Healthy Male and Female SubjectsELBEngLückNCT07140536
The Impact of Treadmills and Cooler Environments for Office Workplaces on Ergonomics, Heating Energy Requirements, Performance, as Well as Back and Cardiometabolic Health
A study testing Environmental temperature and Physical activity in people with Healthy Male and Female Subjects, run by RWTH Aachen University at 1 site in Germany.
Trial summary
The aim of the project is to gain insights into the effects of treadmills at a standing desk and reduced room temperature on back and cardiometabolic health, cognitive performance, thermal comfort, and the associated heating energy requirements of buildings. Read more about this study
- Who is it for?
- Ages 18 to 40 years
- Conditions the study is for
- Healthy Male and Female Subjects
- What is being tested?
- Environmental temperature and Physical activity
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 16 participants
- Where
- 1 siteGermany
- Study dates
- 3 Jul 2025to 31 Aug 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Physically active, healthy test subjects
- Participants who are able to understand the research project
- Adult test volunteers (aged >18 and <40)
- German language skills at B2-C2 level
Who cannot join
- An implanted pacemaker
- Participants who are unable to give consent/participants with a legal representative
- Age under 18 or over 40
- Pregnant participants
- Participants with a BMI >28
- Participants with underlying diseases with significant functional limitations (e.g., rheumatoid arthritis, diabetes mellitus, high blood pressure)
- Reading and/or spelling disorders or combined disorders of scholastic skills (ICD-10 F81.0 - F81.3)
- Participants with a possible SARS-CoV-2 infection will be excluded from the study for the duration of the infection
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Einfluss Von Laufbändern für Büroarbeitsplätze Auf Ergonomie, Heizenergiebedarf, Leistungsfähigkeit Sowie Rücken- Und Kardiometabolische Gesundheit
The aim of the project is to gain insights into the effects of treadmills at a standing desk and reduced room temperature on back and cardiometabolic health, cognitive performance, thermal comfort, and the associated heating energy requirements of buildings.
Healthy young men and women will spend four consecutive days in a controlled laboratory office environment after a baseline visit. During the baseline visit, volunteers are familiarized with the treadmill and start wearing a continuous glucose monitor. The four consecutive laboratory office days are each scheduled from 8:30AM to 04:30PM. In a randomized order, participants the first two office days either at 19°C or 23°C room temperature. The first office day of each temperature conditions is spent only sedentary, while for the second one is regularly interrupted with light walking on the treadmill. Otherwise, the daily routine and test battery will be exactly the same between days, including a standardized breakfast and lunch meal, an attention task in the morning, and frequent subjective thermal comfort ratings and blood pressure measurements. Interstitial glucose as well as heart rate and heart rate variability will be continuously monitored through wearable devices. Treadmill walking will be videorecorded.
Read the detailed description
This is a controlled intervention study with a crossover design. Participants are assigned to different conditions in which they perform both sedentary and walking desk activities at different room temperatures.
Intervention conditions:
I: Sedentary activity at standard room temperature (23°C) II: Walking activity at standard room temperature (23°C) III: Sedentary activity at lowered room temperature (19°C) IV: Walking activity at lowered room temperature (19°C)
Each condition is carried out over a defined period, with corresponding 24-hour washout periods between conditions to minimize carry-over effects.
Participants are expected to attend a total of five in-person appointments at the indoor climate laboratory of the Chair of Building Services Engineering at RWTH Aachen University. On Day 0, an introduction to the local conditions will take place before the actual study week begins, and the continuous glucose monitor is individually placed on the upper arm. In the following study week, four consecutive experimental study days are planned. Participants will go through two different scenarios: Six participants will first experience a warm exposure for two days, followed by a cold exposure for two days, while the other six will start with a cold exposure and end with the warm exposure. Allocation of participants to the two sequences of the four experimental conditions (Sequence 1: I-II-III-IV; Sequence 2: III-IV-I-II) is performed using stratified block randomization. A computer-generated randomization procedure is used to ensure that participants are evenly distributed between both sequences. Randomization is carried out before the first test session. To ensure a balanced gender distribution, ideally three men and three women will start with Sequence 1, and three men and three women with Sequence 2.
Participants meet at 8:30 a.m. at the indoor climate laboratory of the Chair of Building Services Engineering and begin preparations, during which the required sensors for data collection are attached. The clothing level of participants will be approximately 0.8 clo for all conditions (DIN EN ISO 9920, 2009-10: Ergonomics of the thermal environment - Estimation of the thermal insulation and evaporative resistance of a clothing ensemble). In practice, this results in the following clothing requirement, which will be communicated to participants on Day 0: underwear, socks, shoes, long trousers, T-shirt/undershirt, and a long-sleeved shirt.
Each of the four laboratory office days follows in principle the same time course. From 08:30AM onwards, a chest-worn heart rate monitor belt is started to be worn. At 9:00AM, a breakfast meal (standardized liquid meal) will be taken under controlled conditions. This is followed at 10:00AM by the first activity phase: participants in the walking conditions walk for one hour on the treadmill, while those in the sedentary conditions perform seated work and remain seated throughout. From 10 to 11:00AM, participants will perform an attention task on a computer. At 11:00AM, a recovery phase begins, during which participants complete a standardized questionnaires for subjective ratings. At 12:30, lunch is served (e.g., bread, fruit, and cereal bars). Starting at 1:00PM, four consecutive short activity periods take place every hour: for 15 minutes each, participants in the walking conditions walk on the treadmill, while those in the sedentary conditions continue to sit, interspersed with 45 min sitting for all conditions. At 4:15PM after the last walking activity, a final survey is conducted, during which a concluding questionnaire is completed to evaluate the overall experience and any changes in well-being. At regular intervals over each laboratory office day, participants will be asked to rate their thermal comfort on digital scales and blood pressure will be measured preceding and following walking periods. Each laboratory day officially ends at 4:30PM with the removal of sensors and the participants' departure. Only the continuous glucose monitor will only be removed on the fourth and last test day.
- Conditions
- Healthy Male and Female Subjects
- Being tested
- Environmental temperature, Physical activity
- Keywords
- sit less, break sitting time, ergonomics, cardiometabolic health, thermal comfort, office treadmill, glucose control, blood pressure, attention
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Environmental temperatureOther
The office is day is spent in 19 or 23°C room temperature from 08:30AM to 04:30PM.
Physical activityBehavioural
From 08:30AM to 04:30PM, the office is day is spent either fully sedentary or interspersed with light walking on a treadmill (60 min at 10:00AM, 15 min at 01:00PM, 15 min at 02:00PM, 15 min at 03:00PM, 15 min at 04:00PM).
| Study group | Role | What they receive |
|---|---|---|
| Sedentary activity at standard room temperature (23°C) | Experimental | Sedentary activity at standard room temperature (23°C) Receives: Other: Environmental temperature; Behavioral: Physical activity |
| Walking activity at standard room temperature (23°C) | Experimental | Walking activity at standard room temperature (23°C) Receives: Other: Environmental temperature; Behavioral: Physical activity |
| Sedentary activity at lowered room temperature (19°C) | Experimental | Sedentary activity at lowered room temperature (19°C) Receives: Other: Environmental temperature; Behavioral: Physical activity |
| Walking activity at lowered room temperature (19°C) | Experimental | Walking activity at lowered room temperature (19°C) Receives: Other: Environmental temperature; Behavioral: Physical activity |
What is being measured
The primary outcome is the main question the study is designed to answer.
Subjective thermal comfort rating
Measured: At regular intervals over each of the four laboratory office days
Interstitial glucose levels
Interstitial glucose levels measured by continuous glucose monitors
Measured: Continuously sampled every 15 min over all four laboratory office days
Working memory assessed by the TAP (Zimmermann & Fimm, 2002) n-back task
Participants view sequences of numbers and indicate whether the current number matches one presented one or two steps earlier. Outcome variables are accuracy (% correct) and reaction time (ms).
Measured: 10:00-11:00 AM during each of the four laboratory office days
Divided attention assessed by the TAP (Zimmermann & Fimm, 2002) divided attention task
Participants simultaneously perform a visual and an auditory discrimination task. Outcome variables are reaction time (ms) and error rates.
Measured: 10:00-11:00 AM during each of the four laboratory office days
Secondary outcomes (10)
Systolic and diastolic blood pressure
Manually measured via automated blood pressure cuffs
Measured: at 09:00, 11:00, 12:30, 14:30 and 16:00 over all four laboratory office days
Heart rate
assessed continuously via chest-worn belts
Measured: continuously from 08:30AM to 04:30PM over all four laboratory office days
Heart rate variability
assessed continuously via chest-worn belts
Measured: continuously from 08:30AM to 04:30PM over all four laboratory office days
Skin temperature
via adhesive thermal sensors placed on different skin regions
Measured: continuously from 08:30AM to 04:30PM over all four laboratory office days
Cognitive flexibility assessed by the TAP (Zimmermann & Fimm, 2002) task-switching module
Participants alternate their responses to different types of visual stimuli based on changing task rules. Outcome variables are reaction time (ms) and number of errors.
Measured: 10:00-11:00 AM during each of the four laboratory office days
Intrinsic and phasic alertness assessed by the TAP (Zimmermann & Fimm, 2002) alertness task
Participants respond to visual stimuli on a screen with and without an auditory warning cue. Outcome variables are reaction time (ms) and error rates.
Measured: 10:00-11:00 AM during each of the four laboratory office days
Sustained attention assessed by the TAP (Zimmermann & Fimm, 2002) sustained attention task
Participants monitor a continuous stream of visual stimuli and respond when the current item matches the previous one in certain features. Outcome variables are reaction time (ms), omission errors, and commission errors.
Measured: 10:00-11:00 AM during each of the four laboratory office days
Hip joint angles and dynamics during gait assessed by sagittal plane video analysis
Range of motion, angular displacement, and angular velocity of the hip joint will be extracted from sagittal plane video recordings during walking.
Measured: During the walking period between 10:00-11:00 AM on each of the 4 laboratory days
Knee joint angles and dynamics during gait assessed by sagittal plane video analysis
Range of motion, angular displacement, and angular velocity of the knee joint will be extracted from sagittal plane video recordings during walking.
Measured: During the walking period between 10:00-11:00 AM on each of the 4 laboratory days
Spinal joint angles and dynamics during gait assessed by sagittal plane video analysis
Range of motion, angular displacement, and angular velocity of the spine will be extracted from sagittal plane video recordings during walking.
Measured: During the walking period between 10:00-11:00 AM on each of the 4 laboratory days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Aug 2025
- Study start3 Jul 2025
- Primary completion31 Aug 2025
- Study completion31 Aug 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy Male and Female SubjectsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 16 participants (actual)
Sponsor and investigators
- Lead sponsor
- RWTH Aachen University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jan-Frieder Harmsen, RWTH Aachen University
- Investigators
- Jan-Frieder Harmsen, PhD, Principal investigator, RWTH Aachen University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07140536
- Sponsor's protocol ID
- EK 25-134
- Acronym
- ELBEngLück
- Status last verified
- Dec 2025
- First submitted
- 11 Aug 2025
- Last updated
- 16 Dec 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The study protocol can be requested via email to study officials.
Study at a glance
From the registry record, last updated by the sponsor on 16 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Einfluss Von Laufbändern für Büroarbeitsplätze Auf Ergonomie, Heizenergiebedarf, Leistungsfähigkeit Sowie Rücken- Und Kardiometabolische Gesundheit
- ClinicalTrials.gov ID
- NCT07140536
- Acronym / sponsor ID
- ELBEngLück / EK 25-134
- Conditions
- Healthy Male and Female Subjects
- Keywords
- sit less, break sitting time, ergonomics, cardiometabolic health, thermal comfort, office treadmill, glucose control, blood pressure
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 16 participants (actual)
- Lead sponsor
- RWTH Aachen UniversityUniversity, hospital or other
- Study start
- 3 Jul 2025 (actual)
- Primary completion
- 31 Aug 2025 (actual)
- Study completion
- 31 Aug 2025 (actual)
- First posted
- 24 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of the project is to gain insights into the effects of treadmills at a standing desk and reduced room temperature on back and cardiometabolic health, cognitive performance, thermal comfort, and the associated heating energy requirements of buildings.
Healthy young men and women will spend four consecutive days in a controlled laboratory office environment after a baseline visit. During the baseline visit, volunteers are familiarized with the treadmill and start wearing a continuous glucose monitor. The four consecutive laboratory office days are each scheduled from 8:30AM to 04:30PM. In a randomized order, participants the first two office days either at 19°C or 23°C room temperature. The first office day of each temperature conditions is spent only sedentary, while for the second one is regularly interrupted with light walking on the treadmill. Otherwise, the daily routine and test battery will be exactly the same between days, including a standardized breakfast and lunch meal, an attention task in the morning, and frequent subjective thermal comfort ratings and blood pressure measurements. Interstitial glucose as well as heart rate and heart rate variability will be continuously monitored through wearable devices. Treadmill walking will be videorecorded.
Detailed description
This is a controlled intervention study with a crossover design. Participants are assigned to different conditions in which they perform both sedentary and walking desk activities at different room temperatures.
Intervention conditions:
I: Sedentary activity at standard room temperature (23°C) II: Walking activity at standard room temperature (23°C) III: Sedentary activity at lowered room temperature (19°C) IV: Walking activity at lowered room temperature (19°C)
Each condition is carried out over a defined period, with corresponding 24-hour washout periods between conditions to minimize carry-over effects.
Participants are expected to attend a total of five in-person appointments at the indoor climate laboratory of the Chair of Building Services Engineering at RWTH Aachen University. On Day 0, an introduction to the local conditions will take place before the actual study week begins, and the continuous glucose monitor is individually placed on the upper arm. In the following study week, four consecutive experimental study days are planned. Participants will go through two different scenarios: Six participants will first experience a warm exposure for two days, followed by a cold exposure for two days, while the other six will start with a cold exposure and end with the warm exposure. Allocation of participants to the two sequences of the four experimental conditions (Sequence 1: I-II-III-IV; Sequence 2: III-IV-I-II) is performed using stratified block randomization. A computer-generated randomization procedure is used to ensure that participants are evenly distributed between both sequences. Randomization is carried out before the first test session. To ensure a balanced gender distribution, ideally three men and three women will start with Sequence 1, and three men and three women with Sequence 2.
Participants meet at 8:30 a.m. at the indoor climate laboratory of the Chair of Building Services Engineering and begin preparations, during which the required sensors for data collection are attached. The clothing level of participants will be approximately 0.8 clo for all conditions (DIN EN ISO 9920, 2009-10: Ergonomics of the thermal environment - Estimation of the thermal insulation and evaporative resistance of a clothing ensemble). In practice, this results in the following clothing requirement, which will be communicated to participants on Day 0: underwear, socks, shoes, long trousers, T-shirt/undershirt, and a long-sleeved shirt.
Each of the four laboratory office days follows in principle the same time course. From 08:30AM onwards, a chest-worn heart rate monitor belt is started to be worn. At 9:00AM, a breakfast meal (standardized liquid meal) will be taken under controlled conditions. This is followed at 10:00AM by the first activity phase: participants in the walking conditions walk for one hour on the treadmill, while those in the sedentary conditions perform seated work and remain seated throughout. From 10 to 11:00AM, participants will perform an attention task on a computer. At 11:00AM, a recovery phase begins, during which participants complete a standardized questionnaires for subjective ratings. At 12:30, lunch is served (e.g., bread, fruit, and cereal bars). Starting at 1:00PM, four consecutive short activity periods take place every hour: for 15 minutes each, participants in the walking conditions walk on the treadmill, while those in the sedentary conditions continue to sit, interspersed with 45 min sitting for all conditions. At 4:15PM after the last walking activity, a final survey is conducted, during which a concluding questionnaire is completed to evaluate the overall experience and any changes in well-being. At regular intervals over each laboratory office day, participants will be asked to rate their thermal comfort on digital scales and blood pressure will be measured preceding and following walking periods. Each laboratory day officially ends at 4:30PM with the removal of sensors and the participants' departure. Only the continuous glucose monitor will only be removed on the fourth and last test day.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Sedentary activity at standard room temperature (23°C) | Experimental | Other: Environmental temperature, Behavioral: Physical activitySedentary activity at standard room temperature (23°C) |
| Walking activity at standard room temperature (23°C) | Experimental | Other: Environmental temperature, Behavioral: Physical activityWalking activity at standard room temperature (23°C) |
| Sedentary activity at lowered room temperature (19°C) | Experimental | Other: Environmental temperature, Behavioral: Physical activitySedentary activity at lowered room temperature (19°C) |
| Walking activity at lowered room temperature (19°C) | Experimental | Other: Environmental temperature, Behavioral: Physical activityWalking activity at lowered room temperature (19°C) |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Physically active, healthy test subjects
- Participants who are able to understand the research project
- Adult test volunteers (aged >18 and <40)
- German language skills at B2-C2 level
Key exclusion criteria (8 listed)
- An implanted pacemaker
- Participants who are unable to give consent/participants with a legal representative
- Age under 18 or over 40
- Pregnant participants
- Participants with a BMI >28
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Environmental temperatureThe office is day is spent in 19 or 23°C room temperature from 08:30AM to 04:30PM. | Other | Sedentary activity at lowered room temperature (19°C), Sedentary activity at standard room temperature (23°C), Walking activity at lowered room temperature (19°C), Walking activity at standard room temperature (23°C) |
| Physical activityFrom 08:30AM to 04:30PM, the office is day is spent either fully sedentary or interspersed with light walking on a treadmill (60 min at 10:00AM, 15 min at 01:00PM, 15 min at 02:00PM, 15 min at 03:00PM, 15 min at 04:00PM). | Behavioural | Sedentary activity at lowered room temperature (19°C), Sedentary activity at standard room temperature (23°C), Walking activity at lowered room temperature (19°C), Walking activity at standard room temperature (23°C) |
Primary outcome
Subjective thermal comfort rating
Time frame: At regular intervals over each of the four laboratory office days
Interstitial glucose levels
Time frame: Continuously sampled every 15 min over all four laboratory office days
Interstitial glucose levels measured by continuous glucose monitors
Working memory assessed by the TAP (Zimmermann & Fimm, 2002) n-back task
Time frame: 10:00-11:00 AM during each of the four laboratory office days
Participants view sequences of numbers and indicate whether the current number matches one presented one or two steps earlier. Outcome variables are accuracy (% correct) and reaction time (ms).
Divided attention assessed by the TAP (Zimmermann & Fimm, 2002) divided attention task
Time frame: 10:00-11:00 AM during each of the four laboratory office days
Participants simultaneously perform a visual and an auditory discrimination task. Outcome variables are reaction time (ms) and error rates.
10 secondary outcomes
Systolic and diastolic blood pressure
Time frame: at 09:00, 11:00, 12:30, 14:30 and 16:00 over all four laboratory office days
Heart rate
Time frame: continuously from 08:30AM to 04:30PM over all four laboratory office days
Heart rate variability
Time frame: continuously from 08:30AM to 04:30PM over all four laboratory office days
Skin temperature
Time frame: continuously from 08:30AM to 04:30PM over all four laboratory office days
Cognitive flexibility assessed by the TAP (Zimmermann & Fimm, 2002) task-switching module
Time frame: 10:00-11:00 AM during each of the four laboratory office days
Intrinsic and phasic alertness assessed by the TAP (Zimmermann & Fimm, 2002) alertness task
Time frame: 10:00-11:00 AM during each of the four laboratory office days
Sustained attention assessed by the TAP (Zimmermann & Fimm, 2002) sustained attention task
Time frame: 10:00-11:00 AM during each of the four laboratory office days
Hip joint angles and dynamics during gait assessed by sagittal plane video analysis
Time frame: During the walking period between 10:00-11:00 AM on each of the 4 laboratory days
Knee joint angles and dynamics during gait assessed by sagittal plane video analysis
Time frame: During the walking period between 10:00-11:00 AM on each of the 4 laboratory days
Spinal joint angles and dynamics during gait assessed by sagittal plane video analysis
Time frame: During the walking period between 10:00-11:00 AM on each of the 4 laboratory days
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Dec 2025.
- Individual participant dataSharing planned: Yes. The study protocol can be requested via email to study officials.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jan-Frieder Harmsen, PhD principal investigator
RWTH Aachen University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Environmental temperature and Physical activity in people with Healthy Male and Female Subjects, run by RWTH Aachen University at 1 site in Germany.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Subjective thermal comfort rating (time frame: At regular intervals over each of the four laboratory office days). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Dec 2025.