 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No: The IPD will not be shared due to ethical and confidentiality concerns

Publications

  • Tekin L, Akarsu S, Durmus O, Cakar E, Dincer U, Kiralp MZ. The effect of dry needling in the treatment of myofascial pain syndrome: a randomized double-blinded placebo-controlled trial. Clin Rheumatol. 2013 Mar;32(3):309-15. doi: 10.1007/s10067-012-2112-3. Epub 2012 Nov 9.

    PubMed 23138883
  • Cheung Lau HM, Wing Chiu TT, Lam TH. Clinical measurement of craniovertebral angle by electronic head posture instrument: a test of reliability and validity. Man Ther. 2009 Aug;14(4):363-8. doi: 10.1016/j.math.2008.05.004. Epub 2008 Aug 9.

    PubMed 18694655
  • Al Bedah AM, Khalil MK, Posadzki P, Sohaibani I, Aboushanab TS, AlQaed M, Ali GI. Evaluation of Wet Cupping Therapy: Systematic Review of Randomized Clinical Trials. J Altern Complement Med. 2016 Oct;22(10):768-777. doi: 10.1089/acm.2016.0193. Epub 2016 Aug 24.

    PubMed 27557333
  • Joghataei MT, Arab AM, Khaksar H. The effect of cervical traction combined with conventional therapy on grip strength on patients with cervical radiculopathy. Clin Rehabil. 2004 Dec;18(8):879-87. doi: 10.1191/0269215504cr828oa.

    PubMed 15609843
  • Alfawaz S, Lohman E, Alameri M, Daher N, Jaber H. Effect of adding stretching to standardized procedures on cervical range of motion, pain, and disability in patients with non-specific mechanical neck pain: A randomized clinical trial. J Bodyw Mov Ther. 2020 Jul;24(3):50-58. doi: 10.1016/j.jbmt.2020.02.020. Epub 2020 Feb 22.

    PubMed 32826008
  • Mahajan R, Kataria C, Bansal K (2012). Comparative Effectiveness of Muscle Energy Technique and Static Stretching for Treatment of Subacute Mechanical Neck Pain. International Journal of Health and Rehabilitation Sciences; 1(1): 16-24.

  • Arjona Retamal JJ, Fernandez Seijo A, Torres Cintas JD, de-la-Llave-Rincon AI, Caballero Bragado A. Effects of Instrumental, Manipulative and Soft Tissue Approaches for the Suboccipital Region in Subjects with Chronic Mechanical Neck Pain. A Randomized Controlled Trial. Int J Environ Res Public Health. 2021 Aug 16;18(16):8636. doi: 10.3390/ijerph18168636.

    PubMed 34444389
  • Wang SQ, Jiang AY, Gao Q. Effect of manual soft tissue therapy on the pain in patients with chronic neck pain: A systematic review and meta-analysis. Complement Ther Clin Pract. 2022 Nov;49:101619. doi: 10.1016/j.ctcp.2022.101619. Epub 2022 Jun 12.

    PubMed 35988324
  • Kalichman L, Ben David C. Effect of self-myofascial release on myofascial pain, muscle flexibility, and strength: A narrative review. J Bodyw Mov Ther. 2017 Apr;21(2):446-451. doi: 10.1016/j.jbmt.2016.11.006. Epub 2016 Nov 14.

    PubMed 28532889
  • Ümit Dündar, Özlem Solak, Fatma aml, Vural Kavuncu. (2010). Effectiveness of Ultrasound Therapy in Cervical Myofascial Pain Syndrome: A Double Blind, Placebo-Controlled Study. Turk J Rheumatol; 25: 110-5

  • Siddique MAE, Rahman MM, Islam MS, Islam MW, Islam N, Uddin Z, et al. Physiotherapy versus pain medication for managing chronic Cervical Radiculopathy: protocol for a multi-arm parallel-group randomized clinical trial. F1000Research. 2023; 12:465.

  • Titcomb DA, Melton BF, Miyashita T, Bland HW. The Effects of Postural Education or Corrective Exercise on the Craniovertebral Angle in Young Adults with Forward Head Posture: A Randomized Controlled Trial. Int J Exerc Sci. 2023 Aug 1;16(1):954-973. doi: 10.70252/PYPQ8483. eCollection 2023.

    PubMed 37649869
  • Amjad F, Mohseni-Bandpei MA, Gilani SA, Ahmad A, Hanif A. Effects of non-surgical decompression therapy in addition to routine physical therapy on pain, range of motion, endurance, functional disability and quality of life versus routine physical therapy alone in patients with lumbar radiculopathy; a randomized controlled trial. BMC Musculoskelet Disord. 2022 Mar 16;23(1):255. doi: 10.1186/s12891-022-05196-x.

    PubMed 35296293
  • Han SC, Harrison P. Myofascial pain syndrome and trigger-point management. Reg Anesth. 1997 Jan-Feb;22(1):89-101. doi: 10.1016/s1098-7339(06)80062-3.

    PubMed 9010953
  • Cao QW, Peng BG, Wang L, Huang YQ, Jia DL, Jiang H, Lv Y, Liu XG, Liu RG, Li Y, Song T, Shen W, Yu LZ, Zheng YJ, Liu YQ, Huang D. Expert consensus on the diagnosis and treatment of myofascial pain syndrome. World J Clin Cases. 2021 Mar 26;9(9):2077-2089. doi: 10.12998/wjcc.v9.i9.2077.

    PubMed 33850927

Questions about this trial

What is this clinical trial studying?

A study testing Dry Needling, Trigger point therapy and Maitlands' Mobilizations in people with Myofascial Pain Syndrome - Neck, run by National Orthopedic and General Hospital at 1 site in Pakistan.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 1 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Nasir Mehmood, MPhil (+923346165226, n.mehmood777@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Craniovertebral (CV) Angle (time frame: Four Weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07098754, which also lists 16 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Aug 2025.

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