AnxietyBreathIVFNCT07109544
Effect of Breathing Exercises on Embryo Transfer Outcomes
A study testing Breathing Therapy in people with Anxiety and Pregnancy Outcomes, run by Eurofertil IVF Health Center at 1 site in Turkey (Türkiye).
Trial summary
Breathing exercises are being used in many different clinical issues in the area of medicine. Also in gynecological practice, especially during labor, breathing exercises are encouraged by health professionals to aid the patients. Read more about this study
- Who is it for?
- Ages 20 to 40 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Anxiety, Pregnancy Outcomes
- What is being tested?
- Breathing Therapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 16 Jun 2025to 15 Jul 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- good quality blastocyst transfer
Who cannot join
- known psychiatric disorder
- history of recurrent implantation failure or pregnancy loss
- known genetik abnormalities
- known mullerian anomalies except for arcuate uterus
- PGT-a cycles
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Breathing Exercises on Embryo Transfer Success Rates in In Vitro Fertilization Treatment: A Prospective Randomized Controlled Trial
Breathing exercises are being used in many different clinical issues in the area of medicine. Also in gynecological practice, especially during labor, breathing exercises are encouraged by health professionals to aid the patients. These may have benefits of process of labor as it promises attenuating the anxiety and also relaxing the pelvic muscles. IVF, which may be one of most challenging times of couples, particularly women, is reported to be related with increased anxiety. Breathing exercises may potentially help women overcome anxiety before embryo transfer, a critical step in IVF. Being an easy and non-expensive approach, breathing exercises can be recommended in every IVF clinic. Thus, the investigators wanted to observe the effects of breathing exercises on embryo transfer results.
Read the detailed description
The connection between breathing, especially abnormal breathing patterns, and emotions has always attracted attention and has been studied in various ways. There are publications reporting that this situation becomes even more evident when symptoms are associated with anxiety. Emotions are clearly expressed through breathing changes in rhythm, depth, location or regularity. It has been reported that the rhythm related to breathing is lost when there is a period of uncertainty for the person, especially in the near future. From this relationship, the possible positive effects of optimizing movements, breathing patterns and rhythms on emotional states can be expected. Breathing exercises and their effects have been investigated in many different patient groups in the field of medicine and their positive effects have been found.
This interest has also been observed in the field of obstetrics and gynecology. In a study published in 2023 examining the effects of breathing exercises on patients interned for birth, it was reported that breathing exercises increased the rate of normal birth and reduced the rate of caeserean section after labor, and also decreased the time spent for normal birth. Having a child is very important for couples. Therefore, not having a child is often observed as a distressing and worrying experience for couples. This situation can be expected to be even more pronounced, especially in couples who cannot achieve pregnancy after different treatments and trials and who reach the in vitro fertilization process.
There are also studies in the literature on the effect of the emotional state of couples, especially women, on the in vitro fertilization process . Different approaches have been put forward for the increased anxiety seen in these studies, and it has been shown that yoga and some other holistic medical practices can reduce the anxiety levels of women undergoing the in vitro fertilization process . However, to our knowledge, no study has drawn attention in which the possible benefits of breathing therapy have been examined in patients undergoing embryo transfer. The investigators aimed to investigate the effectiveness of breathing therapy, which is easy to apply and does not require any cost, in women who are potentially nervous or anxious due to embryo transfer.
- Conditions
- Anxiety, Pregnancy Outcomes
- Being tested
- Breathing Therapy
- Keywords
- Breathing exercises, IVF, Embryo transfer, Anxiety
- Medical subject headings
- Anxiety Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Breathing TherapyOther
The patients in the control group will be receiving breathing therapy by a certificated clinical nurse
| Study group | Role | What they receive |
|---|---|---|
| Therapy group | Experimental | The arm that the patients will receive breathing exercise therapy Receives: Other: Breathing Therapy |
| Control Arm | Other | The patients with standart care Receives: Other: Breathing Therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pregnancy results after embryo transfer
Blood samples will be taken for beta-HCG test
Measured: 12 days after the embryo transfer
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Aug 2025
- Study start16 Jun 2025
- Primary completion30 Jun 2026 (estimated)
- Study completion15 Jul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AnxietyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- As the possible effects of breathing exercises are planned to be analyzed, two groups are established. The groups are going to be formed by randomisation. While one group of patients will receive breathing exercises throughout their process , the control group patients will not.
- Masking
- None (open label)
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Eurofertil IVF Health Center
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Elif Güler Ergin, Eurofertil IVF Health Center
- Investigators
- Gerçek Aydın, Asst. Prof., Principal investigator, Eurofertil IVF Health Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07109544
- Sponsor's protocol ID
- eurofertil-breathing
- Acronym
- BreathIVF
- Status last verified
- Jul 2025
- First submitted
- 18 Jul 2025
- Last updated
- 7 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: The names of patients will not be shared. The data of study can be shared upon request
Study at a glance
From the registry record, last updated by the sponsor on 7 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Breathing Exercises on Embryo Transfer Success Rates in In Vitro Fertilization Treatment: A Prospective Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07109544
- Acronym / sponsor ID
- BreathIVF / eurofertil-breathing
- Conditions
- Anxiety, Pregnancy Outcomes
- Keywords
- Breathing exercises, IVF, Embryo transfer, Anxiety
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Eurofertil IVF Health CenterUniversity, hospital or other
- Study start
- 16 Jun 2025 (actual)
- Primary completion
- 30 Jun 2026 (estimated)
- Study completion
- 15 Jul 2026 (estimated)
- First posted
- 7 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Breathing exercises are being used in many different clinical issues in the area of medicine. Also in gynecological practice, especially during labor, breathing exercises are encouraged by health professionals to aid the patients. These may have benefits of process of labor as it promises attenuating the anxiety and also relaxing the pelvic muscles. IVF, which may be one of most challenging times of couples, particularly women, is reported to be related with increased anxiety. Breathing exercises may potentially help women overcome anxiety before embryo transfer, a critical step in IVF. Being an easy and non-expensive approach, breathing exercises can be recommended in every IVF clinic. Thus, the investigators wanted to observe the effects of breathing exercises on embryo transfer results.
Detailed description
The connection between breathing, especially abnormal breathing patterns, and emotions has always attracted attention and has been studied in various ways. There are publications reporting that this situation becomes even more evident when symptoms are associated with anxiety. Emotions are clearly expressed through breathing changes in rhythm, depth, location or regularity. It has been reported that the rhythm related to breathing is lost when there is a period of uncertainty for the person, especially in the near future. From this relationship, the possible positive effects of optimizing movements, breathing patterns and rhythms on emotional states can be expected. Breathing exercises and their effects have been investigated in many different patient groups in the field of medicine and their positive effects have been found.
This interest has also been observed in the field of obstetrics and gynecology. In a study published in 2023 examining the effects of breathing exercises on patients interned for birth, it was reported that breathing exercises increased the rate of normal birth and reduced the rate of caeserean section after labor, and also decreased the time spent for normal birth. Having a child is very important for couples. Therefore, not having a child is often observed as a distressing and worrying experience for couples. This situation can be expected to be even more pronounced, especially in couples who cannot achieve pregnancy after different treatments and trials and who reach the in vitro fertilization process.
There are also studies in the literature on the effect of the emotional state of couples, especially women, on the in vitro fertilization process . Different approaches have been put forward for the increased anxiety seen in these studies, and it has been shown that yoga and some other holistic medical practices can reduce the anxiety levels of women undergoing the in vitro fertilization process . However, to our knowledge, no study has drawn attention in which the possible benefits of breathing therapy have been examined in patients undergoing embryo transfer. The investigators aimed to investigate the effectiveness of breathing therapy, which is easy to apply and does not require any cost, in women who are potentially nervous or anxious due to embryo transfer.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- As the possible effects of breathing exercises are planned to be analyzed, two groups are established. The groups are going to be formed by randomisation. While one group of patients will receive breathing exercises throughout their process , the control group patients will not.
| Arm | Type | Receives |
|---|---|---|
| Therapy group | Experimental | Other: Breathing TherapyThe arm that the patients will receive breathing exercise therapy |
| Control Arm | Other | Other: Breathing TherapyThe patients with standart care |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- good quality blastocyst transfer
Key exclusion criteria (5 listed)
- known psychiatric disorder
- history of recurrent implantation failure or pregnancy loss
- known genetik abnormalities
- known mullerian anomalies except for arcuate uterus
- PGT-a cycles
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Breathing TherapyThe patients in the control group will be receiving breathing therapy by a certificated clinical nurse | Other | Control Arm, Therapy group |
Primary outcome
Pregnancy results after embryo transfer
Time frame: 12 days after the embryo transfer
Blood samples will be taken for beta-HCG test
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Aug 2025.
- Individual participant dataSharing planned: No. The names of patients will not be shared. The data of study can be shared upon request
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Gerçek Aydın, Asst. Prof. principal investigator
Eurofertil IVF Health Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Breathing Therapy in people with Anxiety and Pregnancy Outcomes, run by Eurofertil IVF Health Center at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 7 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pregnancy results after embryo transfer (time frame: 12 days after the embryo transfer). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Aug 2025.