Arsenic PoisoningNCT07103356
Table-Top Water Pitcher to Reduce Arsenic Exposure Among Well Users in New Hampshire
A study testing Water Pitcher Filtration System in people with Arsenic Poisoning and Environmental Exposure, run by Trustees of Dartmouth College at 1 site in United States.
Trial summary
The goals of this clinical trial are to: 1. gather preliminary data on the effectiveness of a table-top water pitcher filtration system in reducing arsenic exposure among individuals using private wells with elevated (>5 μg/L) arsenic concentrations, and 2. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Arsenic Poisoning, Environmental Exposure, Water-Related Diseases
- What is being tested?
- Water Pitcher Filtration System
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 25 participants
- Where
- 1 siteUnited States
- Study dates
- 24 Feb 2026to 31 Aug 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age 18 years or older
- NH resident living in Merrimack or Belknap county
- Use a private water system as primary drinking water source
- Water arsenic >5 micrograms/L upon testing
- Confirm would be primary person in home maintaining the provided pitcher filter
Who cannot join
- Use or plan to use a mitigation strategy to reduce exposure to arsenic-contaminated drinking water in the next 12 weeks
Trial locations and contacts
1 site in 1 country.
United States1 site
Geisel School of Medicine at Dartmouth
Lebanon, New Hampshire, 03756
About this study
Official title: Developing a Hybrid Type 1 Effectiveness-Implementation Randomized Controlled Trial to Test a Table-Top Water Pitcher to Reduce Arsenic Exposure in Northern New England
The goals of this clinical trial are to:
- gather preliminary data on the effectiveness of a table-top water pitcher filtration system in reducing arsenic exposure among individuals using private wells with elevated (>5 μg/L) arsenic concentrations, and
- identify the factors influencing implementation of the filter intervention (uptake and sustainability) and barriers and facilitators to its use.
Read more
The main questions it aims to answer are:
Do water and urinary arsenic concentrations change from baseline to Week 4 of the water pitcher intervention?
Are changes in arsenic concentrations maintained during the eight-week sustainability period?
- Which factors facilitate or impede uptake, use, and sustainability of the intervention?
- Are household income and/or home ownership associated with sustained filter use?
Participants will:
- Receive a free 12-cup water filter pitcher and cartridge replacements
- Use the pitcher filtration system, including replacement of filter cartridges, per manufacturer recommendations
- Collect and mail water and urine samples at baseline, 4 weeks, and 12 weeks
- Complete online questionnaires at baseline, 4 weeks, and 12 weeks
- Being tested
- Water Pitcher Filtration System
- Keywords
- Arsenic, Private Well, Environmental Health, Filter
- Medical subject headings
- Arsenic Poisoning, Waterborne Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Water Pitcher Filtration SystemBehavioural
Table-top water pitcher filtration system
| Study group | Role | What they receive |
|---|---|---|
| Water Pitcher Filtration System | Experimental | Arm 1: All participants receive pitcher filter and three replacement filters Receives: Behavioral: Water Pitcher Filtration System |
What is being measured
The primary outcome is the main question the study is designed to answer.
Water arsenic concentrations
Changes in water arsenic concentrations from baseline to week 4
Measured: 4 weeks
Urinary arsenic concentrations
Changes in urinary arsenic concentrations from baseline to week 4
Measured: 4 weeks
Reach
Number of participants who receive the water pitcher filtration system among all eligible individuals and demographics
Measured: 4 weeks
Adoption
Number of participants using the filtration system after receiving it; number of participants who intend to use the system after the study period ends; and demographics of participants who used the filtration system during the study period or intend to use it after the study period ends
Measured: 4 weeks
Implementation
% of participants who adhere to the intervention during the intervention period (Fidelity), including using the pitcher filtration system for all drinking and cooking water and changing filter cartridges as recommended (measured by questionnaire: at home, did you use the pitcher filtration system for all of your drinking water, more than half of your drinking water, half of your drinking water, less than half of your drinking water, or none of your drinking water AND did you use did you use the pitcher filtration system for all of your cooking water, more than half of your cooking water, half of your cooking water, less than half of your cooking water, or none of your cooking water)
Measured: 4 weeks
Maintenance
% of participants who continue to use the pitcher filtration system during the 8-week sustainability period when replacement filter cartridges are no longer provided (measured by questionnaire: at home, did you use the pitcher filtration system for all of your drinking water, more than half of your drinking water, half of your drinking water, less than half of your drinking water, or none of your drinking water AND did you use did you use the pitcher filtration system for all of your cooking water, more than half of your cooking water, half of your cooking water, less than half of your cooking water, or none of your cooking water)
Measured: 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Aug 2025
- Study start24 Feb 2026
- Primary completion31 Aug 2027 (estimated)
- Study completion31 Aug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Arsenic PoisoningStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 25 participants (actual)
Sponsor and investigators
- Lead sponsor
- Trustees of Dartmouth College
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Caitlin G. Howe, Trustees of Dartmouth College
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07103356
- Sponsor's protocol ID
- STUDY00033185
- Status last verified
- Sep 2026
- First submitted
- 8 May 2025
- Last updated
- 28 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Developing a Hybrid Type 1 Effectiveness-Implementation Randomized Controlled Trial to Test a Table-Top Water Pitcher to Reduce Arsenic Exposure in Northern New England
- ClinicalTrials.gov ID
- NCT07103356
- Acronym / sponsor ID
- STUDY00033185
- Keywords
- Arsenic, Private Well, Environmental Health, Filter
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 25 participants (actual)
- Lead sponsor
- Trustees of Dartmouth CollegeUniversity, hospital or other
- Study start
- 24 Feb 2026 (actual)
- Primary completion
- 31 Aug 2027 (estimated)
- Study completion
- 31 Aug 2027 (estimated)
- First posted
- 5 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goals of this clinical trial are to:
- gather preliminary data on the effectiveness of a table-top water pitcher filtration system in reducing arsenic exposure among individuals using private wells with elevated (>5 μg/L) arsenic concentrations, and
- identify the factors influencing implementation of the filter intervention (uptake and sustainability) and barriers and facilitators to its use.
The main questions it aims to answer are:
Do water and urinary arsenic concentrations change from baseline to Week 4 of the water pitcher intervention?
Are changes in arsenic concentrations maintained during the eight-week sustainability period?
- Which factors facilitate or impede uptake, use, and sustainability of the intervention?
- Are household income and/or home ownership associated with sustained filter use?
Participants will:
- Receive a free 12-cup water filter pitcher and cartridge replacements
- Use the pitcher filtration system, including replacement of filter cartridges, per manufacturer recommendations
- Collect and mail water and urine samples at baseline, 4 weeks, and 12 weeks
- Complete online questionnaires at baseline, 4 weeks, and 12 weeks
Study design
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Water Pitcher Filtration System | Experimental | Behavioral: Water Pitcher Filtration SystemArm 1: All participants receive pitcher filter and three replacement filters |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Age 18 years or older
- NH resident living in Merrimack or Belknap county
- Use a private water system as primary drinking water source
- Water arsenic >5 micrograms/L upon testing
- Confirm would be primary person in home maintaining the provided pitcher filter
Key exclusion criteria (1 listed)
- Use or plan to use a mitigation strategy to reduce exposure to arsenic-contaminated drinking water in the next 12 weeks
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Water Pitcher Filtration SystemTable-top water pitcher filtration system | Behavioural | Water Pitcher Filtration System |
Primary outcome
Water arsenic concentrations
Time frame: 4 weeks
Changes in water arsenic concentrations from baseline to week 4
Urinary arsenic concentrations
Time frame: 4 weeks
Changes in urinary arsenic concentrations from baseline to week 4
Reach
Time frame: 4 weeks
Number of participants who receive the water pitcher filtration system among all eligible individuals and demographics
Adoption
Time frame: 4 weeks
Number of participants using the filtration system after receiving it; number of participants who intend to use the system after the study period ends; and demographics of participants who used the filtration system during the study period or intend to use it after the study period ends
Implementation
Time frame: 4 weeks
% of participants who adhere to the intervention during the intervention period (Fidelity), including using the pitcher filtration system for all drinking and cooking water and changing filter cartridges as recommended (measured by questionnaire: at home, did you use the pitcher filtration system for all of your drinking water, more than half of your drinking water, half of your drinking water, less than half of your drinking water, or none of your drinking water AND did you use did you use the pitcher filtration system for all of your cooking water, more than half of your cooking water, half of your cooking water, less than half of your cooking water, or none of your cooking water)
Maintenance
Time frame: 8 weeks
% of participants who continue to use the pitcher filtration system during the 8-week sustainability period when replacement filter cartridges are no longer provided (measured by questionnaire: at home, did you use the pitcher filtration system for all of your drinking water, more than half of your drinking water, half of your drinking water, less than half of your drinking water, or none of your drinking water AND did you use did you use the pitcher filtration system for all of your cooking water, more than half of your cooking water, half of your cooking water, less than half of your cooking water, or none of your cooking water)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Sep 2026.
Related trials for Arsenic Poisoning
Active, not recruiting
Strong Heart Water Study
Arsenic Poisoning
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Water Pitcher Filtration System in people with Arsenic Poisoning and Environmental Exposure, run by Trustees of Dartmouth College at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 28 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Water arsenic concentrations (time frame: 4 weeks). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Sep 2026.