DepressionmultimodalNCT07112118
Multimodal Identification of Depressive Symptoms in the Elderly
An observational study of Depression, run by Wuhan Mental Health Centre at 1 site in China.
Trial summary
Screening with depression scales alone is subjective, and relying on single-modal data often leads to incomplete identification of symptoms that are easily missed or misdiagnosed. Read more about this study
- Who is it for?
- Ages 60 to 100 yearsHealthy volunteers can take part
- Conditions the study is for
- Depression
- What is being tested?
- data collection
- How many people
- 2,000 participants
- Where
- 1 siteChina
- Study dates
- 1 Sep 2025to 30 Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 to 100 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Elderly individuals aged 60 years or older
Who may be able to join
- Elderly individuals aged 60 years or older.
- Residents of the community (with residence time of more than 6 months).
- Possessing certain reading, writing and comprehension skills, being able to communicate with researchers without obstacles, and being able to independently complete the measurement of various indicators or, although unable to independently fill out the questionnaire, being able to independently make evaluations of the questionnaire items.
- Those who have given informed consent.
Who cannot join
- Those who meet the diagnostic criteria for cognitive impairment (dementia) as stipulated in DSM-5, and/or who suffer from severe physical diseases (such as advanced cancer, cardiovascular and cerebrovascular diseases, etc.).
- Those who are undergoing antidepressant treatment.
- Elderly individuals who have had suicidal thoughts in any psychological assessment, should be referred to the psychological hotline platform in Wuhan.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site
Wuhan Mental Health Center
Wuhan, Hubei, 430012
Xiuxiu Zhou, PhD, 86+13545075638, xiuxiuzhou@hust.edu.cn
About this study
Official title: Multimodal Identification of Depressive Symptoms
Screening with depression scales alone is subjective, and relying on single-modal data often leads to incomplete identification of symptoms that are easily missed or misdiagnosed. In this study, we first aim to use artificial intelligence to construct a depression symptom recognition model, concatenate multimodal features such as facial expression, audio, text, and postural behavior, and deeply fuse them to construct a multimodal model.
- Conditions
- Depression
- Being tested
- data collection
- Keywords
- depression symptoms
- Medical subject headings
- Depression
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
data collectionOther
Collect the facial expressions, audio, text and postural behavior data of the respondents using electronic devices.
| Study group | Role | What they receive |
|---|---|---|
| non-depression | Elderly people without depressive symptoms Receives: Other: data collection | |
| depression | Elderly people at risk of depression Receives: Other: data collection |
What is being measured
The primary outcome is the main question the study is designed to answer.
Use the PHQ-9 (Patient Health Questionnaire - 9 ) to assess whether the respondents have depressive symptoms. The scale score is one point for each item.
If the PHQ-9 score is 5 or higher, it is determined as a positive sign of depressive symptoms.
Measured: 2025.09.01-2026.09.01
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Aug 2025
- Study start1 Sep 2025 (estimated)
- Primary completion1 Sep 2026 (estimated)
- Study completion30 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for DepressionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Ecologic or community
- Time perspective
- Cross-sectional
- Enrolment
- 2,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Wuhan Mental Health Centre
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Xiaoxv Yin, PhD, Study chair, Huazhong University of Science and Technology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07112118
- Sponsor's protocol ID
- KY2025.0115.01
- Other IDs
- 72404094
- Acronym
- multimodal
- Status last verified
- Jul 2025
- First submitted
- 17 Jul 2025
- Last updated
- 11 Aug 2025
- Results posted
- No
- Data monitoring committee
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Multimodal Identification of Depressive Symptoms
- ClinicalTrials.gov ID
- NCT07112118
- Acronym / sponsor ID
- multimodal / KY2025.0115.01
- Conditions
- Depression
- Keywords
- depression symptoms
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 2,000 participants (estimated)
- Lead sponsor
- Wuhan Mental Health CentreUniversity, hospital or other
- Study start
- 1 Sep 2025 (estimated)
- Primary completion
- 1 Sep 2026 (estimated)
- Study completion
- 30 Dec 2027 (estimated)
- First posted
- 8 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Screening with depression scales alone is subjective, and relying on single-modal data often leads to incomplete identification of symptoms that are easily missed or misdiagnosed. In this study, we first aim to use artificial intelligence to construct a depression symptom recognition model, concatenate multimodal features such as facial expression, audio, text, and postural behavior, and deeply fuse them to construct a multimodal model.
Study design
- Observational model
- Ecologic or community
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| non-depression | – | Other: data collectionElderly people without depressive symptoms |
| depression | – | Other: data collectionElderly people at risk of depression |
Who may qualify
- Ages
- 60 to 100 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Elderly individuals aged 60 years or older
Key inclusion criteria (4 listed)
- Elderly individuals aged 60 years or older.
- Residents of the community (with residence time of more than 6 months).
- Possessing certain reading, writing and comprehension skills, being able to communicate with researchers without obstacles, and being able to independently complete the measurement of various indicators or, although unable to independently fill out the questionnaire, being able to independently make evaluations of the questionnaire items.
- Those who have given informed consent.
Key exclusion criteria (3 listed)
- Those who meet the diagnostic criteria for cognitive impairment (dementia) as stipulated in DSM-5, and/or who suffer from severe physical diseases (such as advanced cancer, cardiovascular and cerebrovascular diseases, etc.).
- Those who are undergoing antidepressant treatment.
- Elderly individuals who have had suicidal thoughts in any psychological assessment, should be referred to the psychological hotline platform in Wuhan.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| data collectionCollect the facial expressions, audio, text and postural behavior data of the respondents using electronic devices. | Other | depression, non-depression |
Primary outcome
Use the PHQ-9 (Patient Health Questionnaire - 9 ) to assess whether the respondents have depressive symptoms. The scale score is one point for each item.
Time frame: 2025.09.01-2026.09.01
If the PHQ-9 score is 5 or higher, it is determined as a positive sign of depressive symptoms.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Aug 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Xiaoxv Yin, PhD study chair
Huazhong University of Science and Technology
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Depression, run by Wuhan Mental Health Centre at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 11 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Xiuxiu Zhou, PhD (86+13545075638, xiuxiuzhou@hust.edu.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Use the PHQ-9 (Patient Health Questionnaire - 9 ) to assess whether the respondents have depressive symptoms. The scale score is one point for each item. (time frame: 2025.09.01-2026.09.01). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Aug 2025.