Correlation Between Second Molar Calcification Stage and CVMI for Skeletal Maturation Assessment in Egyptian PopulationNCT07141602
Correlation Between Stages of Mandibular 2nd Molar Calcification and CVMI for Assessment of Skeletal Maturation: A Cross Sectional Study
An observational study of Correlation Between Second Molar Calcification Stage and CVMI for Skeletal Maturation Assessment in Egyptian Population, run by Mohamed Abd El-Ghafour at 1 site in Egypt.
Trial summary
The aims of this study will be: 1. To investigate the relationships between mandibular second molar calcification stages and skeletal maturity in Egyptian population, and 2. To evaluate whether the mandibular second molar calcification stages can be used as a reliable diagnostic tool to assess skeletal maturity in… Read more about this study
- Who is it for?
- Ages 9 to 18 yearsHealthy volunteers can take part
- Conditions the study is for
- Correlation Between Second Molar Calcification Stage and CVMI for Skeletal Maturation Assessment in Egyptian Population
- What is being tested?
- lateral cephalometric x- ray and dental panoramic tomogram
- How many people
- 212 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Sep 2024to 1 Jul 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 9 to 18 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Study population: 212 Egyptian subjects with their age ranging between 9 and 18 years old, who will present to outpatient clinic of Orthodontic department, Faculty of Dentistry, Cairo University.
Who may be able to join
- • Chronological age ranging from 9 to 18 years
- No serious illness
- Normal overall growth and development
- Absence of abnormal dental conditions, such as impaction, transposition, and congenitally missing teeth
- Absence of previous history of trauma or disease to the face and neck
- Absence of orthodontic treatment
- No permanent teeth extracted
Who cannot join
- -
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Correlation Between Stages of Mandibular Second Molar Calcification and Cervical Vertebrae Maturation Index for Assessment of Skeletal Maturation: A Cross Sectional Study
The aims of this study will be:
- To investigate the relationships between mandibular second molar calcification stages and skeletal maturity in Egyptian population, and
- To evaluate whether the mandibular second molar calcification stages can be used as a reliable diagnostic tool to assess skeletal maturity in Egyptian population.
Read the detailed description
This cross-sectional study will include 106 Egyptian subjects with age range between 9 and 18 years old, who will present to outpatient clinic of Orthodontic department, Faculty of Dentistry, Cairo University, and will be classified according to their gender into two groups (males and females). Radiographs (panorama and cephalogram) will be collected from all study participants who meet inclusion criteria for data analysis. The inclusion criteria will be as follows:
- Chronological age ranging from 9 to 18 years
- No serious illness
- Normal overall growth and development
- Absence of abnormal dental conditions, such as impaction, transposition, and congenitally missing teeth
- Absence of previous history of trauma or disease to the face and neck
- Absence of orthodontic treatment
- No permanent teeth extracted
We will obtain panoramic and lateral cephalometric radiographs of 106 Egyptian subjects from the pretreatment records of patients attending clinics for orthodontic treatment.
All radiographic assessments will be performed in a darkened room. Any radiograph that shows motion dullness or has poor contrast will be discarded. A single radiologist will expose and develop all radiographs.
- Being tested
- lateral cephalometric x- ray and dental panoramic tomogram
- Keywords
- second molar tooth, cervical vertebrae maturation, skeletal maturation, lateral cephalogram, panorama
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
lateral cephalometric x- ray and dental panoramic tomogramDiagnostic test
lateral cephalometric x- ray and dental panoramic tomogram
| Study group | Role | What they receive |
|---|---|---|
| will include males | Not described Receives: Diagnostic Test: lateral cephalometric x- ray and dental panoramic tomogram | |
| will include females | Not described Receives: Diagnostic Test: lateral cephalometric x- ray and dental panoramic tomogram |
What is being measured
The primary outcome is the main question the study is designed to answer.
to evaluate the frequency of stage E of dental index in female subjects.
to evaluate the frequency of stage E of dental index in female subjects.
Measured: one year
Secondary outcomes (1)
to evaluate relationships between the stages of calcification of mandibular second molar (DI) and cervical vertebrae maturation index (CVMI).
to evaluate relationships between the stages of calcification of mandibular second molar (DI) and cervical vertebrae maturation index (CVMI).
Measured: one year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Aug 2025
- Study start1 Sep 2024
- Primary completion1 Jun 2027 (estimated)
- Study completion1 Jul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Correlation Between Second Molar Calcification Stage and CVMI for Skeletal Maturation Assessment in Egyptian PopulationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Prospective
- Enrolment
- 212 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mohamed Abd El-Ghafour
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Mohamed Abd El-Ghafour, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07141602
- Sponsor's protocol ID
- ORTH7-3-2
- Status last verified
- Jun 2026
- First submitted
- 19 Aug 2025
- Last updated
- 16 Jun 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Correlation Between Stages of Mandibular Second Molar Calcification and Cervical Vertebrae Maturation Index for Assessment of Skeletal Maturation: A Cross Sectional Study
- ClinicalTrials.gov ID
- NCT07141602
- Acronym / sponsor ID
- ORTH7-3-2
- Keywords
- second molar tooth, cervical vertebrae maturation, skeletal maturation, lateral cephalogram, panorama
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 212 participants (estimated)
- Lead sponsor
- Mohamed Abd El-GhafourUniversity, hospital or other
- Study start
- 1 Sep 2024 (actual)
- Primary completion
- 1 Jun 2027 (estimated)
- Study completion
- 1 Jul 2027 (estimated)
- First posted
- 26 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aims of this study will be:
- To investigate the relationships between mandibular second molar calcification stages and skeletal maturity in Egyptian population, and
- To evaluate whether the mandibular second molar calcification stages can be used as a reliable diagnostic tool to assess skeletal maturity in Egyptian population.
Detailed description
This cross-sectional study will include 106 Egyptian subjects with age range between 9 and 18 years old, who will present to outpatient clinic of Orthodontic department, Faculty of Dentistry, Cairo University, and will be classified according to their gender into two groups (males and females). Radiographs (panorama and cephalogram) will be collected from all study participants who meet inclusion criteria for data analysis. The inclusion criteria will be as follows:
- Chronological age ranging from 9 to 18 years
- No serious illness
- Normal overall growth and development
- Absence of abnormal dental conditions, such as impaction, transposition, and congenitally missing teeth
- Absence of previous history of trauma or disease to the face and neck
- Absence of orthodontic treatment
- No permanent teeth extracted
We will obtain panoramic and lateral cephalometric radiographs of 106 Egyptian subjects from the pretreatment records of patients attending clinics for orthodontic treatment.
All radiographic assessments will be performed in a darkened room. Any radiograph that shows motion dullness or has poor contrast will be discarded. A single radiologist will expose and develop all radiographs.
Study design
- Observational model
- Case only
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| will include males | – | Diagnostic Test: lateral cephalometric x- ray and dental panoramic tomogram |
| will include females | – | Diagnostic Test: lateral cephalometric x- ray and dental panoramic tomogram |
Who may qualify
- Ages
- 9 to 18 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
- Study population
- 212 Egyptian subjects with their age ranging between 9 and 18 years old, who will present to outpatient clinic of Orthodontic department, Faculty of Dentistry, Cairo University.
Key inclusion criteria (7 listed)
- • Chronological age ranging from 9 to 18 years
Key exclusion criteria (1 listed)
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| lateral cephalometric x- ray and dental panoramic tomogramlateral cephalometric x- ray and dental panoramic tomogram | Diagnostic test | will include females, will include males |
Primary outcome
to evaluate the frequency of stage E of dental index in female subjects.
Time frame: one year
to evaluate the frequency of stage E of dental index in female subjects.
1 secondary outcome
to evaluate relationships between the stages of calcification of mandibular second molar (DI) and cervical vertebrae maturation index (CVMI).
Time frame: one year
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jun 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Correlation Between Second Molar Calcification Stage and CVMI for Skeletal Maturation Assessment in Egyptian Population, run by Mohamed Abd El-Ghafour at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 16 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
to evaluate the frequency of stage E of dental index in female subjects. (time frame: one year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jun 2026.