TG IndexNCT07130188
Predictors for ACS and Complexity of CAD
An observational study of TG Index and TG/HDL-C Ratio, run by Assiut University.
Trial summary
To evaluate the significance of the Triglyceride index and TG/HDL-C ratio as predictors of acute coronary syndromes in the young population Read more about this study
- Who is it for?
- Ages 18 to 40 years
- Conditions the study is for
- TG Index, TG/HDL-C Ratio, Young Population
- What is being tested?
- PCI
- How many people
- 130 participants
- Where
- No sites listed yet
- Study dates
- 1 Sep 2025to 30 Dec 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- No healthy volunteers
- Adult
Study population: Young adult patients (18-45 years) admitted with acute coronary syndrome (STEMI, NSTEMI) who undergo coronary angiography during index hospitalization. Patients must have fasting lipid profile and fasting glucose measured within 24 hours of admission. Exclusions include familial hyperlipidemia, chronic inflammatory/autoimmune disease, severe renal or liver failure, active infection, recent use of non-statin lipid-altering drugs, or missing data for TyG/TG-HDL-C calculation. Follow-up will be conducted at 12 and 36 months to assess outcomes.
Who may be able to join
- -
- Age 18-40 years. Confirmed diagnosis of ACS (STEMI, NSTEMI). Willingness to participate with informed consent.
Who cannot join
- Age > 40 years old People with Previous ACS Patients known to have familial hyperlipidemia
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
Mohamed Osman Abdelhameed, Lecturer contact
About this study
Official title: The Significance of Triglyceride Index and TG/HDL-C Ratios as Predictors of Acute Coronary Syndromes in Young Population and the Complexity of Coronary Artery Disease
To evaluate the significance of the Triglyceride index and TG/HDL-C ratio as predictors of acute coronary syndromes in the young population
Read the detailed description
Cardiovascular disease (CVD) remains a major cause of morbidity and mortality worldwide, with a rising incidence of acute coronary syndromes (ACS) in young individuals under the age of 40. Early identification of at-risk individuals in this population is essential for implementing preventive strategies and reducing adverse outcomes【1,2】. Traditional risk factors such as hypertension, diabetes, smoking, and dyslipidemia are well-established; however, their predictive value in the young population is often limited【2】.
Recent studies have highlighted the significance of novel lipid-derived markers, particularly the triglyceride-glucose (TyG) index and the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, as potential predictors of insulin resistance, subclinical atherosclerosis, and cardiovascular events【1,3】. The TyG index and TG/HDL-C ratio are simple, cost-effective markers derived from routine laboratory parameters and have shown promising associations with metabolic syndrome, endothelial dysfunction, and coronary artery disease (CAD) severity【3,4】.
Despite emerging evidence in older adults, limited data exist regarding the utility of these markers in predicting ACS among the young population, where conventional risk scores often underestimate risk【4,5】. Early detection through these markers could improve risk stratification and guide preventive strategies.
This study aims to evaluate the significance of the TyG index and TG/HDL-C ratio as predictors of ACS in young adults, providing insight into their potential role in primary prevention
- Conditions
- TG Index, TG/HDL-C Ratio, Young Population
- Being tested
- PCI
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PCIDiagnostic test
Coronary angiography then SYNTAX score calculation
What is being measured
The primary outcome is the main question the study is designed to answer.
Predictive value of TyG index and TG/HDL-C ratio for acute coronary syndrome (ACS) in young adults
Occurrence of ACS (defined as STEMI, NSTEMI confirmed by clinical assessment, ECG changes, and cardiac biomarkers according to accepted guideline criteria) and the diagnostic/predictive performance of baseline Triglyceride-glucose (TyG) index and TG/HDL-C ratio for ACS.
Measured: On second day of admission
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Aug 2025
- Study start1 Sep 2025 (estimated)
- Primary completion1 Sep 2026 (estimated)
- Study completion30 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for TG IndexStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 130 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Saleh Mohamed Saleh, Assiut University
- Investigators
- Khaled Mohamed Abdallah, Professor, Study director, Assuit university - faculty of medicine
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07130188
- Sponsor's protocol ID
- Predictors for ACS
- Status last verified
- Aug 2025
- First submitted
- 12 Aug 2025
- Last updated
- 19 Aug 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Kim MK, Ahn CW, Kang S, Nam JS, Kim KR, Park JS. Relationship between the triglyceride glucose index and coronary artery calcification in Korean adults. Cardiovasc Diabetol. 2017 Aug 23;16(1):108. doi: 10.1186/s12933-017-0589-4.
PubMed 28830471Khalaji A, Behnoush AH, Pasebani Y, Rafati A, Mahmoodi T, Arzhangzadeh A, Shamshiri Khamene S, MohammadKhawajah I, Mehrani M, Vasheghani-Farahani A, Masoudkabir F, Najafi K, Askari MK, Harrison A, Nelson JR, Hosseini K, Hernandez AV. Triglyceride-glucose index as a predictor of cardiac adverse events in acute coronary syndrome patients undergoing percutaneous coronary intervention: role of diabetes. BMC Cardiovasc Disord. 2024 Sep 27;24(1):514. doi: 10.1186/s12872-024-04191-5.
PubMed 39333881Liu Y, Zhu B, Zhou W, Du Y, Qi D, Wang C, Cheng Q, Zhang Y, Wang S, Gao C. Triglyceride-glucose index as a marker of adverse cardiovascular prognosis in patients with coronary heart disease and hypertension. Cardiovasc Diabetol. 2023 Jun 9;22(1):133. doi: 10.1186/s12933-023-01866-9.
PubMed 37296406Ren X, Chen ZA, Zheng S, Han T, Li Y, Liu W, Hu Y. Association between Triglyceride to HDL-C Ratio (TG/HDL-C) and Insulin Resistance in Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus. PLoS One. 2016 Apr 26;11(4):e0154345. doi: 10.1371/journal.pone.0154345. eCollection 2016.
PubMed 27115999da Silva A, Caldas APS, Hermsdorff HHM, Bersch-Ferreira AC, Torreglosa CR, Weber B, Bressan J. Triglyceride-glucose index is associated with symptomatic coronary artery disease in patients in secondary care. Cardiovasc Diabetol. 2019 Jul 11;18(1):89. doi: 10.1186/s12933-019-0893-2.
PubMed 31296225
Study at a glance
From the registry record, last updated by the sponsor on 19 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Significance of Triglyceride Index and TG/HDL-C Ratios as Predictors of Acute Coronary Syndromes in Young Population and the Complexity of Coronary Artery Disease
- ClinicalTrials.gov ID
- NCT07130188
- Acronym / sponsor ID
- Predictors for ACS
- Conditions
- TG Index, TG/HDL-C Ratio, Young Population
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 130 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Sep 2025 (estimated)
- Primary completion
- 1 Sep 2026 (estimated)
- Study completion
- 30 Dec 2026 (estimated)
- First posted
- 19 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To evaluate the significance of the Triglyceride index and TG/HDL-C ratio as predictors of acute coronary syndromes in the young population
Detailed description
Cardiovascular disease (CVD) remains a major cause of morbidity and mortality worldwide, with a rising incidence of acute coronary syndromes (ACS) in young individuals under the age of 40. Early identification of at-risk individuals in this population is essential for implementing preventive strategies and reducing adverse outcomes【1,2】. Traditional risk factors such as hypertension, diabetes, smoking, and dyslipidemia are well-established; however, their predictive value in the young population is often limited【2】.
Recent studies have highlighted the significance of novel lipid-derived markers, particularly the triglyceride-glucose (TyG) index and the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, as potential predictors of insulin resistance, subclinical atherosclerosis, and cardiovascular events【1,3】. The TyG index and TG/HDL-C ratio are simple, cost-effective markers derived from routine laboratory parameters and have shown promising associations with metabolic syndrome, endothelial dysfunction, and coronary artery disease (CAD) severity【3,4】.
Despite emerging evidence in older adults, limited data exist regarding the utility of these markers in predicting ACS among the young population, where conventional risk scores often underestimate risk【4,5】. Early detection through these markers could improve risk stratification and guide preventive strategies.
This study aims to evaluate the significance of the TyG index and TG/HDL-C ratio as predictors of ACS in young adults, providing insight into their potential role in primary prevention
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- Young adult patients (18-45 years) admitted with acute coronary syndrome (STEMI, NSTEMI) who undergo coronary angiography during index hospitalization. Patients must have fasting lipid profile and fasting glucose measured within 24 hours of admission. Exclusions include familial hyperlipidemia, chronic inflammatory/autoimmune disease, severe renal or liver failure, active infection, recent use of non-statin lipid-altering drugs, or missing data for TyG/TG-HDL-C calculation. Follow-up will be conducted at 12 and 36 months to assess outcomes.
Key inclusion criteria (2 listed)
- -
- Age 18-40 years. Confirmed diagnosis of ACS (STEMI, NSTEMI). Willingness to participate with informed consent.
Key exclusion criteria (1 listed)
- Age > 40 years old People with Previous ACS Patients known to have familial hyperlipidemia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PCICoronary angiography then SYNTAX score calculation | Diagnostic test | – |
Primary outcome
Predictive value of TyG index and TG/HDL-C ratio for acute coronary syndrome (ACS) in young adults
Time frame: On second day of admission
Occurrence of ACS (defined as STEMI, NSTEMI confirmed by clinical assessment, ECG changes, and cardiac biomarkers according to accepted guideline criteria) and the diagnostic/predictive performance of baseline Triglyceride-glucose (TyG) index and TG/HDL-C ratio for ACS.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Aug 2025.
- Results publication: PubMed 28830471Kim MK, Ahn CW, Kang S, Nam JS, Kim KR, Park JS. Relationship between the triglyceride glucose index and coronary artery calcification in Korean adults. Cardiovasc Diabetol. 2017 Aug 23;16(1):108. doi: 10.1186/s12933-017-0589-4.
- Results publication: PubMed 39333881Khalaji A, Behnoush AH, Pasebani Y, Rafati A, Mahmoodi T, Arzhangzadeh A, Shamshiri Khamene S, MohammadKhawajah I, Mehrani M, Vasheghani-Farahani A, Masoudkabir F, Najafi K, Askari MK, Harrison A, Nelson JR, Hosseini K, Hernandez AV. Triglyceride-glucose index as a predictor of cardiac adverse events in acute coronary syndrome patients undergoing percutaneous coronary intervention: role of diabetes. BMC Cardiovasc Disord. 2024 Sep 27;24(1):514. doi: 10.1186/s12872-024-04191-5.
- Results publication: PubMed 37296406Liu Y, Zhu B, Zhou W, Du Y, Qi D, Wang C, Cheng Q, Zhang Y, Wang S, Gao C. Triglyceride-glucose index as a marker of adverse cardiovascular prognosis in patients with coronary heart disease and hypertension. Cardiovasc Diabetol. 2023 Jun 9;22(1):133. doi: 10.1186/s12933-023-01866-9.
- Results publication: PubMed 27115999Ren X, Chen ZA, Zheng S, Han T, Li Y, Liu W, Hu Y. Association between Triglyceride to HDL-C Ratio (TG/HDL-C) and Insulin Resistance in Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus. PLoS One. 2016 Apr 26;11(4):e0154345. doi: 10.1371/journal.pone.0154345. eCollection 2016.
- Results publication: PubMed 31296225da Silva A, Caldas APS, Hermsdorff HHM, Bersch-Ferreira AC, Torreglosa CR, Weber B, Bressan J. Triglyceride-glucose index is associated with symptomatic coronary artery disease in patients in secondary care. Cardiovasc Diabetol. 2019 Jul 11;18(1):89. doi: 10.1186/s12933-019-0893-2.
- Individual participant dataSharing planned: Undecided
Related trials for TG Index
Not yet recruitingObservational study
The Correlation Between hs CRP TG Triglycerides Glucose Index in NAFLD and Liver Fibrosis
Liver Fibrosis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mohamed Osman Abdelhameed, Lecturer contact
Khaled Mohamed Abdallah, Professor study director
Assuit university - faculty of medicine
Questions about this trial
What is this clinical trial studying?
An observational study of TG Index and TG/HDL-C Ratio, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 19 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Saleh Mohamed Saleh, Resident (+201094568705, Saleh.17298603@med.aun.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Predictive value of TyG index and TG/HDL-C ratio for acute coronary syndrome (ACS) in young adults (time frame: On second day of admission). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07130188, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Aug 2025.