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Sport NutritionNCT07114341

Effect of Lyophilized Cornelian Cherry on Anaerobic Performance in Young Football Players

A study testing Cranberry Intervention in people with Sport Nutrition and Sports Performance in Children, run by Istanbul Bilgi University at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The goal of this clinical trial is to learn if a lyophilized Cornelian Cherry supplement works to improve anaerobic performance and reduce fatigue in young football players (U14-U19 age group). Read more about this study

Who is it for?
Ages 14 to 19 years, men onlyHealthy volunteers can take part
What is being tested?
Cranberry Intervention
Could I receive a placebo?
No, everyone receives an active treatment
How many people
50 participants
Where
1 siteTurkey (Türkiye)
Study dates
1 Apr 2025to 30 Apr 2025
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 14 to 19 years
  • Men only
  • Healthy volunteers accepted
  • Child, Adult

Who may be able to join

  • 13-18 ages of adolescent football

Who cannot join

  • Disease diagnosis or history,
  • Regular medication use,
  • Regular nutritional supplement use,
  • Being under 14 years of age,
  • Being over 19 years of age.

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site
  • Istanbul Bilgi University

    Istanbul

Other trials in Turkey (Türkiye)

About this study

The goal of this clinical trial is to learn if a lyophilized Cornelian Cherry supplement works to improve anaerobic performance and reduce fatigue in young football players (U14-U19 age group).

The main questions it aims to answer are:

Read more
  • Does taking a lyophilized Cornelian Cherry supplement improve participants' anaerobic performance as measured by the Running-based Anaerobic Sprint Test (RAST)?
  • Does the supplement reduce participants' levels of fatigue after strenuous exercise?

Researchers will measure participants' performance and fatigue levels before the study begins and compare them to the levels measured after 1 week of taking the cranberry supplement. This will help determine the effect of the supplement.

Participants will:

  • Take 30 grams of lyophilized Cornelian Cherry powder every day for 1 week.
  • Visit the study center at the beginning and at the end of the 1-week period for checkups and tests.
  • Undergo anthropometric measurements (such as height, weight, and body composition) at the start of the study.
  • Perform a Running-based Anaerobic Sprint Test (RAST) and a fatigue test at the start and end of the study.
Read the detailed description

A balanced diet plays a role in preventing injuries, improving athletic performance, and accelerating post-exercise recovery in adolescents who engage in physical activity. The physiological response to exercise can vary depending on the duration, intensity, and frequency of exercise, as well as environmental conditions. Excessive reactive oxygen species (ROS) production triggered by high-intensity exercise or other stress factors in athletes can lead to oxidative stress and subsequent tissue damage by weakening the antioxidant defense system. Therefore, athletes may need to maintain increased ROS scavenging activity. Additionally, physical exercise can lead to injuries in skeletal muscle tissue, leading to decreased performance. Therefore, strategies to manage exercise-related injuries and post-exercise inflammatory processes may contribute to accelerating exercise adaptation and recovery. Recently, there has been increasing support for the possibility of improving exercise performance through supplementation with fruit-derived polyphenols. Polyphenols are secondary metabolites abundant in plant foods and are divided into four main groups: lignans, stilbenes, and flavonoids. Anthocyanins, a subclass of flavonoids, are found in red, purple, and blue vegetables and fruits. Anthocyanins are known for their antioxidant and anti-inflammatory properties, and therefore, they are thought to prevent adverse physiological effects such as fatigue and post-exercise inflammation, which can potentially occur during exercise. The potential mechanism of action is thought to be related to antioxidant and vascular effects. Turkey is among the countries where cornelian cherries, another fruit with high biological value due to their anthocyanin and other phenolic compounds, are cultivated. Randomized controlled trials have examined the effectiveness of freeze-dried cornelian cherry supplements in various disease groups. Studies have observed positive effects on lipid profiles, as well as parameters related to body mass index (BMI), body weight, waist and hip circumference, and insulin resistance. Another randomized controlled trial has indicated that cornelian cherry supplementation may be effective in accelerating post-exercise recovery in athletes. While the literature has evaluated the effects of various forms of supplementation with fruits high in anthocyanins on sports performance, studies examining anaerobic power and capacity with cornelian cherry supplementation in adolescent athletes are limited. Therefore, the purpose of this study was to evaluate the effects of freeze-dried cornelian cherry fruit on anaerobic performance in adolescent soccer players.

Being tested
Cranberry Intervention
Keywords
cranberry, sports nutrition, ergogenic acids, football, adolecent athletes

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Cranberry InterventionOther

    30 grams of lyophilized cranberry containing 1187 mg/100 g anthocyanins were given for 7 days.

Study groups in NCT07114341
Study groupRoleWhat they receive
BaselineNo interventionIn order to determine the standard performance of the adolescent football players in the first stage before the intervention, a Running-Based Anaerobic Sprint Test (RAST) was applied to the adolescent football players on a grass field in an open-air environment after a 10-minute warm-up exercise.
Cranberry InterventionActive comparatorIn the second phase of the study, adolescent soccer players were given 30 grams of freeze-dried cranberries containing 1187 mg/100 g anthocyanins daily for 1 week. To determine post-intervention performance, the adolescent soccer players underwent a 10-minute warm-up exercise followed by a Running-Based Anaerobic Sprint Test (RAST) on a grass field in an outdoor environment.
Receives: Other: Cranberry Intervention

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Running-Based Anaerobic Sprint Test (RAST) - Performance Test

    The RAST is a test consisting of six 35-meter sprints at maximum speed, with a 10-second rest interval between each sprint. In this test, power is calculated for each sprint using body mass and the resulting performance data (Power = (Total body mass x Distance2) / Time3). The highest recorded number is called maximum power; the lowest number is called minimum power; and the sum of the six sprints divided by six is called average power. Muscle fatigue is assessed using the Fatigue Index (Maximum Power - Minimum Power) / Sum of the 6 sprint times). A lower value indicates that athletes have better muscular ability to maintain their performance without fatigue.

    Measured: From enrollment to the end of study at 1 week

Secondary outcomes (12)
  1. Anthropometric Measurements - Body weight (kg)

    At the beginning and end of the study, body weights (kg) measured using a bioelectrical impedance (BIA) device with a sensitivity of 50 grams in accordance with the measurement standards.

    Measured: From enrollment to the end of study at 1 week

  2. Anthropometric Measurements - Height

    Height (cm) measured with a stadiometer in the Frankfort plane, standing and with the head upright.

    Measured: 1 week

  3. Body Mass Index

    The body mass index (BMI) of the participants was calculated according to the body weight (kg) / height (m)2 formula.

    Measured: From enrollment to the end of study at 1 week

  4. Anthropometric Measurements - Fat Mass

    At the beginning and end of the study, body fat mass (kg) analysis was performed using a bioelectrical impedance (BIA) device, paying attention to measurement standards.

    Measured: From enrollment to the end of study at 1 week

  5. Anthropometric Measurements - Fat ratio calculation

    At the beginning and end of the study, body composition analyses was performed using a bioelectrical impedance (BIA) device with measurement standards. According to the BIA analysis, fat percentage (%) will be calculated as the ratio of total body fat weight to total body weight.

    Measured: From enrollment to the end of study at 1 week

  6. Anthropometric Measurements - Fat-free mass

    At the beginning and end of the study, fat-free mass (kg) was analyzed using a bioelectrical impedance (BIA) device, paying attention to measurement standards.

    Measured: From enrollment to the end of study at 1 week

  7. Anthropometric Measurements - Muscle mass

    At the beginning and end of the study, lean muscle mass (kg) was analyzed using a bioelectrical impedance (BIA) device, paying attention to measurement standards.

    Measured: From enrollment to the end of study at 1 week

  8. Anthropometric Measurements - Total body water

    At the beginning and end of the study, total body water (kg) was analyzed using a bioelectrical impedance (BIA) device, paying attention to measurement standards.

    Measured: From enrollment to the end of study at 1 week

  9. Food Consumption Record - Energy

    The food consumption record was taken to evaluate the nutritional status of the participants. Food consumption records were evaluated in the BeBIS (Nutrition Information System) program and the daily energy (kcal) intake will be calculated.

    Measured: 1 day

  10. Food Consumption Record

    The food consumption record were taken to evaluate the nutritional status of the participants. Food consumption records were evaluated in the BeBIS (Nutrition Information System) program and the daily carbohydrate (g), protein (g), fat (g), saturated fat (g), monounsaturated fatty acid (g), polyunsaturated fatty acid (g), omega-3 fatty acids (g), omega-6 fatty acids (g), and fiber (g) intake were calculated.

    Measured: 1 day

  11. Food Consumption Record

    The food consumption record was taken to evaluate the nutritional status of the participants. Food consumption records were evaluated in the BeBIS (Nutrition Information System) program and the daily vitamin A (µg), vitamin D (µg), vitamin K (µg), folate (µg), and vitamin B12 (µg) intake were calculated.

    Measured: 1 day

  12. Food Consumption Record

    The food consumption record was taken to evaluate the nutritional status of the participants. Food consumption records were evaluated in the BeBIS (Nutrition Information System) program and the daily vitamin E (mg), thiamine (mg), riboflavine (mg), niacin (mg), vitamine B5 (mg), vitamin B6 (mg), vitamin C, sodium (mg), potassium (mg), calcium (mg), magnesium (mg), phosphor (mg), iron (mg), zinc (mg), copper (mg), cholesterol (mg) intake were calculated.

    Measured: 1 day

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted11 Aug 2025
  2. Study start1 Apr 2025
  3. Primary completion30 Apr 2025
  4. Study completion30 Apr 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Supportive care
Allocation
Not applicable
Intervention model
Single group
Model description
This study designed as an intervention study.
Masking
None (open label)
Enrolment
50 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07114341
Sponsor's protocol ID
CORNELIANCHERRYFOOTBALLSTUDY
Status last verified
Aug 2025
First submitted
3 Aug 2025
Last updated
8 Sep 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Braakhuis AJ, Somerville VX, Hurst RD. The effect of New Zealand blackcurrant on sport performance and related biomarkers: a systematic review and meta-analysis. J Int Soc Sports Nutr. 2020 May 27;17(1):25. doi: 10.1186/s12970-020-00354-9.

    PubMed 32460873
  • Donno D, Neirotti G, Fioccardi A, Razafindrakoto ZR, Tombozara N, Mellano MG, Beccaro GL, Gamba G. Freeze-Drying for the Reduction of Fruit and Vegetable Chain Losses: A Sustainable Solution to Produce Potential Health-Promoting Food Applications. Plants (Basel). 2025 Jan 9;14(2):168. doi: 10.3390/plants14020168.

    PubMed 39861522
  • Jastrzebska AD. Comparison of usefulness of two tests measuring anaerobic performance of untrained and soccer-training girls U12. Sci Rep. 2023 Nov 9;13(1):19498. doi: 10.1038/s41598-023-46825-2.

    PubMed 37945713
  • Rizal M, Segalita C, Mahmudiono T. The Relationship between Body Mass Index, Body Fat Percentage, and Dietary Intake with Muscle Fatigue in Adolescent Football Players. J Nutr Sci Vitaminol (Tokyo). 2020;66(Supplement):S134-S136. doi: 10.3177/jnsv.66.S134.

    PubMed 33612582
  • Bayram HM, Iliaz R, Gunes FE. Effects of Cornus mas L. on anthropometric and biochemical parameters among metabolic associated fatty liver disease patients: Randomized clinical trial. J Ethnopharmacol. 2024 Jan 10;318(Pt B):117068. doi: 10.1016/j.jep.2023.117068. Epub 2023 Aug 21.

    PubMed 37611681
  • Kazimierski M, Regula J, Molska M. Cornelian cherry (Cornus mas L.) - characteristics, nutritional and pro-health properties. Acta Sci Pol Technol Aliment. 2019 Jan-Mar;18(1):5-12. doi: 10.17306/J.AFS.0628.

    PubMed 30927747
  • Godwin C, Cook MD, Willems MET. Effect of New Zealand Blackcurrant Extract on Performance during the Running Based Anaerobic Sprint Test in Trained Youth and Recreationally Active Male Football Players. Sports (Basel). 2017 Sep 15;5(3):69. doi: 10.3390/sports5030069.

    PubMed 29910429
  • Khoo HE, Azlan A, Tang ST, Lim SM. Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food Nutr Res. 2017 Aug 13;61(1):1361779. doi: 10.1080/16546628.2017.1361779. eCollection 2017.

    PubMed 28970777
  • Bowtell J, Kelly V. Fruit-Derived Polyphenol Supplementation for Athlete Recovery and Performance. Sports Med. 2019 Feb;49(Suppl 1):3-23. doi: 10.1007/s40279-018-0998-x.

    PubMed 30671906
  • Bolat E, Saritas S, Duman H, Eker F, Akdasci E, Karav S, Witkowska AM. Polyphenols: Secondary Metabolites with a Biological Impression. Nutrients. 2024 Aug 3;16(15):2550. doi: 10.3390/nu16152550.

    PubMed 39125431
  • Volpe-Fix AR, de Franca E, Silvestre JC, Thomatieli-Santos RV. The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise: A Review. Foods. 2023 Feb 21;12(5):916. doi: 10.3390/foods12050916.

    PubMed 36900433
  • Sawada Y, Ichikawa H, Ebine N, Minamiyama Y, Alharbi AAD, Iwamoto N, Fukuoka Y. Effects of High-Intensity Anaerobic Exercise on the Scavenging Activity of Various Reactive Oxygen Species and Free Radicals in Athletes. Nutrients. 2023 Jan 1;15(1):222. doi: 10.3390/nu15010222.

    PubMed 36615878
  • He F, Li J, Liu Z, Chuang CC, Yang W, Zuo L. Redox Mechanism of Reactive Oxygen Species in Exercise. Front Physiol. 2016 Nov 7;7:486. doi: 10.3389/fphys.2016.00486. eCollection 2016.

    PubMed 27872595
  • Capra ME, Stanyevic B, Giudice A, Monopoli D, Decarolis NM, Esposito S, Biasucci G. Nutrition for Children and Adolescents Who Practice Sport: A Narrative Review. Nutrients. 2024 Aug 22;16(16):2803. doi: 10.3390/nu16162803.

    PubMed 39203939
  • Amawi A, Khataybeh B, Al Aqaili R, Ababneh N, Alnimer L, Qoqazeh A, Oukal F, Jahrami H, Mousa Ay K, Al Saoud H, Ghazzawi H. Junior athletes' nutritional demands: a narrative review of consumption and prevalence of eating disorders. Front Nutr. 2024 Sep 24;11:1390204. doi: 10.3389/fnut.2024.1390204. eCollection 2024.

    PubMed 39381351

Questions about this trial

What is this clinical trial studying?

A study testing Cranberry Intervention in people with Sport Nutrition and Sports Performance in Children, run by Istanbul Bilgi University at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 8 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Running-Based Anaerobic Sprint Test (RAST) - Performance Test (time frame: From enrollment to the end of study at 1 week). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07114341, which also lists 15 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Sep 2025.

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