TinnitusATtDCSNCT07128004
In This Study, we Are Testing Whether Combining Two Interventions, in the Early Stages of Tinnitus, is More Effective in Quieting Tinnitus Than Using One Treatment Alone in the Later Stages of Tinnitus
A study testing tDCS and sound therapy in people with Tinnitus and Acute, run by Newcastle University.
Trial summary
Tinnitus affects one in seven adults long-term Once present persistently for 4 weeks, tinnitus does not usually disappear People generally become less aware of, and less affected by, their tinnitus over time Only one in six people with tinnitus suffers a long-term negative impact on their life Current treatments can… Read more about this study
- Who is it for?
- Ages 18 years and older
- What is being tested?
- tDCS and sound therapy
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 80 participants
- Where
- No sites listed yet
- Study dates
- 5 Aug 2025to 9 Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- The presence of tinnitus (persistent sound heard in one or both ears that is not coming from an external sound source or actual sounds being generated inside your body such as turbulent blood flow), which has persisted for at least 3 days, and began within the last 8 weeks. You do not need to be aware of the tinnitus all the time, but it must be persistent in the sense that is can always hear it if you listen out for it, and there is not enough other sounds around to mask it.
- Age 18 or over
- The ability to make and communicate an informed choice about whether to take part in the study
- The ability to sit still and comfortably in a comfortable chair for around 1 hour at a time.
Who cannot join
- Tinnitus due to a physical sound source in the body, such as turbulent blood flow or muscle contractions in the middle ear.
- Presence of tinnitus over a period of 8 weeks
- Severe or profound hearing loss at high frequencies in the tinnitus ear(s), such that you could not properly hear the sounds used in the study
- Any implanted electronic device, such as a pacemaker, cochlear implant, bone-anchored hearing aid, nerve stimulator, deep brain stimulator or spinal cord stimulator
- Any areas of broken skin on the parts of the scalp where tDCS is applied
- Ménière's disease
Show all 11Show fewer
- Any abnormality of brain structure (e.g. stroke, tumour), or other neurological disorder (e.g. multiple sclerosis or epilepsy)
- The ongoing use of sedating medications, or certain other nerve- or brain-acting medications
- A current mental health condition of sufficient severity to prevent certain activities of everyday life
- In addition to these criteria, the researcher might have other reasons to suspect that participation is either contraindicated, or might be unsuitable. In such cases, the researcher should discuss these concerns with the potential participant and/or a senior member of the research team. Participation should only proceed if all those involved in these discussions agree it should.
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Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effect of Combined Acoustic Ripples and Transcranial Direct Current Stimulation on the Symptoms of New-Onset Subjective Tinnitus
- Tinnitus affects one in seven adults long-term
- Once present persistently for 4 weeks, tinnitus does not usually disappear
- People generally become less aware of, and less affected by, their tinnitus over time
- Only one in six people with tinnitus suffers a long-term negative impact on their life
- Current treatments can help to reduce the impact of tinnitus, but not silence the sound
- Treatments have only so far been tested once tinnitus has been present longer than 6 months
- In this study, the researchers are testing whether combining two interventions, in the early stages of tinnitus, is more effective in quieting tinnitus than using one treatment alone in the later stages of tinnitus
- One intervention (acoustic ripples) involves playing sounds through headphones for up to 60 minutes per day, and is mostly done in your own time
- The other intervention (transcranial direct current stimulation: tDCS) involves applying a weak electrical current to the volunteer's scalp using sponges soaked in salt water. This is performed in Newcastle University Medical School for a total of 8 sessions of 40 minutes each, spread over 4 weeks
- Half the volunteers will receive the 'real' intervention, and half a 'sham' or 'placebo' version. This will be randomly determined, and the volunteers or the research team will not known which you are receiving until the end of the study
- When the study ends, all volunteers will be able to use the 'real' intervention sounds in their own time, for as long as they wish, if they want to do so. No volunteers will be able to receive tDCS after the end of the study.
- All volunteers also complete questionnaires about their tinnitus, related symptoms and general health, and have hearing tests plus EEG (electrical brainwave) recordings
- The study is very low-risk, but does involve a total of 10 visits of around an hour each to Newcastle University Medical School over around a month. These can be arranged flexibly, including daytimes, evenings and weekends
- The researchers will pay all reasonable travel expenses, and £10 per hour for the volunteer's time in participating
- The study only completely ends 6 months after the date the tinnitus first started. At this point, the researchers will send some questionnaires to complete only. There is nothing to do for the study in between the tenth visit and this six-month questionnaire.
Read the detailed description
Tinnitus is a common condition, in which people hear continuous sounds in the absence of an external source producing those sounds. Most people experience tinnitus for short periods of time throughout their life, for instance after exposure to loud noise, and some people experience long-term tinnitus. In most cases of tinnitus, there is a degree of hearing loss (often only mild), but it is rare for tinnitus to represent any serious disorder of the brain or ear. There are no widely effective treatments for tinnitus to reduce its loudness or eliminate it, but the majority of people with long-term tinnitus lead a normal life, without any impairment in quality of life on account of the tinnitus. A minority of people with long-term tinnitus experience distress as a result of it, and most people with long-term tinnitus gradually get used to the sound, and notice it less and less over time.
Previous studies have shown that applying a weak electrical current to the scalp (electrical stimulation) can lead to a small reduction in the loudness and impact of tinnitus for some people who have had tinnitus for many months or years already, and that this is significantly more effective, on average, than applying placebo (i.e. pretend) electrical stimulation. Electrical stimulation has never been tested in people who have recently developed their tinnitus.
Certain specific sounds, tailored to individuals' tinnitus, can significantly quieten tinnitus for some people, when these are listened to for an hour or so each day for weeks or months. However, the average quieting effect is quite modest. Like with electrical stimulation, these have only been tested by people with tinnitus already present for months to years.
Aims of study
The researchers believe that electrical stimulation and tailored sounds may be more effective in quieting tinnitus when given early in the course of tinnitus, compared to later on. Many researchers also believe that combining different types of tinnitus treatment may have a stronger effect than the sum of the effects of each individually.
Finally, the researchers want to test whether using interventions to quieten tinnitus early on in its course, even just for one month, might have a long-lasting or permanent effect in reducing tinnitus symptoms.
The benefits of treating tinnitus early, and using combination interventions, are currently theoretical, and one main aim of the study is to test whether they do exist.
The other main aim is to see how acceptable people find the course of combined intervention in the time period shortly after their tinnitus begins.
The volunteers are being approached because the volunteers have indicated that they have newly developed tinnitus.
What taking part involves
If they take part in the study, they will attend the researcher's laboratory on a total of 10 sessions over one month, to do the following:
- Provide details about their tinnitus and other health symptoms, and complete questionnaires (sessions 1 and 10 only)
- Undergo a hearing test (session 1 only). Note that this is not a substitute for having the volunteer's hearing formally assessed in a clinic.
- Undergo some computer-based sound tests (sessions 1 and 10 only). In these, they match a sound to the volume and pitch of their tinnitus so the researchers can estimate what it sounds like.
- Having an electroencephalography (EEG) recording, which measures their electrical 'brainwaves' (sessions 1 and 10 only)
- Have an electrical stimulation session for around 40 minutes (in each of sessions 2-9), which also includes listening to sounds through headphones.
- Provide quick symptom ratings of their tinnitus and its loudness before and after the electrical stimulation session. (sessions 2-9)
The first session may take up to 2 hours, and other sessions last around 1 hour each. The exact timing of the sessions can be negotiated with the research team to suit their schedule as far as possible. Weekday, evening and weekend appointments are all possible.
Separately to these sessions, we provide a copy of their personalised sound files to take home, and encourage you to listen to these for up to 60 minutes per day.
We will also contact them 6 months after the onset of their tinnitus to ask for them to report their current tinnitus symptoms, in the form of a questionnaire. This can be completed online, and does not require another visit.
- Being tested
- tDCS, sound therapy
- Keywords
- Acute Tinnitus, Treatment, Sound therapy, tDCS
- Medical subject headings
- Tinnitus
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
tDCSDevice
Also called transcranial direct current stimulation
would provide direct current for 40 minutes in 20 minute interval at 2 mA
sound therapyDevice
would provide acoustic ripples along with tDCS
| Study group | Role | What they receive |
|---|---|---|
| tDCS and sound therapy active | Experimental | would present active tDCS and sound therapy for 40 minutes Receives: Device: tDCS; Device: sound therapy |
| tDCS and sound therapy sham | Sham comparator | would provide a sham tDCS and sound therapy Receives: Device: tDCS; Device: sound therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Numerical Rating Scale
Primary outcome will be perceived tinnitus loudness assessed using a self-reported Numerical Rating Scale (NRS), where participants rate the loudness of their tinnitus on a scale from 0 to 10. Higher scores indicate greater perceived loudness. The NRS will be administered at baseline and post-intervention to evaluate changes in subjective tinnitus loudness.
Measured: 6 months for each participant
Secondary outcomes (3)
Tinnitus Distress using Tinnitus Handicap Inventory
Tinnitus-related distress will be assessed using the Tinnitus Handicap Inventory (THI), a 25-item self-report questionnaire measuring the emotional, functional, and catastrophic impact of tinnitus. Higher scores indicate greater perceived handicap. The THI will be administered at baseline and post-intervention to evaluate changes in tinnitus-related distress.
Measured: 6 months
Tinnitus distress using Tinnitus Functional Index
Tinnitus-related functional impact will be measured using the Tinnitus Functional Index (TFI), a validated 25-item questionnaire assessing tinnitus severity across eight subscales including sleep, emotional distress, and concentration. Higher scores reflect greater tinnitus-related burden. The TFI will be completed at baseline and post-intervention to assess changes in tinnitus-related impact.
Measured: 6 months
Changes in tinnitus loudness
In addition to self-reported tinnitus distress, tinnitus loudness will be assessed using audiometric loudness matching, where participants adjust the intensity of a pure tone or narrowband noise presented to the ear ipsilateral to the tinnitus until it matches the perceived loudness of their tinnitus. The matched level will be recorded in decibels sensation level (dB SL), with measurements taken at baseline and post-intervention to evaluate changes in perceived loudness.
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Aug 2025
- Study start5 Aug 2025 (estimated)
- Primary completion31 Dec 2026 (estimated)
- Study completion9 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for TinnitusStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Newcastle University
- Sponsor type
- University, hospital or other
- Collaborators
- American Tinnitus Association
- Responsible party
- Sponsor
- Investigators
- William Sedley, PhD, Principal investigator, Newcastle University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07128004
- Sponsor's protocol ID
- NU-019970
- Other IDs
- American Tinnitus Association
- Acronym
- ATtDCS
- Status last verified
- Aug 2025
- First submitted
- 9 Jul 2025
- Last updated
- 17 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Raw datas including participant's numerical rating scales, tinnitus questionnaires, and tinnitus pitch and loudness
Publications
Vanneste S, Byczynski G, Verplancke T, Ost J, Song JJ, De Ridder D. Switching tinnitus on or off: An initial investigation into the role of the pregenual and rostral to dorsal anterior cingulate cortices. Neuroimage. 2024 Aug 15;297:120713. doi: 10.1016/j.neuroimage.2024.120713. Epub 2024 Jun 27.
PubMed 38944171Umashankar A, Gander P, Alter K, Sedley W. Short- and long-term changes in auditory sensitivity and tinnitus distress between acute and chronic tinnitus: Longitudinal observation in a community-based sample. Hear Res. 2025 Jul;463:109299. doi: 10.1016/j.heares.2025.109299. Epub 2025 May 7.
PubMed 40378541
Study at a glance
From the registry record, last updated by the sponsor on 17 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Combined Acoustic Ripples and Transcranial Direct Current Stimulation on the Symptoms of New-Onset Subjective Tinnitus
- ClinicalTrials.gov ID
- NCT07128004
- Acronym / sponsor ID
- ATtDCS / NU-019970
- Keywords
- Acute Tinnitus, Treatment, Sound therapy, tDCS
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Newcastle UniversityUniversity, hospital or other
- Collaborators
- American Tinnitus Association
- Study start
- 5 Aug 2025 (estimated)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 9 Mar 2027 (estimated)
- First posted
- 17 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
- Tinnitus affects one in seven adults long-term
- Once present persistently for 4 weeks, tinnitus does not usually disappear
- People generally become less aware of, and less affected by, their tinnitus over time
- Only one in six people with tinnitus suffers a long-term negative impact on their life
- Current treatments can help to reduce the impact of tinnitus, but not silence the sound
- Treatments have only so far been tested once tinnitus has been present longer than 6 months
- In this study, the researchers are testing whether combining two interventions, in the early stages of tinnitus, is more effective in quieting tinnitus than using one treatment alone in the later stages of tinnitus
- One intervention (acoustic ripples) involves playing sounds through headphones for up to 60 minutes per day, and is mostly done in your own time
- The other intervention (transcranial direct current stimulation: tDCS) involves applying a weak electrical current to the volunteer's scalp using sponges soaked in salt water. This is performed in Newcastle University Medical School for a total of 8 sessions of 40 minutes each, spread over 4 weeks
- Half the volunteers will receive the 'real' intervention, and half a 'sham' or 'placebo' version. This will be randomly determined, and the volunteers or the research team will not known which you are receiving until the end of the study
- When the study ends, all volunteers will be able to use the 'real' intervention sounds in their own time, for as long as they wish, if they want to do so. No volunteers will be able to receive tDCS after the end of the study.
- All volunteers also complete questionnaires about their tinnitus, related symptoms and general health, and have hearing tests plus EEG (electrical brainwave) recordings
- The study is very low-risk, but does involve a total of 10 visits of around an hour each to Newcastle University Medical School over around a month. These can be arranged flexibly, including daytimes, evenings and weekends
- The researchers will pay all reasonable travel expenses, and £10 per hour for the volunteer's time in participating
- The study only completely ends 6 months after the date the tinnitus first started. At this point, the researchers will send some questionnaires to complete only. There is nothing to do for the study in between the tenth visit and this six-month questionnaire.
Detailed description
Tinnitus is a common condition, in which people hear continuous sounds in the absence of an external source producing those sounds. Most people experience tinnitus for short periods of time throughout their life, for instance after exposure to loud noise, and some people experience long-term tinnitus. In most cases of tinnitus, there is a degree of hearing loss (often only mild), but it is rare for tinnitus to represent any serious disorder of the brain or ear. There are no widely effective treatments for tinnitus to reduce its loudness or eliminate it, but the majority of people with long-term tinnitus lead a normal life, without any impairment in quality of life on account of the tinnitus. A minority of people with long-term tinnitus experience distress as a result of it, and most people with long-term tinnitus gradually get used to the sound, and notice it less and less over time.
Previous studies have shown that applying a weak electrical current to the scalp (electrical stimulation) can lead to a small reduction in the loudness and impact of tinnitus for some people who have had tinnitus for many months or years already, and that this is significantly more effective, on average, than applying placebo (i.e. pretend) electrical stimulation. Electrical stimulation has never been tested in people who have recently developed their tinnitus.
Certain specific sounds, tailored to individuals' tinnitus, can significantly quieten tinnitus for some people, when these are listened to for an hour or so each day for weeks or months. However, the average quieting effect is quite modest. Like with electrical stimulation, these have only been tested by people with tinnitus already present for months to years.
Aims of study
The researchers believe that electrical stimulation and tailored sounds may be more effective in quieting tinnitus when given early in the course of tinnitus, compared to later on. Many researchers also believe that combining different types of tinnitus treatment may have a stronger effect than the sum of the effects of each individually.
Finally, the researchers want to test whether using interventions to quieten tinnitus early on in its course, even just for one month, might have a long-lasting or permanent effect in reducing tinnitus symptoms.
The benefits of treating tinnitus early, and using combination interventions, are currently theoretical, and one main aim of the study is to test whether they do exist.
The other main aim is to see how acceptable people find the course of combined intervention in the time period shortly after their tinnitus begins.
The volunteers are being approached because the volunteers have indicated that they have newly developed tinnitus.
What taking part involves
If they take part in the study, they will attend the researcher's laboratory on a total of 10 sessions over one month, to do the following:
- Provide details about their tinnitus and other health symptoms, and complete questionnaires (sessions 1 and 10 only)
- Undergo a hearing test (session 1 only). Note that this is not a substitute for having the volunteer's hearing formally assessed in a clinic.
- Undergo some computer-based sound tests (sessions 1 and 10 only). In these, they match a sound to the volume and pitch of their tinnitus so the researchers can estimate what it sounds like.
- Having an electroencephalography (EEG) recording, which measures their electrical 'brainwaves' (sessions 1 and 10 only)
- Have an electrical stimulation session for around 40 minutes (in each of sessions 2-9), which also includes listening to sounds through headphones.
- Provide quick symptom ratings of their tinnitus and its loudness before and after the electrical stimulation session. (sessions 2-9)
The first session may take up to 2 hours, and other sessions last around 1 hour each. The exact timing of the sessions can be negotiated with the research team to suit their schedule as far as possible. Weekday, evening and weekend appointments are all possible.
Separately to these sessions, we provide a copy of their personalised sound files to take home, and encourage you to listen to these for up to 60 minutes per day.
We will also contact them 6 months after the onset of their tinnitus to ask for them to report their current tinnitus symptoms, in the form of a questionnaire. This can be completed online, and does not require another visit.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| tDCS and sound therapy active | Experimental | Device: tDCS, Device: sound therapywould present active tDCS and sound therapy for 40 minutes |
| tDCS and sound therapy sham | Sham comparator | Device: tDCS, Device: sound therapywould provide a sham tDCS and sound therapy |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- The presence of tinnitus (persistent sound heard in one or both ears that is not coming from an external sound source or actual sounds being generated inside your body such as turbulent blood flow), which has persisted for at least 3 days, and began within the last 8 weeks. You do not need to be aware of the tinnitus all the time, but it must be persistent in the sense that is can always hear it if you listen out for it, and there is not enough other sounds around to mask it.
- Age 18 or over
- The ability to make and communicate an informed choice about whether to take part in the study
- The ability to sit still and comfortably in a comfortable chair for around 1 hour at a time.
Key exclusion criteria (11 listed)
- Tinnitus due to a physical sound source in the body, such as turbulent blood flow or muscle contractions in the middle ear.
- Presence of tinnitus over a period of 8 weeks
- Severe or profound hearing loss at high frequencies in the tinnitus ear(s), such that you could not properly hear the sounds used in the study
- Any implanted electronic device, such as a pacemaker, cochlear implant, bone-anchored hearing aid, nerve stimulator, deep brain stimulator or spinal cord stimulator
- Any areas of broken skin on the parts of the scalp where tDCS is applied
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| tDCSAlso: transcranial direct current stimulationwould provide direct current for 40 minutes in 20 minute interval at 2 mA | Device | tDCS and sound therapy active, tDCS and sound therapy sham |
| sound therapywould provide acoustic ripples along with tDCS | Device | tDCS and sound therapy active, tDCS and sound therapy sham |
Primary outcome
Numerical Rating Scale
Time frame: 6 months for each participant
Primary outcome will be perceived tinnitus loudness assessed using a self-reported Numerical Rating Scale (NRS), where participants rate the loudness of their tinnitus on a scale from 0 to 10. Higher scores indicate greater perceived loudness. The NRS will be administered at baseline and post-intervention to evaluate changes in subjective tinnitus loudness.
3 secondary outcomes
Tinnitus Distress using Tinnitus Handicap Inventory
Time frame: 6 months
Tinnitus distress using Tinnitus Functional Index
Time frame: 6 months
Changes in tinnitus loudness
Time frame: 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Aug 2025.
- Background: PubMed 38944171Vanneste S, Byczynski G, Verplancke T, Ost J, Song JJ, De Ridder D. Switching tinnitus on or off: An initial investigation into the role of the pregenual and rostral to dorsal anterior cingulate cortices. Neuroimage. 2024 Aug 15;297:120713. doi: 10.1016/j.neuroimage.2024.120713. Epub 2024 Jun 27.
- Background: PubMed 40378541Umashankar A, Gander P, Alter K, Sedley W. Short- and long-term changes in auditory sensitivity and tinnitus distress between acute and chronic tinnitus: Longitudinal observation in a community-based sample. Hear Res. 2025 Jul;463:109299. doi: 10.1016/j.heares.2025.109299. Epub 2025 May 7.
- Individual participant dataSharing planned: Yes. Raw datas including participant's numerical rating scales, tinnitus questionnaires, and tinnitus pitch and loudness
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
William Sedley, PhD principal investigator
Newcastle University
Questions about this trial
What is this clinical trial studying?
A study testing tDCS and sound therapy in people with Tinnitus and Acute, run by Newcastle University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 17 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Abishek Umashankar, PhD (+447776590118, abishek.umashankar@newcastle.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Numerical Rating Scale (time frame: 6 months for each participant). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07128004, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Aug 2025.