Cognitive DeclineMOVENCT07127965
Exercise Adherence and Cognitive Decline: Phase 2
A study testing Goal Setting and Exercise Intensity Intervention in people with Cognitive Decline, run by University of Colorado, Boulder at 2 sites in United States.
Trial summary
The purpose of this study is to conduct a test of a goals-based program to help people exercise more. This program was designed for individuals aged 45-65 from the Black community. Low levels of physical activity are related to health problems such as heart disease, diabetes, and cognitive decline. Read more about this study
- Who is it for?
- Ages 45 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Cognitive Decline
- What is being tested?
- Goal Setting and Exercise Intensity Intervention
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 226 participants
- Where
- 2 sitesUnited States
- Study dates
- 5 Nov 2025to 31 Aug 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- <3 incorrect responses on the Pfeiffer Mental Status Questionnaire
- Ages 45 to 65
- Consent to be randomized to conditions
- Planning to remain in the Denver metro area for the next 14 months
- Identify as Black or African American
Who cannot join
- Currently physically active (i.e., >90 min/week of moderate PA or >40 min/week of vigorous PA consistently for the past 6 months)
- On antipsychotic medications or currently under treatment for any serious psychiatric disorder including Alzheimer's or dementia
- Inability to walk 3 blocks without chest pain, shortness of breath, or lightheadedness
- Inability to climb 2 flights of stairs without chest pain, shortness of breath, or lightheadedness
- PCP Exclusion Criteria:
- Answers "yes" to 1 or more of the 7 general questions of the PAR-Q+ and answers yes to any of the follow up questions.
Show all 9Show fewer
- Blood pressure at baseline is greater than 160/100
- Blood pressure at baseline is between 140/90 - 160/100 and the participant is currently taking blood pressure medication
- Blood pressure > 210/90 mmHg (for men) or > 190/90 mmHg (for women) immediately after exercise
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
United States2 sites, 2 recruiting
- Recruiting
Recreation Centers in the Denver Metro Area
Aurora, Colorado, 80309
Soha Khadem, B.S., 720-853-4676, themovestudy@gmail.com
- Recruiting
Recreation Centers in the Boulder Area
Boulder, Colorado, 80309
Soha Khadem, B.S., 720-853-4676, themovestudy@gmail.com
About this study
Official title: Exercise Adherence and Cognitive Decline: A Goal-setting and Exercise Intensity Intervention Collaboratively Developed With the Black Community
The purpose of this study is to conduct a test of a goals-based program to help people exercise more. This program was designed for individuals aged 45-65 from the Black community. Low levels of physical activity are related to health problems such as heart disease, diabetes, and cognitive decline. People of color are more negatively impacted by these conditions and have also historically been underrepresented by research seeking to increase physical activity. The investigators have developed this goals-based exercise promotion program with the help of a Black-led community-based organization (The Gyedi Project) and a Community Advisory Board made up of stakeholders in the Black community.
- Conditions
- Cognitive Decline
- Being tested
- Goal Setting and Exercise Intensity Intervention
- Keywords
- Goals, Goal Difficulty, Exercise Intensity, Cognitive Decline
- Medical subject headings
- Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Goal Setting and Exercise Intensity InterventionBehavioural
Participants' goal-setting and exercise intensity are manipulated based on group assignment.
| Study group | Role | What they receive |
|---|---|---|
| Moderate Intensity Exercise, Basic Goal Difficulty | Experimental | Participants are assigned to exercise at a moderate intensity and create basic goals Receives: Behavioral: Goal Setting and Exercise Intensity Intervention |
| Moderate Intensity Exercise, Challenging Goal Difficulty | Experimental | Participants are assigned to exercise at a moderate intensity and create challenging goals Receives: Behavioral: Goal Setting and Exercise Intensity Intervention |
| Vigorous Intensity Exercise, Basic Goal Difficulty | Experimental | Participants are assigned to exercise at a vigorous intensity and create basic goals Receives: Behavioral: Goal Setting and Exercise Intensity Intervention |
| Vigorous Intensity Exercise, Challenging Goal Difficulty | Experimental | Participants are assigned to exercise at a vigorous intensity and create challenging goals. Receives: Behavioral: Goal Setting and Exercise Intensity Intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Blood Pressure
Blood pressure (systolic and diastolic) of all participants is collected before the intervention
Measured: Baseline, Visit 15 (6 Months after baseline), Visit 17 (12 months after baseline)
Activity Levels
Exercise Intensity (PAR). Answers are direct (ex. how many hours active) and not scaled. Information is requested for the week and the past 3 months.
Measured: Baseline, Visit 15 (6 months after baseline), Visit 17 (12 months after baseline)
Sleep Levels
Exercise Intensity (PAR). Answers are direct (ex. how many hours did you sleep) and are not scaled. Information is requested for the past 7 days.
Measured: Baseline, Visit 15 (6 months after baseline), Visit 17 (12 months after followup)
Exercise Intensity
Exercise Intensity (PAR). Answers are direct (ex. how many hours did you sleep) and are not scaled. Information is requested for the past 7 days.
Measured: Baseline, Visit 15 (6 months after baseline), Visit 17 (12 months after baseline)
Exercise Behavior
L-Cat. Single question that asks about frequency/rigor of physical activity, with six potential answers ranging from no physical activity to daily physical activity.
Measured: Baseline, Visit 17 (12 months after Baseline)
Exercise Behavior
modified Godin Shepard Leisure Time Physical Activity Questionnaire. Measures physical and leisure activity over a typical one week period
Measured: All study timepoints (Visits 1-17; approximately 14 months)
Theoretical Mediators of Exercise Behavior
Intrinsic Motivation Inventory. Questions relate to how participants think or feel about physical activity, with answers ranging from 1 (strongly disagree) to 7 (strongly agree). Broader scores are broken up into subscales; final subscale scores are summed and averaged. Higher scores indicate higher agreement with that subscale.
Measured: Baseline, Visit 12 (supervised exercise visit), Visits 14-17 (3, 6, 9, and 12 months after baseline)
Theoretical Mediators of Exercise Behavior
Self-Efficacy. 9 questions about confidence in exercise on scale of 1 (disagree strongly) to 7 (agree strongly). Higher scores indicate higher perceived confidence in doing that activity. Total scores are summed.
Measured: Baseline, Visit 12 (supervised exercise visit), Visits 14-17 (3, 6, 9, and 12 months after baseline)
Theoretical Mediators of Exercise Behavior
Exercise Intention Survey. Scored on a Likert scale from 1 (strongly disagree) to 7 (strongly agree) to indicate level of agreement to statements related to intention to exercise. Scores are summed to produce a total score. Higher scores indicate stronger intention to exercise, lower scores indicate weaker intention.
Measured: Baseline, Visit 12 (supervised exercise visit), Visits 14-17 (3, 6, 9, and 12 months after baseline)
Theoretical Mediators of Exercise Behavior
Exercise Identity Score. Scored on a Likert scale from 1 (strongly disagree) to 7 (strongly agree) to indicate level of agreement to statements related to attitudes towards exercise. Scores are summed and averaged to provide an overall score. Higher scores indicate a positive attitude towards exercise, lower scores less favorable attitude.
Measured: Baseline, Visit 12 (supervised exercise visit), Visits 14-17 (3, 6, 9, and 12 months after baseline)
Theoretical Mediators of Exercise Behavior
Exercise alignment with Black identity. Assessment of the extent to which 7 common exercises are aligned with Black identity
Measured: Baseline, Visit 12 (supervised exercise visit), Visits 14-17 (3, 6, 9, and 12 months after baseline)
Heart Rate Variability
Heart Rate Variability is measured using chest strap monitor.
Measured: Baseline, Visit 17 (12 months after Baseline)
Heart Rate
Heart Rate is measured using chest strap monitor.
Measured: Baseline, Visits 2-13 (Supervised Exercise Training, 1 hour 3x/week for 4 weeks), Visit 15 (6-month follow-up), Visit 17 (12-month follow-up)
Ventilatory Threshold
Talk Test. Graded treadmill test where intensity is increased at intervals to determine participant's ventilatory threshold.
Measured: Baseline
Perceived Exertion
A single-item measure from Borg (1973) was used to assess participants' rate of perceived exertion (RPE) during the exercise bout. Participants were asked to rate the average intensity of exercise [at that moment/during the past ten minutes] on a 25-point scale ranging from 6 (no exertion at all) to 20 (maximal exertion).
Measured: Baseline, Visits 2-13 (Supervised Exercise Training, 1 hour 3x/week for 4 weeks)
Pain Levels
A single item measure from Borg (1998) was used to assess participants' pain levels during the exercise bout. Participants were asked to indicate how much pain they felt [at that moment/during the past ten minutes] on an 11-point scale ranging from 0 (nothing at all) to 10 (excruciating).
Measured: Visits 2, 6, 12 (Supervised Exercise Training)
Affective Valence
The Feeling Scale, a single-item measure from Hardy and Rejeski (1989), was used to assess participants' affective valence during the exercise bout. Participants were asked to indicate how they felt [at that moment/during the past ten minutes] on an 11-point scale ranging from -5 (very bad) to +5 (very good).
Measured: Visit 12, Visits 14-16 (3, 6, and 9 months after baseline)
Affective Arousal
The Felt Arousal Scale, a single-item measure from Svebak and Murgatroyd (1985), was used to assess participants' affective arousal during the exercise bout. Participants were asked to indicate how "worked-up" they felt [at that moment/during the past ten minutes] on a 6-point scale ranging from 1 (low arousal) to 6 (high arousal).
Measured: Visits 2, 6, 12 (Supervised Exercise Training)
Enjoyment
A single item measure from Gillman and Bryan (2015) was used to assess participants' enjoyment levels during the exercise bout. Participants were asked to indicate how enjoyable exercise was [at that moment/during the past ten minutes] on a 5-point scale ranging from 1 (no enjoyment at all) to 5 (a great deal of enjoyment).
Measured: Visits 2, 6, 12 (Supervised Exercise Training)
Exercise Check-In
Three short questions assessing if the participant planned to engage in exercise and how many minutes of moderate (0-120) and vigorous (0-60) exercise they engaged in
Measured: Visits 14-17 (3, 6, 9, and 12 months after baseline)
Exercise Benefits and Barriers
A 10 item scale assessing perceived benefits of and barriers to exercise
Measured: Baseline, Visit 12 (supervised exercise visit), Visits 14-17 (3, 6, 9, and 12 months after baseline)
Anthropometrics
Height will be measured in centimeters
Measured: Baseline, Visit 17 (12-month follow-up)
Diet
NCI's Eating at America's Table Study (EATS) Fruit \& Vegetable All-Day Screener. A short dietary assessment instrument for measuring fruit and vegetable intake over the past month.
Measured: Baseline, Visit 17 (12-month follow-up)
Demographics
Survey includes gender, sexual orientation, age, detailed race/ethnicity, and SES
Measured: Baseline
Objective Physical Activity
Objective physical activity will be measured through ActiGraph. Participants will be given the ActiGraph at baseline and will be asked to wear the device for one week. Participants will then be asked to wear the watch continuously for the week before visit 15 (6-month follow-up) and visit 17 (12-month follow-up).
Measured: Baseline, Visit 15 (6 months after baseline), Visit 17 (12 months after baseline)
Biomarkers of Cognitive Aging
Biomarkers of cognitive again will be analyzed by blood samples. Blood samples will be collected at baseline and Visit 17 (12-month follow-up) and stored. At the end of the study, samples will be sent for analysis of biomarkers involved in cognitive aging, including p-tau181, NfL, Ab40, Ab42, GFAP, and IGF-1.
Measured: Baseline and Visit 17 (12 months after baseline)
Anthropometrics
Weight will be measured in pounds
Measured: Baseline, Visit 17 (12-month follow-up)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Aug 2025
- Study start5 Nov 2025
- Primary completion31 Aug 2028 (estimated)
- Study completion31 Aug 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cognitive DeclineStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 226 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Colorado, Boulder
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Angela Bryan, University of Colorado, Boulder
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07127965
- Sponsor's protocol ID
- 25-0479
- Acronym
- MOVE
- Status last verified
- Jun 2026
- First submitted
- 7 Aug 2025
- Last updated
- 11 Jun 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Exercise Adherence and Cognitive Decline: A Goal-setting and Exercise Intensity Intervention Collaboratively Developed With the Black Community
- ClinicalTrials.gov ID
- NCT07127965
- Acronym / sponsor ID
- MOVE / 25-0479
- Conditions
- Cognitive Decline
- Keywords
- Goals, Goal Difficulty, Exercise Intensity, Cognitive Decline
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 226 participants (estimated)
- Lead sponsor
- University of Colorado, BoulderUniversity, hospital or other
- Study start
- 5 Nov 2025 (actual)
- Primary completion
- 31 Aug 2028 (estimated)
- Study completion
- 31 Aug 2028 (estimated)
- First posted
- 17 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to conduct a test of a goals-based program to help people exercise more. This program was designed for individuals aged 45-65 from the Black community. Low levels of physical activity are related to health problems such as heart disease, diabetes, and cognitive decline. People of color are more negatively impacted by these conditions and have also historically been underrepresented by research seeking to increase physical activity. The investigators have developed this goals-based exercise promotion program with the help of a Black-led community-based organization (The Gyedi Project) and a Community Advisory Board made up of stakeholders in the Black community.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Moderate Intensity Exercise, Basic Goal Difficulty | Experimental | Behavioral: Goal Setting and Exercise Intensity InterventionParticipants are assigned to exercise at a moderate intensity and create basic goals |
| Moderate Intensity Exercise, Challenging Goal Difficulty | Experimental | Behavioral: Goal Setting and Exercise Intensity InterventionParticipants are assigned to exercise at a moderate intensity and create challenging goals |
| Vigorous Intensity Exercise, Basic Goal Difficulty | Experimental | Behavioral: Goal Setting and Exercise Intensity InterventionParticipants are assigned to exercise at a vigorous intensity and create basic goals |
| Vigorous Intensity Exercise, Challenging Goal Difficulty | Experimental | Behavioral: Goal Setting and Exercise Intensity InterventionParticipants are assigned to exercise at a vigorous intensity and create challenging goals. |
Who may qualify
- Ages
- 45 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- <3 incorrect responses on the Pfeiffer Mental Status Questionnaire
- Ages 45 to 65
- Consent to be randomized to conditions
- Planning to remain in the Denver metro area for the next 14 months
- Identify as Black or African American
Key exclusion criteria (9 listed)
- Currently physically active (i.e., >90 min/week of moderate PA or >40 min/week of vigorous PA consistently for the past 6 months)
- On antipsychotic medications or currently under treatment for any serious psychiatric disorder including Alzheimer's or dementia
- Inability to walk 3 blocks without chest pain, shortness of breath, or lightheadedness
- Inability to climb 2 flights of stairs without chest pain, shortness of breath, or lightheadedness
- Answers "yes" to 1 or more of the 7 general questions of the PAR-Q+ and answers yes to any of the follow up questions.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Goal Setting and Exercise Intensity InterventionParticipants' goal-setting and exercise intensity are manipulated based on group assignment. | Behavioural | Moderate Intensity Exercise, Basic Goal Difficulty, Moderate Intensity Exercise, Challenging Goal Difficulty, Vigorous Intensity Exercise, Basic Goal Difficulty, Vigorous Intensity Exercise, Challenging Goal Difficulty |
Primary outcome
Blood Pressure
Time frame: Baseline, Visit 15 (6 Months after baseline), Visit 17 (12 months after baseline)
Blood pressure (systolic and diastolic) of all participants is collected before the intervention
Activity Levels
Time frame: Baseline, Visit 15 (6 months after baseline), Visit 17 (12 months after baseline)
Exercise Intensity (PAR). Answers are direct (ex. how many hours active) and not scaled. Information is requested for the week and the past 3 months.
Sleep Levels
Time frame: Baseline, Visit 15 (6 months after baseline), Visit 17 (12 months after followup)
Exercise Intensity (PAR). Answers are direct (ex. how many hours did you sleep) and are not scaled. Information is requested for the past 7 days.
Exercise Intensity
Time frame: Baseline, Visit 15 (6 months after baseline), Visit 17 (12 months after baseline)
Exercise Intensity (PAR). Answers are direct (ex. how many hours did you sleep) and are not scaled. Information is requested for the past 7 days.
Exercise Behavior
Time frame: Baseline, Visit 17 (12 months after Baseline)
L-Cat. Single question that asks about frequency/rigor of physical activity, with six potential answers ranging from no physical activity to daily physical activity.
Exercise Behavior
Time frame: All study timepoints (Visits 1-17; approximately 14 months)
modified Godin Shepard Leisure Time Physical Activity Questionnaire. Measures physical and leisure activity over a typical one week period
Theoretical Mediators of Exercise Behavior
Time frame: Baseline, Visit 12 (supervised exercise visit), Visits 14-17 (3, 6, 9, and 12 months after baseline)
Intrinsic Motivation Inventory. Questions relate to how participants think or feel about physical activity, with answers ranging from 1 (strongly disagree) to 7 (strongly agree). Broader scores are broken up into subscales; final subscale scores are summed and averaged. Higher scores indicate higher agreement with that subscale.
Theoretical Mediators of Exercise Behavior
Time frame: Baseline, Visit 12 (supervised exercise visit), Visits 14-17 (3, 6, 9, and 12 months after baseline)
Self-Efficacy. 9 questions about confidence in exercise on scale of 1 (disagree strongly) to 7 (agree strongly). Higher scores indicate higher perceived confidence in doing that activity. Total scores are summed.
Theoretical Mediators of Exercise Behavior
Time frame: Baseline, Visit 12 (supervised exercise visit), Visits 14-17 (3, 6, 9, and 12 months after baseline)
Exercise Intention Survey. Scored on a Likert scale from 1 (strongly disagree) to 7 (strongly agree) to indicate level of agreement to statements related to intention to exercise. Scores are summed to produce a total score. Higher scores indicate stronger intention to exercise, lower scores indicate weaker intention.
Theoretical Mediators of Exercise Behavior
Time frame: Baseline, Visit 12 (supervised exercise visit), Visits 14-17 (3, 6, 9, and 12 months after baseline)
Exercise Identity Score. Scored on a Likert scale from 1 (strongly disagree) to 7 (strongly agree) to indicate level of agreement to statements related to attitudes towards exercise. Scores are summed and averaged to provide an overall score. Higher scores indicate a positive attitude towards exercise, lower scores less favorable attitude.
Theoretical Mediators of Exercise Behavior
Time frame: Baseline, Visit 12 (supervised exercise visit), Visits 14-17 (3, 6, 9, and 12 months after baseline)
Exercise alignment with Black identity. Assessment of the extent to which 7 common exercises are aligned with Black identity
Heart Rate Variability
Time frame: Baseline, Visit 17 (12 months after Baseline)
Heart Rate Variability is measured using chest strap monitor.
Heart Rate
Time frame: Baseline, Visits 2-13 (Supervised Exercise Training, 1 hour 3x/week for 4 weeks), Visit 15 (6-month follow-up), Visit 17 (12-month follow-up)
Heart Rate is measured using chest strap monitor.
Ventilatory Threshold
Time frame: Baseline
Talk Test. Graded treadmill test where intensity is increased at intervals to determine participant's ventilatory threshold.
Perceived Exertion
Time frame: Baseline, Visits 2-13 (Supervised Exercise Training, 1 hour 3x/week for 4 weeks)
A single-item measure from Borg (1973) was used to assess participants' rate of perceived exertion (RPE) during the exercise bout. Participants were asked to rate the average intensity of exercise [at that moment/during the past ten minutes] on a 25-point scale ranging from 6 (no exertion at all) to 20 (maximal exertion).
Pain Levels
Time frame: Visits 2, 6, 12 (Supervised Exercise Training)
A single item measure from Borg (1998) was used to assess participants' pain levels during the exercise bout. Participants were asked to indicate how much pain they felt [at that moment/during the past ten minutes] on an 11-point scale ranging from 0 (nothing at all) to 10 (excruciating).
Affective Valence
Time frame: Visit 12, Visits 14-16 (3, 6, and 9 months after baseline)
The Feeling Scale, a single-item measure from Hardy and Rejeski (1989), was used to assess participants' affective valence during the exercise bout. Participants were asked to indicate how they felt [at that moment/during the past ten minutes] on an 11-point scale ranging from -5 (very bad) to +5 (very good).
Affective Arousal
Time frame: Visits 2, 6, 12 (Supervised Exercise Training)
The Felt Arousal Scale, a single-item measure from Svebak and Murgatroyd (1985), was used to assess participants' affective arousal during the exercise bout. Participants were asked to indicate how "worked-up" they felt [at that moment/during the past ten minutes] on a 6-point scale ranging from 1 (low arousal) to 6 (high arousal).
Enjoyment
Time frame: Visits 2, 6, 12 (Supervised Exercise Training)
A single item measure from Gillman and Bryan (2015) was used to assess participants' enjoyment levels during the exercise bout. Participants were asked to indicate how enjoyable exercise was [at that moment/during the past ten minutes] on a 5-point scale ranging from 1 (no enjoyment at all) to 5 (a great deal of enjoyment).
Exercise Check-In
Time frame: Visits 14-17 (3, 6, 9, and 12 months after baseline)
Three short questions assessing if the participant planned to engage in exercise and how many minutes of moderate (0-120) and vigorous (0-60) exercise they engaged in
Exercise Benefits and Barriers
Time frame: Baseline, Visit 12 (supervised exercise visit), Visits 14-17 (3, 6, 9, and 12 months after baseline)
A 10 item scale assessing perceived benefits of and barriers to exercise
Anthropometrics
Time frame: Baseline, Visit 17 (12-month follow-up)
Height will be measured in centimeters
Diet
Time frame: Baseline, Visit 17 (12-month follow-up)
NCI's Eating at America's Table Study (EATS) Fruit \& Vegetable All-Day Screener. A short dietary assessment instrument for measuring fruit and vegetable intake over the past month.
Demographics
Time frame: Baseline
Survey includes gender, sexual orientation, age, detailed race/ethnicity, and SES
Objective Physical Activity
Time frame: Baseline, Visit 15 (6 months after baseline), Visit 17 (12 months after baseline)
Objective physical activity will be measured through ActiGraph. Participants will be given the ActiGraph at baseline and will be asked to wear the device for one week. Participants will then be asked to wear the watch continuously for the week before visit 15 (6-month follow-up) and visit 17 (12-month follow-up).
Biomarkers of Cognitive Aging
Time frame: Baseline and Visit 17 (12 months after baseline)
Biomarkers of cognitive again will be analyzed by blood samples. Blood samples will be collected at baseline and Visit 17 (12-month follow-up) and stored. At the end of the study, samples will be sent for analysis of biomarkers involved in cognitive aging, including p-tau181, NfL, Ab40, Ab42, GFAP, and IGF-1.
Anthropometrics
Time frame: Baseline, Visit 17 (12-month follow-up)
Weight will be measured in pounds
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Jun 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Goal Setting and Exercise Intensity Intervention in people with Cognitive Decline, run by University of Colorado, Boulder at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 11 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Soha Khadem, B.S. (720-853-4676, themovestudy@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Blood Pressure (time frame: Baseline, Visit 15 (6 Months after baseline), Visit 17 (12 months after baseline)). The study lists 27 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Jun 2026.