CognitionHACVACNCT07119788
Investigating the Effects of a Haskap Berry Supplement on Cognitive Health
A study testing Pure haskap berry powder and Vitamin-and mineral-enhanced haskap berry powder in people with Cognition, run by University of Reading at 1 site in United Kingdom.
Trial summary
This study aims to investigate the postprandial (2h) and longer term (4 week) effects of a haskap berry supplement on cognitive, vascular, and metabolic function in healthy ageing adults aged 50+. Read more about this study
- Who is it for?
- Ages 50 years and olderHealthy volunteers can take part
- Conditions the study is for
- Cognition
- What is being tested?
- Pure haskap berry powder and Vitamin-and mineral-enhanced haskap berry powder
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 90 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 19 Jun 2025to Apr 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- 50+ years old
- Fruit \& veg intake less than or equal to 4 servings per day
- Adequate English language and visual \& auditory acuity to perform the cognitive tasks
- Normal BMI for age
Who cannot join
- Being diagnosed with psychological or psychiatric disorders
- ADHD or dyslexia
- Any food allergy or intolerance
- Use of medications and dietary supplements that may impact study results
- Antibiotic use within the last 3 months
- Adherence to vegan or vegetarian diets, or other specific diets that may impact study outcomes
Show all 9Show fewer
- Conditions altering absorption of nutrients (e.g. celiac disease)
- Being diagnosed with cardiometabolic disease (including type II diabetes and cardiovascular disease), or suffer from untreated hypertension or thrombosis related disorders
- Taking blood thinners
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United Kingdom1 site, 1 recruiting
- Recruiting
Nutrition, Cognition & Health Lab, School of Psychology and Clinical Language Sciences, University of Reading
Reading, RG6 6ES
Lynne Bell, 01183788313, l.bell@reading.ac.uk
About this study
Official title: Investigating the Cognitive, Vascular, and Metabolic Benefits of a Vitamin- and Mineral-Enhanced Haskap Berry Dietary Supplement
This study aims to investigate the postprandial (2h) and longer term (4 week) effects of a haskap berry supplement on cognitive, vascular, and metabolic function in healthy ageing adults aged 50+.
Read the detailed description
This project aims to investigate the acute benefits (during the immediate post prandial period up to 2 hours) and chronic benefits (following 4 weeks daily supplementation) of a vitamin- and mineral-enhanced haskap berry supplement made from freeze-dried, powdered haskap berries. The main objective of this study is to trial the product in older adults aged 50+ to determine any cognitive, metabolic, or cardiovascular benefits over and above haskap powder alone or a placebo powder. The study will involve a screening visit and two testing visits, 4 weeks apart. For the 24 hours prior to each test visit, participants are asked to follow a low polyphenol diet. They are requested not to consume any food or drinks except water after 8.30pm, and on the morning of test visits to only consume one slice of buttered white toast and a glass of water prior to attending the visit. During the testing visits, cognitive and mood battery tests (to include measures of memory, executive functions, and stress, will be taken at baseline, at 2 hours following the consumption of the supplement as part of a meal, and again at 4 weeks following daily consumption of the supplement added to their usual diet. Blood glucose finger pricks will be recorded at each time point along with FMD (a measure of vascular reactivity).
- Conditions
- Cognition
- Being tested
- Placebo, Pure haskap berry powder, Vitamin-and mineral-enhanced haskap berry powder
- Keywords
- Cognition, Mood, Stress, Vascular, Blood glucose, Haskap berries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PlaceboDietary supplement
6g serving of a calorie-matched powder, artificially coloured and flavoured to resemble berry powder
Pure haskap berry powderDietary supplement
6g serving of a pure, freeze-dried haskap berry powder
Vitamin-and mineral-enhanced haskap berry powderDietary supplement
6g serving of a vitamin- and mineral-enhanced haskap berry powder (fortified with potassium iodide, zinc bisglycinate, vitamin B5, and vitamin B12
| Study group | Role | What they receive |
|---|---|---|
| Placebo | Placebo comparator | 30 participants to receive daily 6g servings of a calorie-matched powder, artificially coloured and flavoured to resemble berry powder Receives: Dietary Supplement: Placebo |
| Pure haskap berry powder | Experimental | 30 participants to receive daily 6g servings of a pure, freeze-dried haskap berry powder Receives: Dietary Supplement: Pure haskap berry powder |
| Vitamin- and mineral-enhanced haskap berry powder | Experimental | 30 participants to receive daily 6g servings of a vitamin- and mineral-enhanced haskap berry powder (fortified with potassium iodide, zinc bisglycinate, vitamin B5, and vitamin B12 Receives: Dietary Supplement: Vitamin-and mineral-enhanced haskap berry powder |
What is being measured
The primary outcome is the main question the study is designed to answer.
Delayed recall (Rey Auditory Verbal Learning Task)
The RAVLT is a verbal learning task that presents participants with 15 words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. After 5 presentations, a new list (list B) is presented and recalled, and finally participants are asked (without hearing list A again) to recall as many words as they can from list A. After a 30 minute period, participants are asked to think back to the task and recall as many words as possible from list A only, providing a measure of delayed recall.
Measured: Baseline
Delayed recall (Rey Auditory Verbal Learning Task)
The RAVLT is a verbal learning task that presents participants with 15 words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. After 5 presentations, a new list (list B) is presented and recalled, and finally participants are asked (without hearing list A again) to recall as many words as they can from list A. After a 30 minute period, participants are asked to think back to the task and recall as many words as possible from list A only, providing a measure of delayed recall.
Measured: 2 hours
Delayed recall (Rey Auditory Verbal Learning Task)
The RAVLT is a verbal learning task that presents participants with 15 words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. After 5 presentations, a new list (list B) is presented and recalled, and finally participants are asked (without hearing list A again) to recall as many words as they can from list A. After a 30 minute period, participants are asked to think back to the task and recall as many words as possible from list A only, providing a measure of delayed recall.
Measured: 4 weeks
Secondary outcomes (29)
Rate of learning (Rey Auditory Verbal Learning Task)
The RAVLT is a verbal learning task that presents participants with 15 sequential words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. Scores are recorded as a percentage of accuracy, and the rate of learning is determined through change in accuracy across the 5 recalls.
Measured: Baseline
Rate of learning (Rey Auditory Verbal Learning Task)
The RAVLT is a verbal learning task that presents participants with 15 sequential words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. Scores are recorded as a percentage of accuracy, and the rate of learning is determined through change in accuracy across the 5 recalls.
Measured: 2 hours
Rate of learning (Rey Auditory Verbal Learning Task)
The RAVLT is a verbal learning task that presents participants with 15 sequential words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. Scores are recorded as a percentage of accuracy, and the rate of learning is determined through change in accuracy across the 5 recalls.
Measured: 4 weeks
Word recognition (Rey Auditory Verbal Learning Task)
Following the delayed word recall, words from list A, list B and novel words are displayed sequentially on the screen and participants are asked to indicate which words were from list A only.
Measured: Baseline
Word recognition (Rey Auditory Verbal Learning Task)
Following the delayed word recall, words from list A, list B and novel words are displayed sequentially on the screen and participants are asked to indicate which words were from list A only.
Measured: 2 hours
Word recognition (Rey Auditory Verbal Learning Task)
Following the delayed word recall, words from list A, list B and novel words are displayed sequentially on the screen and participants are asked to indicate which words were from list A only.
Measured: 4 weeks
Modified Attention Network Task (MANT)
This task examines execution function, attention and inhibition. Participants respond to a centrally presented target arrow pointing to the left or the right by pressing the corresponding key on the keyboard. The target arrow is flanked by arrows that point in the same (congruent) or opposite (incongruent) direction. Previous studies have found that participants show larger latencies and more errors on incongruent trials when compared with congruent trials due to the conflicting interference of the incongruently facing arrows. Response latencies to congruent trials reflect processing speed, while errors on incongruent trials indicate susceptibility to interference. In this study participants will be presented with two blocks of the MANT - one normal block, and one block with the addition of serial 3s. In the serial 3s block, participants will be asked to count backwards in 3s out loud while continuing to perform the MANT, increasing the level of cognitive demand.
Measured: Baseline
Modified Attention Network Task (MANT)
This task examines execution function, attention and inhibition. Participants respond to a centrally presented target arrow pointing to the left or the right by pressing the corresponding key on the keyboard. The target arrow is flanked by arrows that point in the same (congruent) or opposite (incongruent) direction. Previous studies have found that participants show larger latencies and more errors on incongruent trials when compared with congruent trials due to the conflicting interference of the incongruently facing arrows. Response latencies to congruent trials reflect processing speed, while errors on incongruent trials indicate susceptibility to interference. In this study participants will be presented with two blocks of the MANT - one normal block, and one block with the addition of serial 3s. In the serial 3s block, participants will be asked to count backwards in 3s out loud while continuing to perform the MANT, increasing the level of cognitive demand.
Measured: 2 hours
Modified Attention Network Task (MANT)
This task examines execution function, attention and inhibition. Participants respond to a centrally presented target arrow pointing to the left or the right by pressing the corresponding key on the keyboard. The target arrow is flanked by arrows that point in the same (congruent) or opposite (incongruent) direction. Previous studies have found that participants show larger latencies and more errors on incongruent trials when compared with congruent trials due to the conflicting interference of the incongruently facing arrows. Response latencies to congruent trials reflect processing speed, while errors on incongruent trials indicate susceptibility to interference. In this study participants will be presented with two blocks of the MANT - one normal block, and one block with the addition of serial 3s. In the serial 3s block, participants will be asked to count backwards in 3s out loud while continuing to perform the MANT, increasing the level of cognitive demand.
Measured: 4 weeks
Task Switching Task
This task requires executive function and sustained attention, and provides a measure of cognitive flexibility. Participants view a circle with 8 equally spaced radii, 2 of which form a bold bisecting line. Numbers are chosen randomly from a set of 1-4 \& 6-9 and displayed sequentially in a clockwise direction. A response of higher or lower than 5 is made for trials below the bold line, and even or odd for numbers above the line. Outcome measures include overall accuracy and reaction time (RT) on correct trials, as well as accuracy and RT on trials where there is a 'switch cost' from stimuli moving from below to above the bold line and vice versa.
Measured: Baseline
Task Switching Task
This task requires executive function and sustained attention, and provides a measure of cognitive flexibility. Participants view a circle with 8 equally spaced radii, 2 of which form a bold bisecting line. Numbers are chosen randomly from a set of 1-4 \& 6-9 and displayed sequentially in a clockwise direction. A response of higher or lower than 5 is made for trials below the bold line, and even or odd for numbers above the line. Outcome measures include overall accuracy and reaction time (RT) on correct trials, as well as accuracy and RT on trials where there is a 'switch cost' from stimuli moving from below to above the bold line and vice versa.
Measured: 2 hours
Task Switching Task
This task requires executive function and sustained attention, and provides a measure of cognitive flexibility. Participants view a circle with 8 equally spaced radii, 2 of which form a bold bisecting line. Numbers are chosen randomly from a set of 1-4 \& 6-9 and displayed sequentially in a clockwise direction. A response of higher or lower than 5 is made for trials below the bold line, and even or odd for numbers above the line. Outcome measures include overall accuracy and reaction time (RT) on correct trials, as well as accuracy and RT on trials where there is a 'switch cost' from stimuli moving from below to above the bold line and vice versa.
Measured: 4 weeks
Corsi Block Tapping Task
A standardised assessment of visuospatial working memory. The task comprises nine identical squares fixed in a random arrangement on a screen. Participants observe sequences of between two and nine blocks, which they then reproduce as accurately as possible by clicking with the mouse. Outcomes include number of correct sequences identified as a percentage of accuracy, and number of correct blocks identified (not necessarily in the correct sequence). Four versions of each sequence length are presented during the task. A novel sequence will be presented on each occasion, the order of which will be counterbalanced across participants.
Measured: Baseline
Corsi Block Tapping Task
A standardised assessment of visuospatial working memory. The task comprises nine identical squares fixed in a random arrangement on a screen. Participants observe sequences of between two and nine blocks, which they then reproduce as accurately as possible by clicking with the mouse. Outcomes include number of correct sequences identified as a percentage of accuracy, and number of correct blocks identified (not necessarily in the correct sequence). Four versions of each sequence length are presented during the task. A novel sequence will be presented on each occasion, the order of which will be counterbalanced across participants.
Measured: 2 hours
Corsi Block Tapping Task
A standardised assessment of visuospatial working memory. The task comprises nine identical squares fixed in a random arrangement on a screen. Participants observe sequences of between two and nine blocks, which they then reproduce as accurately as possible by clicking with the mouse. Outcomes include number of correct sequences identified as a percentage of accuracy, and number of correct blocks identified (not necessarily in the correct sequence). Four versions of each sequence length are presented during the task. A novel sequence will be presented on each occasion, the order of which will be counterbalanced across participants.
Measured: 4 weeks
Flow mediated dilation (FMD)
Participants will complete FMD assessment prior to each cognitive task battery (baseline, 2 hours, 4 weeks). FMD is a non-invasive ultrasound technique that measures how the brachial artery dilates in response to increased blood flow following occlusion. Participants are required to lie down for 15 minutes before scanning commences. The procedure then takes 9 minutes: the brachial artery is first scanned for 1 minute, a blood pressure cuff is then inflated on the forearm for 5 minutes, before being released and the artery scanned for a further 3 minutes. This data will be analysed using Cardiovascular Suit. During FMD, laser doppler flowometry (LDF) will also be measured using the index finger of the right arm and analysed for % PORH (post occlusive reactive hyperaemia), measured in flux units .
Measured: Baseline
Flow mediated dilation (FMD)
Participants will complete FMD assessment prior to each cognitive task battery (baseline, 2 hours, 4 weeks). FMD is a non-invasive ultrasound technique that measures how the brachial artery dilates in response to increased blood flow following occlusion. Participants are required to lie down for 15 minutes before scanning commences. The procedure then takes 9 minutes: the brachial artery is first scanned for 1 minute, a blood pressure cuff is then inflated on the forearm for 5 minutes, before being released and the artery scanned for a further 3 minutes. This data will be analysed using Cardiovascular Suit. During FMD, laser doppler flowometry (LDF) will also be measured using the index finger of the right arm and analysed for % PORH (post occlusive reactive hyperaemia), measured in flux units .
Measured: 2 hours
Flow mediated dilation (FMD)
Participants will complete FMD assessment prior to each cognitive task battery (baseline, 2 hours, 4 weeks). FMD is a non-invasive ultrasound technique that measures how the brachial artery dilates in response to increased blood flow following occlusion. Participants are required to lie down for 15 minutes before scanning commences. The procedure then takes 9 minutes: the brachial artery is first scanned for 1 minute, a blood pressure cuff is then inflated on the forearm for 5 minutes, before being released and the artery scanned for a further 3 minutes. This data will be analysed using Cardiovascular Suit. During FMD, laser doppler flowometry (LDF) will also be measured using the index finger of the right arm and analysed for % PORH (post occlusive reactive hyperaemia), measured in flux units .
Measured: 4 weeks
Blood glucose
Blood glucose will be measured before each cognitive task battery (baseline, 2h, 4 weeks) using finger prick capillary sampling and an Accu-Chek Instant blood glucose monitor.
Measured: Baseline
Blood glucose
Blood glucose will be measured before each cognitive task battery (baseline, 2h, 4 weeks) using finger prick capillary sampling and an Accu-Chek Instant blood glucose monitor.
Measured: 2 hours
Blood glucose
Blood glucose will be measured before each cognitive task battery (baseline, 2h, 4 weeks) using finger prick capillary sampling and an Accu-Chek Instant blood glucose monitor.
Measured: 4 weeks
Blood pressure
Average (triplicate) resting brachial left arm cuffed systolic and diastolic blood pressure mmHg.
Measured: Baseline
Blood pressure
Average (triplicate) resting brachial left arm cuffed systolic and diastolic blood pressure mmHg.
Measured: 2 hours
Blood pressure
Average (triplicate) resting brachial left arm cuffed systolic and diastolic blood pressure mmHg.
Measured: 4 weeks
Positive and Negative Affect Schedule (PANAS-X) performance
A validated self-report measure of affective state. The PANAS comprises of two distinct affective states (positive and negative), as well as 11 individual affective states (fear, guilt, sadness, surprise, hostility, shyness, joviality, self-assurance, attentiveness, fatigue and serenity). Subjects use a Likert scale from 1 - 5 to indicate how the word relates to how they are currently feeling. As this analysis is exploratory all affective states will be explored.
Measured: Baseline
Positive and Negative Affect Schedule (PANAS-X) performance
A validated self-report measure of affective state. The PANAS comprises of two distinct affective states (positive and negative), as well as 11 individual affective states (fear, guilt, sadness, surprise, hostility, shyness, joviality, self-assurance, attentiveness, fatigue and serenity). Subjects use a Likert scale from 1 - 5 to indicate how the word relates to how they are currently feeling. As this analysis is exploratory all affective states will be explored.
Measured: 2 hours
Positive and Negative Affect Schedule (PANAS-X) performance
A validated self-report measure of affective state. The PANAS comprises of two distinct affective states (positive and negative), as well as 11 individual affective states (fear, guilt, sadness, surprise, hostility, shyness, joviality, self-assurance, attentiveness, fatigue and serenity). Subjects use a Likert scale from 1 - 5 to indicate how the word relates to how they are currently feeling. As this analysis is exploratory all affective states will be explored.
Measured: 4 weeks
Stress (Perceived Stress Scale)
Stress scores will be measured using the Perceived Stress Scale (PSS) at baseline and 4 weeks
Measured: Baseline
Stress (Perceived Stress Scale)
Stress scores will be measured using the Perceived Stress Scale (PSS) at baseline and 4 weeks
Measured: 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Aug 2025
- Study start19 Jun 2025
- Primary completionFeb 2026 (estimated)
- Study completionApr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for CognitionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be allocated to receive either a vitamin- and mineral-enhanced haskap berry powdered supplement, pure haskap berry powder, or a calorie matched placebo powder
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Reading
- Sponsor type
- University, hospital or other
- Collaborators
- Haskapa Ltd
- Responsible party
- Principal investigator, Prof Claire Williams, University of Reading
- Investigators
- Claire Williams, Principal investigator, University of Reading
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07119788
- Sponsor's protocol ID
- UREC 25/08
- Other IDs
- FA2_24-11
- Acronym
- HACVAC
- Status last verified
- Aug 2025
- First submitted
- 5 Aug 2025
- Last updated
- 13 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: All relevant study outcomes described in the Ethics Review Application Form, including demographics, anthropometrics, cognitive performance, blood glucose, and FMD data, will be preserved and made available via a data repository, such as the University of Reading data repository, in anonymised form, so that they can be consulted and re-used by others.
Study at a glance
From the registry record, last updated by the sponsor on 13 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigating the Cognitive, Vascular, and Metabolic Benefits of a Vitamin- and Mineral-Enhanced Haskap Berry Dietary Supplement
- ClinicalTrials.gov ID
- NCT07119788
- Acronym / sponsor ID
- HACVAC / UREC 25/08
- Conditions
- Cognition
- Keywords
- Cognition, Mood, Stress, Vascular, Blood glucose, Haskap berries
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- University of ReadingUniversity, hospital or other
- Collaborators
- Haskapa Ltd
- Study start
- 19 Jun 2025 (actual)
- Primary completion
- Feb 2026 (estimated)
- Study completion
- Apr 2026 (estimated)
- First posted
- 13 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to investigate the postprandial (2h) and longer term (4 week) effects of a haskap berry supplement on cognitive, vascular, and metabolic function in healthy ageing adults aged 50+.
Detailed description
This project aims to investigate the acute benefits (during the immediate post prandial period up to 2 hours) and chronic benefits (following 4 weeks daily supplementation) of a vitamin- and mineral-enhanced haskap berry supplement made from freeze-dried, powdered haskap berries. The main objective of this study is to trial the product in older adults aged 50+ to determine any cognitive, metabolic, or cardiovascular benefits over and above haskap powder alone or a placebo powder. The study will involve a screening visit and two testing visits, 4 weeks apart. For the 24 hours prior to each test visit, participants are asked to follow a low polyphenol diet. They are requested not to consume any food or drinks except water after 8.30pm, and on the morning of test visits to only consume one slice of buttered white toast and a glass of water prior to attending the visit. During the testing visits, cognitive and mood battery tests (to include measures of memory, executive functions, and stress, will be taken at baseline, at 2 hours following the consumption of the supplement as part of a meal, and again at 4 weeks following daily consumption of the supplement added to their usual diet. Blood glucose finger pricks will be recorded at each time point along with FMD (a measure of vascular reactivity).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 3
- Model description
- Participants will be allocated to receive either a vitamin- and mineral-enhanced haskap berry powdered supplement, pure haskap berry powder, or a calorie matched placebo powder
| Arm | Type | Receives |
|---|---|---|
| Placebo | Placebo comparator | Dietary Supplement: Placebo30 participants to receive daily 6g servings of a calorie-matched powder, artificially coloured and flavoured to resemble berry powder |
| Pure haskap berry powder | Experimental | Dietary Supplement: Pure haskap berry powder30 participants to receive daily 6g servings of a pure, freeze-dried haskap berry powder |
| Vitamin- and mineral-enhanced haskap berry powder | Experimental | Dietary Supplement: Vitamin-and mineral-enhanced haskap berry powder30 participants to receive daily 6g servings of a vitamin- and mineral-enhanced haskap berry powder (fortified with potassium iodide, zinc bisglycinate, vitamin B5, and vitamin B12 |
Who may qualify
- Ages
- 50 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- 50+ years old
- Fruit \& veg intake less than or equal to 4 servings per day
- Adequate English language and visual \& auditory acuity to perform the cognitive tasks
- Normal BMI for age
Key exclusion criteria (9 listed)
- Being diagnosed with psychological or psychiatric disorders
- ADHD or dyslexia
- Any food allergy or intolerance
- Use of medications and dietary supplements that may impact study results
- Antibiotic use within the last 3 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Placebo6g serving of a calorie-matched powder, artificially coloured and flavoured to resemble berry powder | Dietary supplement | Placebo |
| Pure haskap berry powder6g serving of a pure, freeze-dried haskap berry powder | Dietary supplement | Pure haskap berry powder |
| Vitamin-and mineral-enhanced haskap berry powder6g serving of a vitamin- and mineral-enhanced haskap berry powder (fortified with potassium iodide, zinc bisglycinate, vitamin B5, and vitamin B12 | Dietary supplement | Vitamin- and mineral-enhanced haskap berry powder |
Primary outcome
Delayed recall (Rey Auditory Verbal Learning Task)
Time frame: Baseline
The RAVLT is a verbal learning task that presents participants with 15 words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. After 5 presentations, a new list (list B) is presented and recalled, and finally participants are asked (without hearing list A again) to recall as many words as they can from list A. After a 30 minute period, participants are asked to think back to the task and recall as many words as possible from list A only, providing a measure of delayed recall.
Delayed recall (Rey Auditory Verbal Learning Task)
Time frame: 2 hours
The RAVLT is a verbal learning task that presents participants with 15 words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. After 5 presentations, a new list (list B) is presented and recalled, and finally participants are asked (without hearing list A again) to recall as many words as they can from list A. After a 30 minute period, participants are asked to think back to the task and recall as many words as possible from list A only, providing a measure of delayed recall.
Delayed recall (Rey Auditory Verbal Learning Task)
Time frame: 4 weeks
The RAVLT is a verbal learning task that presents participants with 15 words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. After 5 presentations, a new list (list B) is presented and recalled, and finally participants are asked (without hearing list A again) to recall as many words as they can from list A. After a 30 minute period, participants are asked to think back to the task and recall as many words as possible from list A only, providing a measure of delayed recall.
29 secondary outcomes
Rate of learning (Rey Auditory Verbal Learning Task)
Time frame: Baseline
Rate of learning (Rey Auditory Verbal Learning Task)
Time frame: 2 hours
Rate of learning (Rey Auditory Verbal Learning Task)
Time frame: 4 weeks
Word recognition (Rey Auditory Verbal Learning Task)
Time frame: Baseline
Word recognition (Rey Auditory Verbal Learning Task)
Time frame: 2 hours
Word recognition (Rey Auditory Verbal Learning Task)
Time frame: 4 weeks
Modified Attention Network Task (MANT)
Time frame: Baseline
Modified Attention Network Task (MANT)
Time frame: 2 hours
Modified Attention Network Task (MANT)
Time frame: 4 weeks
Task Switching Task
Time frame: Baseline
Task Switching Task
Time frame: 2 hours
Task Switching Task
Time frame: 4 weeks
Corsi Block Tapping Task
Time frame: Baseline
Corsi Block Tapping Task
Time frame: 2 hours
Corsi Block Tapping Task
Time frame: 4 weeks
Flow mediated dilation (FMD)
Time frame: Baseline
Flow mediated dilation (FMD)
Time frame: 2 hours
Flow mediated dilation (FMD)
Time frame: 4 weeks
Blood glucose
Time frame: Baseline
Blood glucose
Time frame: 2 hours
Blood glucose
Time frame: 4 weeks
Blood pressure
Time frame: Baseline
Blood pressure
Time frame: 2 hours
Blood pressure
Time frame: 4 weeks
Positive and Negative Affect Schedule (PANAS-X) performance
Time frame: Baseline
Positive and Negative Affect Schedule (PANAS-X) performance
Time frame: 2 hours
Positive and Negative Affect Schedule (PANAS-X) performance
Time frame: 4 weeks
Stress (Perceived Stress Scale)
Time frame: Baseline
Stress (Perceived Stress Scale)
Time frame: 4 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Aug 2025.
- Individual participant dataSharing planned: Yes. All relevant study outcomes described in the Ethics Review Application Form, including demographics, anthropometrics, cognitive performance, blood glucose, and FMD data, will be preserved and made available via a data repository, such as the University of Reading data repository, in anonymised form, so that they can be consulted and re-used by others.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Claire Williams principal investigator
University of Reading
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Pure haskap berry powder and Vitamin-and mineral-enhanced haskap berry powder in people with Cognition, run by University of Reading at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 13 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Lynne Bell (01189788313, l.bell@reading.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Delayed recall (Rey Auditory Verbal Learning Task) (time frame: Baseline). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Aug 2025.