Chronic Rhinosinusitis (CRS)CLIM-RHINO (ClNCT07119879
Impact of Climate Change Anxiety on Sinusitis Symptoms and Quality of Life Among Adults With Chronic Rhinosinusitis: A Cross-Sectional Study
An observational study of Chronic Rhinosinusitis (CRS) and Climate Change Anxiety, run by Sinai University at 1 site in Egypt.
Trial summary
This cross-sectional observational study investigates the relationship between climate change anxiety and chronic rhinosinusitis (CRS) symptom severity and quality of life (QoL) in adults. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Chronic Rhinosinusitis (CRS), Climate Change Anxiety, Quality of Life Impairment
- How many people
- 134 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jan 2025to 25 Jul 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: The study targets adult individuals (aged ≥18 years) residing in Egypt who have self-reported or medically diagnosed Chronic Rhinosinusitis (CRS) with symptom duration of at least 12 weeks. Participants were required to read and understand Arabic in order to complete a structured online questionnaire. Recruitment was conducted electronically through convenience sampling via social media and academic platforms.
Who may be able to join
- Participants must meet all of the following:
- Adults aged 18 years or older Self-reported or clinically diagnosed with Chronic Rhinosinusitis (CRS) with symptoms lasting ≥12 weeks Able to read and understand Arabic Able to complete the online questionnaire independently Provided informed consent prior to participation Exclusion Criteria
- Participants will be excluded if they meet any of the following:
- Diagnosis of severe psychiatric or psychological disorders (e.g., schizophrenia, bipolar disorder) History of major chronic illnesses that may confound outcomes (e.g., cardiovascular disease, cancer, chronic neurological disease) Recent nasal or sinus surgery within the past 3 months Incomplete survey responses that prevent data analysis Participants under 18 years of age
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country.
About this study
This cross-sectional observational study investigates the relationship between climate change anxiety and chronic rhinosinusitis (CRS) symptom severity and quality of life (QoL) in adults. As climate change continues to influence public health, individuals with chronic respiratory diseases may experience worsened symptoms due to heightened psychological stress and perceived environmental instability. The study utilizes standardized instruments including the SNOT-22 (Sino-Nasal Outcome Test), a QoL scale, and a climate change anxiety questionnaire to evaluate associations among these variables.
Read the detailed description
Climate change has emerged as a major global health concern, with growing recognition of its psychological impacts, including anxiety, distress, and perceived environmental instability. These psychosocial effects may exacerbate symptoms in chronic inflammatory conditions such as Chronic Rhinosinusitis (CRS), a disease characterized by persistent nasal congestion, facial pressure, and impaired quality of life.
This study aims to explore the correlation between self-perceived climate change anxiety and CRS symptom severity and QoL in an adult population. A total of 134 participants with CRS, aged ≥18 years, were recruited to complete an online Arabic-language survey. The survey included demographic information, the SNOT-22 scale, a validated quality of life questionnaire, and a climate change stress scale.
The primary objective is to assess the association between climate change stress and symptom severity (SNOT-22 total score). The secondary objective is to determine the relationship between climate change anxiety and QoL. The study uses Pearson's correlation analysis to examine these associations.
This research introduces a novel psychosomatic dimension to CRS management by highlighting how environmental and psychological stressors may influence disease burden. Results may inform multidisciplinary approaches for patient care, incorporating environmental awareness and mental health support.
- Keywords
- SNOT-22, psychosomatic health, environmental stress, quality of life, climate change anxiety, Chronic rhinosinusitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Adults with Chronic Rhinosinusitis | This cross sectional includes adult participants (≥18 years) with self-reported or physician-diagnosed chronic rhinosinusitis who completed an online questionnaire assessing climate change anxiety, SNOT-22 scores, and quality of life. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Correlation between Climate Change Anxiety and CRS Symptom Severity
Evaluate the relationship between participants' climate change anxiety scores and their chronic rhinosinusitis symptom severity using the SNOT-22 questionnaire.
Measured: Day 1 (Single assessment at time of survey completion)
Secondary outcomes (1)
Correlation between Climate Change Anxiety and Quality of Life
Assess the relationship between climate change anxiety scores and health-related quality of life (QoL) scores among adults with CRS.
Measured: Day 1 (Single assessment at time of survey completion)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Aug 2025
- Study start1 Jan 2025
- Primary completion25 May 2026
- Study completion25 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic Rhinosinusitis (CRS)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Retrospective
- Enrolment
- 134 participants (actual)
Sponsor and investigators
- Lead sponsor
- Sinai University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Amany Gomaa Atiaa, Sinai University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07119879
- Sponsor's protocol ID
- IRB00014233-17
- Acronym
- CLIM-RHINO (Cl
- Status last verified
- Aug 2026
- First submitted
- 6 Aug 2025
- Last updated
- 4 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Climate Change Anxiety on Sinusitis Symptoms and Quality of Life Among Adults With Chronic Rhinosinusitis: A Cross-Sectional Study
- ClinicalTrials.gov ID
- NCT07119879
- Acronym / sponsor ID
- CLIM-RHINO (Cl / IRB00014233-17
- Keywords
- SNOT-22, psychosomatic health, environmental stress, quality of life, climate change anxiety, Chronic rhinosinusitis
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 134 participants (actual)
- Lead sponsor
- Sinai UniversityUniversity, hospital or other
- Study start
- 1 Jan 2025 (actual)
- Primary completion
- 25 May 2026 (actual)
- Study completion
- 25 Jul 2026 (actual)
- First posted
- 13 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This cross-sectional observational study investigates the relationship between climate change anxiety and chronic rhinosinusitis (CRS) symptom severity and quality of life (QoL) in adults. As climate change continues to influence public health, individuals with chronic respiratory diseases may experience worsened symptoms due to heightened psychological stress and perceived environmental instability. The study utilizes standardized instruments including the SNOT-22 (Sino-Nasal Outcome Test), a QoL scale, and a climate change anxiety questionnaire to evaluate associations among these variables.
Detailed description
Climate change has emerged as a major global health concern, with growing recognition of its psychological impacts, including anxiety, distress, and perceived environmental instability. These psychosocial effects may exacerbate symptoms in chronic inflammatory conditions such as Chronic Rhinosinusitis (CRS), a disease characterized by persistent nasal congestion, facial pressure, and impaired quality of life.
This study aims to explore the correlation between self-perceived climate change anxiety and CRS symptom severity and QoL in an adult population. A total of 134 participants with CRS, aged ≥18 years, were recruited to complete an online Arabic-language survey. The survey included demographic information, the SNOT-22 scale, a validated quality of life questionnaire, and a climate change stress scale.
The primary objective is to assess the association between climate change stress and symptom severity (SNOT-22 total score). The secondary objective is to determine the relationship between climate change anxiety and QoL. The study uses Pearson's correlation analysis to examine these associations.
This research introduces a novel psychosomatic dimension to CRS management by highlighting how environmental and psychological stressors may influence disease burden. Results may inform multidisciplinary approaches for patient care, incorporating environmental awareness and mental health support.
Study design
- Observational model
- Other
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Adults with Chronic Rhinosinusitis | – | –This cross sectional includes adult participants (≥18 years) with self-reported or physician-diagnosed chronic rhinosinusitis who completed an online questionnaire assessing climate change anxiety, SNOT-22 scores, and quality of life. |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- The study targets adult individuals (aged ≥18 years) residing in Egypt who have self-reported or medically diagnosed Chronic Rhinosinusitis (CRS) with symptom duration of at least 12 weeks. Participants were required to read and understand Arabic in order to complete a structured online questionnaire. Recruitment was conducted electronically through convenience sampling via social media and academic platforms.
Key inclusion criteria (4 listed)
- Adults aged 18 years or older Self-reported or clinically diagnosed with Chronic Rhinosinusitis (CRS) with symptoms lasting ≥12 weeks Able to read and understand Arabic Able to complete the online questionnaire independently Provided informed consent prior to participation Exclusion Criteria
- Diagnosis of severe psychiatric or psychological disorders (e.g., schizophrenia, bipolar disorder) History of major chronic illnesses that may confound outcomes (e.g., cardiovascular disease, cancer, chronic neurological disease) Recent nasal or sinus surgery within the past 3 months Incomplete survey responses that prevent data analysis Participants under 18 years of age
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Correlation between Climate Change Anxiety and CRS Symptom Severity
Time frame: Day 1 (Single assessment at time of survey completion)
Evaluate the relationship between participants' climate change anxiety scores and their chronic rhinosinusitis symptom severity using the SNOT-22 questionnaire.
1 secondary outcome
Correlation between Climate Change Anxiety and Quality of Life
Time frame: Day 1 (Single assessment at time of survey completion)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Chronic Rhinosinusitis (CRS) and Climate Change Anxiety, run by Sinai University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Correlation between Climate Change Anxiety and CRS Symptom Severity (time frame: Day 1 (Single assessment at time of survey completion)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Aug 2026; AzTrials last refreshed its copy on 8 Nov 2026.