OsteoporosisNCT07126002
Yoga Improves Bone Density and Metabolism in Elderly Osteoporosis
A study testing Yoga in people with Osteoporosis, run by Beijing Sport University at 1 site in China.
Trial summary
This study was designed to evaluate the impact of a 16-week yoga program on BMD, bone metabolism markers, and physical fitness in elderly patients with OP. Read more about this study
- Who is it for?
- Ages 50 years and older
- Conditions the study is for
- Osteoporosis
- What is being tested?
- Yoga
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteChina
- Study dates
- 1 Jul 2024to 31 Dec 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- age ≥50 years;
- diagnosed with osteoporosis using dual-energy X-ray absorptiometry (DXA);
- able to independently perform required assessments;
- voluntary participation in yoga intervention.
Who cannot join
- secondary osteoporosis;
- severe cardiovascular, cerebrovascular, hepatic, or renal diseases;
- cognitive impairment;
- severe motor dysfunction;
- regular participation in structured exercise programs, such as yoga or resistance training, within the past six months.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: 16-Week Yoga Improves Bone Density, Metabolism in Elderly Osteoporosis: A Controlled Trial
This study was designed to evaluate the impact of a 16-week yoga program on BMD, bone metabolism markers, and physical fitness in elderly patients with OP.
Read the detailed description
To assess the effects of a 16-week yoga intervention on bone mineral density (BMD), bone metabolism, and physical fitness in elderly patients with osteoporosis. This randomized controlled trial enrolled 60 adults aged 50 years or older with clinically confirmed osteoporosis. Based on personal preference, participants were assigned to either a yoga group or a control group. The intervention consisted of supervised yoga sessions conducted twice weekly for 16 weeks. The yoga intervention included physical postures, breathing exercises, and meditation/relaxation techniques. Health outcomes were assessed at baseline, mid-intervention (8 weeks), and post-intervention (16 weeks). Primary outcomes included changes in BMD at the lumbar spine and hips. Secondary outcomes comprised serum levels of osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), β-CTX, 25-hydroxyvitamin D, calcium, phosphate, and performance in physical function tests, including grip strength, chair stand, single-leg balance, and timed up-and-go. This randomized controlled trial aims to find out the effect of yoga intervention on bone mineral density (BMD), bone metabolism, and physical fitness in elderly patients with osteoporosis.
- Conditions
- Osteoporosis
- Being tested
- Yoga
- Keywords
- Yoga, Bone mineral density, Bone metabolism
- Medical subject headings
- Osteoporosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
YogaBehavioural
: Participants in this arm received a structured yoga course intervention for a period of 4 months. Sessions were held twice weekly, with each lasting 60 minutes. The curriculum was specifically designed to be gentle, slow-paced, and low-impact, making it suitable for older adults while emphasizing body awareness, mind-body integration, and psychological regulation. The course content included: breathing exercises (e.g., basic abdominal breathing combined with simple movements), asana (posture) practice (e.g., seated chair exercises, standing poses, prone poses, supine poses, and side-lying poses, emphasizing muscle activation, joint flexibility, bodybalance training, and coordination of breath with movement), and meditation and relaxation (e.g.supine rest, moon breath training, and OM chanting). All classes were instructed by experienced yoga teachers certified by the Yoga Alliance.
| Study group | Role | What they receive |
|---|---|---|
| experimental group | Experimental | Participants in the yoga intervention group attended supervised yoga classes twice per week for 16 weeks. Each yoga session lasted approximately 60 minutes and was conducted by certified yoga instructors. Sessions comprised breathing exercises, structured yoga postures, and relaxation. Heart rate was monitored regularly during sessions to maintain appropriate intensity. Receives: Behavioral: Yoga |
| control group | No intervention | Participants in the control group were instructed to maintain their usual activities and not initiate any new structured exercise programs during the study period |
What is being measured
The primary outcome is the main question the study is designed to answer.
bone mineral density
assessed by dual-energy X-ray absorptiometry (DXA, HOLOGIC Discovery Wi, Bedford, MA, USA), at lumbar spine and bilateral hips. Osteoporosis was diagnosed according to the World Health Organization criteria based on T-scores.
Measured: baseline and 4 month
Secondary outcomes (5)
N-MID Osteocalcin
N-MID osteocalcin is an important biomarker of bone metabolism, mainly reflecting bone formation activity. It is commonly used in clinical practice to evaluate the efficacy of osteoporosis, bone turnover abnormalities, and anti bone resorption therapy
Measured: baseline and 4 month
Procollagen 1 N-terminal Propeptide
Procollagen I N-terminal propeptide (P1NP) is a biomarker that plays an important role in bone metabolism
Measured: baseline and 4 month
β-terminal telopeptide of I collagen (β-CTx)
β-terminal telopeptide of I collagen (β-CTx) has been reported to be a sensitive biochemical marker of bone turnover
Measured: baseline and 4 month
25-hydroxyvitamin D
25 hydroxyvitamin D (25-OH VitD) is the main storage form of vitamin D in the human body and a core indicator for evaluating the nutritional status of vitamin D. It maintains bone health by regulating calcium and phosphorus metabolism
Measured: baseline and 4 month
Lower Limb Major Muscle Group Strength (Quadriceps Femoris, HamstringsTriceps Surae, Tibialis Anterior, lliopsoas)
Assesses the strength of major lower limb muscle groups, including the quadricepsfemoris, hamstrings, triceps surae, tibialis anterior, and iliopsoas. Maximum isometric contraction values for both sides are recorded using a MlCROFET2 standardized electronic dynamometer to comprehensively reflect individual lower limb support and gait stability.
Measured: Baseline, 2 Months Post-ntervention, and 4 Months Post-Intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Aug 2025
- Study start1 Jul 2024
- Primary completion31 Dec 2024
- Study completion31 Dec 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for OsteoporosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Beijing Sport University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07126002
- Sponsor's protocol ID
- 2025152H
- Status last verified
- Jul 2025
- First submitted
- 31 Jul 2025
- Last updated
- 15 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- 16-Week Yoga Improves Bone Density, Metabolism in Elderly Osteoporosis: A Controlled Trial
- ClinicalTrials.gov ID
- NCT07126002
- Acronym / sponsor ID
- 2025152H
- Conditions
- Osteoporosis
- Keywords
- Yoga, Bone mineral density, Bone metabolism
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Beijing Sport UniversityUniversity, hospital or other
- Study start
- 1 Jul 2024 (actual)
- Primary completion
- 31 Dec 2024 (actual)
- Study completion
- 31 Dec 2024 (actual)
- First posted
- 15 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study was designed to evaluate the impact of a 16-week yoga program on BMD, bone metabolism markers, and physical fitness in elderly patients with OP.
Detailed description
To assess the effects of a 16-week yoga intervention on bone mineral density (BMD), bone metabolism, and physical fitness in elderly patients with osteoporosis. This randomized controlled trial enrolled 60 adults aged 50 years or older with clinically confirmed osteoporosis. Based on personal preference, participants were assigned to either a yoga group or a control group. The intervention consisted of supervised yoga sessions conducted twice weekly for 16 weeks. The yoga intervention included physical postures, breathing exercises, and meditation/relaxation techniques. Health outcomes were assessed at baseline, mid-intervention (8 weeks), and post-intervention (16 weeks). Primary outcomes included changes in BMD at the lumbar spine and hips. Secondary outcomes comprised serum levels of osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), β-CTX, 25-hydroxyvitamin D, calcium, phosphate, and performance in physical function tests, including grip strength, chair stand, single-leg balance, and timed up-and-go. This randomized controlled trial aims to find out the effect of yoga intervention on bone mineral density (BMD), bone metabolism, and physical fitness in elderly patients with osteoporosis.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| experimental group | Experimental | Behavioral: YogaParticipants in the yoga intervention group attended supervised yoga classes twice per week for 16 weeks. Each yoga session lasted approximately 60 minutes and was conducted by certified yoga instructors. Sessions comprised breathing exercises, structured yoga postures, and relaxation. Heart rate was monitored regularly during sessions to maintain appropriate intensity. |
| control group | No intervention | –Participants in the control group were instructed to maintain their usual activities and not initiate any new structured exercise programs during the study period |
Who may qualify
- Ages
- 50 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- age ≥50 years;
- diagnosed with osteoporosis using dual-energy X-ray absorptiometry (DXA);
- able to independently perform required assessments;
- voluntary participation in yoga intervention.
Key exclusion criteria (5 listed)
- secondary osteoporosis;
- severe cardiovascular, cerebrovascular, hepatic, or renal diseases;
- cognitive impairment;
- severe motor dysfunction;
- regular participation in structured exercise programs, such as yoga or resistance training, within the past six months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Yoga: Participants in this arm received a structured yoga course intervention for a period of 4 months. Sessions were held twice weekly, with each lasting 60 minutes. The curriculum was specifically designed to be gentle, slow-paced, and low-impact, making it suitable for older adults while emphasizing body awareness, mind-body integration, and psychological regulation. The course content included: breathing exercises (e.g., basic abdominal breathing combined with simple movements), asana (posture) practice (e.g., seated chair exercises, standing poses, prone poses, supine poses, and side-lying poses, emphasizing muscle activation, joint flexibility, bodybalance training, and coordination of breath with movement), and meditation and relaxation (e.g.supine rest, moon breath training, and OM chanting). All classes were instructed by experienced yoga teachers certified by the Yoga Alliance. | Behavioural | experimental group |
Primary outcome
bone mineral density
Time frame: baseline and 4 month
assessed by dual-energy X-ray absorptiometry (DXA, HOLOGIC Discovery Wi, Bedford, MA, USA), at lumbar spine and bilateral hips. Osteoporosis was diagnosed according to the World Health Organization criteria based on T-scores.
5 secondary outcomes
N-MID Osteocalcin
Time frame: baseline and 4 month
Procollagen 1 N-terminal Propeptide
Time frame: baseline and 4 month
β-terminal telopeptide of I collagen (β-CTx)
Time frame: baseline and 4 month
25-hydroxyvitamin D
Time frame: baseline and 4 month
Lower Limb Major Muscle Group Strength (Quadriceps Femoris, HamstringsTriceps Surae, Tibialis Anterior, lliopsoas)
Time frame: Baseline, 2 Months Post-ntervention, and 4 Months Post-Intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Aug 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Yoga in people with Osteoporosis, run by Beijing Sport University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
bone mineral density (time frame: baseline and 4 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Aug 2025.