Type 2 Diabetes Mellitus (T2DM)NCT07109102
Long-Term Benefits of Eccentric Cycling Exercise in Patients With Type 2 Diabetes Mellitus
A study testing Moderate-intensity eccentric cycling, High-intensity eccentric cycling and Moderate-intensity concentric cycling in people with Type 2 Diabetes Mellitus (T2DM), run by Universiti Sains Malaysia at 1 site in Malaysia.
Trial summary
The goal of this interventional study is to evaluate the long-term benefits of eccentric (ECC) cycling exercise on physiological responses, exercise capacity, and quality of life (QoL) in patients with type 2 diabetes mellitus (T2DM). Read more about this study
- Who is it for?
- Ages 30 to 60 years, men only
- Conditions the study is for
- Type 2 Diabetes Mellitus (T2DM)
- What is being tested?
- Moderate-intensity eccentric cycling, High-intensity eccentric cycling and Moderate-intensity concentric cycling
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteMalaysia
- Study dates
- Aug 2025to Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 60 years
- Men only
- No healthy volunteers
- Adult
Who may be able to join
- Male diagnosed with T2DM
- Age 30 - 60 years old
- Height ≥155cm (To ensure proper ergonomics, comfort and safety during cycling)
- HbA1C level between 6-8%
- No resistance exercise for ≤ 3 months before participating in the current study.
- Physical inactivity (moderate to vigorous exercise ≤60 minutes weekly based on International Physical Activity Questionnaires-Short Form (IPAQ-SF))
Who cannot join
- Acute illness or any foot ulcer, diabetic ulcer, retinopathy, kidney, musculoskeletal, cardiovascular, or neurological disorder that could impair exercise performance or pose a risk to participants during exercise.
- Insulin injection
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Malaysia1 site
Cardio and Muscle Function Laboratory, Pusat Perubatan USM Bertam
Kepala Batas, Pulau Pinang, 13200
Rabiatul Adawiah Abdul Rahman, +60193709614, rabiatuladawiah3105@gmail.com
About this study
Official title: Exploring Long-Term Benefits of Eccentric Cycling Exercise on Physiological Responses, Exercise Capacity, and Quality of Life in Patients With Type 2 Diabetes Mellitus
The goal of this interventional study is to evaluate the long-term benefits of eccentric (ECC) cycling exercise on physiological responses, exercise capacity, and quality of life (QoL) in patients with type 2 diabetes mellitus (T2DM). The main questions it aims to answer are:
- What are the effects of ECC cycling compared to concentric (CON) cycling on physiological responses, exercise capacity, and QoL in patients with T2DM?
- What are the differential effects of moderate- and high-intensity ECC cycling compared to CON cycling on physiological responses, exercise capacity, and QoL in patients with T2DM?
Read more
Researchers will compare moderate- and high-intensity ECC cycling to CON cycling (conventional cycling) to see if ECC cycling can be a viable alternative or complement to existing exercise protocols for managing T2DM.
Participants will:
- Undergo pre-, mid-, and post-intervention assessment
- Perform either moderate- or high-intensity ECC cycling or moderate intensity CON cycling according to group randomisation by the researcher.
- Start with two familiarisation sessions prior to the actual cycling training.
- Perform cycling exercise twice per week for 10 weeks.
- Conditions
- Type 2 Diabetes Mellitus (T2DM)
- Being tested
- Moderate-intensity eccentric cycling, High-intensity eccentric cycling, Moderate-intensity concentric cycling
- Keywords
- Eccentric cycling, eccentric exercise, exercise capacity, quality of life, physiological responses, Type 2 diabetes mellitus
- Medical subject headings
- Diabetes Mellitus, Type 2
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Moderate-intensity eccentric cyclingOther
Also called MI-ECC
- This group will perform eccentric cycling exercise twice per week for ten weeks using the Cyclus2 standard eccentric ergometer.
- The intensity will start at 60% of the peak power output (PPO) of the incremental concentric cycling test.
- The intensity will progressively increase by 5% of PPO every 2 weeks (60%-80% PPO).
High-intensity eccentric cyclingOther
Also called HI-ECC
- This group will perform eccentric cycling exercise twice per week for ten weeks using the Cyclus2 standard eccentric ergometer.
- The intensity will start at 80% of the peak power output (PPO) of the incremental concentric cycling test.
- The intensity will progressively increase by 5% of PPO every 2 weeks (80%-100% PPO).
Moderate-intensity concentric cyclingOther
Also called MI-CON
- This group will perform concentric cycling exercise twice per week for ten weeks using the Lode Excalibur sport ergometer.
- The intensity will start at 60% of the peak power output (PPO) of the incremental concentric cycling test.
- The intensity will progressively increase by 5% of PPO every 2 weeks (60%-80% PPO).
| Study group | Role | What they receive |
|---|---|---|
| Moderate intensity eccentric cycling (MI-ECC) | Experimental | Not described Receives: Other: Moderate-intensity eccentric cycling |
| High intensity eccentric cycling (HI-ECC) | Experimental | Not described Receives: Other: High-intensity eccentric cycling |
| Moderate intensity concentric cycling (MI-CON) | Active comparator | Not described Receives: Other: Moderate-intensity concentric cycling |
What is being measured
The primary outcome is the main question the study is designed to answer.
Glycated haemoglobin (HbA1C)
Measured: Baseline and post-intervention at 10 weeks
Lipid profile
Measured: Baseline and post-intervention at 10 weeks
Maximal voluntary contraction (MVC)
isometric quadriceps peak torque (QPT) and isokinetic QPT
Measured: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks).
Exercise capacity
6-minute walk test (6-MWT)
Measured: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
13-item Revised Version of Diabetes Quality of Life (RV-DQOL13)
Scores range from 13 to 65, with higher scores reflecting reduced quality of life
Measured: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
Short Form-12 (SF-12) health survey
Scoring ranges from 0 to 100, with higher scores indicating better physical and mental health.
Measured: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
Secondary outcomes (9)
Electromyography (EMG) for muscle activity assessment
To assess quadriceps muscle activity (rectus femoris, vastus medialis oblique, and vastus lateralis) during maximal voluntary contraction.
Measured: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
Blood pressure
systolic blood pressure (SBP), diastolic blood pressure (DBP),
Measured: Baseline and up to 10 weeks
Heart rate
Measured: Baseline and up to 10 weeks
Borg Category-Ratio scale (Borg CR-10)
The scale ranges from 0 (nothing at all) to 10 (extremely strong) to represent the participants' subjective feelings of breathlessness and leg fatigue.
Measured: Every cycling training session from week 1 to week 10
Body weight
Body weight in kilograms (kg)
Measured: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
Height
Height in centimeters (cm)
Measured: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
Body mass index (BMI)
BMI is calculated as weight (kg) divided by height (m²).
Measured: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
Body circumference
Measure the waist circumference (WC), hip circumference (HC), and thigh circumference (TC) in centimetres with a measuring tape.
Measured: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
The short version of the physical activity enjoyment scale (PACES-S)
Exercise enjoyment will be assessed using a five-point Likert scale (1 = strongly disagree to 5 = strongly agree), with total scores ranging from 4 to 20; higher scores indicate greater enjoyment.
Measured: Mid-intervention (6 weeks), and post-intervention (10 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Aug 2025
- Study startAug 2025 (estimated)
- Primary completionMay 2026 (estimated)
- Study completionAug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (12)Papers the sponsor has linked to this study.
- Other trials for Type 2 Diabetes Mellitus (T2DM)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This study is an open-label, single-centre, parallel-group, three-arm, randomised controlled study.
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Universiti Sains Malaysia
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Rabiatul Adawiah Abdul Rahman, Universiti Sains Malaysia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07109102
- Sponsor's protocol ID
- USM/JEPeM/PP/25030323
- Status last verified
- Jul 2025
- First submitted
- 29 Jul 2025
- Last updated
- 7 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Ansari M, Hardcastle S, Myers S, Williams AD. The Health and Functional Benefits of Eccentric versus Concentric Exercise Training: A Systematic Review and Meta-Analysis. J Sports Sci Med. 2023 Jun 1;22(2):288-309. doi: 10.52082/jssm.2023.288. eCollection 2023 Jun.
PubMed 37293426Borot L, Pageaux B, Laroche D, Vergotte G, Lepers R, Perrey S. Eccentric cycling involves greater mental demand and cortical activation of the frontoparietal network. Scand J Med Sci Sports. 2024 Jan;34(1):e14517. doi: 10.1111/sms.14517. Epub 2023 Oct 9.
PubMed 37814520Penailillo L, Blazevich AJ, Nosaka K. Factors contributing to lower metabolic demand of eccentric compared with concentric cycling. J Appl Physiol (1985). 2017 Oct 1;123(4):884-893. doi: 10.1152/japplphysiol.00536.2016. Epub 2017 Jun 29.
PubMed 28663378Hoppeler H. Moderate Load Eccentric Exercise; A Distinct Novel Training Modality. Front Physiol. 2016 Nov 16;7:483. doi: 10.3389/fphys.2016.00483. eCollection 2016.
PubMed 27899894Marcus RL, Lastayo PC, Dibble LE, Hill L, McClain DA. Increased strength and physical performance with eccentric training in women with impaired glucose tolerance: a pilot study. J Womens Health (Larchmt). 2009 Feb;18(2):253-60. doi: 10.1089/jwh.2007.0669.
PubMed 19183097Clos P, Laroche D, Stapley PJ, Lepers R. Neuromuscular and Perceptual Responses to Sub-Maximal Eccentric Cycling. Front Physiol. 2019 Mar 28;10:354. doi: 10.3389/fphys.2019.00354. eCollection 2019.
PubMed 30984032Penailillo L, Blazevich A, Numazawa H, Nosaka K. Metabolic and muscle damage profiles of concentric versus repeated eccentric cycling. Med Sci Sports Exerc. 2013 Sep;45(9):1773-81. doi: 10.1249/MSS.0b013e31828f8a73.
PubMed 23475167LaStayo P, Marcus R, Dibble L, Frajacomo F, Lindstedt S. Eccentric exercise in rehabilitation: safety, feasibility, and application. J Appl Physiol (1985). 2014 Jun 1;116(11):1426-34. doi: 10.1152/japplphysiol.00008.2013. Epub 2013 Jul 3.
PubMed 23823152LaStayo PC, Ewy GA, Pierotti DD, Johns RK, Lindstedt S. The positive effects of negative work: increased muscle strength and decreased fall risk in a frail elderly population. J Gerontol A Biol Sci Med Sci. 2003 May;58(5):M419-24. doi: 10.1093/gerona/58.5.m419.
PubMed 12730250Kudiarasu C, Rohadhia W, Katsura Y, Koeda T, Singh F, Nosaka K. Eccentric-only versus concentric-only resistance training effects on biochemical and physiological parameters in patients with type 2 diabetes. BMC Sports Sci Med Rehabil. 2021 Dec 20;13(1):162. doi: 10.1186/s13102-021-00384-z.
PubMed 34930480Julian V, Thivel D, Miguet M, Pereira B, Costes F, Coudeyre E, Duclos M, Richard R. Eccentric cycling is more efficient in reducing fat mass than concentric cycling in adolescents with obesity. Scand J Med Sci Sports. 2019 Jan;29(1):4-15. doi: 10.1111/sms.13301. Epub 2018 Oct 4.
PubMed 30222208Szucs G, Pipicz M, Szabo MR, Csont T, Torok L, Csonka C. Effect of Eccentric Exercise on Metabolic Health in Diabetes and Obesity. Sports Med Open. 2023 Sep 29;9(1):91. doi: 10.1186/s40798-023-00596-2.
PubMed 37775653
Study at a glance
From the registry record, last updated by the sponsor on 7 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Exploring Long-Term Benefits of Eccentric Cycling Exercise on Physiological Responses, Exercise Capacity, and Quality of Life in Patients With Type 2 Diabetes Mellitus
- ClinicalTrials.gov ID
- NCT07109102
- Acronym / sponsor ID
- USM/JEPeM/PP/25030323
- Conditions
- Type 2 Diabetes Mellitus (T2DM)
- Keywords
- Eccentric cycling, eccentric exercise, exercise capacity, quality of life, physiological responses, Type 2 diabetes mellitus
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Universiti Sains MalaysiaUniversity, hospital or other
- Study start
- Aug 2025 (estimated)
- Primary completion
- May 2026 (estimated)
- Study completion
- Aug 2026 (estimated)
- First posted
- 7 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this interventional study is to evaluate the long-term benefits of eccentric (ECC) cycling exercise on physiological responses, exercise capacity, and quality of life (QoL) in patients with type 2 diabetes mellitus (T2DM). The main questions it aims to answer are:
- What are the effects of ECC cycling compared to concentric (CON) cycling on physiological responses, exercise capacity, and QoL in patients with T2DM?
- What are the differential effects of moderate- and high-intensity ECC cycling compared to CON cycling on physiological responses, exercise capacity, and QoL in patients with T2DM?
Researchers will compare moderate- and high-intensity ECC cycling to CON cycling (conventional cycling) to see if ECC cycling can be a viable alternative or complement to existing exercise protocols for managing T2DM.
Participants will:
- Undergo pre-, mid-, and post-intervention assessment
- Perform either moderate- or high-intensity ECC cycling or moderate intensity CON cycling according to group randomisation by the researcher.
- Start with two familiarisation sessions prior to the actual cycling training.
- Perform cycling exercise twice per week for 10 weeks.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- This study is an open-label, single-centre, parallel-group, three-arm, randomised controlled study.
| Arm | Type | Receives |
|---|---|---|
| Moderate intensity eccentric cycling (MI-ECC) | Experimental | Other: Moderate-intensity eccentric cycling |
| High intensity eccentric cycling (HI-ECC) | Experimental | Other: High-intensity eccentric cycling |
| Moderate intensity concentric cycling (MI-CON) | Active comparator | Other: Moderate-intensity concentric cycling |
Who may qualify
- Ages
- 30 to 60 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Male diagnosed with T2DM
- Age 30 - 60 years old
- Height ≥155cm (To ensure proper ergonomics, comfort and safety during cycling)
- HbA1C level between 6-8%
- No resistance exercise for ≤ 3 months before participating in the current study.
Key exclusion criteria (2 listed)
- Acute illness or any foot ulcer, diabetic ulcer, retinopathy, kidney, musculoskeletal, cardiovascular, or neurological disorder that could impair exercise performance or pose a risk to participants during exercise.
- Insulin injection
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Moderate-intensity eccentric cyclingAlso: MI-ECC* This group will perform eccentric cycling exercise twice per week for ten weeks using the Cyclus2 standard eccentric ergometer. * The intensity will start at 60% of the peak power output (PPO) of the incremental concentric cycling test. * The intensity will progressively increase by 5% of PPO every 2 weeks (60%-80% PPO). | Other | Moderate intensity eccentric cycling (MI-ECC) |
| High-intensity eccentric cyclingAlso: HI-ECC* This group will perform eccentric cycling exercise twice per week for ten weeks using the Cyclus2 standard eccentric ergometer. * The intensity will start at 80% of the peak power output (PPO) of the incremental concentric cycling test. * The intensity will progressively increase by 5% of PPO every 2 weeks (80%-100% PPO). | Other | High intensity eccentric cycling (HI-ECC) |
| Moderate-intensity concentric cyclingAlso: MI-CON* This group will perform concentric cycling exercise twice per week for ten weeks using the Lode Excalibur sport ergometer. * The intensity will start at 60% of the peak power output (PPO) of the incremental concentric cycling test. * The intensity will progressively increase by 5% of PPO every 2 weeks (60%-80% PPO). | Other | Moderate intensity concentric cycling (MI-CON) |
Primary outcome
Glycated haemoglobin (HbA1C)
Time frame: Baseline and post-intervention at 10 weeks
Lipid profile
Time frame: Baseline and post-intervention at 10 weeks
Maximal voluntary contraction (MVC)
Time frame: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks).
isometric quadriceps peak torque (QPT) and isokinetic QPT
Exercise capacity
Time frame: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
6-minute walk test (6-MWT)
13-item Revised Version of Diabetes Quality of Life (RV-DQOL13)
Time frame: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
Scores range from 13 to 65, with higher scores reflecting reduced quality of life
Short Form-12 (SF-12) health survey
Time frame: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
Scoring ranges from 0 to 100, with higher scores indicating better physical and mental health.
9 secondary outcomes
Electromyography (EMG) for muscle activity assessment
Time frame: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
Blood pressure
Time frame: Baseline and up to 10 weeks
Heart rate
Time frame: Baseline and up to 10 weeks
Borg Category-Ratio scale (Borg CR-10)
Time frame: Every cycling training session from week 1 to week 10
Body weight
Time frame: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
Height
Time frame: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
Body mass index (BMI)
Time frame: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
Body circumference
Time frame: Baseline, mid-intervention (6 weeks), and post-intervention (10 weeks)
The short version of the physical activity enjoyment scale (PACES-S)
Time frame: Mid-intervention (6 weeks), and post-intervention (10 weeks)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Aug 2025.
- Background: PubMed 37293426Ansari M, Hardcastle S, Myers S, Williams AD. The Health and Functional Benefits of Eccentric versus Concentric Exercise Training: A Systematic Review and Meta-Analysis. J Sports Sci Med. 2023 Jun 1;22(2):288-309. doi: 10.52082/jssm.2023.288. eCollection 2023 Jun.
- Background: PubMed 37814520Borot L, Pageaux B, Laroche D, Vergotte G, Lepers R, Perrey S. Eccentric cycling involves greater mental demand and cortical activation of the frontoparietal network. Scand J Med Sci Sports. 2024 Jan;34(1):e14517. doi: 10.1111/sms.14517. Epub 2023 Oct 9.
- Background: PubMed 28663378Penailillo L, Blazevich AJ, Nosaka K. Factors contributing to lower metabolic demand of eccentric compared with concentric cycling. J Appl Physiol (1985). 2017 Oct 1;123(4):884-893. doi: 10.1152/japplphysiol.00536.2016. Epub 2017 Jun 29.
- Background: PubMed 27899894Hoppeler H. Moderate Load Eccentric Exercise; A Distinct Novel Training Modality. Front Physiol. 2016 Nov 16;7:483. doi: 10.3389/fphys.2016.00483. eCollection 2016.
- Background: PubMed 19183097Marcus RL, Lastayo PC, Dibble LE, Hill L, McClain DA. Increased strength and physical performance with eccentric training in women with impaired glucose tolerance: a pilot study. J Womens Health (Larchmt). 2009 Feb;18(2):253-60. doi: 10.1089/jwh.2007.0669.
- Background: PubMed 30984032Clos P, Laroche D, Stapley PJ, Lepers R. Neuromuscular and Perceptual Responses to Sub-Maximal Eccentric Cycling. Front Physiol. 2019 Mar 28;10:354. doi: 10.3389/fphys.2019.00354. eCollection 2019.
- Background: PubMed 23475167Penailillo L, Blazevich A, Numazawa H, Nosaka K. Metabolic and muscle damage profiles of concentric versus repeated eccentric cycling. Med Sci Sports Exerc. 2013 Sep;45(9):1773-81. doi: 10.1249/MSS.0b013e31828f8a73.
- Background: PubMed 23823152LaStayo P, Marcus R, Dibble L, Frajacomo F, Lindstedt S. Eccentric exercise in rehabilitation: safety, feasibility, and application. J Appl Physiol (1985). 2014 Jun 1;116(11):1426-34. doi: 10.1152/japplphysiol.00008.2013. Epub 2013 Jul 3.
- Background: PubMed 12730250LaStayo PC, Ewy GA, Pierotti DD, Johns RK, Lindstedt S. The positive effects of negative work: increased muscle strength and decreased fall risk in a frail elderly population. J Gerontol A Biol Sci Med Sci. 2003 May;58(5):M419-24. doi: 10.1093/gerona/58.5.m419.
- Background: PubMed 34930480Kudiarasu C, Rohadhia W, Katsura Y, Koeda T, Singh F, Nosaka K. Eccentric-only versus concentric-only resistance training effects on biochemical and physiological parameters in patients with type 2 diabetes. BMC Sports Sci Med Rehabil. 2021 Dec 20;13(1):162. doi: 10.1186/s13102-021-00384-z.
- Background: PubMed 30222208Julian V, Thivel D, Miguet M, Pereira B, Costes F, Coudeyre E, Duclos M, Richard R. Eccentric cycling is more efficient in reducing fat mass than concentric cycling in adolescents with obesity. Scand J Med Sci Sports. 2019 Jan;29(1):4-15. doi: 10.1111/sms.13301. Epub 2018 Oct 4.
- Background: PubMed 37775653Szucs G, Pipicz M, Szabo MR, Csont T, Torok L, Csonka C. Effect of Eccentric Exercise on Metabolic Health in Diabetes and Obesity. Sports Med Open. 2023 Sep 29;9(1):91. doi: 10.1186/s40798-023-00596-2.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Moderate-intensity eccentric cycling, High-intensity eccentric cycling and Moderate-intensity concentric cycling in people with Type 2 Diabetes Mellitus (T2DM), run by Universiti Sains Malaysia at 1 site in Malaysia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 7 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Malaysia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Syamimi Shamsuddin (+6045622024, syamimi.s@usm.my), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Glycated haemoglobin (HbA1C) (time frame: Baseline and post-intervention at 10 weeks). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07109102, which also lists 12 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Aug 2025.