PerformanceCROSSUVANCT07106281
Chronic Grape Extract in Crosstraining Athletes: A Randomized Crossover Trial
A study testing Grape Seed Extract in people with Performance, run by Universidad de Granada at 1 site in Spain.
Trial summary
The aim of this study is to investigate the effect of cronic GSE intake in crosstraining may have a favorable impact on biochemical markers, recovery, and performance. Read more about this study
- Who is it for?
- Ages 18 to 35 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Performance
- What is being tested?
- Grape Seed Extract
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 30 participants
- Where
- 1 siteSpain
- Study dates
- 1 Sep 2025to 31 Jan 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age: 18-35 years.
- Body mass index: 18.5-30 kg/m2.
- Ability to understand the instructions, objectives, and study protocol.
- Minimum of 3 years of experience in crosstraining, with at least 6 hours of weekly training over the past 3 months.
- Resident on the island of Tenerife.
Who cannot join
- History of a significant adverse cardiovascular event, renal insufficiency, cirrhosis, eating disorder, weight control surgical intervention, or type 2 diabetes mellitus.
- Any chronic pathology in which the intake of nutritional supplements, especially use of antioxidant supplements during the 4 weeks prior to the start of the study.
- Any condition that, in the investigator's judgment, would impair the ability to participate in the study or represent a personal risk to the participant.
- Use of medications that may affect the study results.
- Unstable body weight for 3 months prior to the start of the study (> 4 kg loss or gain in weight).
- Active tobacco abuse or illicit drug use, or history of treatment for alcohol abuse.
- On a special diet or prescribed for other reasons (e.g., celiac disease).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Spain1 site
Universidad de la Laguna
Santa Cruz de Tenerife
Alejandro R. Triviño, 616 53 57 61 ext. +34, nutrievidence@gmail.com
About this study
Official title: Effect of Chronic Grape Extract Supplementation in Trained Cross-training Athletes: A Randomized, Triple-blinded, Placebo-Controlled Crossover Study
The aim of this study is to investigate the effect of cronic GSE intake in crosstraining may have a favorable impact on biochemical markers, recovery, and performance.
Read the detailed description
Supplementation with certain antioxidant nutrients is a feasible strategy to accelerate recovery from fatigue and prevent exercise-induced oxidative damage. Grape seed extract (GSE) contains flavonoids such as proanthocyanidins, which are potent antioxidants with numerous health benefits. Therefore, optimizing the recovery process after training is essential for athletes engaged in strength and power sports who aim to enhance performance.
Thirty trained CrossFit athletes consumed grape seed extract or a placebo for one week. The training session consisted of a 12-minute strength block, a 13-minute metabolic conditioning (MetCon), and a final 15-minute MetCon. The Rating of Perceived Exertion (RPE), Gastrointestinal Distress Score (GDS), blood pressure and the Perceived Recovery Status scale (RPS) were administered at the beginning of the session and at the end of each segment of the CrossFit session. DOMS was assessed using a visual analog scale at 24 and 48 hours after the CrossFit session.
- Conditions
- Performance
- Being tested
- Grape Seed Extract, Placebo
- Keywords
- grape seed extract, muscle damage, concurrent exercise, nutrition, recovery
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Grape Seed ExtractDietary supplement
600mg of Grape Seed Extract
PlaceboDietary supplement
Placebo
| Study group | Role | What they receive |
|---|---|---|
| Grape seed extract | Experimental | 600 mg of Grape seed extract Receives: Dietary Supplement: Grape Seed Extract |
| Placebo | Placebo comparator | Preparation of colorants, sweeteners, aromas, and acidulants Receives: Dietary Supplement: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Performance
Performance measured through the countermovement jump
Measured: 48 hours
Performance
Deep squat test at 70% of repetition maximum
Measured: 60 minutes
Secondary outcomes (11)
Attention
Selective attention and inhibitory control measured by the Stroop test
Measured: 60 minutes
Performance: Weight used in the crosstraining session
Weight used in the crosstraining session
Measured: 60 minutes
Performance: Time performed in the crosstraining session
Time performed in the crosstraining session
Measured: 60 minutes
Subjective fatigue throug the the RPE scale
Rate of perceived exertion scale
Measured: 60 minutes
Gastrointestinal distress
Gastrointestinal distress through the Gastrointestinal Distress Score (GDS)
Measured: 60 minutes
Recovery
Perceived Recovery Status Scale (RPS)
Measured: 60 minutes
Delayed-onset muscle soreness (DOMS)
Delayed-onset muscle soreness (DOMS) scale (0-10 arbitrary units)
Measured: 24 hours
Capillar lactate levels
Capillar lactate levels
Measured: 60 minutes
Heart rate
Heart rate
Measured: 60 minutes
Blood pressure
Blood pressure
Measured: 60 minutes
Biochemical parameters
Biochemical parameters of muscle damage: Glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), creatine kinase (CK), urea, lactate dehydrogenase (LDH), myoglobin, glutathione peroxidase (GPx), catalase, superoxide dismutase (SOD), and interleukin 6 (IL-6)
Measured: 48 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Aug 2025
- Study start1 Sep 2025 (estimated)
- Primary completion20 Dec 2025 (estimated)
- Study completion31 Jan 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PerformanceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Universidad de Granada
- Sponsor type
- University, hospital or other
- Collaborators
- Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
- Responsible party
- Principal investigator, Lucas Jurado-Fasoli, Universidad de Granada
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07106281
- Sponsor's protocol ID
- CROSSUVA
- Acronym
- CROSSUVA
- Status last verified
- Jul 2025
- First submitted
- 21 Jul 2025
- Last updated
- 6 Aug 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 6 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Chronic Grape Extract Supplementation in Trained Cross-training Athletes: A Randomized, Triple-blinded, Placebo-Controlled Crossover Study
- ClinicalTrials.gov ID
- NCT07106281
- Acronym / sponsor ID
- CROSSUVA / CROSSUVA
- Conditions
- Performance
- Keywords
- grape seed extract, muscle damage, concurrent exercise, nutrition, recovery
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Universidad de GranadaUniversity, hospital or other
- Collaborators
- Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
- Study start
- 1 Sep 2025 (estimated)
- Primary completion
- 20 Dec 2025 (estimated)
- Study completion
- 31 Jan 2026 (estimated)
- First posted
- 6 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to investigate the effect of cronic GSE intake in crosstraining may have a favorable impact on biochemical markers, recovery, and performance.
Detailed description
Supplementation with certain antioxidant nutrients is a feasible strategy to accelerate recovery from fatigue and prevent exercise-induced oxidative damage. Grape seed extract (GSE) contains flavonoids such as proanthocyanidins, which are potent antioxidants with numerous health benefits. Therefore, optimizing the recovery process after training is essential for athletes engaged in strength and power sports who aim to enhance performance.
Thirty trained CrossFit athletes consumed grape seed extract or a placebo for one week. The training session consisted of a 12-minute strength block, a 13-minute metabolic conditioning (MetCon), and a final 15-minute MetCon. The Rating of Perceived Exertion (RPE), Gastrointestinal Distress Score (GDS), blood pressure and the Perceived Recovery Status scale (RPS) were administered at the beginning of the session and at the end of each segment of the CrossFit session. DOMS was assessed using a visual analog scale at 24 and 48 hours after the CrossFit session.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Grape seed extract | Experimental | Dietary Supplement: Grape Seed Extract600 mg of Grape seed extract |
| Placebo | Placebo comparator | Dietary Supplement: PlaceboPreparation of colorants, sweeteners, aromas, and acidulants |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Age: 18-35 years.
- Body mass index: 18.5-30 kg/m2.
- Ability to understand the instructions, objectives, and study protocol.
- Minimum of 3 years of experience in crosstraining, with at least 6 hours of weekly training over the past 3 months.
- Resident on the island of Tenerife.
Key exclusion criteria (7 listed)
- History of a significant adverse cardiovascular event, renal insufficiency, cirrhosis, eating disorder, weight control surgical intervention, or type 2 diabetes mellitus.
- Any chronic pathology in which the intake of nutritional supplements, especially use of antioxidant supplements during the 4 weeks prior to the start of the study.
- Any condition that, in the investigator's judgment, would impair the ability to participate in the study or represent a personal risk to the participant.
- Use of medications that may affect the study results.
- Unstable body weight for 3 months prior to the start of the study (> 4 kg loss or gain in weight).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Grape Seed Extract600mg of Grape Seed Extract | Dietary supplement | Grape seed extract |
| PlaceboPlacebo | Dietary supplement | Placebo |
Primary outcome
Performance
Time frame: 48 hours
Performance measured through the countermovement jump
Performance
Time frame: 60 minutes
Deep squat test at 70% of repetition maximum
11 secondary outcomes
Attention
Time frame: 60 minutes
Performance: Weight used in the crosstraining session
Time frame: 60 minutes
Performance: Time performed in the crosstraining session
Time frame: 60 minutes
Subjective fatigue throug the the RPE scale
Time frame: 60 minutes
Gastrointestinal distress
Time frame: 60 minutes
Recovery
Time frame: 60 minutes
Delayed-onset muscle soreness (DOMS)
Time frame: 24 hours
Capillar lactate levels
Time frame: 60 minutes
Heart rate
Time frame: 60 minutes
Blood pressure
Time frame: 60 minutes
Biochemical parameters
Time frame: 48 hours
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Aug 2025.
- Individual participant dataSharing planned: Undecided
Related trials for Performance
Active, not recruitingObservational study
Possible Sarcopenia, Sarcopenia, and Functional Status in Patients With Primary Sjögren's Syndrome
Primary Sjögren Syndrome, Sarcopenia
Recruiting
A Clinical Trial to Evaluate the Effects of Adrenal Adapt on Sleep Quality, Daytime Energy, Stress Resilience, and Cognitive Performance.
Improves Daytime Energy Levels, Reduces Afternoon Energy Crashes and Midday Fatigue
Not yet recruiting
Performance Evaluation of the OCUTOP Hand-held Corneal Topographer
Corneal Topography, Dry Eye Syndromes
Active, not recruiting
Enhancing Male Nursing Students' Competence in Maternity Care: A Quasi-Experimental Study in Egypt
Maternity Nursing Obstetric Nursing Clinical Competence Education, Nursing Simulation Training
Not yet recruitingObservational study
Diagnosis of ECMO Cannula Infection: Prospective Comparison of Sampling Methods
ECMO Cannula Infection, Extracorporel Membrane Oxygenation Complication
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Grape Seed Extract in people with Performance, run by Universidad de Granada at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 6 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Lucas Jurado-Fasoli, PhD (618375662 ext. +34, juradofasoli@ugr.es), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Performance (time frame: 48 hours). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Aug 2025.