StrokeNCT07139379
Effects of Virtual Reality Multisensory Cooperative Task-Oriented Mirror Therapy
A study testing task-oriented training, Virtual Reality Mirror Therapy and Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy in people with Stroke and Rehabilitation, run by National Cheng-Kung University Hospital at 1 site in Taiwan.
Trial summary
In the proposed study, the investigators assumed that Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Therapy (VRMCTOMT) will provide a better treatment effects than traditional virtual reality mirror therapy (VRMT) for the patients with unilateral stroke. Read more about this study
- Who is it for?
- Ages 18 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Stroke, Rehabilitation, Virtual Reality
- What is being tested?
- task-oriented training, Virtual Reality Mirror Therapy and Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 1 siteTaiwan
- Study dates
- 24 Jun 2025to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Clinical diagnosis of stroke with unilateral side involved;
- A score of Mini-mental state examination greater than 24 for proving higher mental function
- Time of onset > 6 months before treatment begins; and
- Premorbid right-handedness.
Who cannot join
- Severe vision impairment;
- Major cognitive-perceptual deficit;
- Other brain disease.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan1 site, 1 recruiting
- Recruiting
National Cheng-Kung University Hospital
Tainan, Taiwan, 704
Hsiu-Yun Hsu, 886-6-2353535 ext. 2669, hyhsu@mail.ncku.edu.tw
About this study
Official title: Virtual Reality Multisensory Cooperative Task-Oriented Mirror Therapy for Neuro-Rehabilitation
In the proposed study, the investigators assumed that Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Therapy (VRMCTOMT) will provide a better treatment effects than traditional virtual reality mirror therapy (VRMT) for the patients with unilateral stroke. The aim of the study is to examine the difference in the treatment effects among the combination of task-oriented training with either VRMCTOMT, or VRMT on the upper extremity function and brain activity of the stroke patients.
- Being tested
- task-oriented training, Virtual Reality Mirror Therapy, Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
task-oriented trainingOther
Motor training targeted to goals that are relevant to the functional needs of the patient
Virtual Reality Mirror TherapyOther
Virtual Reality Mirror Therapy using goggle
Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror TherapyOther
Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy using goggle
| Study group | Role | What they receive |
|---|---|---|
| Virtual Reality Mirror Therapy Group | Active comparator | 30 minutes of task-based Virtual Reality Mirror Therapy combined with 20 minutes of conventional task-oriented therapy. Receives: Other: task-oriented training; Other: Virtual Reality Mirror Therapy |
| Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy Group | Experimental | 30 minutes of Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy combined with 20 minutes of conventional task-oriented therapy. Receives: Other: task-oriented training; Other: Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in the result of Fugl-Meyer assessment (FMA) for motor function of upper extremity test
Each item is rated on a three-point ordinal scale (2 points for the detail being performed completely, 1 point for the detail being performed partially, and 0 for the detail not being performed). The maximum motor performance score is 66 points for the upper extremity.
Measured: baseline, 9 weeks and 21 weeks
Secondary outcomes (1)
Change in the result of Modified Ashworth scale (MAS)
Muscle tone is defined by assess muscle tone by evaluating resistance to passive stretch, reflecting the level of spasticity, with scores ranging from 0 (no increase in tone) to 4 (rigidity in flexion or extension).
Measured: baseline, 9 weeks and 21 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Aug 2025
- Study start24 Jun 2025
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 44 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Cheng-Kung University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07139379
- Sponsor's protocol ID
- A-ER-113-307
- Status last verified
- May 2025
- First submitted
- 15 Aug 2025
- Last updated
- 15 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Virtual Reality Multisensory Cooperative Task-Oriented Mirror Therapy for Neuro-Rehabilitation
- ClinicalTrials.gov ID
- NCT07139379
- Acronym / sponsor ID
- A-ER-113-307
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 44 participants (estimated)
- Lead sponsor
- National Cheng-Kung University HospitalUniversity, hospital or other
- Study start
- 24 Jun 2025 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 24 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In the proposed study, the investigators assumed that Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Therapy (VRMCTOMT) will provide a better treatment effects than traditional virtual reality mirror therapy (VRMT) for the patients with unilateral stroke. The aim of the study is to examine the difference in the treatment effects among the combination of task-oriented training with either VRMCTOMT, or VRMT on the upper extremity function and brain activity of the stroke patients.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Virtual Reality Mirror Therapy Group | Active comparator | Other: task-oriented training, Other: Virtual Reality Mirror Therapy30 minutes of task-based Virtual Reality Mirror Therapy combined with 20 minutes of conventional task-oriented therapy. |
| Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy Group | Experimental | Other: task-oriented training, Other: Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy30 minutes of Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy combined with 20 minutes of conventional task-oriented therapy. |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Clinical diagnosis of stroke with unilateral side involved;
- A score of Mini-mental state examination greater than 24 for proving higher mental function
- Time of onset > 6 months before treatment begins; and
- Premorbid right-handedness.
Key exclusion criteria (3 listed)
- Severe vision impairment;
- Major cognitive-perceptual deficit;
- Other brain disease.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| task-oriented trainingMotor training targeted to goals that are relevant to the functional needs of the patient | Other | Virtual Reality Mirror Therapy Group, Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy Group |
| Virtual Reality Mirror TherapyVirtual Reality Mirror Therapy using goggle | Other | Virtual Reality Mirror Therapy Group |
| Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror TherapyVirtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy using goggle | Other | Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy Group |
Primary outcome
Change in the result of Fugl-Meyer assessment (FMA) for motor function of upper extremity test
Time frame: baseline, 9 weeks and 21 weeks
Each item is rated on a three-point ordinal scale (2 points for the detail being performed completely, 1 point for the detail being performed partially, and 0 for the detail not being performed). The maximum motor performance score is 66 points for the upper extremity.
1 secondary outcome
Change in the result of Modified Ashworth scale (MAS)
Time frame: baseline, 9 weeks and 21 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Apr 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing task-oriented training, Virtual Reality Mirror Therapy and Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy in people with Stroke and Rehabilitation, run by National Cheng-Kung University Hospital at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 15 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Hsiu-Yun Hsu, Ph.D (886-6-2353535 ext. 2669, hyhsu@mail.ncku.edu.tw), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in the result of Fugl-Meyer assessment (FMA) for motor function of upper extremity test (time frame: baseline, 9 weeks and 21 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Apr 2026.