Lifting EfficacyNCT07127653
Lotion and Toner Bundle 4-Week Lifting Efficacy Study
A study testing Retinol-Based Day Cream and Lotion and Toner Bundle in people with Lifting Efficacy and Facial Aging, run by ChinaNorm at 1 site in China.
Trial summary
This is a single-center, parallel-arm, 4-week interventional study designed to evaluate the lifting and firming efficacy of two facial care regimens in middle-aged Chinese women. Participants were randomly assigned to use either a retinol-based day cream or a lotion-and-toner bundle. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Lifting Efficacy, Facial Aging
- What is being tested?
- Retinol-Based Day Cream and Lotion and Toner Bundle
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 132 participants
- Where
- 1 siteChina
- Study dates
- 23 Jan 2025to 31 Mar 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- 1. Chinese female with 45-55 years old. 2. All skin types (dry, normal, oily or mixed). 3. Regular users for toner, lotion and cream. 4. Self-claim with lack of firmness and has sagging concern. 5. Presenting with corresponding severity for the attribute evaluated by Dermatologist included:
- Lifting (global face): 3≤grade≤6 (0-9 scale) 6. The BMI range should ≤24.9, and the BMI (BMI =Weight (kg)/ Height²(m²)) should remain stable within the range throughout the entire testing period. 7. Did not participate any clinical test or cosmetic product test on skin within 3 months.
- 8. Did not participate any chemical procedures for previous 6 months and during the whole study.
- 9. No disagreement of dermatologist because of other reasons that exclude the participation of the subject.
- 10. In general, good health at the time of the study. 11. Willing and able to participate as evidenced by signing of informed consent \& photo release form.
- 12. Must be willing to comply with all study protocol requirements (pay attention: only use the skin care products provided during the study, not take topical or oral treatment like retinol, hormone, antioxidant health-care products which may affect the test product).
Who cannot join
- 1. Pregnant or breast-feeding woman or woman planning pregnancy during the study.
- 2. Subject deprived of rights by a court or administrative order. 3. Major subject to a guardianship order. 4. Subject residing in a health or social care establishment. 5. Patient in an emergency setting. 6. Subject with a skin disease in the test areas as well as skin allergy (particularly e.g., acne, rosacea, eczema). 7. Subject presenting a stable or progressive serious disease (per investigator's assessment).
- 8. Immuno-compromised subject. 9. Subject with history of allergy to cosmetic or personal care products or ingredients.
- 10. Subject presenting excessive exposure to sunlight or UV radiation (investigator's assessment).
- 11. Subject with history of sunlight sensitivity or allergies. 12. Subjects regularly practicing aquatic or nautical sports. 13. Subjects regularly attending a sauna. 14. Subject with physical highly sensitive constitution. 15. Subject with cardiovascular or circulatory history. 16. Subject with a history of skin cancer or malignant melanoma. 17. Intake of antihistamines, antibiotics, corticosteroids, non-steroidal anti-inflammatories or immune suppressants in the last 6 months before study
Trial locations and contacts
1 site in 1 country.
China1 site
Shanghai China-norm Quality Technical Service Co., Ltd., Shanghai, Shanghai 200072
Shanghai
About this study
Official title: A 4-Week Lifting and Firming Efficacy Study Comparing a Retinol-Based Day Cream and a Lotion and Toner Bundle
This is a single-center, parallel-arm, 4-week interventional study designed to evaluate the lifting and firming efficacy of two facial care regimens in middle-aged Chinese women. Participants were randomly assigned to use either a retinol-based day cream or a lotion-and-toner bundle. The study included dermatologist assessment, standardized facial photography, and self-assessment questionnaires. A total of 132 healthy women aged 45-55 with facial skin sagging were enrolled. The primary objective was to compare improvement in lifting grades after 4 weeks of product use. The trial was conducted at China-Norm Quality Technical Service Co., Ltd., in Shanghai, China.
Read the detailed description
This 4-week study evaluated the efficacy of two skincare regimens on facial lifting and firmness in middle-aged Chinese women. Participants were randomly assigned to one of two arms: (1) retinol-based day cream or (2) a bundle of toner and lotion. The study included a 3-week wash-out period, followed by a 4-week treatment phase with full-face application. Assessments were conducted at T0 (baseline), Timm (immediate post-use), and T4w (end of 4-week use), using dermatologist grading (0-9 scale), DEEP imaging system, and self-reported questionnaires. Participants were required to avoid other skincare products during the study. A total of 132 subjects were enrolled; at least 80 completed clinical evaluation. The primary outcome was improvement in lifting grade from T0 to T4w; secondary outcomes included imaging analysis and subjective satisfaction. The study followed GCP principles and received ethical approval from the Ethics Committee at China-Norm. No serious adverse events were reported.
- Conditions
- Lifting Efficacy, Facial Aging
- Being tested
- Retinol-Based Day Cream, Lotion and Toner Bundle
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Retinol-Based Day CreamOther
A commercially available day cream containing retinol and moisturizing ingredients. Applied twice daily (morning and evening) to the full face for 4 weeks.
Lotion and Toner BundleOther
A skincare regimen including a dermalift toner and a milky lotion. Applied twice daily (morning and evening) to the full face for 4 weeks.
| Study group | Role | What they receive |
|---|---|---|
| Retinol Day Cream Group | Experimental | Participants in this arm applied a retinol-based anti-wrinkle day cream to the full face for 4 weeks following a 3-week washout period. Assessments were conducted at baseline (T0), immediate post-use (Timm), and after 4 weeks of use (T4w). Evaluations included dermatologist lifting grade, DEEP imaging, and self-assessment questionnaire. Receives: Other: Lotion and Toner Bundle |
| Lotion and Toner Group | Experimental | Participants in this arm applied a lotion and toner bundle to the full face for 4 weeks following a 3-week washout period. Assessments were conducted at baseline (T0), immediate post-use (Timm), and after 4 weeks of use (T4w). Evaluations included dermatologist lifting grade, DEEP imaging, and self-assessment questionnaire. Receives: Other: Retinol-Based Day Cream |
What is being measured
The primary outcome is the main question the study is designed to answer.
Clinical Assessment by Dermatologist
Lifting grade (0-9 scale) will be evaluated by dermatologist at T-3w, T0 (baseline), Timm and T4w.Six areas will be evaluated separately: eyebrow, upper eyelid, nasolabial zone, apple cheek, corner of mouth and jaw.
Measured: Baseline and Week 4
Secondary outcomes (2)
Change in Facial Wrinkle Depth Measured by Standardized Digital Photography and Image Analysis Software
Measured: Baseline and Week 4
Questionnaire
Change in self-reported score for skin smoothness and softness from baseline to week 4, based on 5-point Likert scale questionnaire
Measured: Baseline and Week 4
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Aug 2025
- Study start23 Jan 2025
- Primary completion16 Mar 2025
- Study completion31 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Lifting EfficacyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 132 participants (actual)
Sponsor and investigators
- Lead sponsor
- ChinaNorm
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07127653
- Sponsor's protocol ID
- C25005018
- Status last verified
- Aug 2025
- First submitted
- 1 Aug 2025
- Last updated
- 17 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A 4-Week Lifting and Firming Efficacy Study Comparing a Retinol-Based Day Cream and a Lotion and Toner Bundle
- ClinicalTrials.gov ID
- NCT07127653
- Acronym / sponsor ID
- C25005018
- Conditions
- Lifting Efficacy, Facial Aging
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 132 participants (actual)
- Lead sponsor
- ChinaNormIndustry (pharma, biotech, devices)
- Study start
- 23 Jan 2025 (actual)
- Primary completion
- 16 Mar 2025 (actual)
- Study completion
- 31 Mar 2025 (actual)
- First posted
- 17 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a single-center, parallel-arm, 4-week interventional study designed to evaluate the lifting and firming efficacy of two facial care regimens in middle-aged Chinese women. Participants were randomly assigned to use either a retinol-based day cream or a lotion-and-toner bundle. The study included dermatologist assessment, standardized facial photography, and self-assessment questionnaires. A total of 132 healthy women aged 45-55 with facial skin sagging were enrolled. The primary objective was to compare improvement in lifting grades after 4 weeks of product use. The trial was conducted at China-Norm Quality Technical Service Co., Ltd., in Shanghai, China.
Detailed description
This 4-week study evaluated the efficacy of two skincare regimens on facial lifting and firmness in middle-aged Chinese women. Participants were randomly assigned to one of two arms: (1) retinol-based day cream or (2) a bundle of toner and lotion. The study included a 3-week wash-out period, followed by a 4-week treatment phase with full-face application. Assessments were conducted at T0 (baseline), Timm (immediate post-use), and T4w (end of 4-week use), using dermatologist grading (0-9 scale), DEEP imaging system, and self-reported questionnaires. Participants were required to avoid other skincare products during the study. A total of 132 subjects were enrolled; at least 80 completed clinical evaluation. The primary outcome was improvement in lifting grade from T0 to T4w; secondary outcomes included imaging analysis and subjective satisfaction. The study followed GCP principles and received ethical approval from the Ethics Committee at China-Norm. No serious adverse events were reported.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Retinol Day Cream Group | Experimental | Other: Lotion and Toner BundleParticipants in this arm applied a retinol-based anti-wrinkle day cream to the full face for 4 weeks following a 3-week washout period. Assessments were conducted at baseline (T0), immediate post-use (Timm), and after 4 weeks of use (T4w). Evaluations included dermatologist lifting grade, DEEP imaging, and self-assessment questionnaire. |
| Lotion and Toner Group | Experimental | Other: Retinol-Based Day CreamParticipants in this arm applied a lotion and toner bundle to the full face for 4 weeks following a 3-week washout period. Assessments were conducted at baseline (T0), immediate post-use (Timm), and after 4 weeks of use (T4w). Evaluations included dermatologist lifting grade, DEEP imaging, and self-assessment questionnaire. |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- 1. Chinese female with 45-55 years old. 2. All skin types (dry, normal, oily or mixed). 3. Regular users for toner, lotion and cream. 4. Self-claim with lack of firmness and has sagging concern. 5. Presenting with corresponding severity for the attribute evaluated by Dermatologist included:
- 8. Did not participate any chemical procedures for previous 6 months and during the whole study.
- 9. No disagreement of dermatologist because of other reasons that exclude the participation of the subject.
- 10. In general, good health at the time of the study. 11. Willing and able to participate as evidenced by signing of informed consent \& photo release form.
- 12. Must be willing to comply with all study protocol requirements (pay attention: only use the skin care products provided during the study, not take topical or oral treatment like retinol, hormone, antioxidant health-care products which may affect the test product).
Key exclusion criteria (5 listed)
- 1. Pregnant or breast-feeding woman or woman planning pregnancy during the study.
- 2. Subject deprived of rights by a court or administrative order. 3. Major subject to a guardianship order. 4. Subject residing in a health or social care establishment. 5. Patient in an emergency setting. 6. Subject with a skin disease in the test areas as well as skin allergy (particularly e.g., acne, rosacea, eczema). 7. Subject presenting a stable or progressive serious disease (per investigator's assessment).
- 8. Immuno-compromised subject. 9. Subject with history of allergy to cosmetic or personal care products or ingredients.
- 10. Subject presenting excessive exposure to sunlight or UV radiation (investigator's assessment).
- 11. Subject with history of sunlight sensitivity or allergies. 12. Subjects regularly practicing aquatic or nautical sports. 13. Subjects regularly attending a sauna. 14. Subject with physical highly sensitive constitution. 15. Subject with cardiovascular or circulatory history. 16. Subject with a history of skin cancer or malignant melanoma. 17. Intake of antihistamines, antibiotics, corticosteroids, non-steroidal anti-inflammatories or immune suppressants in the last 6 months before study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Retinol-Based Day CreamA commercially available day cream containing retinol and moisturizing ingredients. Applied twice daily (morning and evening) to the full face for 4 weeks. | Other | Lotion and Toner Group |
| Lotion and Toner BundleA skincare regimen including a dermalift toner and a milky lotion. Applied twice daily (morning and evening) to the full face for 4 weeks. | Other | Retinol Day Cream Group |
Primary outcome
Clinical Assessment by Dermatologist
Time frame: Baseline and Week 4
Lifting grade (0-9 scale) will be evaluated by dermatologist at T-3w, T0 (baseline), Timm and T4w.Six areas will be evaluated separately: eyebrow, upper eyelid, nasolabial zone, apple cheek, corner of mouth and jaw.
2 secondary outcomes
Change in Facial Wrinkle Depth Measured by Standardized Digital Photography and Image Analysis Software
Time frame: Baseline and Week 4
Questionnaire
Time frame: Baseline and Week 4
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Aug 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Retinol-Based Day Cream and Lotion and Toner Bundle in people with Lifting Efficacy and Facial Aging, run by ChinaNorm at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Clinical Assessment by Dermatologist (time frame: Baseline and Week 4). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Aug 2025.