Hypertension (HTN)NCT07114952
The Effect of Alternate Nasal Breathing Exercise ın Hypertension
A study testing alternative nasal breathing in people with Hypertension (HTN), run by Adiyaman University at 1 site in Turkey (Türkiye).
Trial summary
This study is a randomized controlled experimental trial designed to examine the effect of alternative nasal breathing exercises on blood pressure and perceived stress levels in patients with hypertension. The study sample includes a total of 52 patients, with 26 in the intervention group and 26 in the control group. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Hypertension (HTN)
- What is being tested?
- alternative nasal breathing
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 52 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 6 Jan 2025to 26 May 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged between 18 and 65,
- Literate,
- Diagnosed with hypertension at least 6 months ago,
- No change in hypertension medications in the last three months,
- Functionally capable of performing alternative nasal breathing exercises,
- Patients who volunteered to participate in the study were included.
Who cannot join
- Patients with psychiatric diagnoses,
- Patients with cognitive impairment,
- Patients practicing yoga or breathing exercises for hypertension,
- Patients with heart failure, cancer, kidney failure, or respiratory diseases were not included in the study.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Adana City Training and Research Hospital, Cardiology Outpatient Clinic
Adana, Yüreğir, 1370
About this study
Official title: The Effect of Alternate Nasal Breathing Exercise on Blood Pressure and Stress Levels in Individuals With Hypertension: A Randomized Controlled Experimental Study
This study is a randomized controlled experimental trial designed to examine the effect of alternative nasal breathing exercises on blood pressure and perceived stress levels in patients with hypertension. The study sample includes a total of 52 patients, with 26 in the intervention group and 26 in the control group.
Read the detailed description
Aim: This study is being conducted as a randomized controlled experimental study to examine the effect of alternate nasal breathing exercises on blood pressure and stress levels in hypertensive patients.
Materials and Methods: The study sample consists of 52 patients (26 intervention and 26 control) from cardiology outpatient clinics. Ethics committee approval, institutional permissions, and verbal and written informed consent were obtained from the participants. Patients in the intervention group are instructed to perform alternate nasal breathing exercises for 10 minutes daily for four weeks, while the control group continues with routine treatment. Data collection tools include the Patient Introduction Form, Perceived Stress Scale, Life Findings Follow-up Form, and Blood Pressure Monitoring Forms. Planned statistical analyses include Independent Sample t-test, Paired Sample t-test, chi-square test, Mann-Whitney U test, and Wilcoxon test.
- Conditions
- Hypertension (HTN)
- Being tested
- alternative nasal breathing
- Keywords
- Hypertension, Breathing Exercises, Blood pressure, Stress, Nursing
- Medical subject headings
- Hypertension
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
alternative nasal breathingBehavioural
The alternate nasal breathing exercise involves breathing in and out through both nostrils in a certain pattern and for a certain period of time. For example, an individual who breathes in through the right nostril for 5 seconds with the left nostril closed, then closes the right nostril and exhales through the left nostril for 5 seconds. Then he/she inhales through the left nostril for 5 seconds and exhales through the right nostril. A total of 6 breaths are taken per minute. The application is applied for 5 minutes, the patient rests in a calm environment for two minutes and the application is performed for another 5 minutes. In order to increase the compliance of individuals with the application, a sample video was watched and application instructions were given by the researcher. The application was performed while the patients were in an upright sitting position.
| Study group | Role | What they receive |
|---|---|---|
| alternative nasal breathing exercise intervention group | Experimental | The intervention group of 26 participants practiced an alternative nasal breathing exercise. This group practiced alternate nasal breathing exercise for 4 weeks. Receives: Behavioral: alternative nasal breathing |
| control group | No intervention | The group consisted of 26 participants. No intervention was administered. Participants continued their usual care without any additional exercises or treatments during the study period. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in systolic and diastolic blood pressure
The blood pressure of the patients in the control group was measured twice, at the beginning of the study and 1 month later. In the measurement to be performed in the morning hours, the patients rested for 5 minutes in a calm environment before the measurement and then the measurement was made from the brachial artery in the arm. The same automatic sphygmomanometer was used for blood pressure measurement in all patients. " https://www.stridebp.org/bp-monitors/ " A blood pressure measuring device listed at
Measured: Baseline and 4 weeks after intervention
Secondary outcomes (2)
Change in perceived stress scores
The Perceived Stress Scale was used to assess perceived stress. The 10-question form was used in our study. The scale has a two-factor structure consisting of perceived inadequacy/self-efficacy and stress/distress. Responses are based on a five-point Likert scale, ranging from never (0) to very often (4), with reverse-scored items (4, 5, 7, 8). As the score from the scale increases, stress levels also increase.
Measured: Baseline and 4 weeks after intervention
Change in self-measured home blood pressure
Blood pressure measurements at home were taken using automatic blood pressure monitors. Patients were instructed on blood pressure measurement rules, such as taking measurements two hours after breakfast and after resting for five minutes, and were given a home blood pressure monitoring form to ensure follow-up. The form, which is intended for blood pressure monitoring, also ensures communication between the researcher and the patient.
The four-week form includes patients' home blood pressure measurements.
Measured: Daily measurements during the 4-week intervention period
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Aug 2025
- Study start6 Jan 2025
- Primary completion26 May 2025
- Study completion26 May 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hypertension (HTN)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- "In this randomized controlled trial, participants were divided into two groups: an intervention group performing alternate nasal breathing exercises and a control group with no intervention. Outcomes were measured before and 4 weeks after the intervention period."
- Masking
- None (open label)
- Enrolment
- 52 participants (actual)
Sponsor and investigators
- Lead sponsor
- Adiyaman University
- Sponsor type
- University, hospital or other
- Collaborators
- Cukurova University
- Responsible party
- Principal investigator, Leyla Senem Ün, Cukurova University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07114952
- Sponsor's protocol ID
- CU-SBF-LSU-01
- Status last verified
- Aug 2025
- First submitted
- 29 Jul 2025
- Last updated
- 11 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Alternate Nasal Breathing Exercise on Blood Pressure and Stress Levels in Individuals With Hypertension: A Randomized Controlled Experimental Study
- ClinicalTrials.gov ID
- NCT07114952
- Acronym / sponsor ID
- CU-SBF-LSU-01
- Conditions
- Hypertension (HTN)
- Keywords
- Hypertension, Breathing Exercises, Blood pressure, Stress, Nursing
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 52 participants (actual)
- Lead sponsor
- Adiyaman UniversityUniversity, hospital or other
- Collaborators
- Cukurova University
- Study start
- 6 Jan 2025 (actual)
- Primary completion
- 26 May 2025 (actual)
- Study completion
- 26 May 2025 (actual)
- First posted
- 11 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is a randomized controlled experimental trial designed to examine the effect of alternative nasal breathing exercises on blood pressure and perceived stress levels in patients with hypertension. The study sample includes a total of 52 patients, with 26 in the intervention group and 26 in the control group.
Detailed description
Aim: This study is being conducted as a randomized controlled experimental study to examine the effect of alternate nasal breathing exercises on blood pressure and stress levels in hypertensive patients.
Materials and Methods: The study sample consists of 52 patients (26 intervention and 26 control) from cardiology outpatient clinics. Ethics committee approval, institutional permissions, and verbal and written informed consent were obtained from the participants. Patients in the intervention group are instructed to perform alternate nasal breathing exercises for 10 minutes daily for four weeks, while the control group continues with routine treatment. Data collection tools include the Patient Introduction Form, Perceived Stress Scale, Life Findings Follow-up Form, and Blood Pressure Monitoring Forms. Planned statistical analyses include Independent Sample t-test, Paired Sample t-test, chi-square test, Mann-Whitney U test, and Wilcoxon test.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- "In this randomized controlled trial, participants were divided into two groups: an intervention group performing alternate nasal breathing exercises and a control group with no intervention. Outcomes were measured before and 4 weeks after the intervention period."
| Arm | Type | Receives |
|---|---|---|
| alternative nasal breathing exercise intervention group | Experimental | Behavioral: alternative nasal breathingThe intervention group of 26 participants practiced an alternative nasal breathing exercise. This group practiced alternate nasal breathing exercise for 4 weeks. |
| control group | No intervention | –The group consisted of 26 participants. No intervention was administered. Participants continued their usual care without any additional exercises or treatments during the study period. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Aged between 18 and 65,
- Literate,
- Diagnosed with hypertension at least 6 months ago,
- No change in hypertension medications in the last three months,
- Functionally capable of performing alternative nasal breathing exercises,
Key exclusion criteria (4 listed)
- Patients with psychiatric diagnoses,
- Patients with cognitive impairment,
- Patients practicing yoga or breathing exercises for hypertension,
- Patients with heart failure, cancer, kidney failure, or respiratory diseases were not included in the study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| alternative nasal breathingThe alternate nasal breathing exercise involves breathing in and out through both nostrils in a certain pattern and for a certain period of time. For example, an individual who breathes in through the right nostril for 5 seconds with the left nostril closed, then closes the right nostril and exhales through the left nostril for 5 seconds. Then he/she inhales through the left nostril for 5 seconds and exhales through the right nostril. A total of 6 breaths are taken per minute. The application is applied for 5 minutes, the patient rests in a calm environment for two minutes and the application is performed for another 5 minutes. In order to increase the compliance of individuals with the application, a sample video was watched and application instructions were given by the researcher. The application was performed while the patients were in an upright sitting position. | Behavioural | alternative nasal breathing exercise intervention group |
Primary outcome
Change in systolic and diastolic blood pressure
Time frame: Baseline and 4 weeks after intervention
The blood pressure of the patients in the control group was measured twice, at the beginning of the study and 1 month later. In the measurement to be performed in the morning hours, the patients rested for 5 minutes in a calm environment before the measurement and then the measurement was made from the brachial artery in the arm. The same automatic sphygmomanometer was used for blood pressure measurement in all patients. " https://www.stridebp.org/bp-monitors/ " A blood pressure measuring device listed at
2 secondary outcomes
Change in perceived stress scores
Time frame: Baseline and 4 weeks after intervention
Change in self-measured home blood pressure
Time frame: Daily measurements during the 4-week intervention period
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Aug 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing alternative nasal breathing in people with Hypertension (HTN), run by Adiyaman University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 11 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in systolic and diastolic blood pressure (time frame: Baseline and 4 weeks after intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Aug 2025.