AppendicitisNCT07115303
Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure
A study testing Laparoscopic Appendectomy with application of clips for stump closure and Laparoscopic Appendectomy with ligature for stump closure in people with Appendicitis, run by Sohag University at 1 site in Egypt.
Trial summary
This a prospective study to compare between clipping and ligation of appendicular stump in laparoscopic appendectomies regarding ;technical feasibility , post operative complications as fecal fistula and economic consideration. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Appendicitis
- What is being tested?
- Laparoscopic Appendectomy with application of clips for stump closure and Laparoscopic Appendectomy with ligature for stump closure
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 siteEgypt
- Study dates
- 14 Jul 2025to 28 Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Any patient diagnosed with acute appendicitis of any age and of any sex presented to ER of the Department of General, Laparoscopic and Oncologic Surgery Department, Sohag University Hospital will be enrolled in this study.
Who cannot join
- Patients with complicated appendicitis.
- Patients with unstable cardiac or pulmonary condition.
- Patients with suspicious crhon's disease or mass intraoperative.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Mohamed M Ali, Professor contact
Egypt1 site, 1 recruiting
- Recruiting
Sohag university hospital
Sohag
magdy M Amin, professor
About this study
Official title: Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure: A Comparative Study
This a prospective study to compare between clipping and ligation of appendicular stump in laparoscopic appendectomies regarding ;technical feasibility , post operative complications as fecal fistula and economic consideration.
- Conditions
- Appendicitis
- Being tested
- Laparoscopic Appendectomy with application of clips for stump closure, Laparoscopic Appendectomy with ligature for stump closure
- Medical subject headings
- Appendicitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Laparoscopic Appendectomy with application of clips for stump closureProcedure or surgery
in patients who will undergo Laparoscopic Appendectomy, appendicular stump will be closed by application of clips
Laparoscopic Appendectomy with ligature for stump closureProcedure or surgery
in patients who will undergo Laparoscopic Appendectomy, appendicular stump will be closed by ligation
| Study group | Role | What they receive |
|---|---|---|
| Laparoscopic Appendectomy with application of clips for stump closure | Active comparator | Not described Receives: Procedure: Laparoscopic Appendectomy with application of clips for stump closure |
| Laparoscopic Appendectomy with ligature for stump closure | Active comparator | Not described Receives: Procedure: Laparoscopic Appendectomy with ligature for stump closure |
What is being measured
The primary outcome is the main question the study is designed to answer.
Results of Laparoscopic Appendectomy with application of clips versus ligature for stump closure
postoperative hospital stay
Measured: 24 hours postoperative
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Aug 2025
- Study start14 Jul 2025
- Primary completion28 Feb 2026 (estimated)
- Study completion28 Feb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for AppendicitisStudies of the same condition, open and under way.
- More trials run by Sohag UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sohag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Amer Abdelraheem, Sohag University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07115303
- Sponsor's protocol ID
- Soh-Med-25-7---18MS
- Status last verified
- Aug 2025
- First submitted
- 4 Aug 2025
- Last updated
- 11 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Makaram N, Knight SR, Ibrahim A, Patil P, Wilson MSJ. Closure of the appendiceal stump in laparoscopic appendectomy: A systematic review of the literature. Ann Med Surg (Lond). 2020 Aug 4;57:228-235. doi: 10.1016/j.amsu.2020.07.058. eCollection 2020 Sep.
PubMed 32802324Farahani PK, Safaei N. Comparison of two methods: Clipping and suturing in laparoscopic appendectomy. Surg Open Sci. 2024 May 3;19:162-165. doi: 10.1016/j.sopen.2024.04.007. eCollection 2024 Jun.
PubMed 38764557Poon SHT, Law SY, Lai ATY. Clips closure versus endoloop ligation in laparoscopic appendectomy: a systematic review and meta-analysis of comparative studies. Ann Med Surg (Lond). 2023 Sep 6;85(10):5011-5021. doi: 10.1097/MS9.0000000000001260. eCollection 2023 Oct.
PubMed 37811063
Study at a glance
From the registry record, last updated by the sponsor on 11 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure: A Comparative Study
- ClinicalTrials.gov ID
- NCT07115303
- Acronym / sponsor ID
- Soh-Med-25-7---18MS
- Conditions
- Appendicitis
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Sohag UniversityUniversity, hospital or other
- Study start
- 14 Jul 2025 (actual)
- Primary completion
- 28 Feb 2026 (estimated)
- Study completion
- 28 Feb 2026 (estimated)
- First posted
- 11 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This a prospective study to compare between clipping and ligation of appendicular stump in laparoscopic appendectomies regarding ;technical feasibility , post operative complications as fecal fistula and economic consideration.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Laparoscopic Appendectomy with application of clips for stump closure | Active comparator | Procedure: Laparoscopic Appendectomy with application of clips for stump closure |
| Laparoscopic Appendectomy with ligature for stump closure | Active comparator | Procedure: Laparoscopic Appendectomy with ligature for stump closure |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (1 listed)
- Any patient diagnosed with acute appendicitis of any age and of any sex presented to ER of the Department of General, Laparoscopic and Oncologic Surgery Department, Sohag University Hospital will be enrolled in this study.
Key exclusion criteria (3 listed)
- Patients with complicated appendicitis.
- Patients with unstable cardiac or pulmonary condition.
- Patients with suspicious crhon's disease or mass intraoperative.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Laparoscopic Appendectomy with application of clips for stump closurein patients who will undergo Laparoscopic Appendectomy, appendicular stump will be closed by application of clips | Procedure or surgery | Laparoscopic Appendectomy with application of clips for stump closure |
| Laparoscopic Appendectomy with ligature for stump closurein patients who will undergo Laparoscopic Appendectomy, appendicular stump will be closed by ligation | Procedure or surgery | Laparoscopic Appendectomy with ligature for stump closure |
Primary outcome
Results of Laparoscopic Appendectomy with application of clips versus ligature for stump closure
Time frame: 24 hours postoperative
postoperative hospital stay
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Aug 2025.
- Background: PubMed 32802324Makaram N, Knight SR, Ibrahim A, Patil P, Wilson MSJ. Closure of the appendiceal stump in laparoscopic appendectomy: A systematic review of the literature. Ann Med Surg (Lond). 2020 Aug 4;57:228-235. doi: 10.1016/j.amsu.2020.07.058. eCollection 2020 Sep.
- Background: PubMed 38764557Farahani PK, Safaei N. Comparison of two methods: Clipping and suturing in laparoscopic appendectomy. Surg Open Sci. 2024 May 3;19:162-165. doi: 10.1016/j.sopen.2024.04.007. eCollection 2024 Jun.
- Background: PubMed 37811063Poon SHT, Law SY, Lai ATY. Clips closure versus endoloop ligation in laparoscopic appendectomy: a systematic review and meta-analysis of comparative studies. Ann Med Surg (Lond). 2023 Sep 6;85(10):5011-5021. doi: 10.1097/MS9.0000000000001260. eCollection 2023 Oct.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mohamed M Ali, Professor contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Laparoscopic Appendectomy with application of clips for stump closure and Laparoscopic Appendectomy with ligature for stump closure in people with Appendicitis, run by Sohag University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 11 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ahmed A Abdelreheem, Resident (01026675749, ahmeddd_amerrr@yahoo.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Results of Laparoscopic Appendectomy with application of clips versus ligature for stump closure (time frame: 24 hours postoperative). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07115303, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Aug 2025.