Pleural Tissue CultureNCT07140003
Pleural Tissue Culture Versus Pleural Fluid Culture in Infected Effusion
A study testing pleural biopsy in people with Pleural Tissue Culture, run by Alexandria University at 1 site in Egypt.
Trial summary
comparison between the result of fluid culture and that of pleural tissue culture Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Pleural Tissue Culture
- What is being tested?
- pleural biopsy
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jul 2025to Oct 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Exudate neutrophilic pleural fluid aspirate, or met at least one or more of the following criteria: grossly frank purulent, gram stain positive for bacteria, bacterial culture positive, acidic with a pH <7.20, low pleural fluid glucose (<55mg/dL), and CT evidence of pleural infection. Exclusion criteria: Pleural infections by Mycobacterium tuberculosis.Malignant effusion.Coagulation defects.
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site
Chest Department -Faculty of Medicine
Alexandria, Chest Department, 11511
About this study
Official title: Microbiological Value of Sonographic Guided Pleural Tissue Culture Plus Pleural Fluid Culture in Patients With Infected Pleural Fluid
comparison between the result of fluid culture and that of pleural tissue culture
Read the detailed description
MICROBIOLOGICAL VALUE OF SONOGRAPHIC GUIDED PLEURAL TISSUE CULTURE PLUS PLEURAL FLUID CULTURE IN PATIENTS WITH INFECTED PLEURAL FLUID
- Conditions
- Pleural Tissue Culture
- Being tested
- pleural biopsy
- Keywords
- pleural tissue culture ,infected pleural fluid
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
pleural biopsyProcedure or surgery
To assess whether pleural tissue culture can improve the identification of causative organisms in pleural infections (using the pleural fluid culture), which can aid in selecting appropriate antimicrobial therapy and improve treatment outcomes, thus may provide valuable insights into the utility of pleural tissue culture in managing pleural infection and may guide clinicians in selecting the most appropriate diagnostic approach.
| Study group | Role | What they receive |
|---|---|---|
| one group of patients will undergo pleural fluid culture taken by ultrasound chest by 18 gauge needl | Active comparator | microbiological culture of the fluid Receives: Procedure: pleural biopsy |
| sonographic guided pleural tissue culture | Active comparator | pareital pleural biobsy will be taken from the posterior costal pleura by ultrasound via true cut biopsy 12 french and tissue will be sent to the micro alab Receives: Procedure: pleural biopsy |
What is being measured
The primary outcome is the main question the study is designed to answer.
initial pleural fluid and parietal pleural tissue
the result of culture
Measured: 2 weeks
result of culture
the result of pleural fluid culture and the pleural tissue culture result
Measured: one month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Aug 2025
- Study start1 Jul 2025
- Primary completionSep 2025 (estimated)
- Study completionOct 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pleural Tissue CultureStudies of the same condition, open and under way.
- More trials run by Alexandria UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- MICROBIOLOGICAL VALUE OF SONOGRAPHIC GUIDED PLEURAL TISSUE CULTURE PLUS PLEURAL FLUID CULTURE IN PATIENTS WITH INFECTED PLEURAL FLUID
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Alexandria University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- mohamed sabry eltarhony, lecturer, Principal investigator, Alexandria Universityhatem essam hamed, lecturer, Study director, Alexandria University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07140003
- Sponsor's protocol ID
- pleura,tissue culture,sonograp
- Status last verified
- Jul 2025
- First submitted
- 12 Aug 2025
- Last updated
- 24 Aug 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: according to the policy of ethics committee
Study at a glance
From the registry record, last updated by the sponsor on 24 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Microbiological Value of Sonographic Guided Pleural Tissue Culture Plus Pleural Fluid Culture in Patients With Infected Pleural Fluid
- ClinicalTrials.gov ID
- NCT07140003
- Acronym / sponsor ID
- pleura,tissue culture,sonograp
- Conditions
- Pleural Tissue Culture
- Keywords
- pleural tissue culture ,infected pleural fluid
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Alexandria UniversityUniversity, hospital or other
- Study start
- 1 Jul 2025 (actual)
- Primary completion
- Sep 2025 (estimated)
- Study completion
- Oct 2025 (estimated)
- First posted
- 24 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
comparison between the result of fluid culture and that of pleural tissue culture
Detailed description
MICROBIOLOGICAL VALUE OF SONOGRAPHIC GUIDED PLEURAL TISSUE CULTURE PLUS PLEURAL FLUID CULTURE IN PATIENTS WITH INFECTED PLEURAL FLUID
Study design
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- MICROBIOLOGICAL VALUE OF SONOGRAPHIC GUIDED PLEURAL TISSUE CULTURE PLUS PLEURAL FLUID CULTURE IN PATIENTS WITH INFECTED PLEURAL FLUID
| Arm | Type | Receives |
|---|---|---|
| one group of patients will undergo pleural fluid culture taken by ultrasound chest by 18 gauge needl | Active comparator | Procedure: pleural biopsymicrobiological culture of the fluid |
| sonographic guided pleural tissue culture | Active comparator | Procedure: pleural biopsypareital pleural biobsy will be taken from the posterior costal pleura by ultrasound via true cut biopsy 12 french and tissue will be sent to the micro alab |
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (1 listed)
- Exudate neutrophilic pleural fluid aspirate, or met at least one or more of the following criteria: grossly frank purulent, gram stain positive for bacteria, bacterial culture positive, acidic with a pH <7.20, low pleural fluid glucose (<55mg/dL), and CT evidence of pleural infection. Exclusion criteria: Pleural infections by Mycobacterium tuberculosis.Malignant effusion.Coagulation defects.
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| pleural biopsyTo assess whether pleural tissue culture can improve the identification of causative organisms in pleural infections (using the pleural fluid culture), which can aid in selecting appropriate antimicrobial therapy and improve treatment outcomes, thus may provide valuable insights into the utility of pleural tissue culture in managing pleural infection and may guide clinicians in selecting the most appropriate diagnostic approach. | Procedure or surgery | one group of patients will undergo pleural fluid culture taken by ultrasound chest by 18 gauge needl, sonographic guided pleural tissue culture |
Primary outcome
initial pleural fluid and parietal pleural tissue
Time frame: 2 weeks
the result of culture
result of culture
Time frame: one month
the result of pleural fluid culture and the pleural tissue culture result
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Aug 2025.
- national library of informationLink provided by the sponsor.
- Individual participant dataSharing planned: No. according to the policy of ethics committee
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
mohamed sabry eltarhony, lecturer principal investigator
Alexandria University
hatem essam hamed, lecturer study director
Alexandria University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing pleural biopsy in people with Pleural Tissue Culture, run by Alexandria University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 24 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
initial pleural fluid and parietal pleural tissue (time frame: 2 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Aug 2025.